知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

137 条记录 (耗时 0.032 秒)

    In vitro method for estimating in vivo protein digestibility
    3.
    发明授权
    In vitro method for estimating in vivo protein digestibility 有权

    公开(公告)号：US09738920B2

    公开(公告)日：2017-08-22

    申请号：US14599050

    申请日：2015-01-16

    申请人： General Mills, Inc.

    发明人： David W. Plank

    IPC分类号： C12Q1/37 ,  G01N21/75

    CPC分类号： C12Q1/37 ,  G01N21/75 ,  G01N33/02 ,  G01N33/6806

    摘要： An analysis technique can be performed to quantify the digestible protein content of a protein-containing sample outside the body of a living organism. Traditionally, protein digestibility is evaluated in vivo, for example using a rat subject to measure protein digestibility after being fed the protein-containing sample. In some examples, an in vitro technique involves enzymatically digesting the protein-containing sample to simulate digestion that would occur inside a mammalian body. The sample can then be optically analyzed to measure the amount of reactive amine present in the sample, which can provide an indication of the amount of amino acid released during digestion. In some examples, the measured reactive amine value is adjusted to account for the stronger and/or weaker optical response of certain amino acids due to their relative reactivity with an optical tagging agent. Thereafter, an in vivo protein digestibility value can be calculated based on adjusted amine concentration.

    METHOD FOR ANALYSIS OF COMPOUNDS WITH AMINO GROUP AND ANALYTICAL REAGENT THEREFOR
    4.
    发明申请
    METHOD FOR ANALYSIS OF COMPOUNDS WITH AMINO GROUP AND ANALYTICAL REAGENT THEREFOR 有权
    用氨基和其分析试剂分析化合物的方法

    公开(公告)号：US20160139134A1

    公开(公告)日：2016-05-19

    申请号：US15003235

    申请日：2016-01-21

    申请人： AJINOMOTO CO., INC.

    发明人： Hiroshi MIYANO ,  Akihisa YAHASHI ,  Kazutaka SHIMBO ,  Masakazu NAKAZAWA ,  Kazuo HIRAYAMA

    IPC分类号： G01N33/58 ,  C07D207/46 ,  G01N33/68

    CPC分类号： G01N33/58 ,  C07D207/46 ,  G01N33/6803 ,  G01N33/6806 ,  G01N33/6848 ,  G01N2458/15 ,  G01N2560/00 ,  Y10T436/13 ,  Y10T436/14 ,  Y10T436/145555 ,  Y10T436/24

    摘要： The present invention provides a method for the analysis of a compound with amino group (e.g., an amino acid or peptide) contained in a sample and convenient manner with a high sensitivity. The compound with amino group in a sample containing the compound with amino group is labeled with a specific carbamate compound such as p-trimethylammonium anilyl-N-hydroxysuccinimidyl carbamate iodide to enhance the selectivity and sensitivity. The present invention is preferably used in conjunction with mass spectrometry such as MS/MS method to facilitate quantitative analysis. The present invention further provides labeling reagents for mass spectrometry.

    摘要翻译： 本发明提供了用于分析样品中所含的氨基（例如氨基酸或肽）的化合物的方法，并且以高灵敏度方便地进行分析。 含有氨基化合物的样品中具有氨基的化合物用特定的氨基甲酸酯化合物如对三甲基铵苯乙烯基-N-羟基琥珀酰亚胺基氨基甲酸酯碘化物进行标记以提高选择性和灵敏度。 本发明优选与诸如MS / MS方法的质谱结合使用以促进定量分析。 本发明还提供用于质谱的标记试剂。

    Compositions and Methods for Modulation and Detection of Immune and Inflammatory Responses
    5.
    发明申请
    Compositions and Methods for Modulation and Detection of Immune and Inflammatory Responses 审中-公开
    用于调节和检测免疫和炎症反应的组合物和方法

    公开(公告)号：US20160084855A1

    公开(公告)日：2016-03-24

    申请号：US14784717

    申请日：2014-04-18

    申请人： UNIVERSITY OF CONNECTICUT

    发明人： Robert B. Clark ,  Frank C. Nichols

    IPC分类号： G01N33/92 ,  C07K16/12 ,  G01N30/72 ,  A61K38/05

    CPC分类号： G01N33/92 ,  A61K38/05 ,  C07K16/1203 ,  C07K2317/34 ,  C07K2317/76 ,  G01N30/72 ,  G01N33/564 ,  G01N33/6806 ,  G01N33/6893 ,  G01N2333/195 ,  G01N2405/08 ,  G01N2560/00 ,  G01N2800/285 ,  G01N2800/7095

    摘要： Methods for detecting inflammatory or autoimmune conditions, comprising analyzing bacterial L-serine containing lipids in a sample; and, comparing results of the analysis of the bacterial L-serine containing lipids in the sample with information on occurrence of the bacterial L-serine containing lipids in a control sample, wherein a decreased occurrence of the bacterial L-serine containing lipids in the test sample over the occurrence of bacterial L-serine containing lipids in the control sample indicates the presence of an inflammatory or an autoimmune condition, are described herein. An example of the autoimmune condition is multiple sclerosis (MS). The use of bacterial L-serine containing lipids as biomarkers for detection of MS is described. Antibodies specific to L-serine containing lipids and their uses are also provided. Also provided are compositions comprising bacterial L-serine containing lipids for modulating immune responses or TLR pathways in humans, animals, and human or animal cells or tissues.

    摘要翻译： 用于检测炎症或自身免疫病症的方法，包括分析样品中含有L-丝氨酸的脂质; 比较对照样品中含有细菌L-丝氨酸的脂质的分析结果与对照样品中含有L-丝氨酸的细菌的发生的信息的比较，其中在试验中含有L-丝氨酸的细菌的出现减少 在对照样品中含有细菌L-丝氨酸的脂质的出现中的样品表明存在炎症或自身免疫病症，这里描述。 自身免疫病症的一个例子是多发性硬化症（MS）。 描述了使用含有L-丝氨酸的细菌作为检测MS的生物标志物。 还提供了对含有L-丝氨酸的脂质及其用途特异性的抗体。 还提供了包含用于调节人，动物和人或动物细胞或组织中的免疫应答或TLR途径的含有细菌L-丝氨酸的脂质的组合物。

    ADVANCED GLYCATION END PRODUCT ANALOGUES
    7.
    发明申请
    ADVANCED GLYCATION END PRODUCT ANALOGUES 审中-公开
    高级糖果终产品模拟

    公开(公告)号：US20150191501A1

    公开(公告)日：2015-07-09

    申请号：US14410053

    申请日：2013-06-25

    申请人： Phytoquest Limited

    发明人： Robert James Nash

    IPC分类号： C07H7/02 ,  G01N30/72 ,  H01J49/00 ,  G01N33/68 ,  G01N30/06

    CPC分类号： C07H7/02 ,  A61K36/19 ,  A61K36/23 ,  A61K36/28 ,  A61K36/38 ,  A61K36/66 ,  A61K36/81 ,  A61K36/87 ,  G01N30/06 ,  G01N30/7206 ,  G01N33/6806 ,  H01J49/0027

    摘要： Disclosed are processes for the production of composition comprising one or more fructose amino acids, said process comprising the steps of: (a) providing plant material derived from a botanical source selected from plants of the families Solanaceae, Compositae, (Asteraceae), Guttiferae, Umbelliferae, Papaveraceae, Vitidaceae or Acanthaceae; (b) extracting one or more fructose amino acid(s) from said plant material; and optionally (c) detecting the presence and/or measuring the amount of said fructose amino acid(s) in the extract of step (b).

    摘要翻译： 本发明公开了包含一种或多种果糖氨基酸的组合物的生产方法，所述方法包括以下步骤：（a）提供源自选自茄科，菊科，菊科， 伞形科，罂粟科，紫菜科或菊科; （b）从所述植物材料中提取一种或多种果糖氨基酸; 和（c）检测步骤（b）的提取物中存在和/或测量所述果糖氨基酸的量的量。