公开(公告)号：US20240053367A1

公开(公告)日：2024-02-15

申请号：US18222429

申请日：2023-07-15

Applicant: IDEXX Laboratories, Inc.

Inventor： Murthy VSN Yerramilli ,  Mahalakshmi Yerramilli ,  Edward Obare ,  Daniel Wayne Patch

IPC: G01N33/72 ,  G01N21/33 ,  G01N30/86 ,  C12Q1/32

CPC classification number: G01N33/72 ,  G01N21/33 ,  G01N30/8675 ,  C12Q1/32 ,  G01N2333/904

Abstract: Methods and devices for determining the hematocrit of blood samples.

公开(公告)号：US20190316171A1

公开(公告)日：2019-10-17

申请号：US16362478

申请日：2019-03-22

Applicant: IDEXX LABORATORIES, INC.

Inventor： Giosi Farace ,  Jon Braff ,  Murthy VSN Yerramilli

IPC: C12Q1/06 ,  G01N33/493 ,  C12Q1/22 ,  G01N33/52 ,  G01N15/02 ,  C12Q1/24

Abstract: The disclosure relates generally to methods for measuring bacteria in biological samples. More particularly, the disclosure relates to methods for measuring bacteria using an aqueous clearance solution.

公开(公告)号：US20240248081A1

公开(公告)日：2024-07-25

申请号：US18390909

申请日：2023-12-20

Applicant: IDEXX Laboratories, Inc.

Inventor： Murthy VSN Yerramilli ,  Hongzhi Xie ,  Daniel Wayne Patch ,  Giosi Farace

IPC: G01N33/53 ,  C12N9/04 ,  G01N33/542 ,  G01N33/68

CPC classification number: G01N33/5308 ,  C12N9/0006 ,  G01N33/542 ,  G01N33/6812 ,  C12Y101/01049 ,  G01N2800/347

Abstract: Homogeneous immunoassays that allow for compensation of background signals inherent in samples and reagents. The use of homogeneous immunoassays for the detection of the presence or amount of symmetrical Dimethyl Arginine (SDMA) in biological samples. Reagents and kits for conducting the assays.

公开(公告)号：US20240016426A1

公开(公告)日：2024-01-18

申请号：US18352792

申请日：2023-07-14

Applicant: IDEXX Laboratories, Inc.

Inventor： Murthy VSN Yerramilli ,  Justin Griffin

IPC: A61B5/15 ,  C12Q1/32 ,  G01N33/72

CPC classification number: A61B5/150984 ,  A61B5/150114 ,  A61B5/150755 ,  C12Q1/32 ,  G01N33/72 ,  A61B2503/40 ,  G01N2333/902

Abstract: A method of analyzing a blood sample from an animal is disclosed. The method includes: (a) extracting a blood sample from a blood collection device, wherein the blood collection device comprises: (i) a microneedle array and (ii) a blood storage layer, and wherein the microneedle array transports the blood sample from the animal to the blood storage layer, and wherein the microneedle array comprises one or more microneedles; (b) conducting at least one test on the extracted blood sample; and (c) reporting results from the at least one test to a customer.

公开(公告)号：US20220137059A1

公开(公告)日：2022-05-05

申请号：US17343369

申请日：2021-06-09

Applicant: IDEXX Laboratories, inc.

Inventor： Mahalakshmi Yerramilli ,  Murthy VSN Yerramilli

IPC: G01N33/68 ,  G01N33/70

Abstract: The disclosure is directed to methods and apparatus for the determination, diagnosis, progression and prognosis of kidney disease and mortality associated with kidney disease. The disclosure includes methods for determining renal function, in particular estimating glomerular filtration rate (GFR), in an animal. GFR can be useful in the diagnosis and treatment of kidney disease or dysfunction. In various aspects, the disclosure is directed to the use of free symmetrical dimethylarginine (SDMA) and creatinine in blood samples from animals, in particular cats and dogs, to determine glomerular filtration rate and kidney disease.

公开(公告)号：US20180142009A1

公开(公告)日：2018-05-24

申请号：US15568653

申请日：2016-04-29

Applicant: IDEXX Laboratories, Inc.

Inventor： John Joseph Quinn ,  Murthy VSN Yerramilli

IPC: C07K16/18 ,  G01N33/68 ,  G01N33/52 ,  G01N33/533 ,  G01N33/534 ,  G01N33/535 ,  G01N33/543

CPC classification number: C07K16/18 ,  G01N33/523 ,  G01N33/533 ,  G01N33/534 ,  G01N33/535 ,  G01N33/54326 ,  G01N33/54386 ,  G01N33/68 ,  G01N33/6893 ,  G01N2333/775 ,  G01N2800/347

Abstract: The invention provides methods and compositions for the detection of specific isoforms of clusterin.

公开(公告)号：US20240327894A1

公开(公告)日：2024-10-03

申请号：US18742024

申请日：2024-06-13

Applicant: IDEXX LABORATORIES, Inc.

Inventor： Giosi Farace ,  Jon Braff ,  Murthy VSN Yerramilli

IPC: C12Q1/06 ,  C12Q1/22 ,  C12Q1/24 ,  G01N15/02 ,  G01N15/0227 ,  G01N33/493 ,  G01N33/52

CPC classification number: C12Q1/06 ,  C12Q1/22 ,  C12Q1/24 ,  G01N15/0227 ,  G01N33/493 ,  G01N33/52 ,  G01N2015/0294 ,  G01N2800/26

Abstract: The disclosure relates generally to methods for measuring bacteria in biological samples. More particularly, the disclosure relates to methods for measuring bacteria using an aqueous clearance solution.

公开(公告)号：US20230102277A1

公开(公告)日：2023-03-30

申请号：US17877410

申请日：2022-07-29

Applicant: IDEXX LABORATORIES, INC.

Inventor： Honghzhi Xie ,  Sreenivasa Rao Ramisetty ,  Murthy VSN Yerramilli

IPC: G01N33/68 ,  G01N33/563 ,  G01N33/58 ,  G01N33/60

Abstract: The disclosure generally relates to the detection of symmetrical dimethylarginine (SDMA). More particularly, the disclosure relates to the detection of SDMA using a solid phase. The disclosure provides devices, reagents, kits and methods for detecting symmetrical dimethyl arginine (SDMA) in sample, such as a biological sample from an animal. The method includes detecting the presence or amount of SDMA in the sample by using an immunoassay format, such as a competitive immunoassay. The assay includes the use of antibodies to SDMA that are specific for SDMA and that have less affinity for other arginine derivatives.

公开(公告)号：US20210018496A1

公开(公告)日：2021-01-21

申请号：US16924081

申请日：2020-07-08

Applicant: IDEXX LABORATORIES, INC.

Inventor： Murthy VSN Yerramilli ,  Hongzhi Xie ,  Daniel Wayne Patch ,  Giosi Farace

IPC: G01N33/53 ,  G01N33/542 ,  G01N33/68 ,  C12N9/04

Abstract: Homogeneous immunoassays that allow for compensation of background signals inherent in samples and reagents. The use of homogeneous immunoassays for the detection of the presence or amount of symmetrical Dimethyl Arginine (SDMA) in biological samples. Reagents and kits for conducting the assays.

公开(公告)号：US20190219589A1

公开(公告)日：2019-07-18

申请号：US16243882

申请日：2019-01-09

Applicant: IDEXX LABORATORIES, INC.

Inventor： Patrick Doherty ,  Kevin Kirspel ,  Giosi Farace ,  Murthy VSN Yerramilli

IPC: G01N33/68 ,  G01N21/78 ,  G01N33/52 ,  G06T7/00 ,  H04N5/235

CPC classification number: G01N33/6827 ,  G01N1/30 ,  G01N21/272 ,  G01N21/78 ,  G01N21/82 ,  G01N33/52 ,  G06T7/0012 ,  G06T2207/10144 ,  G06T2207/30242 ,  H04N5/2353

Abstract: The disclosure directed to methods for measuring an analyte alone or in combination with total protein in biological samples. More particularly, the disclosure relates to methods for measuring an analyte and/or total protein using one or more colorimetric reagents alone or in combination with protein precipitation reagents.