公开(公告)号：US20160213733A1

公开(公告)日：2016-07-28

申请号：US15008336

申请日：2016-01-27

申请人： Phytoquest Limited

发明人： Robert James Nash

IPC分类号： A61K36/899 ,  A61K8/97 ,  A61Q19/00 ,  G01N30/72 ,  A61K31/445 ,  A23L2/52 ,  G01N33/10 ,  A01H5/10 ,  A61K8/60

CPC分类号： A61K36/899 ,  A01H1/04 ,  A01H5/10 ,  A23L2/52 ,  A23L33/105 ,  A23V2002/00 ,  A61K8/60 ,  A61K8/97 ,  A61K31/445 ,  A61K36/889 ,  A61Q19/00 ,  G01N30/7206 ,  G01N33/10

摘要： Processes for the production of a composition comprising material derived from seeds of plants of the genus Oryza, the process comprise the steps of: (a) providing material derived from seeds of the genus Oryza; and (b) determining the presence or absence and/or measuring the amount of at least one iminosugar in the material of step (a). Also described is the use of material derived from seeds of plants of the genus Oryza, which material comprises at least one iminosugar, as a food or feed supplement for lowering the glycaemic index (GI) value of said food or feed.

摘要翻译： 用于生产包含衍生自Oryza植物种子的物质的组合物的方法，该方法包括以下步骤：（a）提供衍生自Oryza属种子的物质; 和（b）确定步骤（a）的材料中存在或不存在和/或测量至少一种亚氨基糖苷的量。 还描述了使用源自Oryza属植物的种子的材料，该材料包含至少一种亚氨基甘露糖，作为用于降低所述食物或饲料的血糖指数（GI）值的食物或饲料补充剂。

公开(公告)号：US20210054012A1

公开(公告)日：2021-02-25

申请号：US16990890

申请日：2020-08-11

申请人： Phytoquest Limited

发明人： Robert James Nash

IPC分类号： C07H7/02 ,  A61K36/81 ,  A61K36/87 ,  A61K36/19 ,  A61K36/23 ,  A61K36/28 ,  A61K36/38 ,  A61K36/66 ,  G01N30/06 ,  G01N30/72 ,  G01N33/68 ,  H01J49/00

摘要： Disclosed are processes for the production of composition comprising one or more fructose amino acids, said process comprising the steps of: (a) providing plant material derived from a botanical source selected from plants of the families Solanaceae, Compositae, (Asteraceae), Guttiferae, Umbelliferae, Papaveraceae, Vitidaceae or Acanthaceae; (b) extracting one or more fructose amino acid(s) from said plant material; and optionally (c) detecting the presence and/or measuring the amount of said fructose amino acid(s) in the extract of step (b).

公开(公告)号：US20180094013A1

公开(公告)日：2018-04-05

申请号：US15832028

申请日：2017-12-05

申请人： Phytoquest Limited

发明人： Robert James Nash

IPC分类号： C07H7/02 ,  H01J49/00 ,  G01N33/68 ,  G01N30/72 ,  G01N30/06 ,  A61K36/81 ,  A61K36/38 ,  A61K36/28 ,  A61K36/23 ,  A61K36/19 ,  A61K36/87 ,  A61K36/66

CPC分类号： C07H7/02 ,  A61K36/19 ,  A61K36/23 ,  A61K36/28 ,  A61K36/38 ,  A61K36/66 ,  A61K36/81 ,  A61K36/87 ,  G01N30/06 ,  G01N30/7206 ,  G01N33/6806 ,  H01J49/0027

摘要： Disclosed are processes for the production of composition comprising one or more fructose amino acids, said process comprising the steps of: (a) providing plant material derived from a botanical source selected from plants of the families Solanaceae, Compositae, (Asteraceae), Guttiferae, Umbelliferae, Papaveraceae, Vitidaceae or Acanthaceae; (b) extracting one or more fructose amino acid(s) from said plant material; and optionally (c) detecting the presence and/or measuring the amount of said fructose amino acid(s) in the extract of step (b).

公开(公告)号：US20240360171A1

公开(公告)日：2024-10-31

申请号：US18598200

申请日：2024-03-07

申请人： Phytoquest Limited

发明人： Robert James Nash

IPC分类号： C07H7/02 ,  A61K36/19 ,  A61K36/23 ,  A61K36/28 ,  A61K36/38 ,  A61K36/66 ,  A61K36/81 ,  A61K36/87 ,  G01N30/06 ,  G01N30/72 ,  G01N33/68 ,  H01J49/00

CPC分类号： C07H7/02 ,  A61K36/19 ,  A61K36/23 ,  A61K36/28 ,  A61K36/38 ,  A61K36/66 ,  A61K36/81 ,  A61K36/87 ,  G01N30/06 ,  G01N30/7206 ,  G01N33/6806 ,  H01J49/0027

摘要： Disclosed are processes for the production of composition comprising one or more fructose amino acids, said process comprising the steps of: (a) providing plant material derived from a botanical source selected from plants of the families Solanaceae, Compositae, (Asteraceae), Guttiferae, Umbelliferae, Papaveraceae, Vitidaceae or Acanthaceae; (b) extracting one or more fructose amino acid(s) from said plant material; and optionally (c) detecting the presence and/or measuring the amount of said fructose amino acid(s) in the extract of step (b).

公开(公告)号：US09717718B2

公开(公告)日：2017-08-01

申请号：US15086796

申请日：2016-03-31

申请人： Phytoquest Limited

发明人： Robert James Nash

IPC分类号： A61K31/445 ,  A61K36/42 ,  C07D211/60 ,  A61K8/49 ,  A61Q19/00 ,  A61K45/06 ,  A61Q19/10 ,  G01N33/94 ,  A23L33/105 ,  A61K9/00

CPC分类号： A61K31/445 ,  A23L33/105 ,  A61K8/4926 ,  A61K9/0014 ,  A61K9/0053 ,  A61K9/006 ,  A61K36/42 ,  A61K45/06 ,  A61Q19/00 ,  A61Q19/10 ,  C07D211/60 ,  G01N33/94 ,  Y10T436/145555

摘要： Compositions comprising isolated ido-BR1 are described for use in therapy or prophylaxis, including the treatment of inflammatory diseases (for example as anti-inflammatory drugs) and to reduce inflammation. Also described are methods for monitoring the quality of a Cucurbitaceae extract, to processes for producing a Cucurbitaceae extract as well as to Cucurbitaceae extracts obtainable by such processes.

公开(公告)号：US20210403424A1

公开(公告)日：2021-12-30

申请号：US17338422

申请日：2021-06-03

申请人： Phytoquest Limited

发明人： Robert James Nash

IPC分类号： C07D207/16 ,  C07D207/12 ,  A23L33/105 ,  A61K8/49 ,  A61K36/725 ,  A61Q19/00

摘要： Described are compositions comprising selected isolated 4-hydroxymethyl-prolines, or pharmaceutically acceptable salts or derivatives thereof. Also described are novel 4-hydroxymethyl-N-methyl-prolines, together with processes for their preparation, compositions containing them, as well as their use as medicaments and pharmaceuticals. Also described are processes for producing a herbal medicine comprising the step of monitoring the quality of said herbal medicine by detecting the presence or absence or measuring the amount of one or more 4-hydroxymethyl-N-methyl-prolines in a sample of said herbal medicine.

公开(公告)号：US09326977B2

公开(公告)日：2016-05-03

申请号：US14251074

申请日：2014-04-11

申请人： Phytoquest Limited

发明人： Robert James Nash

IPC分类号： A61K31/445 ,  A61Q19/00 ,  G01N33/94 ,  A61K36/42 ,  C07D211/60 ,  A61K8/49 ,  A23L1/30 ,  A61K45/06 ,  A61Q19/10

CPC分类号： A61K31/445 ,  A23L33/105 ,  A61K8/4926 ,  A61K9/0014 ,  A61K9/0053 ,  A61K9/006 ,  A61K36/42 ,  A61K45/06 ,  A61Q19/00 ,  A61Q19/10 ,  C07D211/60 ,  G01N33/94 ,  Y10T436/145555

摘要： Compositions comprising isolated ido-BR1 are described for use in therapy or prophylaxis, including the treatment of inflammatory diseases (for example as anti-inflammatory drugs) and to reduce inflammation. Also described are methods for monitoring the quality of a Cucurbitaceae extract, to processes for producing a Cucurbitaceae extract as well as to Cucurbitaceae extracts obtainable by such processes.

摘要翻译： 描述了包含分离的ido-BR1的组合物用于治疗或预防，包括治疗炎性疾病（例如抗炎药物）和减轻炎症。 还描述了用于监测葫芦科提取物的质量，用于生产葫芦科提取物的方法以及可通过这些方法获得的葫芦科提取物的方法。

公开(公告)号：US20140309258A1

公开(公告)日：2014-10-16

申请号：US14251074

申请日：2014-04-11

申请人： Phytoquest Limited

发明人： Robert James Nash

IPC分类号： A61K31/445 ,  A61K36/42 ,  A23L1/30 ,  A61Q19/00 ,  A61Q19/10 ,  G01N33/94 ,  A61K8/49 ,  A61K45/06

CPC分类号： A61K31/445 ,  A23L33/105 ,  A61K8/4926 ,  A61K9/0014 ,  A61K9/0053 ,  A61K9/006 ,  A61K36/42 ,  A61K45/06 ,  A61Q19/00 ,  A61Q19/10 ,  C07D211/60 ,  G01N33/94 ,  Y10T436/145555

摘要： Compositions comprising isolated ido-BR1 are described for use in therapy or prophylaxis, including the treatment of inflammatory diseases (for example as anti-inflammatory drugs) and to reduce inflammation. Also described are methods for monitoring the quality of a Cucurbitaceae extract, to processes for producing a Cucurbitaceae extract as well as to Cucurbitaceae extracts obtainable by such processes.

摘要翻译： 描述了包含分离的ido-BR1的组合物用于治疗或预防，包括治疗炎性疾病（例如抗炎药物）和减轻炎症。 还描述了用于监测葫芦科提取物的质量，用于生产葫芦科提取物的方法以及可通过这些方法获得的葫芦科提取物的方法。

公开(公告)号：US11970513B2

公开(公告)日：2024-04-30

申请号：US16990890

申请日：2020-08-11

申请人： Phytoquest Limited

发明人： Robert James Nash

IPC分类号： A61K36/00 ,  A61K36/19 ,  A61K36/23 ,  A61K36/28 ,  A61K36/38 ,  A61K36/66 ,  A61K36/81 ,  A61K36/87 ,  C07H7/02 ,  G01N30/06 ,  G01N30/72 ,  G01N33/68 ,  H01J49/00

CPC分类号： C07H7/02 ,  A61K36/19 ,  A61K36/23 ,  A61K36/28 ,  A61K36/38 ,  A61K36/66 ,  A61K36/81 ,  A61K36/87 ,  G01N30/06 ,  G01N30/7206 ,  G01N33/6806 ,  H01J49/0027

摘要： Disclosed are processes for the production of composition comprising one or more fructose amino acids, and related. Such a process may comprise the steps of: (a) providing plant material derived from a botanical source selected from plants of the families Solanaceae, Compositae, Asteraceae, Guttiferae, Umbelliferae, Papaveraceae, Vitidaceae or Acanthaceae; (b) extracting one or more fructose amino acid(s) from said plant material; and optionally, (c) detecting the presence and/or measuring the amount of said fructose amino acid(s) in the extract of step (b).

公开(公告)号：US20220288049A1

公开(公告)日：2022-09-15

申请号：US17584744

申请日：2022-01-26

申请人： Phytoquest Limited

发明人： Robert James Nash

IPC分类号： A61K31/45 ,  A61K36/42 ,  A61K8/9789 ,  A61K8/49 ,  A61Q19/00 ,  A61P29/00 ,  G01N33/68 ,  A23L33/105

摘要： Described are processes for the production of a composition comprising (2R, 3R, 4R, 5S)-3, 4, 5-trihydroxypiperidine-2-carboxylic acid (idoBR1), said process comprising the steps of: a) providing plant material from a botanical source comprising plant of the family Cucurbitaceae; b) fractionating said plant material to produce an extract enriched in idoBR1 c) assaying said extract for: i) inhibitory activity against sialidase or TNF-alpha or ii) IL-10 stimulatory activity; and d) formulating said assayed extract with a cosmetically-, nutraceutically- or pharmaceutically-acceptable excipient or carrier to produce a cosmetic, nutraceutical or pharmaceutical composition.