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公开(公告)号：US20190271014A1
公开(公告)日：2019-09-05
申请号：US16256140
申请日：2019-01-24
发明人： Alexander Brett Foster , Mariusz Kamionka , Nadia Fatma Kadi , Adriana Leonora Botes , Alex Van Eck Conradie
摘要： This document describes materials and methods for, for example, producing 6-hydroxyhexanoic acid using a β-ketothiolase or synthase and an alcohol O-acetyltransferase to form a 6-acetyloxy-3-oxohexanoyl-CoA intermediate. This document describes biochemical pathways for producing 6-hydroxyhexanoic acid using a β-ketothiolase or synthase and an alcohol O-acetyltransferase to form a 6-acetyloxy-3-oxohexanoyl-CoA intermediate. 6-hydroxyhexanoic acid can be enzymatically converted to adipic acid, caprolactam, 6-aminohexanoic acid, hexamethylenediamine or 1,6-hexanediol. This document also describes recombinant hosts producing 6-hydroxyhexanoic acid as well as adipic acid, caprolactam, 6-aminohexanoic acid, hexamethylenediamine and 1,6-hexanediol.
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公开(公告)号：US10072150B2
公开(公告)日：2018-09-11
申请号：US14976966
申请日：2015-12-21
IPC分类号： C08L77/12 , C12P7/18 , C12P7/42 , C12P13/00 , C12N15/52 , C12N9/88 , C12N9/00 , C12N9/10 , C07C209/68 , C07C213/02 , C07C221/00 , C07C227/18 , C07C227/32 , C08G69/08 , C08G69/26 , C12N9/02 , C12N9/04
CPC分类号： C08L77/12 , C07B2200/07 , C07C209/68 , C07C213/02 , C07C221/00 , C07C227/18 , C07C227/32 , C08G69/08 , C08G69/26 , C12N9/0006 , C12N9/0008 , C12N9/1096 , C12N9/88 , C12N15/52 , C12P7/18 , C12P7/42 , C12P13/001 , C12Y101/01061 , C12Y102/99006 , C12Y206/01018 , C12Y401/01015 , C12Y401/01071 , C07C229/24 , C07C229/12 , C07C223/02 , C07C215/08 , C07C211/09
摘要： This document describes biochemical pathways for producing 4-hydroxybutyrate, 4-aminobutyrate, putrescine or 1,4-butanediol by forming one or two terminal functional groups, comprised of amine or hydroxyl group, in a C5 backbone substrate such as 2-oxoglutarate or L-glutamate.
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公开(公告)号：US20160159723A1
公开(公告)日：2016-06-09
申请号：US14842696
申请日：2015-09-01
CPC分类号： C07C51/42 , B01D15/02 , B01D15/185 , B01D15/1892 , B01D15/22 , C07C51/47 , C07C55/02 , C07C55/21 , C07C55/14
摘要： The present disclosure relates to methods for separating and purifying a long chain diacid from other long chain diacids, monocarboxylic acids, hydroxyl acids or alkanes by simulated or actual moving bed chromatography.
摘要翻译： 本公开涉及通过模拟或实际移动床层析从其它长链二酸，单羧酸，羟基酸或烷烃中分离和纯化长链二酸的方法。
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公开(公告)号：US20200283809A1
公开(公告)日：2020-09-10
申请号：US16683570
申请日：2019-11-14
IPC分类号： C12P13/00 , C12P7/42 , C12P7/44 , C12P11/00 , C12P19/32 , C12P7/26 , C12P7/18 , C08G69/28 , C12N9/10 , C12N15/52 , C12P7/04
摘要： This document describes biochemical pathways for biosynthesizing a 3-oxo-7-hydroxyheptanoyl-CoA intermediate using a β-ketothiolase, and enzymatically converting 3-oxo-7-hydroxyheptanoyl-CoA to 7-hydroxyheptanoic acid. —7-hydroxyheptanoic acid can be further enzymatically converted to pimelic acid, 7-aminoheptanoic acid, heptamethylenediamine or 1,7-heptanediol. This document also describes recombinant hosts producing 7-hydroxyheptanoic acid as well as pimelic acid, 7-aminoheptanoic acid, heptamethylenediamine and 1,7-heptanediol.
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5.发明申请公开(公告)号：US20180320205A1
公开(公告)日：2018-11-08
申请号：US15885927
申请日：2018-02-01
CPC分类号： C12P7/46 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/005
摘要： This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the fatty acid synthesis pathway and oxidative cleavage of long chain acyl-[acp] intermediates by a monooxgenase (e.g., cytochrome P450) such as that encoded by BioI from microorganisms such as Bacillus subtillis.
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6.发明申请公开(公告)号：US20160145657A1
公开(公告)日：2016-05-26
申请号：US14947570
申请日：2015-11-20
IPC分类号： C12P7/64 , C12N9/02 , C12N9/18 , C07C59/01 , C07C47/12 , C07C55/16 , C07C47/19 , C07C225/06 , C07C233/31 , C12N9/10 , C07C229/08
摘要： This document describes biochemical pathways for producing 7-hydroxyheptanoic acid using a polypeptide having monooxygenase activity to form a 8-hydroxynonanoate intermediate, which can be converted to 7-hydroxyheptanoate using a polypeptide having monooxygenase activity, a polypeptide having secondary alcohol dehydrogenase activity, and a polypeptide having esterase activity. 7-hydroxyheptanoic acid can be enzymatically converted to pimelic acid, 7-aminoheptanoic acid, heptamethylenediamine or 1,7 heptanediol. This document also describes recombinant hosts producing 7-hydroxyheptanoic acid as well as pimelic acid, 7-aminoheptanoic acid, heptamethylenediamine and 1,7 heptanediol.
摘要翻译： 本文件描述了使用具有单加氧酶活性的多肽形成8-羟基壬酸酯中间体以产生7-羟基庚酸的生物化学途径，其可以使用具有单加氧酶活性的多肽，具有仲醇脱氢酶活性的多肽转化为7-羟基庚酸酯， 具有酯酶活性的多肽。 7-羟基庚酸可以酶促转化成庚二酸，7-氨基庚酸，七亚甲基二胺或1,7庚二醇。 该文献还描述了产生7-羟基庚酸以及庚二酸，7-氨基庚酸，七亚甲基二胺和1,7庚二醇的重组宿主。
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公开(公告)号：US10533180B2
公开(公告)日：2020-01-14
申请号：US16199704
申请日：2018-11-26
IPC分类号： C12N15/81 , C12P13/00 , C12P7/18 , C12P7/44 , C12P7/42 , C12N15/52 , C12N9/00 , C12N9/10 , C12N9/16 , C12N9/80 , C12N9/86 , C12P17/10 , C12N9/02
摘要： This document describes biochemical pathways for producing adipic acid, caprolactam, 6-aminohexanoic acid, 6-hydroxyhexanoic acid, hexamethylenediamine or 1,6-hexanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C6 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on CoA-dependent elongation enzymes or analogues enzymes associated with the carbon storage pathways from polyhydroxyalkanoate accumulating bacteria.
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公开(公告)号：US20170044446A1
公开(公告)日：2017-02-16
申请号：US14825815
申请日：2015-08-13
CPC分类号： C10G57/00 , C10G50/00 , C10G70/00 , C10G2300/1092
摘要： Described herein are processes for the conversion of ethylene into C5+ olefins, naphthenics, and aromatics via a dual catalyst reaction utilizing a dehydroaromatization catalyst.
摘要翻译： 本文描述的是通过使用脱氢芳构化催化剂的双重催化剂反应将乙烯转化成C5 +烯烃，环烷烃和芳族化合物的方法。
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公开(公告)号：US20160222425A1
公开(公告)日：2016-08-04
申请号：US14977004
申请日：2015-12-21
CPC分类号： C12P19/32 , C07H1/00 , C07H19/207 , C12N9/1029 , C12P7/18 , C12P7/24 , C12P7/26 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/005 , C12P17/10 , C12Y203/01
摘要： This document describes materials and methods for, for example, producing 6-hydroxyhexanoic acid using a β-ketothiolase or synthase and an alcohol O-acetyltransferase to form a 6-acetyloxy-3-oxohexanoyl-CoA intermediate. This document describes biochemical pathways for producing 6-hydroxyhexanoic acid using a β-ketothiolase or synthase and an alcohol O-acetyltransferase to form a 6-acetyloxy-3-oxohexanoyl-CoA intermediate. 6-hydroxyhexanoic acid can be enzymatically converted to adipic acid, caprolactam, 6-aminohexanoic acid, hexamethylenediamine or 1,6-hexanediol. This document also describes recombinant hosts producing 6-hydroxyhexanoic acid as well as adipic acid, caprolactam, 6-aminohexanoic acid, hexamethylenediamine and 1,6-hexanediol.
摘要翻译： 该文献描述了例如使用β-酮硫解酶或合酶和醇O-乙酰转移酶产生6-羟基己酸以形成6-乙酰氧基-3-氧代己酰-CoA中间体的材料和方法。 本文件描述了使用β-酮硫解酶或合酶和醇O-乙酰转移酶生成6-羟基己酸的生物化学途径以形成6-乙酰氧基-3-氧代己酰-CoA中间体。 6-羟基己酸可以酶促转化为己二酸，己内酰胺，6-氨基己酸，六亚甲基二胺或1,6-己二醇。 该文献还描述了生产6-羟基己酸以及己二酸，己内酰胺，6-氨基己酸，六亚甲基二胺和1,6-己二醇的重组宿主。
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10.发明申请Methods and Materials for the Production of Monomers for Nylon-4/Polyester Production 审中-公开生产尼龙-4 /聚酯生产单体的方法和材料公开(公告)号：US20160222420A1
公开(公告)日：2016-08-04
申请号：US14976966
申请日：2015-12-21
IPC分类号： C12P7/24 , C12P7/42 , C12P13/00 , C12N15/52 , C08L77/12 , C07C211/09 , C12N9/88 , C12N9/02 , C12N9/10 , C12N9/04 , C12P7/18 , C07C31/20
CPC分类号： C08L77/12 , C07B2200/07 , C07C209/68 , C07C213/02 , C07C221/00 , C07C227/18 , C07C227/32 , C08G69/08 , C08G69/26 , C12N9/0006 , C12N9/0008 , C12N9/1096 , C12N9/88 , C12N15/52 , C12P7/18 , C12P7/42 , C12P13/001 , C12Y101/01061 , C12Y102/99006 , C12Y206/01018 , C12Y401/01015 , C12Y401/01071 , C07C229/24 , C07C229/12 , C07C223/02 , C07C215/08 , C07C211/09
摘要： This document describes biochemical pathways for producing 4-hydroxybutyrate, 4-aminobutyrate, putrescine or 1,4-butanediol by forming one or two terminal functional groups, comprised of amine or hydroxyl group, in a C5 backbone substrate such as 2-oxoglutarate or L-glutamate.
摘要翻译： 该文献描述了通过在C5主链基质如2-氧戊二酸或L（其中包括胺或羟基）形成一个或两个末端官能团来生产4-羟基丁酸酯，4-氨基丁酸酯，腐胺或1,4-丁二醇的生化途径 谷氨酸
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