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公开(公告)号：US20180355394A1
公开(公告)日：2018-12-13
申请号：US15562606
申请日：2016-03-31
Applicant: Ramon Gonzales
Inventor： Ramon Gonzales
IPC: C12P19/32 , C12N9/02 , C12N9/04 , C12N9/00 , C12N9/88 , C12N9/10 , C12N9/90 , C12P7/40 , C12P7/46 , C12P7/42 , C12P9/00 , C12P7/02 , C12P7/24 , C12P5/02 , C12P13/00 , C12P13/04
CPC classification number: C12P19/32 , C12N9/00 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0077 , C12N9/13 , C12N9/88 , C12N9/90 , C12N9/93 , C12P5/02 , C12P5/026 , C12P7/02 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/46 , C12P7/625 , C12P9/00 , C12P13/001 , C12P13/04 , C12Y101/01 , C12Y101/03039 , C12Y102/01 , C12Y102/04001 , C12Y103/05001 , C12Y103/99 , C12Y108/01004 , C12Y114/15003 , C12Y203/01012 , C12Y203/01054 , C12Y207/01031 , C12Y208/03 , C12Y401/00 , C12Y401/01 , C12Y401/01047 , C12Y401/03024 , C12Y402/01 , C12Y402/01002 , C12Y402/01011 , C12Y501/99001 , C12Y501/99002 , C12Y504/02 , C12Y504/99 , C12Y504/99001 , C12Y504/99002 , C12Y602/01 , C12Y602/01005 , C12Y604/01003 , Y02E50/343
Abstract: An engineered microorganism(s) with novel pathways for the conversion of short-chain hydrocarbons to fuels and chemicals (e.g. carboxylic acids, alcohols, hydrocarbons, and their alpha-, beta-, and omega-functionalized derivatives) is described. Key to this approach is the use of hydrocarbon activation enzymes able to overcome the high stability and low reactivity of hydrocarbon compounds through the cleavage of an inert C—H bond. Oxygen-dependent or oxygen-independent activation enzymes can be exploited for this purpose, which when combined with appropriate pathways for the conversion of activated hydrocarbons to key metabolic intermediates, enables the generation of product precursors that can subsequently be converted to desired compounds through established pathways. These novel engineered microorganism(s) provide a route for the production of fuels and chemicals from short chain hydrocarbons such as methane, ethane, propane, butane, and pentane.
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公开(公告)号：US09944918B2
公开(公告)日：2018-04-17
申请号：US15070787
申请日：2016-03-15
Applicant: The United States of America, as represented by the Secretary, Dept. of Health and Human Services
Inventor： Charles P. Venditti , Randy J. Chandler
CPC classification number: C12N9/90 , A61K38/00 , C12Y504/99002
Abstract: Synthetic polynucleotides encoding human methylmalonyl-CoA mutase (synMUT) and exhibiting augmented expression in cell culture and/or in a subject are described herein. An adeno-associated viral (AAV) gene therapy vector encoding synMUT under the control of a liver-specific promoter (AAV2/8-HCR-hAAT-synMUT-RBG) successfully rescued the neonatal lethal phenotype displayed by methylmalonyl-CoA mutase-deficient mice, lowered circulating methylmalonic acid levels in the treated animals, and resulted in prolonged hepatic expression of the product of synMUT transgene in vivo, human methylmalonyl-CoA mutase (MUT).
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3.发明申请Mutant Microorganism Comprising Gene Encoding Methylmalonyl-CoA Reductase and Use Thereof 审中-公开突变型微生物包括编码甲基丙二酰辅酶A还原酶的基因及其用途公开(公告)号：US20170016033A1
公开(公告)日：2017-01-19
申请号：US15207953
申请日：2016-07-12
Applicant: SK Innovation Co., Ltd.
Inventor： Young Bin Seo , Ki Sung Lee , Jae Yeon Park , Joong Min Park , Woo Chan Park , Jong Joo Lee , Hye Sung Lee , Kyeong Hyeon Kang
CPC classification number: C12P7/42 , C12N9/0006 , C12N9/0008 , C12N9/90 , C12Y101/01031 , C12Y102/01075 , C12Y501/99001 , C12Y504/99002
Abstract: Provided herein is a mutant microorganism containing a methylmalonyl-CoA reductase-encoding gene having an activity of converting methylmalonyl-CoA to methylmalonate semialdehyde and uses of the mutant microorganism. The mutant microorganism includes a gene encoding kingdom Archaea-derived methylmalonyl-CoA reductase.
Abstract translation: 本文提供的是含有甲基丙二酰辅酶A还原酶编码基因的突变微生物，其具有将甲基丙二酰-CoA转化为甲基丙二酸半醛的活性和突变微生物的用途。 突变体微生物包括编码王国来源的甲基丙二酰辅酶A还原酶的基因。
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4.发明申请Intermediates And Surfactants useful In Household Cleaning And Personal Care Compositions, And Methods Of Making The Same 有权中间体和表面活性剂在家用清洁和个人护理组合物中的应用以及制造方法公开(公告)号：US20110171155A1
公开(公告)日：2011-07-14
申请号：US13004072
申请日：2011-01-11
Applicant: Thomas Walter Federle , Jeffrey John Scheibel , Zaiyou Liu , Phillip Kyle Vinson , Howard David Hutton, III , John David Carter , Charles Winston Saunders , Jun Xu , Phillip Richard Green
Inventor： Thomas Walter Federle , Jeffrey John Scheibel , Zaiyou Liu , Phillip Kyle Vinson , Howard David Hutton, III , John David Carter , Charles Winston Saunders , Jun Xu , Phillip Richard Green
CPC classification number: C12P7/6409 , C12N9/90 , C12N9/93 , C12Y504/99002 , C12Y604/01003
Abstract: Disclosed herein are novel mixtures of scattered-branched chain fatty acids and derivatives of scattered-branched chain fatty acids. Further disclosed are uses of these mixtures in cleaning compositions (e.g., dishcare, laundry, hard surface cleaners,) and/or personal care compositions (e.g., skin cleansers, shampoo, hair conditioners).
Abstract translation: 本文公开了分散支链脂肪酸和分散支链脂肪酸衍生物的新型混合物。 还公开了这些混合物在清洁组合物（例如餐具，衣物，硬表面清洁剂）和/或个人护理组合物（例如，皮肤清洁剂，洗发剂，护发素）中的用途。
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5.发明公开公开(公告)号：US20240226025A1
公开(公告)日：2024-07-11
申请号：US18282676
申请日：2022-03-24
Applicant: ModernaTX, Inc.
Inventor： Kerry Benenato , Mark Cornebise , Edward Hennessy , Ruchi Jain , Vladimir Presnyak
CPC classification number: A61K9/5123 , A61K38/52 , A61P3/00 , C12N9/90 , C12Y504/99002
Abstract: This disclosure relates to messenger RNA (mRNA) therapy for the treatment of methylmalonic acidemia. mRNAs for use in the invention, when administered in vivo, encode methylmalonyl-CoA mutase. mRNA therapies of the disclosure increase and/or restore deficient levels of MUT expression and/or activity in subjects.
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Patent Agency Ranking
6.发明授权公开(公告)号：US12031123B2
公开(公告)日：2024-07-09
申请号：US18319444
申请日：2023-05-17
Applicant: GENECIS BIOINDUSTRIES INC.
Inventor： Adam William Westbrook
IPC: C12P7/625 , C07K14/21 , C12N1/20 , C12N1/21 , C12N9/04 , C12N9/10 , C12N9/90 , C12N15/52 , C12P7/52 , C12R1/19
CPC classification number: C12N1/20 , C07K14/21 , C12N1/205 , C12N9/0006 , C12N9/1029 , C12N9/13 , C12N9/90 , C12N15/52 , C12P7/52 , C12P7/625 , C12Y101/01036 , C12Y203/01009 , C12Y203/01016 , C12Y208/03001 , C12Y504/99002 , C12R2001/19
Abstract: The disclosure provides recombinant bacterial host cells that metabolize and convert glycerol or volatile fatty acids (VFAs) to poly(3-hydroxybutyrate-co-3-hydroxyvalerate) or PHBV. The disclosure further provides methods of producing PHBV using the recombinant bacteria disclosed herein.
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公开(公告)号：US20230145188A1
公开(公告)日：2023-05-11
申请号：US17275803
申请日：2019-09-13
Applicant: Translate Bio, Inc.
Inventor： Lianne Boeglin , Christian Cobaugh , Frank DeRosa , Michael Heartlein , Kim Askew
CPC classification number: A61K48/005 , A61K9/1271 , C12N15/88 , C12N15/52 , A61P3/00 , C12Y504/99002
Abstract: The present invention provides, among other things, methods and compositions for treating methylmalonic academia (MMA) based on mRNA therapy. The compositions used in treatment of MMA comprise an mRNA comprising a methymalonyl-CoA mutase (MUT) coding sequence and are administered at an effective dose and an administration interval such that at least one symptom or feature of MMA is reduced in intensity, severity, or frequency or has a delayed onset. mRNAs with optimized MUT coding sequences are provided that can be administered without the need for modifying the nucleotides of the mRNA to achieve sustained in vivo function.
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公开(公告)号：US20180271795A1
公开(公告)日：2018-09-27
申请号：US16002376
申请日：2018-06-07
Applicant: ModernaTX, Inc.
Inventor： Paolo Martini , Vladimir Presnyak
CPC classification number: A61K9/5123 , A61K9/1272 , A61K38/00 , A61K38/52 , A61K48/005 , A61P3/00 , A61P43/00 , C12N9/90 , C12N15/52 , C12Y504/99002
Abstract: The disclosure relates to polynucleotides comprising an open reading frame of linked nucleosides encoding human methylmalonyl-CoA mutase precursor, human methylmalonyl-CoA mutase (MCM) mature form, or functional fragments thereof. In some embodiments, the disclosure includes methods of treating methylmalonic acidemia in a subject in need thereof comprising administering an mRNA encoding an MCM polypeptide.
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9.发明申请SYNTHETIC METHYLMALONYL-COA MUTASE TRANSGENE FOR THE TREATMENT OF MUT CLASS METHYLMALONIC ACIDEMIA (MMA) 有权用于处理MAM类甲基马来酰亚胺（MMA）的合成甲基马来酰亚胺转移酶公开(公告)号：US20170067042A1
公开(公告)日：2017-03-09
申请号：US15070787
申请日：2016-03-15
Applicant: The United States of America, as represented by the Secretary, Dept. of Health and Human Services
Inventor： Charles P. VENDITTI , Randy J. CHANDLER
IPC: C12N9/90
CPC classification number: C12N9/90 , A61K38/00 , C12Y504/99002
Abstract: Synthetic polynucleotides encoding human methylmalonyl-CoA mutase (synMUT) and exhibiting augmented expression in cell culture and/or in a subject are described herein. An adeno-associated viral (AAV) gene therapy vector encoding synMUT under the control of a liver-specific promoter (AAV2/8-HCR-hAAT-synMUT-RBG) successfully rescued the neonatal lethal phenotype displayed by methylmalonyl-CoA mutase-deficient mice, lowered circulating methylmalonic acid levels in the treated animals, and resulted in prolonged hepatic expression of the product of synMUT transgene in vivo, human methylmalonyl-CoA mutase (MUT).
Abstract translation: 本文描述了编码人甲基丙二酰-CoA变位酶（synMUT）并在细胞培养和/或受试者中表现出增强表达的合成多核苷酸。 在肝特异性启动子（AAV2 / 8-HCR-hAAT-synMUT-RBG）的控制下编码synMUT的腺相关病毒（AAV）基因治疗载体成功地拯救了由甲基丙二酰辅酶A变位酶缺陷小鼠显示的新生儿致死表型 降低了处理动物中的循环甲基丙二酸水平，并导致体内synMUT转基因产物的长期肝表达，人甲基丙二酰辅酶A变位酶（MUT）。
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10.发明授权Intermediates and surfactants useful in household cleaning and personal care compositions, and methods of making the same 有权用于家庭清洁和个人护理组合物的中间体和表面活性剂及其制备方法公开(公告)号：US08933131B2
公开(公告)日：2015-01-13
申请号：US13004072
申请日：2011-01-11
Applicant: Thomas Walter Federle , Jeffrey John Scheibel , Zaiyou Liu , Phillip Kyle Vinson , Howard David Hutton, III , John David Carter , Charles Winston Saunders , Jun Xu , Phillip Richard Green
Inventor： Thomas Walter Federle , Jeffrey John Scheibel , Zaiyou Liu , Phillip Kyle Vinson , Howard David Hutton, III , John David Carter , Charles Winston Saunders , Jun Xu , Phillip Richard Green
IPC: A61K31/045 , A61K31/255 , C12P7/64 , C12N9/90 , C12N9/00
CPC classification number: C12P7/6409 , C12N9/90 , C12N9/93 , C12Y504/99002 , C12Y604/01003
Abstract: Disclosed herein are novel mixtures of scattered-branched chain fatty acids and derivatives of scattered-branched chain fatty acids. Further disclosed are uses of these mixtures in cleaning compositions (e.g., dishcare, laundry, hard surface cleaners) and/or personal care compositions (e.g., skin cleansers, shampoo, hair conditioners).
Abstract translation: 本文公开了分散支链脂肪酸和分散支链脂肪酸衍生物的新型混合物。 还公开了这些混合物在清洁组合物（例如，保健，洗衣，硬表面清洁剂）和/或个人护理组合物（例如，皮肤清洁剂，洗发剂，护发素）中的用途。
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