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    Biological Conversion of Multi-Carbon Compounds from Methane
    2.
    发明申请
    Biological Conversion of Multi-Carbon Compounds from Methane 有权
    多碳化合物从甲烷的生物转化

    公开(公告)号：US20140273128A1

    公开(公告)日：2014-09-18

    申请号：US14206835

    申请日：2014-03-12

    Applicant: Intrexon Corporation

    Inventor： William J. COLEMAN ,  Genevieve M. VIDANES ,  Guillaume COTTAREL ,  Sheela MULEY ,  Roy KAMIMURA ,  Akbar F. JAVAN ,  Jianping SUN ,  Eli S. GROBAN

    IPC: C12P7/16 ,  C12N15/74

    CPC classification number: C12P7/16 ,  C12N9/0006 ,  C12N9/1022 ,  C12N9/1025 ,  C12N9/88 ,  C12N15/52 ,  C12Y101/01001 ,  C12Y101/01004 ,  C12Y101/01086 ,  C12Y202/01006 ,  C12Y203/03006 ,  C12Y401/01072 ,  C12Y402/01009 ,  C12Y402/01033 ,  C12Y403/01019 ,  Y02E50/10

    Abstract: Multi-carbon compounds such as ethanol, n-butanol, sec-butanol, isobutanol, tert-butanol, fatty (or aliphatic long chain) alcohols, fatty acid methyl esters, 2,3-butanediol and the like, are important industrial commodity chemicals with a variety of applications. The present invention provides metabolically engineered host microorganisms which metabolize methane (CH4) as their sole carbon source to produce multi-carbon compounds for use in fuels (e.g., bio-fuel, bio-diesel) and bio-based chemicals. Furthermore, use of the metabolically engineered host microorganisms of the invention (which utilize methane as the sole carbon source) mitigate current industry practices and methods of producing multi-carbon compounds from petroleum or petroleum-derived feedstocks, and ameliorate much of the ongoing depletion of arable food source “farmland” currently being diverted to grow bio-fuel feedstocks, and as such, improve the environmental footprint of future bio-fuel, bio-diesel and bio-based chemical compositions.

    Abstract translation: 多碳化合物如乙醇，正丁醇，仲丁醇，异丁醇，叔丁醇，脂肪（或脂肪族长链）醇，脂肪酸甲酯，2,3-丁二醇等是重要的工业商品化学品 具有多种应用。 本发明提供代谢工程的宿主微生物，其代谢甲烷（CH4）作为其唯一的碳源，以生产用于燃料（例如生物燃料，生物柴油）和生物基化学品的多碳化合物。 此外，使用本发明的代谢工程的宿主微生物（其利用甲烷作为唯一碳源）减轻了目前的行业实践和从石油或石油衍生的原料生产多碳化合物的方法，并且改善了大部分正在进行的耗尽 目前正在转用生物燃料原料的可耕食源“农田”，从而改善未来生物燃料，生物柴油和生物基化学成分的环境足迹。

    Biological production of multi-carbon compounds from methane
    4.
    发明授权
    Biological production of multi-carbon compounds from methane 有权
    从甲烷生物生产多碳化合物

    公开(公告)号：US09267158B2

    公开(公告)日：2016-02-23

    申请号：US14206835

    申请日：2014-03-12

    Applicant: Intrexon Corporation

    Inventor： William J. Coleman ,  Genevieve M. Vidanes ,  Guillaume Cottarel ,  Sheela Muley ,  Roy Kamimura ,  Akbar F. Javan ,  Jianping Sun ,  Eli S. Groban

    IPC: C12P7/16 ,  C12N9/04 ,  C12N9/10 ,  C12N9/88

    CPC classification number: C12P7/16 ,  C12N9/0006 ,  C12N9/1022 ,  C12N9/1025 ,  C12N9/88 ,  C12N15/52 ,  C12Y101/01001 ,  C12Y101/01004 ,  C12Y101/01086 ,  C12Y202/01006 ,  C12Y203/03006 ,  C12Y401/01072 ,  C12Y402/01009 ,  C12Y402/01033 ,  C12Y403/01019 ,  Y02E50/10

    Abstract: Multi-carbon compounds such as ethanol, n-butanol, sec-butanol, isobutanol, tert-butanol, fatty (or aliphatic long chain) alcohols, fatty acid methyl esters, 2,3-butanediol and the like, are important industrial commodity chemicals with a variety of applications. The present invention provides metabolically engineered host microorganisms which metabolize methane (CH4) as their sole carbon source to produce multi-carbon compounds for use in fuels (e.g., bio-fuel, bio-diesel) and bio-based chemicals. Furthermore, use of the metabolically engineered host microorganisms of the invention (which utilize methane as the sole carbon source) mitigate current industry practices and methods of producing multi-carbon compounds from petroleum or petroleum-derived feedstocks, and ameliorate much of the ongoing depletion of arable food source “farmland” currently being diverted to grow bio-fuel feedstocks, and as such, improve the environmental footprint of future bio-fuel, bio-diesel and bio-based chemical compositions.

    Abstract translation: 多碳化合物如乙醇，正丁醇，仲丁醇，异丁醇，叔丁醇，脂肪（或脂肪族长链）醇，脂肪酸甲酯，2,3-丁二醇等是重要的工业商品化学品 具有多种应用。 本发明提供代谢工程的宿主微生物，其代谢甲烷（CH4）作为其唯一的碳源，以生产用于燃料（例如生物燃料，生物柴油）和生物基化学品的多碳化合物。 此外，使用本发明的代谢工程的宿主微生物（其利用甲烷作为唯一碳源）减轻了目前的行业实践和从石油或石油衍生的原料生产多碳化合物的方法，并且改善了大部分正在进行的耗尽 目前正在转用生物燃料原料的可耕食源“农田”，从而改善未来生物燃料，生物柴油和生物基化学成分的环境足迹。

    PROCESSES TO PREPARE ELONGATED 2-KETOACIDS AND C6-C10 COMPOUNDS THEREFROM VIA GENETIC MODIFICATIONS TO MICROBIAL METABOLIC PATHWAYS
    9.
    发明申请
    PROCESSES TO PREPARE ELONGATED 2-KETOACIDS AND C6-C10 COMPOUNDS THEREFROM VIA GENETIC MODIFICATIONS TO MICROBIAL METABOLIC PATHWAYS 有权
    通过遗传修饰向微生物代谢途径制备长链2-酮酸酯和其通过C6-C10化合物的方法

    公开(公告)号：US20160355850A1

    公开(公告)日：2016-12-08

    申请号：US15030616

    申请日：2014-12-10

    Applicant: DOW GLOBAL TECHNOLOGIES LLC

    Inventor： Paresh C. Sanghani ,  Brandon A. Rodriguez ,  Christopher C. Stowers ,  Amudhan Venkateswaran

    IPC: C12P7/64 ,  C12N9/10 ,  C12N9/88 ,  C12N9/04

    CPC classification number: C12P7/6409 ,  C12N1/14 ,  C12N1/20 ,  C12N9/0006 ,  C12N9/1025 ,  C12N9/88 ,  C12N15/52 ,  C12P7/24 ,  C12P7/26 ,  C12P7/40 ,  C12Y101/01085 ,  C12Y203/03013 ,  C12Y402/01033

    Abstract: Modification of metabolic pathways includes genetically engineering at least one enzyme involved in elongating 2-ketoacids during leucine biosynthesis, and preferably at least isopropylmalate dehydrogenase or synthase (LeuB or LeuA in E. coli), to include at least such non-native enzyme, enzyme complex, or combination thereof to convert 2-ketobutyrate or 2-ketoisovalerate to a C7-C11 2-ketoacid, wherein the production of such is at a higher efficiency than if a purely native pathway is followed. The C7-C11 2-ketoacid may then be converted, via a native or genetically engineered thiamin dependent decarboxylase, to form a C6-C10 aldehyde having one less carbon than the C7-C11 2-ketoacid being converted. In some embodiments the C6-C10 aldehyde may then be converted via additional native or genetically engineered enzymes to form other C6-C10 products, including alcohols, carboxylic acids, and alkanes. This genetic engineering offers the opportunity for commercial scale of in vivo biosynthetic processes that may be more cost-efficient than non-biobased approaches to produce the same products.

    Abstract translation: 代谢途径的修饰包括在亮氨酸生物合成过程中，优选至少包含异丙基丙酸脱氢酶或合酶（大肠杆菌中的LeuB或LeuA），将至少一种参与延伸2-酮酸的酶基因工程化，至少包括这种非天然酶，酶 复合物或其组合以将2-酮丁酸酯或2-酮异戊酸酯转化成C7-C11 2-酮酸，其中与其遵循纯天然途径相比，其生产效率更高。 然后可以通过天然或遗传工程化的硫胺素依赖性脱羧酶将C7-C11 2-酮酸转化成与被转化的C7-C11 2-酮酸一碳多一碳的C6-C10醛。 在一些实施方案中，然后可以通过另外的天然或遗传工程改造的C 6 -C 10醛转化成其它C6-C10产物，包括醇，羧酸和烷烃。 这种基因工程提供了商业规模的体内生物合成过程的机会，其可能比非生物基生产相同产品的方法更具成本效益。

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