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    Electrochemical biosensor and uses thereof
    1.
    发明授权
    Electrochemical biosensor and uses thereof 有权

    公开(公告)号：US12297485B2

    公开(公告)日：2025-05-13

    申请号：US17812876

    申请日：2022-07-15

    Applicant: UNIVERSITY OF CONNECTICUT

    Inventor： Changchun Liu ,  Ziyue Li

    IPC: C12Q1/6825 ,  C12Q1/6823 ,  G01N27/327

    Abstract: Described herein is an immobilization-free, electrochemical method of detecting a target DNA sequence in a sample. The method includes: incubating the sample with a detection mixture, applying an electric field including an alternating current electric field and a direct current offset to the detection mixture to concentrate nucleic acids in the sample and the nucleic acid probe on a positively charged working electrode, wherein a Class 2 Cas protein trans-cleaved electroactive probe is released from the nucleic acid probe when the target DNA is present in the sample and diffuses toward a negatively charged electrode; and measuring the current as potential is applied, wherein detection of a current in the detection mixture indicates the presence of the target DNA sequence in the sample.

    METHOD AND APPARATUS FOR IMPROVING INTELLIGIBILITY OF SPEECH AND AUDIBILITY OF WARNING SOUNDS IN NOISE
    6.
    发明申请
    METHOD AND APPARATUS FOR IMPROVING INTELLIGIBILITY OF SPEECH AND AUDIBILITY OF WARNING SOUNDS IN NOISE 有权

    公开(公告)号：US20250022481A1

    公开(公告)日：2025-01-16

    申请号：US18770039

    申请日：2024-07-11

    Applicant: University of Connecticut

    Inventor： Anthony John Brammer ,  Insoo Kim

    IPC: G10L21/0364 ,  G10L21/0208

    Abstract: A method for improving intelligibility of speech and/or warning sounds generated in a noisy environment including receiving an audio signal from the noisy environment, segmenting the audio signal into a plurality of frequency bandwidths to provide a plurality of temporal bandwidth limited signals, and providing each temporal bandwidth limited signal to an associated signal path and an associated control path in parallel with the associated signal path. The method also includes filtering the temporal envelope bandwidth signal in each associated control path using a delayless filter to provide an associated control signal, modulating an amplitude of the temporal bandpass signal in each associated signal path using the associated control signal to provide an associated output signal, and combining the associated output signals to provide a combined output signal that improves the intelligibility of the speech and/or warning sounds generated in the noisy environment.

    CARDIOPULMONARY RESUSCITATION, TREATMENT, AND ANALYSIS
    7.
    发明公开
    CARDIOPULMONARY RESUSCITATION, TREATMENT, AND ANALYSIS 审中-公开

    公开(公告)号：US20240342496A1

    公开(公告)日：2024-10-17

    申请号：US18659762

    申请日：2024-05-09

    Applicant: University of Connecticut

    Inventor： Ki Chon ,  Mahdi Pirayesh Shirazi Nejad

    IPC: A61N1/39

    CPC classification number: A61N1/395 ,  A61N1/3987 ,  G06N3/045 ,  G06N3/0464

    Abstract: An apparatus for treating a person having cardiac arrest includes a processor and a lead in communication with the processor, the lead being configured to receive a segment of electrocardiogram (ECG) data from the person while undergoing cardiopulmonary resuscitation (CPR). The apparatus also includes a non-transitory computer-readable medium having: a first Convolutional Neural Network-based Encoder-Decoder (CNNED) structure to reduce artifacts due to the CPR; a second CNNED structure cascaded with the first CNNED structure to further reduce artifacts; and instructions to determine a first arrhythmia classification using the first CNNED structure, determine a second arrhythmia classification using the second CNNED structure in response to the first arrhythmia classification indicating a shockable arrhythmia event; and transmit a signal to apply a defibrillation shock to the person in response to the first arrhythmia classification and the second arrhythmia classification indicating a shockable arrhythmia of the person.

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