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    Biological production of multi-carbon compounds from methane
    4.
    发明授权
    Biological production of multi-carbon compounds from methane 有权
    从甲烷生物生产多碳化合物

    公开(公告)号：US09267158B2

    公开(公告)日：2016-02-23

    申请号：US14206835

    申请日：2014-03-12

    Applicant: Intrexon Corporation

    Inventor： William J. Coleman ,  Genevieve M. Vidanes ,  Guillaume Cottarel ,  Sheela Muley ,  Roy Kamimura ,  Akbar F. Javan ,  Jianping Sun ,  Eli S. Groban

    IPC: C12P7/16 ,  C12N9/04 ,  C12N9/10 ,  C12N9/88

    CPC classification number: C12P7/16 ,  C12N9/0006 ,  C12N9/1022 ,  C12N9/1025 ,  C12N9/88 ,  C12N15/52 ,  C12Y101/01001 ,  C12Y101/01004 ,  C12Y101/01086 ,  C12Y202/01006 ,  C12Y203/03006 ,  C12Y401/01072 ,  C12Y402/01009 ,  C12Y402/01033 ,  C12Y403/01019 ,  Y02E50/10

    Abstract: Multi-carbon compounds such as ethanol, n-butanol, sec-butanol, isobutanol, tert-butanol, fatty (or aliphatic long chain) alcohols, fatty acid methyl esters, 2,3-butanediol and the like, are important industrial commodity chemicals with a variety of applications. The present invention provides metabolically engineered host microorganisms which metabolize methane (CH4) as their sole carbon source to produce multi-carbon compounds for use in fuels (e.g., bio-fuel, bio-diesel) and bio-based chemicals. Furthermore, use of the metabolically engineered host microorganisms of the invention (which utilize methane as the sole carbon source) mitigate current industry practices and methods of producing multi-carbon compounds from petroleum or petroleum-derived feedstocks, and ameliorate much of the ongoing depletion of arable food source “farmland” currently being diverted to grow bio-fuel feedstocks, and as such, improve the environmental footprint of future bio-fuel, bio-diesel and bio-based chemical compositions.

    Abstract translation: 多碳化合物如乙醇，正丁醇，仲丁醇，异丁醇，叔丁醇，脂肪（或脂肪族长链）醇，脂肪酸甲酯，2,3-丁二醇等是重要的工业商品化学品 具有多种应用。 本发明提供代谢工程的宿主微生物，其代谢甲烷（CH4）作为其唯一的碳源，以生产用于燃料（例如生物燃料，生物柴油）和生物基化学品的多碳化合物。 此外，使用本发明的代谢工程的宿主微生物（其利用甲烷作为唯一碳源）减轻了目前的行业实践和从石油或石油衍生的原料生产多碳化合物的方法，并且改善了大部分正在进行的耗尽 目前正在转用生物燃料原料的可耕食源“农田”，从而改善未来生物燃料，生物柴油和生物基化学成分的环境足迹。

    Biological Production of Multi-Carbon Compounds from Methane
    7.
    发明申请
    Biological Production of Multi-Carbon Compounds from Methane 有权
    从甲烷生物制备多碳化合物

    公开(公告)号：US20160160243A1

    公开(公告)日：2016-06-09

    申请号：US14989859

    申请日：2016-01-07

    Applicant: Intrexon Corporation

    Inventor： William J. Coleman ,  Genevieve M. Vidanes ,  Guillaume Cottarel ,  Sheela Muley ,  Roy Kamimura ,  Akbar F. Javan ,  Jianping Sun ,  Eli S. Groban

    IPC: C12P7/16 ,  C12N9/04 ,  C12N9/88 ,  C12N9/10

    CPC classification number: C12P7/16 ,  C12N9/0006 ,  C12N9/1022 ,  C12N9/1025 ,  C12N9/88 ,  C12N15/52 ,  C12Y101/01001 ,  C12Y101/01004 ,  C12Y101/01086 ,  C12Y202/01006 ,  C12Y203/03006 ,  C12Y401/01072 ,  C12Y402/01009 ,  C12Y402/01033 ,  C12Y403/01019 ,  Y02E50/10

    Abstract: Multi-carbon compounds such as ethanol, n-butanol, sec-butanol, isobutanol, tert-butanol, fatty (or aliphatic long chain) alcohols, fatty acid methyl esters, 2,3-butanediol and the like, are important industrial commodity chemicals with a variety of applications. The present invention provides metabolically engineered host microorganisms which metabolize methane (CH4) as their sole carbon source to produce multi-carbon compounds for use in fuels (e.g., bio-fuel, bio-diesel) and bio-based chemicals. Furthermore, use of the metabolically engineered host microorganisms of the invention (which utilize methane as the sole carbon source) mitigate current industry practices and methods of producing multi-carbon compounds from petroleum or petroleum-derived feedstocks, and ameliorate much of the ongoing depletion of arable food source “farmland” currently being diverted to grow bio-fuel feedstocks, and as such, improve the environmental footprint of future bio-fuel, bio-diesel and bio-based chemical compositions.

    Abstract translation: 多碳化合物如乙醇，正丁醇，仲丁醇，异丁醇，叔丁醇，脂肪（或脂肪族长链）醇，脂肪酸甲酯，2,3-丁二醇等是重要的工业商品化学品 具有多种应用。 本发明提供代谢工程的宿主微生物，其代谢甲烷（CH4）作为其唯一的碳源，以生产用于燃料（例如生物燃料，生物柴油）和生物基化学品的多碳化合物。 此外，使用本发明的代谢工程的宿主微生物（其利用甲烷作为唯一碳源）减轻了目前的行业实践和从石油或石油衍生的原料生产多碳化合物的方法，并且改善了大部分正在进行的耗尽 目前正在转用生物燃料原料的可耕食源“农田”，从而改善未来生物燃料，生物柴油和生物基化学成分的环境足迹。

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