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公开(公告)号：US20230264198A1
公开(公告)日：2023-08-24
申请号：US18170765
申请日：2023-02-17
发明人： Alan J. O'Donnell , Jan Kubík , Jochen Schmitt , Stanislav Jolondcovschi , Shaun Bradley , Gavin Patrick Cosgrave , Alfonso Berduque , Javier Calpe Maravilla , Padraig L. Fitzgerald , Eoin Edward English , Michael P. Lynch
IPC分类号： B01L3/00
CPC分类号： B01L3/502761 , B01L3/50851 , B01L2200/0647 , B01L2300/023 , B01L2300/0663 , B01L2300/0861 , B01L2300/18 , B01L2400/043 , B01L2400/08
摘要： Aspects of this disclosure relate to systems that include a channel with at least one fluid in particle in fluid. The at least one particle can move along a defined path of the channel in response to a magnetic field. At least one structure is integrated with the channel, such as a sensor to generate an output signal related to the magnetic field or a magnetic structure to apply the magnetic field. Relates methods are also disclosed.
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2.发明授权Fluid transport in microfluidic applications with sensors for detecting fluid presence and pressure 有权微流体应用中的流体传输，用于检测流体存在和压力的传感器公开(公告)号：US09399216B2
公开(公告)日：2016-07-26
申请号：US14144066
申请日：2013-12-30
发明人： Victor Donald Samper , Christian Friedrich Peter Rensch , Christoph Boeld , Ruben Julian Salvamoser
CPC分类号： B01L3/502746 , B01J19/004 , B01J19/0093 , B01J2219/00783 , B01J2219/0084 , B01J2219/00891 , B01J2219/00903 , B01J2219/00959 , B01J2219/00963 , B01J2219/0097 , B01J2219/00986 , B01L3/0293 , B01L2400/08 , G01F22/02 , Y10T137/0318
摘要： A method includes flowing a liquid into a channel of a microfluidic cassette filled with a gas. The channel includes an inlet section and an outlet section. The method also includes detecting the liquid, the gas, or a combination thereof at a measuring location within the inlet section. The measuring location has a first sensor that may detect a signal indicative of a presence of the liquid, the gas, or a combination thereof. The method also includes compressing the gas, determining a pressure change of the gas within the channel, and determining a volume of the liquid within the channel based on the pressure change of the gas.
摘要翻译： 一种方法包括将液体流入填充有气体的微流控盒的通道中。 通道包括入口部分和出口部分。 该方法还包括在入口部分内的测量位置检测液体，气体或其组合。 测量位置具有可以检测指示液体，气体或其组合的存在的信号的第一传感器。 该方法还包括压缩气体，确定通道内的气体的压力变化，以及基于气体的压力变化来确定通道内的液体的体积。
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公开(公告)号：US20160100783A1
公开(公告)日：2016-04-14
申请号：US14861136
申请日：2015-09-22
CPC分类号： A61B5/150755 , A61B5/150022 , A61B5/150221 , A61B5/150236 , A61B5/150244 , A61B5/150259 , A61B5/150305 , A61B5/150343 , A61B5/150351 , A61B5/150366 , A61B5/151 , A61B5/15113 , A61B5/15142 , A61B10/0045 , A61J1/067 , A61J1/1412 , A61J1/1475 , B01L3/502 , B01L3/502707 , B01L3/502746 , B01L3/567 , B01L2200/12 , B01L2300/042 , B01L2300/069 , B01L2300/0838 , B01L2300/0858 , B01L2300/12 , B01L2300/123 , B01L2300/16 , B01L2400/0478 , B01L2400/06 , B01L2400/08 , B01L2400/086 , B01L2400/088 , G01N1/36
摘要： A specimen transfer device adapted to receive a blood sample is disclosed. The specimen transfer device includes a housing and an actuation member. A deformable material is disposed within the housing and is deformable from an initial position in which the material is adapted to hold the sample to a deformed position in which at least a portion of the sample is released from the material. A viscoelastic member is disposed within the housing between the material and the housing and between the material and the actuation member. The viscoelastic member is engaged with the actuation member and the material such that movement of the actuation member from a first position to a second position deforms the material from the initial position to the deformed position.
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公开(公告)号：US20190217296A1
公开(公告)日：2019-07-18
申请号：US15873039
申请日：2018-01-17
申请人： Pall Corporation
发明人： Grishma Patel , Mark S. Szczypka
CPC分类号： B01L3/502761 , B01L3/50273 , B01L3/502746 , B01L3/502753 , B01L2200/0636 , B01L2200/0652 , B01L2200/0668 , B01L2400/08 , C12N1/02 , G01N33/491
摘要： Cell separation systems, and methods for separating cells from microcarriers, and harvesting the separated cells, are provided, wherein the system comprises a cell separation device, a cell settling device, and a cell screening device.
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公开(公告)号：US20170160204A1
公开(公告)日：2017-06-08
申请号：US15047720
申请日：2016-02-19
发明人： CHIA-CHUN WEI , SZU-HSIEN HO , HUNG-WEI CHEN
CPC分类号： G01N21/77 , B01L3/502 , B01L3/5023 , B01L2200/06 , B01L2300/0803 , B01L2300/0825 , B01L2300/0848 , B01L2300/0864 , B01L2300/12 , B01L2400/0409 , B01L2400/08 , G01N2021/752 , G01N2021/754 , G01N2021/7759
摘要： Disclosed is a test strip device, comprising a strip body and a blocking element. The strip body has a first face and a second face. The strip body has an injection opening, a flow channel and a reaction receptacle. The injection opening reaches the first face, the flow channel is in fluid communication between the injection opening and the reaction receptacle, and the flow channel is in fluid communication with the injection opening through a flow channel opening. The blocking element is vertically movably disposed in the injection opening, and the blocking element selectively closes the flow channel opening. Therefore, the back flow of a sample can be prevented, so as to ensure chemical reaction of the sample and a reagent and thus improve accuracy of the test results.
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公开(公告)号：US08534909B2
公开(公告)日：2013-09-17
申请号：US12568318
申请日：2009-09-28
CPC分类号： B01F5/0641 , B01F5/0603 , B01F5/061 , B01F5/0646 , B01F5/0647 , B01F5/0655 , B01F13/0059 , B01F2005/0022 , B01F2005/0621 , B01F2005/0636 , B01L3/502746 , B01L2300/0816 , B01L2400/08 , B01L2400/086 , Y10T137/8593
摘要： A microfluidic device comprises at least one reactant passage defined by walls and comprising at least one parallel multiple flow path configuration comprising a group of elementary design patterns being able to provide mixing and/or residence time which are arranged in series with fluid communication so as to constitute flow paths, and in parallel so as to constitute a multiple flow path elementary design pattern, wherein the parallel multiple flow path configuration comprises at least two communicating zones between elementary design patterns of two adjacent parallel flow paths, said communicating zones being in the same plane as that defined by said elementary design patterns between which said communicating zone is placed and allowing passage of fluid in order to minimize mass flow rate difference between adjacent parallel flow paths which have the same flow direction.
摘要翻译： 微流体装置包括由壁限定的至少一个反应物通道，并且包括至少一个平行的多个流动路径构造，其包括一组基本设计模式，其能够提供与流体连通串联布置的混合和/或停留时间，以便 构成流动路径并且并联，以便构成多流路基本设计模式，其中所述并行多流路构造包括在两个相邻的平行流动路径的基本设计模式之间的至少两个连通区域，所述连通区域是相同的 平面，如所述基本设计图案所限定的，所述基本设计图案位于所述连通区域之间，并且允许流体通过，以使具有相同流动方向的相邻平行流动路径之间的质量流量差最小化。
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7.发明授权Passive components for micro-fluidic flow profile shaping and related method thereof 有权微流体流动剖面成形的被动元件及其相关方法公开(公告)号：US08220493B2
公开(公告)日：2012-07-17
申请号：US12064557
申请日：2006-08-23
CPC分类号： B01L3/502738 , A61M2206/22 , B01L3/502746 , B01L2200/0621 , B01L2300/0816 , B01L2300/0887 , B01L2400/0487 , B01L2400/06 , B01L2400/0638 , B01L2400/08 , F04B43/043 , F16K99/0001 , F16K99/0015 , F16K99/0057 , F16K2099/008 , F16K2099/0084 , Y10T137/0318 , Y10T137/212 , Y10T137/2202 , Y10T137/6579 , Y10T137/7895 , Y10T137/85978 , Y10T137/86348 , Y10T428/24562
摘要： The present invention relates to microfluidic systems and methods for controlling the flow of fluid using passive components engineered into the microchannels. These passive flow components include fluidic diodes, fluidic capacitors, and fluidic inductors. Various fluidic circuits are provided to control fluid flow including fluid rectifiers, fluid band pass filters, and fluid timers.
摘要翻译： 本发明涉及使用被设计成微通道的被动元件来控制流体流动的微流体系统和方法。 这些被动流动元件包括流体二极管，流体电容器和流体电感器。 提供各种流体回路以控制流体流动，包括流体整流器，流体带通滤波器和流体计时器。
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公开(公告)号：US11691146B2
公开(公告)日：2023-07-04
申请号：US17898663
申请日：2022-08-30
申请人： ILLUMINA, INC.
发明人： Ali Agah , Aathavan Karunakaran , Tarun Khurana , Stanley Hong , Merek Siu , Arvin Emadi , Craig Ciesla
IPC分类号： B01L3/00 , G11C13/02 , B01J19/00 , C12Q1/6874 , C12N15/09
CPC分类号： B01L3/502715 , B01J19/0046 , B01L3/502707 , B01L3/502738 , G11C13/02 , B01J2219/00711 , B01J2219/00713 , B01J2219/00722 , B01L2200/026 , B01L2300/0645 , B01L2300/0816 , B01L2300/0867 , B01L2400/0487 , B01L2400/0622 , B01L2400/0655 , B01L2400/08 , C12N15/09 , C12Q1/6874
摘要： An apparatus includes a flow cell body, a plurality of electrodes, an integrated circuit, and an imaging assembly. The flow cell body defines one or more flow channels and a plurality of wells. Each flow channel is configured to receive a flow of fluid. Each well is fluidically coupled with the corresponding flow channel. Each well is configured to contain at least one polynucleotide. Each electrode is positioned in a corresponding well of the plurality of wells. The electrodes are operable to effect writing of polynucleotides in the corresponding wells. The integrated circuit is operable to drive selective deposition or activation of selected nucleotides to attach to polynucleotides in the wells to thereby generate polynucleotides representing machine-written data in the wells. The imaging assembly is operable to capture images indicative of one or more nucleotides in a polynucleotide.
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公开(公告)号：US20230182136A1
公开(公告)日：2023-06-15
申请号：US18164124
申请日：2023-02-03
发明人： Kristin G. Beaumont , Non-Linda Ding , Volker L.S. Kurz , Troy A. Lionberger , Randall D. Lowe, JR. , Daniele Malleo , Andrew W. McFarland , J. Tanner Nevill , Xiaohua Wang
IPC分类号： B01L3/00 , B01J19/00 , G01N27/447
CPC分类号： B01L3/502753 , B01L3/502761 , B01L3/502738 , B01J19/0093 , B01L3/5023 , B01L3/502707 , G01N27/44791 , B01L2400/0424 , B01L2300/0816 , B01L2300/0864 , B01L2400/0677 , B01L2200/0668 , B01L2300/16 , B01L2400/08
摘要： In situ-generated microfluidic isolation structures incorporating a solidified polymer network, methods of preparation and use, compositions and kits therefor are described. The ability to introduce in real time, a variety of isolating structures including pens and barriers offers improved methods of micro-object manipulation in microfluidic devices. The in situ-generated isolation structures may be permanently or temporarily installed.
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公开(公告)号：US20170265797A1
公开(公告)日：2017-09-21
申请号：US15612225
申请日：2017-06-02
CPC分类号： A61B5/150755 , A61B5/150022 , A61B5/150221 , A61B5/150236 , A61B5/150244 , A61B5/150259 , A61B5/150305 , A61B5/150343 , A61B5/150351 , A61B5/150366 , A61B5/151 , A61B5/15113 , A61B5/15142 , A61B10/0045 , A61J1/067 , A61J1/1412 , A61J1/1475 , B01L3/502 , B01L3/502707 , B01L3/502746 , B01L3/567 , B01L2200/12 , B01L2300/042 , B01L2300/069 , B01L2300/0838 , B01L2300/0858 , B01L2300/12 , B01L2300/123 , B01L2300/16 , B01L2400/0478 , B01L2400/06 , B01L2400/08 , B01L2400/086 , B01L2400/088 , G01N1/36
摘要： A specimen transfer device adapted to receive a blood sample is disclosed. The specimen transfer device includes a housing and an actuation member. A deformable material is disposed within the housing and is deformable from an initial position in which the material is adapted to hold the sample to a deformed position in which at least a portion of the sample is released from the material. A viscoelastic member is disposed within the housing between the material and the housing and between the material and the actuation member. The viscoelastic member is engaged with the actuation member and the material such that movement of the actuation member from a first position to a second position deforms the material from the initial position to the deformed position.
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