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1.发明申请METHODS OF PRODUCING 6-CARBON CHEMICALS VIA CoA-DEPENDENT CARBON CHAIN ELONGATION ASSOCIATED WITH CARBON STORAGE 审中-公开通过与碳储存相关的辅助碳链延伸生产6碳化合物的方法公开(公告)号：US20150267211A1
公开(公告)日：2015-09-24
申请号：US14666085
申请日：2015-03-23
Applicant: INVISTA North America S.á r.l.
Inventor： Adriana Leonora Botes , Alex Van Eck Conradie
CPC classification number: C12N15/81 , C12N9/0008 , C12N9/0077 , C12N9/1029 , C12N9/1096 , C12N9/16 , C12N9/80 , C12N9/86 , C12N15/52 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/005 , C12P17/10 , C12Y102/01002 , C12Y102/99006 , C12Y114/15001 , C12Y203/01032 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082 , C12Y301/02 , C12Y305/01062
Abstract: This document describes biochemical pathways for producing adipic acid, caprolactam, 6-aminohexanoic acid, 6-hydroxyhexanoic acid, hexamethylenediamine or 1,6-hexanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C6; backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on CoA-dependent elongation enzymes or analogues enzymes associated with the carbon storage pathways from polyhydroxyalkanoate accumulating bacteria.
Abstract translation: 该文献描述了通过在C6中形成由羧基，胺或羟基组成的两个末端官能团来生产己二酸，己内酰胺，6-氨基己酸，6-羟基己酸，六亚甲基二胺或1,6-己二醇的生化途径。 骨架底物。 本文描述的这些途径，代谢工程和培养策略依赖于CoA依赖性延长酶或与聚羟基链烷酸酯累积细菌的碳储存途径相关的类似物酶。
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公开(公告)号：US20170240933A1
公开(公告)日：2017-08-24
申请号：US15441343
申请日：2017-02-24
Applicant: INVISTA North America S.á r.I.
Inventor： Paul S. Pearlman , Alex Van Eck Conradie , Changlin Chen , Adriana Leonora Botes
IPC: C12P7/44 , C12P7/18 , C12P7/42 , C12N9/04 , C12N15/52 , C12N9/10 , C12N9/00 , C12N9/02 , C12N9/16 , C12P13/00 , C12N9/80
CPC classification number: C12P7/44 , C12N9/0006 , C12N9/0008 , C12N9/1096 , C12N9/13 , C12N9/16 , C12N9/80 , C12N9/93 , C12N15/52 , C12P7/18 , C12P7/42 , C12P13/001 , C12P13/005 , C12Y101/01258 , C12Y102/01063 , C12Y206/01 , C12Y208/03012 , C12Y301/02 , C12Y305/01062 , C12Y602/01005
Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate produced from chorismate or benzoate. These pathways, metabolic engineering and cultivation strategies described herein rely on the anaerobic benzoyl-CoA degradation pathway enzymes.
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公开(公告)号：US09617572B2
公开(公告)日：2017-04-11
申请号：US14138827
申请日：2013-12-23
Applicant: INVISTA North America S.á r.l.
Inventor： Adriana Leonora Botes , Alex Van Eck Conradie , Changlin Chen , Paul S. Pearlman
CPC classification number: C12P7/44 , C12N9/0006 , C12N9/0008 , C12N9/1096 , C12N9/13 , C12N9/16 , C12N9/80 , C12N9/93 , C12N15/52 , C12P7/18 , C12P7/42 , C12P13/001 , C12P13/005 , C12Y101/01258 , C12Y102/01063 , C12Y206/01 , C12Y208/03012 , C12Y301/02 , C12Y305/01062 , C12Y602/01005
Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate produced from chorismate or benzoate. These pathways, metabolic engineering and cultivation strategies described herein rely on the anaerobic benzoyl-CoA degradation pathway enzymes.
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4.发明授权Methods of producing 7-carbon chemicals via c1 carbon chain elongation associated with coenzyme B synthesis 有权通过与辅酶B合成相关的c1碳链延长生产7-碳化学物质的方法公开(公告)号：US09580731B2
公开(公告)日：2017-02-28
申请号：US14138971
申请日：2013-12-23
Applicant: INVISTA North America S.á r.l.
Inventor： Adriana Leonora Botes , Alex Van Eck Conradie , Changlin Chen , Paul S. Pearlman
CPC classification number: C12N15/52 , C12N9/0006 , C12N9/0008 , C12N9/1025 , C12N9/1029 , C12N9/1096 , C12N9/1288 , C12N9/16 , C12N9/80 , C12N9/88 , C12N9/93 , C12P7/18 , C12P7/24 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/005 , C12Y101/01 , C12Y101/01085 , C12Y101/01087 , C12Y101/01258 , C12Y101/01286 , C12Y102/01 , C12Y102/01003 , C12Y102/0101 , C12Y102/99006 , C12Y203/01032 , C12Y203/03013 , C12Y203/03014 , C12Y206/01 , C12Y207/08 , C12Y208/03012 , C12Y301/02 , C12Y305/01062 , C12Y401/01043 , C12Y402/01033 , C12Y402/01036 , C12Y402/01114 , C12Y602/01005
Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming one or two terminal functional groups, each comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the C1 elongation enzymes or homolog associated with coenzyme B biosynthesis.
Abstract translation: 本文件描述了通过在C7脂肪族中形成一个或两个由羧基，胺或羟基组成的末端官能团，生成庚二酸，7-氨基庚酸，7-羟基庚酸，七亚甲基二胺或1,7-庚二醇的生化途径 骨架底物。 本文描述的这些途径，代谢工程和培养策略依赖于C1延长酶或与辅酶B生物合成相关的同源物。
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5.发明申请METHODS OF PRODUCING 6-CARBON CHEMICALS VIA CoA-DEPENDENT CARBON CHAIN ELONGATION ASSOCIATED WITH CARBON STORAGE 有权通过与碳储存相关的辅助碳链延伸生产6碳化合物的方法公开(公告)号：US20140186902A1
公开(公告)日：2014-07-03
申请号：US14106124
申请日：2013-12-13
Applicant: INVISTA North America S. a r.l.
Inventor： Adriana Leonora Botes , Alex Van Eck Conradie
CPC classification number: C12N15/81 , C12N9/0008 , C12N9/0077 , C12N9/1029 , C12N9/1096 , C12N9/16 , C12N9/80 , C12N9/86 , C12N15/52 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/005 , C12P17/10 , C12Y102/01002 , C12Y102/99006 , C12Y114/15001 , C12Y203/01032 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082 , C12Y301/02 , C12Y305/01062
Abstract: This document describes biochemical pathways for producing adipic acid, caprolactam, 6-aminohexanoic acid, 6-hydroxyhexanoic acid, hexamethylenediamine or 1,6-hexanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C6 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on CoA-dependent elongation enzymes or analogues enzymes associated with the carbon storage pathways from polyhydroxyalkanoate accumulating bacteria.
Abstract translation: 该文献描述了通过在C6脂肪族骨架中形成由羧基，胺或羟基组成的两个末端官能团来生产己二酸，己内酰胺，6-氨基己酸，6-羟基己酸，六亚甲基二胺或1,6-己二醇的生化途径 基质。 本文描述的这些途径，代谢工程和培养策略依赖于CoA依赖性延长酶或与聚羟基链烷酸酯累积细菌的碳储存途径相关的类似物酶。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20190078103A1
公开(公告)日：2019-03-14
申请号：US16199704
申请日：2018-11-26
Applicant: INVISTA North America S.á.r.l.
Inventor： Alex Van Eck Conradie , Adriana Leonora Botes
IPC: C12N15/81 , C12N9/16 , C12N9/80 , C12P7/18 , C12P13/00 , C12N15/52 , C12P17/10 , C12P7/42 , C12N9/02 , C12N9/10 , C12N9/86 , C12P7/44
CPC classification number: C12N15/81 , C12N9/0008 , C12N9/0077 , C12N9/1029 , C12N9/1096 , C12N9/16 , C12N9/80 , C12N9/86 , C12N15/52 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/005 , C12P17/10 , C12Y102/01002 , C12Y102/99006 , C12Y114/15001 , C12Y203/01032 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082 , C12Y301/02 , C12Y305/01062
Abstract: This document describes biochemical pathways for producing adipic acid, caprolactam, 6-aminohexanoic acid, 6-hydroxyhexanoic acid, hexamethylenediamine or 1,6-hexanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C6 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on CoA-dependent elongation enzymes or analogues enzymes associated with the carbon storage pathways from polyhydroxyalkanoate accumulating bacteria.
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7.发明申请公开(公告)号：US20170204420A1
公开(公告)日：2017-07-20
申请号：US15405514
申请日：2017-01-13
Applicant: INVISTA North American S.á r.I.
Inventor： Adriana Leonora Botes , Alex Van Eck Conradie , Changlin Chen , Paul S. Pearlman
IPC: C12N15/52 , C12N9/10 , C12N9/12 , C12N9/88 , C12P7/24 , C12N9/02 , C12N9/00 , C12N9/80 , C12P7/44 , C12P13/00 , C12N9/04 , C12N9/16
CPC classification number: C12N15/52 , C12N9/0006 , C12N9/0008 , C12N9/1025 , C12N9/1029 , C12N9/1096 , C12N9/1288 , C12N9/16 , C12N9/80 , C12N9/88 , C12N9/93 , C12P7/18 , C12P7/24 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/005 , C12Y101/01 , C12Y101/01085 , C12Y101/01087 , C12Y101/01258 , C12Y101/01286 , C12Y102/01 , C12Y102/01003 , C12Y102/0101 , C12Y102/99006 , C12Y203/01032 , C12Y203/03013 , C12Y203/03014 , C12Y206/01 , C12Y207/08 , C12Y208/03012 , C12Y301/02 , C12Y305/01062 , C12Y401/01043 , C12Y402/01033 , C12Y402/01036 , C12Y402/01114 , C12Y602/01005
Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming one or two terminal functional groups, each comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the C1 elongation enzymes or homolog associated with coenzyme B biosynthesis.
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8.发明授权Methods of producing 6-carbon chemicals via CoA-dependent carbon chain elongation associated with carbon storage 有权通过与碳储存相关的CoA依赖性碳链延长生产6碳化学品的方法公开(公告)号：US09102960B2
公开(公告)日：2015-08-11
申请号：US14106124
申请日：2013-12-13
Applicant: INVISTA North America S.á r.l.
Inventor： Adriana Leonora Botes , Alex Van Eck Conradie
CPC classification number: C12N15/81 , C12N9/0008 , C12N9/0077 , C12N9/1029 , C12N9/1096 , C12N9/16 , C12N9/80 , C12N9/86 , C12N15/52 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/005 , C12P17/10 , C12Y102/01002 , C12Y102/99006 , C12Y114/15001 , C12Y203/01032 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082 , C12Y301/02 , C12Y305/01062
Abstract: This document describes biochemical pathways for producing adipic acid, caprolactam, 6-aminohexanoic acid, 6-hydroxyhexanoic acid, hexamethylenediamine or 1,6-hexanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C6 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on CoA-dependent elongation enzymes or analogs enzymes associated with the carbon storage pathways from polyhydroxyalkanoate accumulating bacteria.
Abstract translation: 该文献描述了通过在C6脂肪族骨架中形成由羧基，胺或羟基组成的两个末端官能团来生产己二酸，己内酰胺，6-氨基己酸，6-羟基己酸，六亚甲基二胺或1,6-己二醇的生化途径 基质。 本文描述的这些途径，代谢工程和培养策略依赖于CoA依赖性延伸酶或与聚羟基链烷酸酯累积细菌的碳储存途径相关的类似物酶。
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9.发明申请Methods Of Producing 7-Carbon Chemicals Via C1 Carbon Chain Elongation Associated With Coenzyme B Synthesis 有权通过与辅酶B合成相关的C1碳链伸长率生产7碳化合物的方法公开(公告)号：US20140193863A1
公开(公告)日：2014-07-10
申请号：US14138971
申请日：2013-12-23
Applicant: INVISTA North America S.á r.I.
Inventor： Adriana Leonora Botes , Alex Van Eck Conradie , Changlin Chen , Paul S. Pearlman
CPC classification number: C12N15/52 , C12N9/0006 , C12N9/0008 , C12N9/1025 , C12N9/1029 , C12N9/1096 , C12N9/1288 , C12N9/16 , C12N9/80 , C12N9/88 , C12N9/93 , C12P7/18 , C12P7/24 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/005 , C12Y101/01 , C12Y101/01085 , C12Y101/01087 , C12Y101/01258 , C12Y101/01286 , C12Y102/01 , C12Y102/01003 , C12Y102/0101 , C12Y102/99006 , C12Y203/01032 , C12Y203/03013 , C12Y203/03014 , C12Y206/01 , C12Y207/08 , C12Y208/03012 , C12Y301/02 , C12Y305/01062 , C12Y401/01043 , C12Y402/01033 , C12Y402/01036 , C12Y402/01114 , C12Y602/01005
Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming one or two terminal functional groups, each comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the C1 elongation enzymes or homolog associated with coenzyme B biosynthesis.
Abstract translation: 本文件描述了通过在C7脂肪族中形成一个或两个由羧基，胺或羟基组成的末端官能团，生成庚二酸，7-氨基庚酸，7-羟基庚酸，七亚甲基二胺或1,7-庚二醇的生化途径 骨架底物。 本文描述的这些途径，代谢工程和培养策略依赖于C1延长酶或与辅酶B生物合成相关的同源物。
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公开(公告)号：US20140193861A1
公开(公告)日：2014-07-10
申请号：US14138827
申请日：2013-12-23
Applicant: INVISTA North America S.á.r.l.
Inventor： Adriana Leonora Botes , Alex Van Eck Conradie , Changlin Chen , Paul S. Pearlman
CPC classification number: C12P7/44 , C12N9/0006 , C12N9/0008 , C12N9/1096 , C12N9/13 , C12N9/16 , C12N9/80 , C12N9/93 , C12N15/52 , C12P7/18 , C12P7/42 , C12P13/001 , C12P13/005 , C12Y101/01258 , C12Y102/01063 , C12Y206/01 , C12Y208/03012 , C12Y301/02 , C12Y305/01062 , C12Y602/01005
Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate produced from chorismate or benzoate. These pathways, metabolic engineering and cultivation strategies described herein rely on the anaerobic benzoyl-CoA degradation pathway enzymes.
Abstract translation: 本文件描述了通过在C7脂肪族主链基质中形成由羧基，胺或羟基组成的两个末端官能团，生成庚二酸，7-氨基庚酸酯，7-羟基庚酸酯，七亚甲基二胺或1,7-庚二醇的生化途径， 草酸盐或苯甲酸盐。 本文描述的这些途径，代谢工程和培养策略依赖于厌氧苯甲酰辅酶A降解途径酶。
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