公开(公告)号：US20240053367A1

公开(公告)日：2024-02-15

申请号：US18222429

申请日：2023-07-15

申请人： IDEXX Laboratories, Inc.

发明人： Murthy VSN Yerramilli ,  Mahalakshmi Yerramilli ,  Edward Obare ,  Daniel Wayne Patch

IPC分类号： G01N33/72 ,  G01N21/33 ,  G01N30/86 ,  C12Q1/32

CPC分类号： G01N33/72 ,  G01N21/33 ,  G01N30/8675 ,  C12Q1/32 ,  G01N2333/904

摘要： Methods and devices for determining the hematocrit of blood samples.

公开(公告)号：US20190316171A1

公开(公告)日：2019-10-17

申请号：US16362478

申请日：2019-03-22

申请人： IDEXX LABORATORIES, INC.

发明人： Giosi Farace ,  Jon Braff ,  Murthy VSN Yerramilli

IPC分类号： C12Q1/06 ,  G01N33/493 ,  C12Q1/22 ,  G01N33/52 ,  G01N15/02 ,  C12Q1/24

摘要： The disclosure relates generally to methods for measuring bacteria in biological samples. More particularly, the disclosure relates to methods for measuring bacteria using an aqueous clearance solution.

公开(公告)号：US20240248081A1

公开(公告)日：2024-07-25

申请号：US18390909

申请日：2023-12-20

申请人： IDEXX Laboratories, Inc.

发明人： Murthy VSN Yerramilli ,  Hongzhi Xie ,  Daniel Wayne Patch ,  Giosi Farace

IPC分类号： G01N33/53 ,  C12N9/04 ,  G01N33/542 ,  G01N33/68

CPC分类号： G01N33/5308 ,  C12N9/0006 ,  G01N33/542 ,  G01N33/6812 ,  C12Y101/01049 ,  G01N2800/347

摘要： Homogeneous immunoassays that allow for compensation of background signals inherent in samples and reagents. The use of homogeneous immunoassays for the detection of the presence or amount of symmetrical Dimethyl Arginine (SDMA) in biological samples. Reagents and kits for conducting the assays.

公开(公告)号：US20240016426A1

公开(公告)日：2024-01-18

申请号：US18352792

申请日：2023-07-14

申请人： IDEXX Laboratories, Inc.

发明人： Murthy VSN Yerramilli ,  Justin Griffin

IPC分类号： A61B5/15 ,  C12Q1/32 ,  G01N33/72

CPC分类号： A61B5/150984 ,  A61B5/150114 ,  A61B5/150755 ,  C12Q1/32 ,  G01N33/72 ,  A61B2503/40 ,  G01N2333/902

摘要： A method of analyzing a blood sample from an animal is disclosed. The method includes: (a) extracting a blood sample from a blood collection device, wherein the blood collection device comprises: (i) a microneedle array and (ii) a blood storage layer, and wherein the microneedle array transports the blood sample from the animal to the blood storage layer, and wherein the microneedle array comprises one or more microneedles; (b) conducting at least one test on the extracted blood sample; and (c) reporting results from the at least one test to a customer.

公开(公告)号：US20220137059A1

公开(公告)日：2022-05-05

申请号：US17343369

申请日：2021-06-09

申请人： IDEXX Laboratories, inc.

发明人： Mahalakshmi Yerramilli ,  Murthy VSN Yerramilli

IPC分类号： G01N33/68 ,  G01N33/70

摘要： The disclosure is directed to methods and apparatus for the determination, diagnosis, progression and prognosis of kidney disease and mortality associated with kidney disease. The disclosure includes methods for determining renal function, in particular estimating glomerular filtration rate (GFR), in an animal. GFR can be useful in the diagnosis and treatment of kidney disease or dysfunction. In various aspects, the disclosure is directed to the use of free symmetrical dimethylarginine (SDMA) and creatinine in blood samples from animals, in particular cats and dogs, to determine glomerular filtration rate and kidney disease.

公开(公告)号：US20180142009A1

公开(公告)日：2018-05-24

申请号：US15568653

申请日：2016-04-29

申请人： IDEXX Laboratories, Inc.

发明人： John Joseph Quinn ,  Murthy VSN Yerramilli

IPC分类号： C07K16/18 ,  G01N33/68 ,  G01N33/52 ,  G01N33/533 ,  G01N33/534 ,  G01N33/535 ,  G01N33/543

CPC分类号： C07K16/18 ,  G01N33/523 ,  G01N33/533 ,  G01N33/534 ,  G01N33/535 ,  G01N33/54326 ,  G01N33/54386 ,  G01N33/68 ,  G01N33/6893 ,  G01N2333/775 ,  G01N2800/347

摘要： The invention provides methods and compositions for the detection of specific isoforms of clusterin.

公开(公告)号：US11531032B2

公开(公告)日：2022-12-20

申请号：US16243882

申请日：2019-01-09

申请人： IDEXX LABORATORIES, INC.

发明人： Patrick Doherty ,  Kevin Kirspel ,  Giosi Farace ,  Murthy VSN Yerramilli

IPC分类号： G01N33/52 ,  G06T7/00 ,  H04N5/235 ,  G01N33/68 ,  G01N31/22 ,  G01N21/27 ,  G01N1/30 ,  G01N21/82 ,  G01N21/78

摘要： The disclosure directed to methods for measuring an analyte alone or in combination with total protein in biological samples. More particularly, the disclosure relates to methods for measuring an analyte and/or total protein using one or more colorimetric reagents alone or in combination with protein precipitation reagents.

公开(公告)号：US20210239704A1

公开(公告)日：2021-08-05

申请号：US17188710

申请日：2021-03-01

申请人： IDEXX LABORATORIES, INC.

发明人： Mahalakshmi Yerramilli ,  Edward Obare ,  John Joseph Quinn ,  Murthy VSN Yerramilli

IPC分类号： G01N33/68 ,  G01N33/53 ,  C07C229/16 ,  C07K16/44

摘要： Analogs and conjugates of β-Aminoisobutyric Acid (BAIB).

公开(公告)号：US20190120856A1

公开(公告)日：2019-04-25

申请号：US16165337

申请日：2018-10-19

申请人： IDEXX LABORATORIES, INC.

发明人： Hongzhi Xie ,  Sreenivasa Rao Ramisetty ,  Murthy VSN Yerramilli

IPC分类号： G01N33/68 ,  G01N33/563

摘要： The disclosure generally relates to the detection of symmetrical dimethylarginine (SDMA). More particularly, the disclosure relates to the detection of SDMA using a solid phase. The disclosure provides devices, reagents, kits and methods for detecting symmetrical dimethyl arginine (SDMA) in sample, such as a biological sample from an animal. The method includes detecting the presence or amount of SDMA in the sample by using an immunoassay format, such as a competitive immunoassay. The assay includes the use of antibodies to SDMA that are specific for SDMA and that have less affinity for other arginine derivatives.

公开(公告)号：US20180120326A1

公开(公告)日：2018-05-03

申请号：US15569619

申请日：2016-05-02

申请人： IDEXX LABORATORIES, INC.

发明人： Mahalakshmi Yerramilli ,  Edward Obare ,  John Joseph Quinn ,  Murthy VSN Yerramilli

IPC分类号： G01N33/68 ,  G01N33/53 ,  C07C229/16 ,  C07K16/44

CPC分类号： G01N33/6812 ,  C07C229/16 ,  C07K16/44 ,  G01N33/5308 ,  G01N33/6806 ,  G01N2800/347

摘要： Methods for determining renal function in an animal subject, the method including measuring the concentration of β-ammoisobutyric acid (β-amino isobutyrate) (BAIB) in patients samples and determining the presence, likelihood, or progression of kidney disease as a result of structural damage, or mortality associated with kidney disease. The methods also include measuring the concentration of BAIB in combination is symmetrical dimethyl arginine (SDMA) and determining kidney disease based upon the concentrations of BAIB and SDMA in the samples. Anti-BAIB antibodies, BAIB-conjugates, and assay methods using the antibodies and conjugates are also disclosed.