公开(公告)号：US20160325248A1

公开(公告)日：2016-11-10

申请号：US15167712

申请日：2016-05-27

Applicant: The University Court of the University of Glasgow

Inventor： Rab Wilson ,  Jonathan M. Cooper ,  Julien Reboud

IPC: B01F13/00 ,  B01J19/00 ,  B01L3/00 ,  B01F11/02 ,  C12N13/00

CPC classification number: B01F13/0071 ,  B01F11/0266 ,  B01F2215/0073 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00824 ,  B01J2219/00828 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00905 ,  B01J2219/00932 ,  B01J2219/00952 ,  B01L3/502792 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/089 ,  B01L2400/0436 ,  B01L2400/0439 ,  B01L2400/0496 ,  C12N13/00 ,  G01N33/48 ,  Y10T436/25125

Abstract: A fluidics apparatus is disclosed for manipulation of at least one fluid sample, typically in the form of a droplet. The apparatus has a substrate surface with a sample manipulation zone for location of the fluid sample. A transducer arrangement such as an interdigitated electrode structure on a piezoelectric body provides surface acoustic waves at the substrate surface for manipulation of the fluid sample. The substrate surface has an arrangement of surface acoustic wave scattering elements forming a phononic crystal structure for affecting the transmission, distribution and/or behaviour of surface acoustic waves at the substrate surface. Also disclosed is a method for lysing a cell. In this method, the cell is comprised in a fluid sample contacting a substrate surface, the method comprising providing surface acoustic waves at the substrate surface, such that the cell lyses.

Abstract translation: 公开了用于操纵至少一种流体样品的流体装置，通常为液滴的形式。 该设备具有一个具有用于定位流体样品的样品操作区的基底表面。 诸如压电体之间的交错电极结构的换能器装置在衬底表面上提供表面声波，用于操纵流体样品。 衬底表面具有形成声子晶体结构的表面声波散射元件的布置，用于影响衬底表面处的表面声波的透射，分布和/或行为。 还公开了一种裂解细胞的方法。 在该方法中，电池被包含在与衬底表面接触的流体样品中，该方法包括在衬底表面提供表面声波，使得细胞裂解。

公开(公告)号：US09751057B2

公开(公告)日：2017-09-05

申请号：US15167712

申请日：2016-05-27

Applicant: The University Court of the University of Glasgow

Inventor： Rab Wilson ,  Jonathan M. Cooper ,  Julien Reboud

IPC: B01F13/00 ,  B01F11/02 ,  B01J19/00 ,  B01L3/00 ,  C12N13/00 ,  G01N33/48

CPC classification number: B01F13/0071 ,  B01F11/0266 ,  B01F2215/0073 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00824 ,  B01J2219/00828 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00905 ,  B01J2219/00932 ,  B01J2219/00952 ,  B01L3/502792 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/089 ,  B01L2400/0436 ,  B01L2400/0439 ,  B01L2400/0496 ,  C12N13/00 ,  G01N33/48 ,  Y10T436/25125

Abstract: A method of using a fluidics apparatus for lysing a cell. In the method, the cell is placed in a fluid sample contacting a substrate surface. The method further includes providing surface acoustic waves (SAWs) at the substrate surface, causing cell lyses.