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公开(公告)号：US11249025B2
公开(公告)日：2022-02-15
申请号：US16482630
申请日：2018-01-31
申请人： Illumina, Inc.
发明人： John S. Vieceli , Alex Nemiroski , Paul Belitz , Robert Langlois , M. Shane Bowen , Danny Yuan Chan , Bala Murali K. Venkatesan , Hui Han , Kevan Samiee , Stephen Tanner
IPC分类号： G01N21/64
摘要： Fiducial markers are provided on a patterned array of the type that may be used for molecular analysis, such as sequencing. The fiducial markers may have configurations and layouts that enhance their detection in image or detection data, that facilitate or improve processing, that provide encoding of useful information, and so forth. Examples of the fiducial markers may include non-rectilinear layouts that may provide for more robust location of both the fiducial markers and sites of the patterned array.
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公开(公告)号：US20200009525A1
公开(公告)日：2020-01-09
申请号：US16482592
申请日：2018-01-31
申请人： Illumina, Inc.
发明人： John S. Vieceli , Alex Nemiroski , Paul Belitz , Robert Langlois , M. Shane Bowen , Danny Yuan Chan , Bala Murali K. Venkatesan , Hui Han , Kevan Samiee , Stephen Tanner
IPC分类号： B01J19/00 , G06T7/00 , C12Q1/6837 , G01N21/64
摘要： Fiducial markers are provided on patterned arrays of the type that may be used for molecular analysis, such as sequencing. The fiducials may have configurations that enhance their detection in image or detection data, that facilitate or improve processing, that provide encoding of useful information, and so forth. Examples of the fiducials may include an “always on” type that respond to multiple frequencies of radiation used during processing and detection so as to return signals during successive cycles of imaging.
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公开(公告)号：US20200248252A1
公开(公告)日：2020-08-06
申请号：US16482613
申请日：2018-01-31
申请人： Illumina, Inc.
发明人： John S. Vieceli , Alex Nemiroski , Paul Belitz , Robert Langlois , M. Shane Bowen , Danny Yuan Chan , Bala Murali K. Venkatesan , Hui Han , Kevan Samiee , Stephen Tanner
IPC分类号： C12Q1/6874 , G01N21/64
摘要： Fiducial markers are provided on patterned arrays of the type that may be used for molecular analysis, such as sequencing. The fiducials may have configurations that enhance their detection in image or detection data, that facilitate or improve processing, that provide encoding of useful information, and so forth. Examples of the fiducials may include a non-closed shape that may encode information, allow for bubbles to escape during manufacture, and provide additional advantages over closed shape fiducials.
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公开(公告)号：US20200064266A1
公开(公告)日：2020-02-27
申请号：US16482653
申请日：2018-01-31
申请人： Illumina, Inc.
发明人： John S. Vieceli , Alex Nemiroski , Paul Belitz , Robert Langlois , M. Shane Bowen , Danny Yuan Chan , Bala Murali K. Venkatesan , Hui Han , Kevan Samiee , Stephen Tanner
IPC分类号： G01N21/64
摘要： Fiducial markers are provided on patterned arrays of the type that may be used for molecular analysis, such as sequencing. The fiducials may have configurations that enhance their detection in image or detection data, that facilitate or improve processing, that provide encoding of useful information, and so forth. Examples of the fiducials may include features and materials that are provided on or in the support of the array and that return at least a portion of incident light by reflection. The fiducials may form gratings or other encoding configurations that assist in image processing, alignment, or other aspects of processing of the array.
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公开(公告)号：US20180195950A1
公开(公告)日：2018-07-12
申请号：US15848450
申请日：2017-12-20
发明人： James Tsay , Anmiv Prabhu , David Heiner , Edwin Li , Alexandre Richez , John M. Beierle , Kevan Samiee , Kristina Munoz , Leonid Malevanchik , Ludovic Vincent , Naiqian Zhan , Peyton Shieh , Robert Yang , Samantha Schmitt , Sang Park , Scott Bailey , Sean M. Ramirez , Sunmin Ahn , Valerie Uzzell , Wei Wei , Yuxiang Huang , Tyler Jamison Dill
IPC分类号： G01N15/14 , C12Q1/6874 , B01L3/00 , C09D133/24 , C09D133/26
摘要： A flow cell package includes first and second surface-modified patterned wafers and a spacer layer. The first surface-modified patterned wafer includes first depressions separated by first interstitial regions, a first functionalized molecule bound to a first silane or silane derivative in at least some of the first depressions, and a first primer grafted to the first functionalized molecule in the at least some of the first depressions. The second surface-modified patterned wafer includes second depressions separated by second interstitial regions, a second functionalized molecule bound to a second silane or silane derivative in at least some of the second depressions, and a second primer grafted to the second functionalized molecule in the at least some of the second depressions. The spacer layer bonds at least some first interstitial regions to at least some second interstitial regions, and at least partially defines respective fluidic chambers of the flow cell package.
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公开(公告)号：US11835460B2
公开(公告)日：2023-12-05
申请号：US16482638
申请日：2018-01-31
申请人： Illumina, Inc.
发明人： John S. Vieceli , Alex Nemiroski , Paul Belitz , Robert Langlois , M. Shane Bowen , Danny Yuan Chan , Bala Murali K. Venkatesan , Hui Han , Kevan Samiee , Stephen Tanner
IPC分类号： G01N21/64 , B01J19/00 , C12Q1/6837
CPC分类号： G01N21/6456 , B01J19/0046 , C12Q1/6837 , G01N21/6452 , B01J2219/0056 , B01J2219/00317 , B01J2219/00529 , B01J2219/00547 , B01J2219/00549 , B01J2219/00576 , B01J2219/00608 , B01J2219/00648 , B01J2219/00722 , B01L2300/021 , G01N2021/6419 , G01N2021/6421 , H01J2237/24578
摘要： Fiducial markers are provided on patterned arrays of the type that may be used for molecular analysis, such as sequencing. The fiducials may have configurations and layouts that enhance their detection in image or detection data, that facilitate or improve processing, that provide encoding of useful information, and so forth. Examples of the fiducials may include offset layouts that may be useful in detecting the fiducials in different types and approaches in imaging, and that may help to distinguish regions of the array from one another in image data.
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公开(公告)号：US11680906B2
公开(公告)日：2023-06-20
申请号：US16607354
申请日：2018-04-19
申请人： ILLUMINA, INC.
发明人： Tracy Helen Fung , Xiuyu Cai , Lisa Kwok , Hai Tran , Kevan Samiee , Liangliang Qiang , Boyan Boyanov
CPC分类号： G01N21/6454 , B01L3/502715 , G01N15/1436 , G01N21/6486 , G01N21/7703 , G01N2021/7763
摘要： An example sensor includes a flow cell, a detection device, and a controller. The flow cell includes a passivation layer having opposed surfaces and a reaction site at a first of the opposed surfaces. The flow cell also includes a lid operatively connected to the passivation layer to partially define a flow channel between the lid and the reaction site. The detection device is in contact with a second of the opposed surfaces of the passivation layer, and includes an embedded metal layer that is electrically isolated from other detection circuitry of the detection device. The controller is to ground the embedded metal layer.
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公开(公告)号：US10955332B2
公开(公告)日：2021-03-23
申请号：US15848450
申请日：2017-12-20
发明人： James Tsay , Anmiv Prabhu , David Heiner , Edwin Li , Alexandre Richez , John M. Beierle , Kevan Samiee , Kristina Munoz , Leonid Malevanchik , Ludovic Vincent , Naiqian Zhan , Peyton Shieh , Robert Yang , Samantha Schmitt , Sang Park , Scott Bailey , Sean M. Ramirez , Sunmin Ahn , Valerie Uzzell , Wei Wei , Yuxiang Huang , Tyler Jamison Dill
IPC分类号： G01N15/14 , C12Q1/6874 , B01L3/00 , C09D133/24 , C09D133/26 , B01J19/00 , G01N15/10
摘要： A flow cell package includes first and second surface-modified patterned wafers and a spacer layer. The first surface-modified patterned wafer includes first depressions separated by first interstitial regions, a first functionalized molecule bound to a first silane or silane derivative in at least some of the first depressions, and a first primer grafted to the first functionalized molecule in the at least some of the first depressions. The second surface-modified patterned wafer includes second depressions separated by second interstitial regions, a second functionalized molecule bound to a second silane or silane derivative in at least some of the second depressions, and a second primer grafted to the second functionalized molecule in the at least some of the second depressions. The spacer layer bonds at least some first interstitial regions to at least some second interstitial regions, and at least partially defines respective fluidic chambers of the flow cell package.
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公开(公告)号：US20180214977A1
公开(公告)日：2018-08-02
申请号：US15848127
申请日：2017-12-20
申请人： Illumina, Inc.
发明人： Peter Mains , Anmiv S. Prabhu , Richard Capella , Kevan Samiee
CPC分类号： B23K26/02 , B23K26/032 , B23K26/0853 , B23K26/21 , B23K26/324 , B23K26/38 , B23K26/402 , B23K2101/40 , B23K2103/54 , B29C65/7814
摘要： Wafers are aligned with one another by reference to features formed on or in each wafer. Notches are formed in each wafer, including a pivot-notch that allows for two-point contact, and a stop-notch that provides for single-point contact. A bias-notch is formed for pressing the wafers into engagement with the two-contact element when it is in the pivot-notch and with the single-contact element when it is in the stop-notch. The wafers may be bonded to one another to maintain the alignment of the referenced features.
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公开(公告)号：US11427868B2
公开(公告)日：2022-08-30
申请号：US16482613
申请日：2018-01-31
申请人： Illumina, Inc.
发明人： John S. Vieceli , Alex Nemiroski , Paul Belitz , Robert Langlois , M. Shane Bowen , Danny Yuan Chan , Bala Murali K. Venkatesan , Hui Han , Kevan Samiee , Stephen Tanner
IPC分类号： C12Q1/6874 , G01N21/64
摘要： Fiducial markers are provided on patterned arrays of the type that may be used for molecular analysis, such as sequencing. The fiducials may have configurations that enhance their detection in image or detection data, that facilitate or improve processing, that provide encoding of useful information, and so forth. Examples of the fiducials may include a non-closed shape that may encode information, allow for bubbles to escape during manufacture, and provide additional advantages over closed shape fiducials.
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