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    POLYNUCLEOTIDE SEQUENCING USING IONOPHORES
    1.
    发明申请
    POLYNUCLEOTIDE SEQUENCING USING IONOPHORES 有权

    公开(公告)号：US20250129415A1

    公开(公告)日：2025-04-24

    申请号：US18565027

    申请日：2022-06-30

    Applicant: Illumina, Inc.

    Inventor： Jeffrey Mandell ,  Boyan Boyanov

    IPC: C12Q1/6869 ,  G01N27/12

    Abstract: Polynucleotide sequencing using ionophores is provided herein. In some examples, a sequencing method includes inhibiting current flow across a barrier; contacting a polymerase with a first polynucleotide, a second polynucleotide, and a fluid comprising a first nucleotide coupled to a first ionophore; while the polymerase adds the first nucleotide to the second polynucleotide based on a sequence of the first polynucleotide, providing a first current flow across the barrier using the first ionophore; and identifying the first nucleotide using an electrical characteristic of the first ionophore.

    Sensors having integrated protection circuitry
    2.
    发明授权
    Sensors having integrated protection circuitry 有权

    公开(公告)号：US12241835B2

    公开(公告)日：2025-03-04

    申请号：US18313015

    申请日：2023-05-05

    Applicant: ILLUMINA, INC.

    Inventor： Tracy Helen Fung ,  Xiuyu Cai ,  Lisa Kwok ,  Hai Tran ,  Kevan Samiee ,  Liangliang Qiang ,  Boyan Boyanov

    IPC: G01N21/64 ,  B01L3/00 ,  G01N15/1434 ,  G01N21/77

    Abstract: An example sensor includes a flow cell, a detection device, and a controller. The flow cell includes a passivation layer having opposed surfaces and a reaction site at a first of the opposed surfaces. The flow cell also includes a lid operatively connected to the passivation layer to partially define a flow channel between the lid and the reaction site. The detection device is in contact with a second of the opposed surfaces of the passivation layer, and includes an embedded metal layer that is electrically isolated from other detection circuitry of the detection device. The controller is to ground the embedded metal layer.

    SCALABLE CIRCUIT FOR MOLECULAR DETECTION
    6.
    发明公开
    SCALABLE CIRCUIT FOR MOLECULAR DETECTION 审中-公开

    公开(公告)号：US20240094189A1

    公开(公告)日：2024-03-21

    申请号：US18003883

    申请日：2022-03-15

    Applicant: Illumina, Inc.

    Inventor： John Moon ,  Boyan Boyanov

    IPC: G01N33/487

    CPC classification number: G01N33/48721

    Abstract: In one aspect, the disclosed technology relates to systems and methods for sequencing polynucleotides. In one embodiment, the disclosed technology relates to a nanopore sensor device for identifying nucleotides, the nanopore sensor device including: one or more cis wells; one or more cis electrodes associated with the one or more cis wells; a plurality of trans wells, each of the plurality of trans wells separated from the one or more cis wells by a lipid or solid-state membrane having a nanopore; a plurality of field effect transistors (FETs), each of the plurality of FETs associated with one of the plurality of trans wells; an electrical source configured to provide alternating current (AC) inputs between the one or more cis electrodes and the source terminals of the plurality of FETs; and a controller operably coupled to the plurality of FETs, the controller configured to measure AC responses of the plurality of FETs, wherein the AC responses depend on the identities of the nucleotides within or near the nanopores.

    FAST PULSING FOR NANOPORE SENSORS
    10.
    发明公开
    FAST PULSING FOR NANOPORE SENSORS 审中-公开

    公开(公告)号：US20240110889A1

    公开(公告)日：2024-04-04

    申请号：US18471484

    申请日：2023-09-21

    Applicant: ILLUMINA, INC.

    Inventor： Boyan Boyanov

    IPC: G01N27/447 ,  C12Q1/6869

    CPC classification number: G01N27/44713 ,  C12Q1/6869 ,  G01N27/44791

    Abstract: Sequencing systems and methods are provided that include a nanopore well that includes a cis well associated with a cis electrode and a trans well associated with a trans electrode, a membrane separating the cis well and the trans well, and a nanopore well embedded in the membrane providing a channel through the membrane; a command node connected directly to the nanopore well. The command node is configured to apply a potential across the nanopore well and a command pulse. The system further includes an amplifier with a feedback loop coupled to the nanopore well and a switch disposed between the amplifier and the nanopore well. The switch is driven by a clock pulse and configured to ground an inverting input of the amplifier.

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