公开(公告)号：US20180142009A1

公开(公告)日：2018-05-24

申请号：US15568653

申请日：2016-04-29

申请人： IDEXX Laboratories, Inc.

发明人： John Joseph Quinn ,  Murthy VSN Yerramilli

IPC分类号： C07K16/18 ,  G01N33/68 ,  G01N33/52 ,  G01N33/533 ,  G01N33/534 ,  G01N33/535 ,  G01N33/543

CPC分类号： C07K16/18 ,  G01N33/523 ,  G01N33/533 ,  G01N33/534 ,  G01N33/535 ,  G01N33/54326 ,  G01N33/54386 ,  G01N33/68 ,  G01N33/6893 ,  G01N2333/775 ,  G01N2800/347

摘要： The invention provides methods and compositions for the detection of specific isoforms of clusterin.

公开(公告)号：US20210239704A1

公开(公告)日：2021-08-05

申请号：US17188710

申请日：2021-03-01

申请人： IDEXX LABORATORIES, INC.

发明人： Mahalakshmi Yerramilli ,  Edward Obare ,  John Joseph Quinn ,  Murthy VSN Yerramilli

IPC分类号： G01N33/68 ,  G01N33/53 ,  C07C229/16 ,  C07K16/44

摘要： Analogs and conjugates of β-Aminoisobutyric Acid (BAIB).

公开(公告)号：US20180120326A1

公开(公告)日：2018-05-03

申请号：US15569619

申请日：2016-05-02

申请人： IDEXX LABORATORIES, INC.

发明人： Mahalakshmi Yerramilli ,  Edward Obare ,  John Joseph Quinn ,  Murthy VSN Yerramilli

IPC分类号： G01N33/68 ,  G01N33/53 ,  C07C229/16 ,  C07K16/44

CPC分类号： G01N33/6812 ,  C07C229/16 ,  C07K16/44 ,  G01N33/5308 ,  G01N33/6806 ,  G01N2800/347

摘要： Methods for determining renal function in an animal subject, the method including measuring the concentration of β-ammoisobutyric acid (β-amino isobutyrate) (BAIB) in patients samples and determining the presence, likelihood, or progression of kidney disease as a result of structural damage, or mortality associated with kidney disease. The methods also include measuring the concentration of BAIB in combination is symmetrical dimethyl arginine (SDMA) and determining kidney disease based upon the concentrations of BAIB and SDMA in the samples. Anti-BAIB antibodies, BAIB-conjugates, and assay methods using the antibodies and conjugates are also disclosed.