-
公开(公告)号：US11952575B2
公开(公告)日：2024-04-09
申请号：US16652291
申请日：2017-11-15
发明人： Hao Hong , Gage James , Jiangping Lu , Xingfu Xu , Wenyan Yu , Xin Huang , Yulei Ma , Yibing Cheng
CPC分类号： C12N15/70 , C12P13/001 , C12Y206/01
摘要： A transaminase mutant and use hereof, the amino acid sequence of the transaminase mutant is an amino acid sequence in which the amino acid sequence as represented by SEQ ID NO: 1 is mutated, the mutated amino acid position being one or more selected from among F89, K193, P243, V234, I262, Q280, V379, R416, A417 and C418. The enzymatic activity and/or stability of the transaminase mutant is improved.
-
公开(公告)号：US20240110216A1
公开(公告)日：2024-04-04
申请号：US18329744
申请日：2023-06-06
申请人： ZuChem, Inc.
CPC分类号： C12P19/60 , A61K35/66 , C12N9/0006 , C12N9/1029 , C12N9/1096 , C12N9/1241 , C12N9/88 , C12N9/90 , C12P19/18 , C12Y101/01049 , C12Y206/01 , C12Y207/07024 , C12Y402/01046 , C12Y501/03013 , A61K35/00
摘要： The invention provides compositions and methods for the production of TDP-deoxysugars.
-
公开(公告)号：US20180327724A1
公开(公告)日：2018-11-15
申请号：US15771812
申请日：2016-10-27
发明人： Jung Oh AHN , Hong Weon LEE , Gyu Yeon PARK , Min Jeong JANG , Woo Young JEON
CPC分类号： C12N9/1096 , C12N9/10 , C12N15/815 , C12P7/64 , C12P13/00 , C12P13/005 , C12Y206/01
摘要： The present invention relates to a method for producing a medium chain aminocarboxylic acid and, more particularly, to a recombinant microorganism in which a fatty aldehyde dehydrogenase gene in ω-oxidative metabolic pathway and a β-oxidative metabolic pathway-related gene are deleted and a ω-transaminase gene is introduced, and a method for producing a medium chain aminocarboxylic acid by culturing the recombinant microorganism. The recombinant microorganism of the present invention can prevent additional oxidation of fatty aldehyde and β-oxidative metabolism and also produce a medium chain aminocarboxylic acid, such as 12-aminodecane, as a raw material of nylon 12 from a substrate such as fatty acid with a high yield by introducing an amine group into a terminal thereof.
-
公开(公告)号：US10053701B2
公开(公告)日：2018-08-21
申请号：US14358568
申请日：2012-11-19
发明人： Naoyuki Umemoto
IPC分类号： C12N15/82 , A01H1/04 , A01H5/04 , C12N15/01 , C07K14/415 , C12N9/10 , C12Q1/6895
CPC分类号： C12N15/8243 , A01H1/04 , A01H5/04 , C07K14/415 , C12N9/1096 , C12Q1/6895 , C12Q2600/156 , C12Y206/01 , C12Y206/01019
摘要： Provided is DNA of biosynthetic enzyme of glycoalkaloid of solanaceous plant (Solanaceae) such as potato. Provided are a protein having activity on a biosynthetic enzyme of glycoalkaloid of solanaceous plant such as potato, and a method of creating and assaying a novel organism using a gene encoding the protein.
-
公开(公告)号：US20180201911A1
公开(公告)日：2018-07-19
申请号：US15912892
申请日：2018-03-06
申请人： Codexis Inc.
发明人： Ish K. Dhawan , Gregory Miller , Xiyun Zhang
CPC分类号： C12N9/1096 , C12P13/001 , C12P41/006 , C12Y206/01 , C12Y206/01018 , Y02P20/52
摘要： The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.
-
公开(公告)号：US09932596B2
公开(公告)日：2018-04-03
申请号：US15299928
申请日：2016-10-21
发明人： Sang Yup Lee , Tong Un Chae
CPC分类号： C12N15/52 , C12N1/16 , C12N1/20 , C12N9/1096 , C12N9/88 , C12P13/001 , C12Y206/01 , C12Y401/01086
摘要： The present disclosure relates to a recombinant microorganism producing 1,3-diaminopropane, and a method for producing 1,3-diaminopropane using the same, and specifically, to a recombinant microorganism producing 1,3-diaminopropane into which genes encoding an enzyme involved in a metabolic pathway of 1,3-diaminopropane, dat and ddc, are introduced, and a method for producing 1,3-diaminopropane using the same.When the recombinant microorganism producing the 1,3-diaminopropane according to the present disclosure is used, 1,3-diaminopropane may be mass-produced to be industrially useful in various fields such as pharmaceutical products, agricultural products, fibers for clothing, etc.
-
公开(公告)号：US20170275654A1
公开(公告)日：2017-09-28
申请号：US15616841
申请日：2017-06-07
申请人： Genomatica, Inc.
CPC分类号： C12P7/18 , C07C29/80 , C12N9/0006 , C12N9/0008 , C12N9/1029 , C12N9/1096 , C12N9/88 , C12N15/52 , C12Y101/01 , C12Y101/01157 , C12Y102/01 , C12Y203/01 , C12Y206/01 , C12Y401/01 , C12Y402/01 , C12Y403/01
摘要： A non-naturally occurring microbial organism includes a microbial organism having a 1,3-butanediol (1,3-BDO) pathway having at least one exogenous nucleic acid encoding a 1,3-BDO pathway enzyme expressed in a sufficient amount to produce 1,3-BDO. The pathway includes an enzyme selected from a 2-amino-4-ketopentanoate (AKP) thiolase, an AKP dehydrogenase, a 2-amino-4-hydroxypentanoate aminotransferase, a 2-amino-4-hydroxypentanoate oxidoreductase (deaminating), a 2-oxo-4-hydroxypentanoate decarboxylase, a 3-hydroxybutyraldehyde reductase, an AKP aminotransferase, an AKP oxidoreductase (deaminating), a 2,4-dioxopentanoate decarboxylase, a 3-oxobutyraldehyde reductase (ketone reducing), a 3-oxobutyraldehyde reductase (aldehyde reducing), a 4-hydroxy-2-butanone reductase, an AKP decarboxylase, a 4-aminobutan-2-one aminotransferase, a 4-aminobutan-2-one oxidoreductase (deaminating), a 4-aminobutan-2-one ammonia-lyase, a butenone hydratase, an AKP ammonia-lyase, an acetylacrylate decarboxylase, an acetoacetyl-CoA reductase (CoA-dependent, aldehyde forming), an acetoacetyl-CoA reductase (CoA-dependent, alcohol forming), an acetoacetyl-CoA reductase (ketone reducing), a 3-hydroxybutyryl-CoA reductase (aldehyde forming), a 3-hydroxybutyryl-CoA reductase (alcohol forming), a 4-hydroxybutyryl-CoA dehydratase, and a crotonase. A method for producing 1,3-BDO, includes culturing such microbial organisms under conditions and for a sufficient period of time to produce 1,3-BDO.
-
公开(公告)号：US09738915B2
公开(公告)日：2017-08-22
申请号：US14649308
申请日：2013-12-03
发明人： Paul Gerard Bulger , Birgit Kosjek , Nelo Rivera
IPC分类号： C12P17/12 , C12P13/00 , C12N9/10 , C07D211/02
CPC分类号： C12P17/12 , C07D211/02 , C12N9/1096 , C12P13/001 , C12Y206/01
摘要： A novel process is provided for the efficient preparation of an asymmetric compound of structural formula I: employing dynamic kinetic resolution (DKR). The DKR process involves an enzymatic enantioselective amination reaction catalyzed by transaminases. The process can be used to manufacture key intermediates in the preparation of poly (ADP-ribose) polymerase (PARP) inhibitors which may be useful for the treatment of cancer.
-
9.发明申请公开(公告)号：US20170233777A1
公开(公告)日：2017-08-17
申请号：US15310228
申请日：2015-05-13
CPC分类号： C12P13/001 , C08G83/00 , C12N15/52 , C12P7/04 , C12P7/40 , C12P7/42 , C12P7/44 , C12P7/625 , C12P17/10 , C12Y102/99006 , C12Y206/01
摘要： This document describes biochemical pathways for producing adipyl-[acp] and either hexanoic acid or acetic acid from a long chain acyl-[acp] such as dodecanoyl-[acp] or octanoyl-[acp] using a polypeptide having pimeloyl-[acp] synthase activity and biochemical pathways for converting adipyl-[acp] and/or hexanoic acid to one of more of adipic acid, 6-aminohexanoic acid, 6-hydroxyhexanoic acid, hexamethylenediamine, caprolactam, and 1,6-hexanediol.
-
公开(公告)号：US20170175090A1
公开(公告)日：2017-06-22
申请号：US15443792
申请日：2017-02-27
申请人： Codexis, Inc.
IPC分类号： C12N9/10 , C12P17/18 , C12P13/00 , C07D487/04
CPC分类号： C12N9/1096 , C07D487/04 , C12P13/001 , C12P17/182 , C12Y206/01
摘要： The present disclosure provides engineered transaminase polypeptides useful for the synthesis of chiral amine compounds under industrially relevant conditions. The disclosure also provides polynucleotides encoding the engineered transaminase polypeptides, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases for the production of chiral amine compounds.
-
-
-
-
-
-
-
-
-
搜索结果
133 条记录 (耗时 0.039 秒)
