公开(公告)号：US20140155267A1

公开(公告)日：2014-06-05

申请号：US14174442

申请日：2014-02-06

申请人： UNIVERSITAT RAMON LLULL, FUNDACIO PRIVADA ,  INSTITUT QUIMIC DE SARRIA CETS, FUNDACIO PRIVADA

发明人： Salvador Borros Gomez ,  David Horna Tomas

IPC分类号： A61K47/34 ,  A01N59/20 ,  A01N25/02 ,  A61K33/42

CPC分类号： A61K47/34 ,  A01N25/02 ,  A01N59/20 ,  A61K33/42 ,  A61L27/44 ,  C08K3/22 ,  C08K3/30 ,  C08K3/38 ,  C08K3/40 ,  C08K2003/325

摘要： This invention relates to a thermoplastic paste with a highly thixotropic rheology, the components of which are a block biopolymer and a bioceramic. The material described herein can be used in bone implants and in the regeneration of both animal and plant live tissues.

摘要翻译： 本发明涉及具有高触变性流变性的热塑性糊料，其组分为块状生物聚合物和生物陶瓷。 本文所述的材料可用于骨植入物和动物和植物活组织的再生。

公开(公告)号：US06777231B1

公开(公告)日：2004-08-17

申请号：US09936665

申请日：2001-09-10

申请人： Adam J. Katz ,  Ramon Llull ,  William J. Futrell ,  Marc H. Hedrick ,  Prosper Benhaim ,  Hermann Peter Lorenz ,  Min Zhu

发明人： Adam J. Katz ,  Ramon Llull ,  William J. Futrell ,  Marc H. Hedrick ,  Prosper Benhaim ,  Hermann Peter Lorenz ,  Min Zhu

IPC分类号： C12N500

CPC分类号： C12N5/0667 ,  A61K35/12 ,  A61K48/00 ,  C12N5/0068 ,  C12N5/06 ,  C12N5/0647 ,  C12N5/0654 ,  C12N5/0655 ,  C12N5/0658 ,  C12N2500/25 ,  C12N2500/38 ,  C12N2500/42 ,  C12N2501/01 ,  C12N2501/33 ,  C12N2501/39 ,  C12N2502/1305 ,  C12N2506/1384 ,  C12N2510/00 ,  C12N2533/90

摘要： The present invention provides adipose-derived stem cells and lattices. In one aspect, the present invention provides a lipo-derived stem cell substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The cells can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the cells can be expanded and cultured to produce hormones and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a lipo-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.

摘要翻译： 本发明提供脂肪来源的干细胞和晶格。 一方面，本发明提供了一种基本上不含脂肪细胞和结缔组织干细胞的红细胞和克隆群的脂衍生的干细胞。 细胞可以单独使用或在生物相容性组合物内使用，以在体内和体外产生分化的组织和结构。 此外，细胞可以扩增和培养以产生激素，并提供条件培养基以支持其他细胞群的生长和扩增。 另一方面，本发明提供了一种基本上不含细胞的脂衍生晶格，其包括来自脂肪组织的细胞外基质材料。 晶格可以用作底物，以促进细胞的生长和分化，无论是在体内还是在体外，成为成体组织或甚至成熟的组织或结构。

公开(公告)号：US20130224858A1

公开(公告)日：2013-08-29

申请号：US13852463

申请日：2013-03-28

申请人： Adam J. Katz ,  Ramon Llull ,  J. William Futrell ,  Marc H. Hedrick ,  Prosper Benhaim ,  Hermann Peter Lorenz ,  Min Zhu

发明人： Adam J. Katz ,  Ramon Llull ,  J. William Futrell ,  Marc H. Hedrick ,  Prosper Benhaim ,  Hermann Peter Lorenz ,  Min Zhu

IPC分类号： C12N5/07

CPC分类号： C12N5/0667 ,  A61K35/12 ,  A61K48/00 ,  C12N5/0068 ,  C12N5/06 ,  C12N5/0647 ,  C12N5/0654 ,  C12N5/0655 ,  C12N5/0658 ,  C12N2500/25 ,  C12N2500/38 ,  C12N2500/42 ,  C12N2501/01 ,  C12N2501/33 ,  C12N2501/39 ,  C12N2502/1305 ,  C12N2506/1384 ,  C12N2510/00 ,  C12N2533/90

摘要： The present invention provides adipose-derived stem cells and lattices. In one aspect, the present invention provides a lipo-derived stem cell substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The cells can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the cells can be expanded and cultured to produce hormones and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a lipo-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.

公开(公告)号：US20130217118A1

公开(公告)日：2013-08-22

申请号：US13712546

申请日：2012-12-12

申请人： Adam J. Katz ,  Ramon Llull ,  J. William Futrell ,  Marc H. Hedrick ,  Prosper Benhaim ,  Hermann Peter Lorenz ,  Min Zhu ,  Patricia Zuk

发明人： Adam J. Katz ,  Ramon Llull ,  J. William Futrell ,  Marc H. Hedrick ,  Prosper Benhaim ,  Hermann Peter Lorenz ,  Min Zhu ,  Patricia Zuk

IPC分类号： C12N5/071

CPC分类号： C12N5/0653 ,  A61K35/12 ,  A61K48/00 ,  C12N5/0068 ,  C12N5/0607 ,  C12N5/0647 ,  C12N5/0654 ,  C12N5/0655 ,  C12N5/0658 ,  C12N5/0667 ,  C12N9/1276 ,  C12N2500/25 ,  C12N2500/38 ,  C12N2500/42 ,  C12N2501/01 ,  C12N2501/15 ,  C12N2501/33 ,  C12N2501/39 ,  C12N2510/00 ,  C12N2533/90 ,  C12Y207/07049

摘要： The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.

公开(公告)号：US20120208274A1

公开(公告)日：2012-08-16

申请号：US13408840

申请日：2012-02-29

申请人： Adam J. Katz ,  Ramon Llull ,  J. William Futrell ,  Marc H. Hedrick ,  Prosper Benhaim ,  Hermann Peter Lorenz ,  Min Zhu ,  Patricia Zuk ,  Peter H. Ashjian

发明人： Adam J. Katz ,  Ramon Llull ,  J. William Futrell ,  Marc H. Hedrick ,  Prosper Benhaim ,  Hermann Peter Lorenz ,  Min Zhu ,  Patricia Zuk ,  Peter H. Ashjian

IPC分类号： C12N5/0775

CPC分类号： C12N5/0653 ,  A61K35/12 ,  A61K48/00 ,  C12N5/0068 ,  C12N5/0607 ,  C12N5/0647 ,  C12N5/0654 ,  C12N5/0655 ,  C12N5/0658 ,  C12N5/0667 ,  C12N9/1276 ,  C12N2500/25 ,  C12N2500/38 ,  C12N2500/42 ,  C12N2501/01 ,  C12N2501/15 ,  C12N2501/33 ,  C12N2501/39 ,  C12N2510/00 ,  C12N2533/90 ,  C12Y207/07049

摘要： The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.

摘要翻译： 本发明单独提供脂肪来源的干细胞（ADSCs），脂肪来源的干细胞富含级分（ADSC-EF）和脂肪衍生的格子，并与本发明的ADSC组合。 一方面，本发明提供了基本上不含结缔组织干细胞的脂肪细胞和红细胞和克隆群体的ADSC。 ADSC可以单独使用或在生物相容性组合物内使用，以在体内和体外产生分化的组织和结构。 另外，可以扩增和培养ADSC以产生分子如激素，并提供条件培养基以支持其它细胞群的生长和扩增。 另一方面，本发明提供了一种基本上不含细胞的脂肪衍生的晶格，其包括来自脂肪组织的细胞外基质材料。 晶格可以用作底物，以促进细胞的生长和分化，无论是在体内还是在体外，成为成体组织或甚至成熟的组织或结构。

公开(公告)号：US20050076396A1

公开(公告)日：2005-04-07

申请号：US10651564

申请日：2003-08-29

申请人： Adam Katz ,  Ramon Llull ,  J. Futrell ,  Marc Hedrick ,  Prosper Benhaim ,  Hermann Lorenz ,  Min Zhu ,  Patricia Zuk ,  Peter Ashjian

发明人： Adam Katz ,  Ramon Llull ,  J. Futrell ,  Marc Hedrick ,  Prosper Benhaim ,  Hermann Lorenz ,  Min Zhu ,  Patricia Zuk ,  Peter Ashjian

IPC分类号： A61K35/12 ,  A61K48/00 ,  C12N5/00 ,  C12N5/074 ,  C12N5/077 ,  C12N5/0775 ,  C12N5/0789 ,  A01K67/00 ,  C12N5/08

CPC分类号： C12N5/0653 ,  A61K35/12 ,  A61K48/00 ,  C12N5/0068 ,  C12N5/0607 ,  C12N5/0647 ,  C12N5/0654 ,  C12N5/0655 ,  C12N5/0658 ,  C12N5/0667 ,  C12N9/1276 ,  C12N2500/25 ,  C12N2500/38 ,  C12N2500/42 ,  C12N2501/01 ,  C12N2501/15 ,  C12N2501/33 ,  C12N2501/39 ,  C12N2510/00 ,  C12N2533/90 ,  C12Y207/07049

摘要： The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.

公开(公告)号：US09381251B2

公开(公告)日：2016-07-05

申请号：US14174442

申请日：2014-02-06

申请人： INSTITUT QUIMIC DE SARRIA CETS, FUNDACIO PRIVADA ,  UNIVERSITAT RAMON LLULL, FUNDACIO PRIVADA

发明人： Salvador Borros Gomez ,  David Horna Tomas

IPC分类号： A61K47/34 ,  A01N59/20 ,  C08G63/80 ,  C08L67/02 ,  A61L27/44 ,  C08K3/22 ,  C08K3/38 ,  C08K3/40 ,  A01N25/02 ,  A61K33/42 ,  C08K3/30 ,  C08K3/32

CPC分类号： A61K47/34 ,  A01N25/02 ,  A01N59/20 ,  A61K33/42 ,  A61L27/44 ,  C08K3/22 ,  C08K3/30 ,  C08K3/38 ,  C08K3/40 ,  C08K2003/325

摘要： This invention relates to a thermoplastic paste with a highly thixotropic rheology, the components of which are a block biopolymer and a bioceramic. The material described herein can be used in bone implants and in the regeneration of both animal and plant live tissues.

摘要翻译： 本发明涉及具有高触变性流变性的热塑性糊料，其组分为块状生物聚合物和生物陶瓷。 本文所述的材料可用于骨植入物和动物和植物活组织的再生。

公开(公告)号：US09260697B2

公开(公告)日：2016-02-16

申请号：US13808550

申请日：2011-07-08

申请人： William W. Cimino ,  Adam J. Katz ,  Ramon Llull

发明人： William W. Cimino ,  Adam J. Katz ,  Ramon Llull

IPC分类号： A61M5/165 ,  C12N5/077 ,  A61M1/00 ,  C12M1/00

CPC分类号： C12N5/0653 ,  A61M1/0001 ,  A61M1/0094 ,  A61M1/0204 ,  A61M2202/08 ,  A61M2205/103 ,  C12M47/04

摘要： A portable apparatus for collection and processing of human biological material containing adipose, such as extracted during a lipoplasty procedure, is useful for multi-step processing to prepare a concentrated product (e.g., stromal vascular fraction) or a fat graft composition. The apparatus has a container with a containment volume with a tissue retention volume and a filtrate volume separated by a filter and with a tapered portion to a collection volume for collecting concentrate product. Inlet and suction ports provide access to the tissue retention volume and filtrate volume, respectively, and an extraction port provides versatile access for removal of target processed concentrate material or fat graft material, which access may be via a lumen through a rotatable mixer shaft. Access ports may be configured for access only from above the container. The apparatus is incorporatable into a variety of assemblies, systems, kits, methods and uses.

摘要翻译： 用于收集和加工含有脂肪的人体生物材料的便携式装置，例如在脂肪成形术过程中提取的，可用于多步骤加工以制备浓缩产物（例如基质血管部分）或脂肪移植组合物。 该装置具有容器，其具有容纳体积，具有组织保持体积，滤液体积由过滤器分离，并具有锥形部分，用于收集浓缩物产品的收集容积。 入口和吸入口分别提供对组织保持体积和滤液体积的访问，并且提取端口提供用于去除目标处理的浓缩物质或脂肪移植材料的通用途径，其可通过可旋转的混合器轴通过管腔进入。 访问端口可以被配置为仅从容器上方访问。 该装置可并入各种组件，系统，套件，方法和用途中。

公开(公告)号：US20150191698A1

公开(公告)日：2015-07-09

申请号：US14659308

申请日：2015-03-16

申请人： Adam J. Katz ,  Ramon Llull ,  J. William Futrell ,  Marc H. Hedrick ,  Prosper Benhaim ,  Hermann Peter Lorenz ,  Min Zhu

发明人： Adam J. Katz ,  Ramon Llull ,  J. William Futrell ,  Marc H. Hedrick ,  Prosper Benhaim ,  Hermann Peter Lorenz ,  Min Zhu

IPC分类号： C12N5/0775

CPC分类号： C12N5/0667 ,  A61K35/12 ,  A61K48/00 ,  C12N5/0068 ,  C12N5/06 ,  C12N5/0647 ,  C12N5/0654 ,  C12N5/0655 ,  C12N5/0658 ,  C12N2500/25 ,  C12N2500/38 ,  C12N2500/42 ,  C12N2501/01 ,  C12N2501/33 ,  C12N2501/39 ,  C12N2502/1305 ,  C12N2506/1384 ,  C12N2510/00 ,  C12N2533/90

摘要： The present invention provides adipose-derived stem cells and lattices. In one aspect, the present invention provides a lipo-derived stem cell substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The cells can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the cells can be expanded and cultured to produce hormones and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a lipo-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.

摘要翻译： 本发明提供脂肪来源的干细胞和晶格。 一方面，本发明提供了一种基本上不含脂肪细胞和结缔组织干细胞的红细胞和克隆群的脂衍生的干细胞。 细胞可以单独使用或在生物相容性组合物内使用，以在体内和体外产生分化的组织和结构。 此外，细胞可以扩增和培养以产生激素，并提供条件培养基以支持其他细胞群的生长和扩增。 另一方面，本发明提供了一种基本上不含细胞的脂衍生晶格，其包括来自脂肪组织的细胞外基质材料。 晶格可以用作底物，以促进细胞的生长和分化，无论是在体内还是在体外，成为成体组织或甚至成熟的组织或结构。

公开(公告)号：US20100173411A1

公开(公告)日：2010-07-08

申请号：US12653940

申请日：2009-12-18

申请人： Adam J. Katz ,  Ramon Llull ,  J. William Futrell ,  Marc H. Hedrick ,  Prosper Benhaim ,  Hermann Peter Lorenz ,  Min Zhu

发明人： Adam J. Katz ,  Ramon Llull ,  J. William Futrell ,  Marc H. Hedrick ,  Prosper Benhaim ,  Hermann Peter Lorenz ,  Min Zhu

IPC分类号： C12N5/0775 ,  C12N5/10

CPC分类号： C12N5/0667 ,  A61K35/12 ,  A61K48/00 ,  C12N5/0068 ,  C12N5/06 ,  C12N5/0647 ,  C12N5/0654 ,  C12N5/0655 ,  C12N5/0658 ,  C12N2500/25 ,  C12N2500/38 ,  C12N2500/42 ,  C12N2501/01 ,  C12N2501/33 ,  C12N2501/39 ,  C12N2502/1305 ,  C12N2506/1384 ,  C12N2510/00 ,  C12N2533/90

摘要： The present invention provides adipose-derived stem cells and lattices. In one aspect, the present invention provides a lipo-derived stem cell substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The cells can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the cells can be expanded and cultured to produce hormones and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a lipo-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.

摘要翻译： 本发明提供脂肪来源的干细胞和晶格。 一方面，本发明提供了一种基本上不含脂肪细胞和结缔组织干细胞的红细胞和克隆群的脂衍生的干细胞。 细胞可以单独使用或在生物相容性组合物内使用，以在体内和体外产生分化的组织和结构。 此外，细胞可以扩增和培养以产生激素，并提供条件培养基以支持其他细胞群的生长和扩增。 另一方面，本发明提供了一种基本上不含细胞的脂衍生晶格，其包括来自脂肪组织的细胞外基质材料。 晶格可以用作底物，以促进细胞的生长和分化，无论是在体内还是在体外，成为成体组织或甚至成熟的组织或结构。