公开(公告)号：US09683210B2

公开(公告)日：2017-06-20

申请号：US14868235

申请日：2015-09-28

申请人： TISSUE GENESIS, LLC

发明人： Gregory D. Ariff ,  Thomas Cannon ,  Jennifer L. Case ,  Christian L. Haller ,  Paul Kosnik ,  Charles P. Luddy ,  Craig A. Mauch ,  Erik Vossman ,  Stuart K. Williams

IPC分类号： C12M3/00 ,  C12M1/00 ,  A61K35/12

CPC分类号： C12M47/04 ,  A61K35/12 ,  C12M45/05 ,  C12M45/06 ,  C12M45/09

摘要： The present invention provides automated devices for use in supporting various cell therapies and tissue engineering methods. The present invention provides an automated cell separation apparatus capable of separating cells from a tissue sample for use in cell therapies and/or tissue engineering. The cell separation apparatus can be used in combination with complementary devices such as cell collection device and/or a sodding apparatus to support various therapies. The automated apparatus includes media and tissue dissociating chemical reservoirs, filters, a cell separator and a perfusion flow loop through a graft chamber which supports a graft substrate or other endovascular device. The present invention further provides methods for using the tissue grafts and cell samples prepared by the devices described herein in a multitude of therapies including revascularization, regeneration and reconstruction of tissues and organs, as well as treatment and prevention of diseases.

公开(公告)号：US20160237396A1

公开(公告)日：2016-08-18

申请号：US14868235

申请日：2015-09-28

申请人： TISSUE GENESIS, LLC

发明人： Gregory D. Ariff ,  Thomas Cannon ,  Jennifer L. Case ,  Christian L. Haller ,  Paul Kosnik ,  Charles P. Luddy ,  Craig A. Mauch ,  Erik Vossman ,  Stuart K. Williams

IPC分类号： C12M1/00

CPC分类号： C12M47/04 ,  A61K35/12 ,  C12M45/05 ,  C12M45/06 ,  C12M45/09

摘要： The present invention provides automated devices for use in supporting various cell therapies and tissue engineering methods. The present invention provides an automated cell separation apparatus capable of separating cells from a tissue sample for use in cell therapies and/or tissue engineering. The cell separation apparatus can be used in combination with complementary devices such as cell collection device and/or a sodding apparatus to support various therapies. The automated apparatus includes media and tissue dissociating chemical reservoirs, filters, a cell separator and a perfusion flow loop through a graft chamber which supports a graft substrate or other endovascular device. The present invention further provides methods for using the tissue grafts and cell samples prepared by the devices described herein in a multitude of therapies including revascularization, regeneration and reconstruction of tissues and organs, as well as treatment and prevention of diseases.

摘要翻译： 本发明提供了用于支持各种细胞疗法和组织工程方法的自动化装置。 本发明提供了一种能够从用于细胞疗法和/或组织工程的组织样品中分离细胞的自动细胞分离装置。 细胞分离装置可以与诸如细胞收集装置和/或Sodding装置的补充装置组合使用以支持各种疗法。 自动化装置包括介质和组织解离化学储存器，过滤器，细胞分离器和通过支撑移植物基质或其它血管内装置的移植室的灌注流动回路。 本发明还提供了使用本文所述装置制备的组织移植物和细胞样品在包括血管重建，组织和器官的再血管重建和重建以及治疗和预防疾病的多种疗法中的方法。