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1.发明申请METHODS OF PRODUCING 6-CARBON CHEMICALS VIA CoA-DEPENDENT CARBON CHAIN ELONGATION ASSOCIATED WITH CARBON STORAGE 审中-公开通过与碳储存相关的辅助碳链延伸生产6碳化合物的方法公开(公告)号：US20150267211A1
公开(公告)日：2015-09-24
申请号：US14666085
申请日：2015-03-23
Applicant: INVISTA North America S.á r.l.
Inventor： Adriana Leonora Botes , Alex Van Eck Conradie
CPC classification number: C12N15/81 , C12N9/0008 , C12N9/0077 , C12N9/1029 , C12N9/1096 , C12N9/16 , C12N9/80 , C12N9/86 , C12N15/52 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/005 , C12P17/10 , C12Y102/01002 , C12Y102/99006 , C12Y114/15001 , C12Y203/01032 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082 , C12Y301/02 , C12Y305/01062
Abstract: This document describes biochemical pathways for producing adipic acid, caprolactam, 6-aminohexanoic acid, 6-hydroxyhexanoic acid, hexamethylenediamine or 1,6-hexanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C6; backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on CoA-dependent elongation enzymes or analogues enzymes associated with the carbon storage pathways from polyhydroxyalkanoate accumulating bacteria.
Abstract translation: 该文献描述了通过在C6中形成由羧基，胺或羟基组成的两个末端官能团来生产己二酸，己内酰胺，6-氨基己酸，6-羟基己酸，六亚甲基二胺或1,6-己二醇的生化途径。 骨架底物。 本文描述的这些途径，代谢工程和培养策略依赖于CoA依赖性延长酶或与聚羟基链烷酸酯累积细菌的碳储存途径相关的类似物酶。
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2.发明授权Methods of producing 7-carbon chemicals via c1 carbon chain elongation associated with coenzyme B synthesis 有权通过与辅酶B合成相关的c1碳链延长生产7-碳化学物质的方法公开(公告)号：US09580731B2
公开(公告)日：2017-02-28
申请号：US14138971
申请日：2013-12-23
Applicant: INVISTA North America S.á r.l.
Inventor： Adriana Leonora Botes , Alex Van Eck Conradie , Changlin Chen , Paul S. Pearlman
CPC classification number: C12N15/52 , C12N9/0006 , C12N9/0008 , C12N9/1025 , C12N9/1029 , C12N9/1096 , C12N9/1288 , C12N9/16 , C12N9/80 , C12N9/88 , C12N9/93 , C12P7/18 , C12P7/24 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/005 , C12Y101/01 , C12Y101/01085 , C12Y101/01087 , C12Y101/01258 , C12Y101/01286 , C12Y102/01 , C12Y102/01003 , C12Y102/0101 , C12Y102/99006 , C12Y203/01032 , C12Y203/03013 , C12Y203/03014 , C12Y206/01 , C12Y207/08 , C12Y208/03012 , C12Y301/02 , C12Y305/01062 , C12Y401/01043 , C12Y402/01033 , C12Y402/01036 , C12Y402/01114 , C12Y602/01005
Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming one or two terminal functional groups, each comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the C1 elongation enzymes or homolog associated with coenzyme B biosynthesis.
Abstract translation: 本文件描述了通过在C7脂肪族中形成一个或两个由羧基，胺或羟基组成的末端官能团，生成庚二酸，7-氨基庚酸，7-羟基庚酸，七亚甲基二胺或1,7-庚二醇的生化途径 骨架底物。 本文描述的这些途径，代谢工程和培养策略依赖于C1延长酶或与辅酶B生物合成相关的同源物。
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3.发明申请METHODS OF PRODUCING 6-CARBON CHEMICALS VIA CoA-DEPENDENT CARBON CHAIN ELONGATION ASSOCIATED WITH CARBON STORAGE 有权通过与碳储存相关的辅助碳链延伸生产6碳化合物的方法公开(公告)号：US20140186902A1
公开(公告)日：2014-07-03
申请号：US14106124
申请日：2013-12-13
Applicant: INVISTA North America S. a r.l.
Inventor： Adriana Leonora Botes , Alex Van Eck Conradie
CPC classification number: C12N15/81 , C12N9/0008 , C12N9/0077 , C12N9/1029 , C12N9/1096 , C12N9/16 , C12N9/80 , C12N9/86 , C12N15/52 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/005 , C12P17/10 , C12Y102/01002 , C12Y102/99006 , C12Y114/15001 , C12Y203/01032 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082 , C12Y301/02 , C12Y305/01062
Abstract: This document describes biochemical pathways for producing adipic acid, caprolactam, 6-aminohexanoic acid, 6-hydroxyhexanoic acid, hexamethylenediamine or 1,6-hexanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C6 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on CoA-dependent elongation enzymes or analogues enzymes associated with the carbon storage pathways from polyhydroxyalkanoate accumulating bacteria.
Abstract translation: 该文献描述了通过在C6脂肪族骨架中形成由羧基，胺或羟基组成的两个末端官能团来生产己二酸，己内酰胺，6-氨基己酸，6-羟基己酸，六亚甲基二胺或1,6-己二醇的生化途径 基质。 本文描述的这些途径，代谢工程和培养策略依赖于CoA依赖性延长酶或与聚羟基链烷酸酯累积细菌的碳储存途径相关的类似物酶。
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公开(公告)号：US12104160B2
公开(公告)日：2024-10-01
申请号：US17307850
申请日：2021-05-04
Applicant: ZYMOCHEM, INC.
Inventor： Harshal Chokhawala
IPC: C12P7/42 , C12N9/00 , C12N9/02 , C12N9/04 , C12N9/06 , C12N9/10 , C12N9/12 , C12N9/16 , C12N9/24 , C12N9/88 , C12N15/52 , C12P7/04 , C12P7/18 , C12P7/24 , C12P7/40 , C12P7/44 , C12P7/6409 , C12P13/00 , C12P17/08 , C12P17/10
CPC classification number: C12N15/52 , C12N9/00 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0016 , C12N9/1029 , C12N9/1096 , C12N9/1205 , C12N9/13 , C12N9/16 , C12N9/2402 , C12N9/88 , C12N9/93 , C12P7/04 , C12P7/18 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/44 , C12P7/6409 , C12P13/001 , C12P13/005 , C12P17/08 , C12P17/10 , C12Y101/01001 , C12Y101/01002 , C12Y101/01035 , C12Y101/01078 , C12Y101/01268 , C12Y101/01269 , C12Y102/01003 , C12Y102/01005 , C12Y102/01022 , C12Y102/01024 , C12Y102/01026 , C12Y102/01048 , C12Y102/01063 , C12Y102/07005 , C12Y102/99006 , C12Y103/01044 , C12Y103/01045 , C12Y103/01086 , C12Y104/01 , C12Y203/01001 , C12Y203/01032 , C12Y203/01035 , C12Y203/01057 , C12Y206/01008 , C12Y206/01009 , C12Y206/01036 , C12Y206/01043 , C12Y206/01048 , C12Y206/01076 , C12Y206/01082 , C12Y207/01031 , C12Y207/01165 , C12Y208/03 , C12Y301/03 , C12Y301/03002 , C12Y301/03008 , C12Y301/03019 , C12Y301/0302 , C12Y302/01 , C12Y401/01001 , C12Y401/02 , C12Y401/02014 , C12Y401/0202 , C12Y401/02021 , C12Y401/03016 , C12Y401/03017 , C12Y402/01002 , C12Y402/01003 , C12Y402/01028 , C12Y402/0103 , C12Y402/01079 , C12Y402/0112 , C12Y602/01 , Y02E50/30
Abstract: Provided herein are methods, compositions, and non-naturally occurring microbial organism for preparing compounds such as1-butanol, butyric acid, succinic acid, 1,4-butanediol, 1-pentanol, pentanoic acid, glutaric acid, 1,5-pentanediol, 1-hexanol, hexanoic acid, adipic acid, 1,6-hexanediol, 6-hydroxy hexanoic acid, ε-Caprolactone, 6-amino-hexanoic acid, ε-Caprolactam, hexamethylenediamine, linear fatty acids and linear fatty alcohols that are between 7-25 carbons long, linear alkanes and linear α-alkenes that are between 6-24 carbons long, sebacic acid and dodecanedioic acid comprising: a) converting a CN aldehyde and pyruvate to a CN+3 β-hydroxyketone intermediate through an aldol addition; and b) converting the CN+3 β-hydroxyketone intermediate to the compounds through enzymatic steps, or a combination of enzymatic and chemical steps.
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5.发明申请公开(公告)号：US20190078103A1
公开(公告)日：2019-03-14
申请号：US16199704
申请日：2018-11-26
Applicant: INVISTA North America S.á.r.l.
Inventor： Alex Van Eck Conradie , Adriana Leonora Botes
IPC: C12N15/81 , C12N9/16 , C12N9/80 , C12P7/18 , C12P13/00 , C12N15/52 , C12P17/10 , C12P7/42 , C12N9/02 , C12N9/10 , C12N9/86 , C12P7/44
CPC classification number: C12N15/81 , C12N9/0008 , C12N9/0077 , C12N9/1029 , C12N9/1096 , C12N9/16 , C12N9/80 , C12N9/86 , C12N15/52 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/005 , C12P17/10 , C12Y102/01002 , C12Y102/99006 , C12Y114/15001 , C12Y203/01032 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082 , C12Y301/02 , C12Y305/01062
Abstract: This document describes biochemical pathways for producing adipic acid, caprolactam, 6-aminohexanoic acid, 6-hydroxyhexanoic acid, hexamethylenediamine or 1,6-hexanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C6 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on CoA-dependent elongation enzymes or analogues enzymes associated with the carbon storage pathways from polyhydroxyalkanoate accumulating bacteria.
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Patent Agency Ranking
公开(公告)号：US20170218406A1
公开(公告)日：2017-08-03
申请号：US15421164
申请日：2017-01-31
Applicant: INVISTA North America S.a.r.l.
Inventor： Alexander Van Eck CONRADIE , Adriana L. BOTES , Alec FOSTER , Changlin CHEN
IPC: C12P7/40 , C07C59/147 , C12N9/80 , C12N9/10 , C08G69/10 , C12N9/90 , C12N9/02 , C12P7/24 , C12P17/18 , C08G69/26 , C07C47/21 , C12N9/88
CPC classification number: C12P7/40 , C07C47/21 , C07C59/147 , C08G69/10 , C08G69/26 , C12N9/0008 , C12N9/001 , C12N9/1029 , C12N9/1096 , C12N9/80 , C12N9/88 , C12N9/90 , C12P7/04 , C12P7/24 , C12P7/42 , C12P7/46 , C12P7/50 , C12P7/6409 , C12P7/6427 , C12P13/001 , C12P17/182 , C12Y102/99006 , C12Y103/01031 , C12Y203/01032 , C12Y206/01018 , C12Y305/01 , C12Y402/99 , C12Y503/03008
Abstract: This document describes biochemical pathways for producing pimeloyl-CoA using a polypeptide having the enzymatic activity of a hydroperoxide lyase to form non-3-enal and 9-oxononanoate from 9-hydroxyperoxyoctadec-10,12-dienoate. Non-3-enal and 9-oxononanoate can be enzymatically converted to pimeloyl-CoA or a salt thereof using one or more polypeptides having the activity of a dehydrogenase, a CoA ligase, an isomerase, a reductase, a thioesterase, a monooxygenase, a hydratase, and/or a thiolase. Pimeloyl-CoA can be enzymatically converted to pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine, or 1,7-heptanediol, or corresponding salts thereof. This document also describes recombinant microorganisms producing pimeloyl-CoA, as well as pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine, and 1,7-heptanediol, or corresponding salts thereof.
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7.发明申请公开(公告)号：US20170204420A1
公开(公告)日：2017-07-20
申请号：US15405514
申请日：2017-01-13
Applicant: INVISTA North American S.á r.I.
Inventor： Adriana Leonora Botes , Alex Van Eck Conradie , Changlin Chen , Paul S. Pearlman
IPC: C12N15/52 , C12N9/10 , C12N9/12 , C12N9/88 , C12P7/24 , C12N9/02 , C12N9/00 , C12N9/80 , C12P7/44 , C12P13/00 , C12N9/04 , C12N9/16
CPC classification number: C12N15/52 , C12N9/0006 , C12N9/0008 , C12N9/1025 , C12N9/1029 , C12N9/1096 , C12N9/1288 , C12N9/16 , C12N9/80 , C12N9/88 , C12N9/93 , C12P7/18 , C12P7/24 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/005 , C12Y101/01 , C12Y101/01085 , C12Y101/01087 , C12Y101/01258 , C12Y101/01286 , C12Y102/01 , C12Y102/01003 , C12Y102/0101 , C12Y102/99006 , C12Y203/01032 , C12Y203/03013 , C12Y203/03014 , C12Y206/01 , C12Y207/08 , C12Y208/03012 , C12Y301/02 , C12Y305/01062 , C12Y401/01043 , C12Y402/01033 , C12Y402/01036 , C12Y402/01114 , C12Y602/01005
Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming one or two terminal functional groups, each comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the C1 elongation enzymes or homolog associated with coenzyme B biosynthesis.
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8.发明申请公开(公告)号：US20170044551A1
公开(公告)日：2017-02-16
申请号：US15072140
申请日：2016-03-16
Applicant: ZYMOCHEM INC.
Inventor： Harshal Chokhawala
IPC: C12N15/52 , C12N9/16 , C12N9/12 , C12N9/88 , C12P7/24 , C12N9/02 , C12P7/40 , C12P7/44 , C12P13/00 , C12P17/10 , C12P7/18 , C12P7/04 , C12P7/64 , C12N9/04 , C12N9/10 , C12N9/00 , C12N9/24 , C12N9/06 , C12P7/42
CPC classification number: C12N15/52 , C12N9/00 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0016 , C12N9/1029 , C12N9/1096 , C12N9/1205 , C12N9/13 , C12N9/16 , C12N9/2402 , C12N9/88 , C12N9/93 , C12P7/04 , C12P7/18 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/44 , C12P7/6409 , C12P13/001 , C12P13/005 , C12P17/08 , C12P17/10 , C12Y101/01001 , C12Y101/01002 , C12Y101/01035 , C12Y101/01078 , C12Y101/01268 , C12Y101/01269 , C12Y102/01003 , C12Y102/01005 , C12Y102/01022 , C12Y102/01024 , C12Y102/01026 , C12Y102/01048 , C12Y102/01063 , C12Y102/07005 , C12Y102/99006 , C12Y103/01044 , C12Y103/01045 , C12Y103/01086 , C12Y104/01 , C12Y203/01001 , C12Y203/01032 , C12Y203/01035 , C12Y203/01057 , C12Y206/01008 , C12Y206/01009 , C12Y206/01036 , C12Y206/01043 , C12Y206/01048 , C12Y206/01076 , C12Y206/01082 , C12Y207/01031 , C12Y207/01165 , C12Y208/03 , C12Y301/03 , C12Y301/03002 , C12Y301/03008 , C12Y301/03019 , C12Y301/0302 , C12Y302/01 , C12Y401/01001 , C12Y401/02 , C12Y401/02014 , C12Y401/0202 , C12Y401/02021 , C12Y401/03016 , C12Y401/03017 , C12Y402/01002 , C12Y402/01003 , C12Y402/01028 , C12Y402/0103 , C12Y402/01079 , C12Y402/0112 , C12Y602/01 , Y02E50/343
Abstract: Provided herein are methods, compositions, and non-naturally occurring microbial organism for preparing compounds such as 1-butanol, butyric acid, succinic acid, 1,4-butanediol, 1-pentanol, pentanoic acid, glutaric acid, 1,5-pentanediol, 1-hexanol, hexanoic acid, adipic acid, 1,6-hexanediol, 6-hydroxy hexanoic acid, ε-Caprolactone, 6-amino-hexanoic acid, ε-Caprolactam, hexamethylenediamine, linear fatty acids and linear fatty alcohols that are between 7-25 carbons long, linear alkanes and linear α-alkenes that are between 6-24 carbons long, sebacic acid and dodecanedioic acid comprising: a) converting a CN aldehyde and pyruvate to a CN+3 β-hydroxyketone intermediate through an aldol addition; and b) converting the CN+3β-hydroxyketone intermediate to the compounds through enzymatic steps, or a combination of enzymatic and chemical steps.
Abstract translation: 本文提供了用于制备化合物如1-丁醇，丁酸，琥珀酸，1,4-丁二醇，1-戊醇，戊酸，戊二酸，1,5-戊二醇的方法，组合物和非天然存在的微生物生物 ，1-己醇，己酸，己二酸，1,6-己二醇，6-羟基己酸，ε-己内酯，6-氨基 - 己酸，ε-己内酰胺，六亚甲基二胺，线性脂肪酸和线性脂肪醇， 7-25碳原子长度为6-24个碳原子的直链烷烃和直链α-烯烃，癸二酸和十二烷二酸包括：a）通过醛醇加成将CN醛和丙酮酸盐转化为CN +3β-羟基酮中间体 ; 和b）通过酶促步骤或酶和化学步骤的组合将CN +3β-羟基酮中间体转化为化合物。
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9.发明授权Methods of producing 6-carbon chemicals via CoA-dependent carbon chain elongation associated with carbon storage 有权通过与碳储存相关的CoA依赖性碳链延长生产6碳化学品的方法公开(公告)号：US09102960B2
公开(公告)日：2015-08-11
申请号：US14106124
申请日：2013-12-13
Applicant: INVISTA North America S.á r.l.
Inventor： Adriana Leonora Botes , Alex Van Eck Conradie
CPC classification number: C12N15/81 , C12N9/0008 , C12N9/0077 , C12N9/1029 , C12N9/1096 , C12N9/16 , C12N9/80 , C12N9/86 , C12N15/52 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/005 , C12P17/10 , C12Y102/01002 , C12Y102/99006 , C12Y114/15001 , C12Y203/01032 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082 , C12Y301/02 , C12Y305/01062
Abstract: This document describes biochemical pathways for producing adipic acid, caprolactam, 6-aminohexanoic acid, 6-hydroxyhexanoic acid, hexamethylenediamine or 1,6-hexanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C6 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on CoA-dependent elongation enzymes or analogs enzymes associated with the carbon storage pathways from polyhydroxyalkanoate accumulating bacteria.
Abstract translation: 该文献描述了通过在C6脂肪族骨架中形成由羧基，胺或羟基组成的两个末端官能团来生产己二酸，己内酰胺，6-氨基己酸，6-羟基己酸，六亚甲基二胺或1,6-己二醇的生化途径 基质。 本文描述的这些途径，代谢工程和培养策略依赖于CoA依赖性延伸酶或与聚羟基链烷酸酯累积细菌的碳储存途径相关的类似物酶。
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10.发明申请Methods Of Producing 7-Carbon Chemicals Via C1 Carbon Chain Elongation Associated With Coenzyme B Synthesis 有权通过与辅酶B合成相关的C1碳链伸长率生产7碳化合物的方法公开(公告)号：US20140193863A1
公开(公告)日：2014-07-10
申请号：US14138971
申请日：2013-12-23
Applicant: INVISTA North America S.á r.I.
Inventor： Adriana Leonora Botes , Alex Van Eck Conradie , Changlin Chen , Paul S. Pearlman
CPC classification number: C12N15/52 , C12N9/0006 , C12N9/0008 , C12N9/1025 , C12N9/1029 , C12N9/1096 , C12N9/1288 , C12N9/16 , C12N9/80 , C12N9/88 , C12N9/93 , C12P7/18 , C12P7/24 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/005 , C12Y101/01 , C12Y101/01085 , C12Y101/01087 , C12Y101/01258 , C12Y101/01286 , C12Y102/01 , C12Y102/01003 , C12Y102/0101 , C12Y102/99006 , C12Y203/01032 , C12Y203/03013 , C12Y203/03014 , C12Y206/01 , C12Y207/08 , C12Y208/03012 , C12Y301/02 , C12Y305/01062 , C12Y401/01043 , C12Y402/01033 , C12Y402/01036 , C12Y402/01114 , C12Y602/01005
Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming one or two terminal functional groups, each comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the C1 elongation enzymes or homolog associated with coenzyme B biosynthesis.
Abstract translation: 本文件描述了通过在C7脂肪族中形成一个或两个由羧基，胺或羟基组成的末端官能团，生成庚二酸，7-氨基庚酸，7-羟基庚酸，七亚甲基二胺或1,7-庚二醇的生化途径 骨架底物。 本文描述的这些途径，代谢工程和培养策略依赖于C1延长酶或与辅酶B生物合成相关的同源物。
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