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106 条记录 (耗时 0.026 秒)

    Storage device, system, and method
    1.
    发明授权
    Storage device, system, and method 有权

    公开(公告)号：US12062419B2

    公开(公告)日：2024-08-13

    申请号：US17683426

    申请日：2022-03-01

    申请人： ILLUMINA, INC.

    发明人： Craig Ciesla ,  Ali Agah ,  Stanley Hong ,  Tarun Khurana ,  Aathavan Karunakaran ,  Arvin Emadi ,  Merek Siu

    IPC分类号： G16B50/30 ,  B01L3/00 ,  G11C13/02 ,  G16B30/10 ,  C12Q1/6874

    CPC分类号： G16B50/30 ,  B01L3/5027 ,  G11C13/02 ,  G16B30/10 ,  C12Q1/6874

    摘要： A system writes input data to a storage device as machine-written polynucleotides; and reads machine written polynucleotides from the storage device as output data. The storage device includes a flow cell including a plurality of storage wells in which machine written polynucleotides may be stored. The storage device may include a set of electrodes corresponding to the storage wells that allow for selective interactions with wells across the surface of a flow cell. Operation of the storage device may include receiving a read request associated with a particular location in the storage device, creating a copy of a nucleotide sequence located at the particular location in the storage device, transferring the copy of the nucleotide sequence to a read location, and reading the copy of the nucleotide sequence at the read location.

    STORAGE DEVICE, SYSTEM, AND METHOD
    5.
    发明申请
    STORAGE DEVICE, SYSTEM, AND METHOD 有权

    公开(公告)号：US20220254452A1

    公开(公告)日：2022-08-11

    申请号：US17683426

    申请日：2022-03-01

    申请人： ILLUMINA, INC.

    发明人： Craig Ciesla ,  Ali Agah ,  Stanley Hong ,  Tarun Khurana ,  Aathavan Karunakaran ,  Arvin Emadi ,  Merek Siu

    IPC分类号： G16B50/30 ,  G16B30/10 ,  G11C13/02 ,  B01L3/00

    摘要： A system writes input data to a storage device as machine-written polynucleotides; and reads machine written polynucleotides from the storage device as output data. The storage device includes a flow cell including a plurality of storage wells in which machine written polynucleotides may be stored. The storage device may include a set of electrodes corresponding to the storage wells that allow for selective interactions with wells across the surface of a flow cell. Operation of the storage device may include receiving a read request associated with a particular location in the storage device, creating a copy of a nucleotide sequence located at the particular location in the storage device, transferring the copy of the nucleotide sequence to a read location, and reading the copy of the nucleotide sequence at the read location.

    Flow cell with integrated manifold
    6.
    发明授权
    Flow cell with integrated manifold 有权

    公开(公告)号：US11376584B2

    公开(公告)日：2022-07-05

    申请号：US16400629

    申请日：2019-05-01

    申请人： Illumina, Inc.

    发明人： Sz-Chin Lin ,  Jay Taylor ,  Minsoung Rhee ,  Jennifer Foley ,  Wesley Cox-Muranami ,  Cyril Delattre ,  Tarun Khurana ,  Paul Crivelli

    IPC分类号： G01N21/05 ,  G01N21/03 ,  B01L3/00

    摘要： In one example, a flow cell includes a plurality of inlet ports sized to receive a flow of reagent from one of a plurality of reagents into the flow cell. An outlet port of the flow cell is sized to pass each flow of reagent out of the flow cell. A flow channel of the flow cell is positioned between, and in fluid communication with, each inlet port and the outlet port. The flow channel includes a manifold section and a detection section. The manifold section has a plurality of manifold branches in fluid communication with a common line, wherein each branch is connected to one of each inlet port. The detection section is in fluid communication with the common line and the outlet port. The detection section is operable to perform a plurality of different chemical reactions between the plurality of reagents and analytes positioned in the detection section.

    FLOW CELL WITH SELECTIVE DEPOSITION OR ACTIVATION OF NUCLEOTIDES
    7.
    发明申请
    FLOW CELL WITH SELECTIVE DEPOSITION OR ACTIVATION OF NUCLEOTIDES 有权

    公开(公告)号：US20220097060A1

    公开(公告)日：2022-03-31

    申请号：US17550063

    申请日：2021-12-14

    申请人： ILLUMINA, INC.

    发明人： Ali Agah ,  Aathavan Karunakaran ,  Tarun Khurana ,  Stanley Hong ,  Merek Siu ,  Arvin Emadi ,  Craig Ciesla

    IPC分类号： B01L3/00 ,  G11C13/02 ,  B01J19/00

    摘要： An apparatus includes a flow cell body, a plurality of electrodes, an integrated circuit, and an imaging assembly. The flow cell body defines one or more flow channels and a plurality of wells. Each flow channel is configured to receive a flow of fluid. Each well is fluidically coupled with the corresponding flow channel. Each well is configured to contain at least one polynucleotide. Each electrode is positioned in a corresponding well of the plurality of wells. The electrodes are operable to effect writing of polynucleotides in the corresponding wells. The integrated circuit is operable to drive selective deposition or activation of selected nucleotides to attach to polynucleotides in the wells to thereby generate polynucleotides representing machine-written data in the wells. The imaging assembly is operable to capture images indicative of one or more nucleotides in a polynucleotide.

    Disposable, integrated microfluidic cartridge and methods of making and using same
    8.
    发明授权
    Disposable, integrated microfluidic cartridge and methods of making and using same 有权

    公开(公告)号：US11174513B2

    公开(公告)日：2021-11-16

    申请号：US16405547

    申请日：2019-05-07

    申请人： ILLUMINA, INC.

    发明人： Poorya Sabounchi ,  Behnam Javanmardi ,  Tarun Khurana ,  Philip Paik ,  Yan-You Lin

    IPC分类号： B01L3/00 ,  B01L7/00 ,  C12Q1/6869 ,  C12Q1/6806 ,  C12Q1/68

    摘要： A stack of fluidics layers of a microfluidic cartridge for sequencing nucleic acid molecules includes a sequencing chamber layer having a sequencing chamber area configured for carrying out clustering and sequencing reactions, and a sequencing chamber bottom layer disposed under the sequencing chamber layer. The sequencing chamber bottom layer has an opening configured to hold an image sensor with the image sensor having an active area disposed under the sequencing chamber area. The sequencing chamber area spans substantially all of the active area of the image sensor. The stack of fluidics layers includes a flexible printed circuit board (PCB) layer under the sequencing chamber bottom layer, and a fluidics channels layer disposed under the flexible PCB layer. The fluidics channels layer includes fluidics channels that are configured to deliver reactants to the sequencing chamber area. The fluidics channels do not substantially overlap with the active area of the image sensor.

    FLOW CELL WITH ONE OR MORE BARRIER FEATURES
    9.
    发明申请
    FLOW CELL WITH ONE OR MORE BARRIER FEATURES 有权

    公开(公告)号：US20210148872A1

    公开(公告)日：2021-05-20

    申请号：US17254466

    申请日：2020-05-26

    申请人： ILLUMINA, INC.

    发明人： Tarun Khurana ,  Ali Agah ,  Aathavan Karunakaran ,  Stanley Hong ,  Merek Siu ,  Arvin Emadi ,  Craig Ciesla

    IPC分类号： G01N30/74 ,  C12Q1/6874

    摘要： An apparatus includes a flow cell body, a plurality of electrodes, an imaging assembly, and one or more barrier features. The flow cell body defines one or more flow channels and a plurality of wells defined as recesses in the floor of each flow channel. Each well is fluidically coupled with the corresponding flow channel. The flow cell body further defines interstitial surfaces between adjacent wells. Each well defines a corresponding depth. Each electrode is positioned in a corresponding well of the plurality of wells. The electrodes are to effect writing of polynucleotides in the wells. The imaging assembly is to capture images of polynucleotides written in the wells. The one or more barrier features are positioned in the wells, between the wells, or above the wells. The one or more barrier features contain reactions in each well, reduce diffusion between the wells, or reduce optical cross-talk between the wells.

    FLOW CELL WITH SELECTIVE DEPOSITION OR ACTIVATION OF NUCLEOTIDES
    10.
    发明申请
    FLOW CELL WITH SELECTIVE DEPOSITION OR ACTIVATION OF NUCLEOTIDES 有权

    公开(公告)号：US20210146356A1

    公开(公告)日：2021-05-20

    申请号：US17254469

    申请日：2020-05-26

    申请人： ILLUMINA, INC.

    发明人： Ali Agah ,  Aathavan Karunakaran ,  Tarun Khurana ,  Stanley Hong ,  Merek Siu ,  Arvin Emadi ,  Craig Ciesla

    IPC分类号： B01L3/00

    摘要： An apparatus includes a flow cell body, a plurality of electrodes, an integrated circuit, and an imaging assembly. The flow cell body defines one or more flow channels and a plurality of wells. Each flow channel is configured to receive a flow of fluid. Each well is fluidically coupled with the corresponding flow channel. Each well is configured to contain at least one polynucleotide. Each electrode is positioned in a corresponding well of the plurality of wells. The electrodes are operable to effect writing of polynucleotides in the corresponding wells. The integrated circuit is operable to drive selective deposition or activation of selected nucleotides to attach to polynucleotides in the wells to thereby generate polynucleotides representing machine-written data in the wells. The imaging assembly is operable to capture images indicative of one or more nucleotides in a polynucleotide.