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公开(公告)号：US20180327724A1
公开(公告)日：2018-11-15
申请号：US15771812
申请日：2016-10-27
发明人： Jung Oh AHN , Hong Weon LEE , Gyu Yeon PARK , Min Jeong JANG , Woo Young JEON
CPC分类号： C12N9/1096 , C12N9/10 , C12N15/815 , C12P7/64 , C12P13/00 , C12P13/005 , C12Y206/01
摘要： The present invention relates to a method for producing a medium chain aminocarboxylic acid and, more particularly, to a recombinant microorganism in which a fatty aldehyde dehydrogenase gene in ω-oxidative metabolic pathway and a β-oxidative metabolic pathway-related gene are deleted and a ω-transaminase gene is introduced, and a method for producing a medium chain aminocarboxylic acid by culturing the recombinant microorganism. The recombinant microorganism of the present invention can prevent additional oxidation of fatty aldehyde and β-oxidative metabolism and also produce a medium chain aminocarboxylic acid, such as 12-aminodecane, as a raw material of nylon 12 from a substrate such as fatty acid with a high yield by introducing an amine group into a terminal thereof.
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公开(公告)号：US20180312889A1
公开(公告)日：2018-11-01
申请号：US15771830
申请日：2016-10-27
发明人： Jung Oh AHN , Hong Weon LEE , Gyu Yeon PARK , Hee Suk LEE , Min Jeong JANG , Woo Young JEON
IPC分类号： C12P13/00
摘要： The present invention relates to a method for producing a medium chain diamine and, more specifically, to a method for producing a medium chain diamine from an alcohol or alkane derived from a fatty acid, by culturing a recombinant microorganism from which a fatty aldehyde dehydrogenase gene in a ω-oxidative metabolic pathway and a β-oxidative metabolic pathway related gene have been deleted, and also into which a ω-transaminase gene has been introduced. The recombinant microorganism disclosed in the present invention can prevent the additional oxidation and β-oxidation metabolism of fatty aldehyde and can produce a medium chain diamine with a high yield by introducing an amine group to the terminus thereof.
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公开(公告)号：US20180340195A1
公开(公告)日：2018-11-29
申请号：US15771799
申请日：2016-10-27
发明人： Jung Oh AHN , Hong Weon LEE , Min Jeong JANG , Chun Sug KIM , Gyu Yeon PARK
摘要： The present invention relates to a method for producing medium chain diol and, more particularly to recombinant microorganisms in which fatty alcohol dehydrogenase and/or fatty alcohol oxidase genes on a ω-oxidative metabolism pathway are deleted, the fatty aldehyde dehydrogenase genes are optionally deleted, and β-oxidative metabolism pathway-related genes are deleted, and to a method for producing medium chain diol from fatty acid-derived alcohol or alkane by culturing the recombinant microorganisms. The recombinant microorganisms of the present invention can produce a high yield of medium chain diol by preventing further oxidation and β-oxidative metabolism of fatty alcohols.
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