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公开(公告)号：US12104160B2
公开(公告)日：2024-10-01
申请号：US17307850
申请日：2021-05-04
申请人： ZYMOCHEM, INC.
发明人： Harshal Chokhawala
IPC分类号： C12P7/42 , C12N9/00 , C12N9/02 , C12N9/04 , C12N9/06 , C12N9/10 , C12N9/12 , C12N9/16 , C12N9/24 , C12N9/88 , C12N15/52 , C12P7/04 , C12P7/18 , C12P7/24 , C12P7/40 , C12P7/44 , C12P7/6409 , C12P13/00 , C12P17/08 , C12P17/10
CPC分类号： C12N15/52 , C12N9/00 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0016 , C12N9/1029 , C12N9/1096 , C12N9/1205 , C12N9/13 , C12N9/16 , C12N9/2402 , C12N9/88 , C12N9/93 , C12P7/04 , C12P7/18 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/44 , C12P7/6409 , C12P13/001 , C12P13/005 , C12P17/08 , C12P17/10 , C12Y101/01001 , C12Y101/01002 , C12Y101/01035 , C12Y101/01078 , C12Y101/01268 , C12Y101/01269 , C12Y102/01003 , C12Y102/01005 , C12Y102/01022 , C12Y102/01024 , C12Y102/01026 , C12Y102/01048 , C12Y102/01063 , C12Y102/07005 , C12Y102/99006 , C12Y103/01044 , C12Y103/01045 , C12Y103/01086 , C12Y104/01 , C12Y203/01001 , C12Y203/01032 , C12Y203/01035 , C12Y203/01057 , C12Y206/01008 , C12Y206/01009 , C12Y206/01036 , C12Y206/01043 , C12Y206/01048 , C12Y206/01076 , C12Y206/01082 , C12Y207/01031 , C12Y207/01165 , C12Y208/03 , C12Y301/03 , C12Y301/03002 , C12Y301/03008 , C12Y301/03019 , C12Y301/0302 , C12Y302/01 , C12Y401/01001 , C12Y401/02 , C12Y401/02014 , C12Y401/0202 , C12Y401/02021 , C12Y401/03016 , C12Y401/03017 , C12Y402/01002 , C12Y402/01003 , C12Y402/01028 , C12Y402/0103 , C12Y402/01079 , C12Y402/0112 , C12Y602/01 , Y02E50/30
摘要： Provided herein are methods, compositions, and non-naturally occurring microbial organism for preparing compounds such as1-butanol, butyric acid, succinic acid, 1,4-butanediol, 1-pentanol, pentanoic acid, glutaric acid, 1,5-pentanediol, 1-hexanol, hexanoic acid, adipic acid, 1,6-hexanediol, 6-hydroxy hexanoic acid, ε-Caprolactone, 6-amino-hexanoic acid, ε-Caprolactam, hexamethylenediamine, linear fatty acids and linear fatty alcohols that are between 7-25 carbons long, linear alkanes and linear α-alkenes that are between 6-24 carbons long, sebacic acid and dodecanedioic acid comprising: a) converting a CN aldehyde and pyruvate to a CN+3 β-hydroxyketone intermediate through an aldol addition; and b) converting the CN+3 β-hydroxyketone intermediate to the compounds through enzymatic steps, or a combination of enzymatic and chemical steps.
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2.发明申请公开(公告)号：US20170044551A1
公开(公告)日：2017-02-16
申请号：US15072140
申请日：2016-03-16
申请人： ZYMOCHEM INC.
发明人： Harshal Chokhawala
IPC分类号： C12N15/52 , C12N9/16 , C12N9/12 , C12N9/88 , C12P7/24 , C12N9/02 , C12P7/40 , C12P7/44 , C12P13/00 , C12P17/10 , C12P7/18 , C12P7/04 , C12P7/64 , C12N9/04 , C12N9/10 , C12N9/00 , C12N9/24 , C12N9/06 , C12P7/42
CPC分类号： C12N15/52 , C12N9/00 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0016 , C12N9/1029 , C12N9/1096 , C12N9/1205 , C12N9/13 , C12N9/16 , C12N9/2402 , C12N9/88 , C12N9/93 , C12P7/04 , C12P7/18 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/44 , C12P7/6409 , C12P13/001 , C12P13/005 , C12P17/08 , C12P17/10 , C12Y101/01001 , C12Y101/01002 , C12Y101/01035 , C12Y101/01078 , C12Y101/01268 , C12Y101/01269 , C12Y102/01003 , C12Y102/01005 , C12Y102/01022 , C12Y102/01024 , C12Y102/01026 , C12Y102/01048 , C12Y102/01063 , C12Y102/07005 , C12Y102/99006 , C12Y103/01044 , C12Y103/01045 , C12Y103/01086 , C12Y104/01 , C12Y203/01001 , C12Y203/01032 , C12Y203/01035 , C12Y203/01057 , C12Y206/01008 , C12Y206/01009 , C12Y206/01036 , C12Y206/01043 , C12Y206/01048 , C12Y206/01076 , C12Y206/01082 , C12Y207/01031 , C12Y207/01165 , C12Y208/03 , C12Y301/03 , C12Y301/03002 , C12Y301/03008 , C12Y301/03019 , C12Y301/0302 , C12Y302/01 , C12Y401/01001 , C12Y401/02 , C12Y401/02014 , C12Y401/0202 , C12Y401/02021 , C12Y401/03016 , C12Y401/03017 , C12Y402/01002 , C12Y402/01003 , C12Y402/01028 , C12Y402/0103 , C12Y402/01079 , C12Y402/0112 , C12Y602/01 , Y02E50/343
摘要： Provided herein are methods, compositions, and non-naturally occurring microbial organism for preparing compounds such as 1-butanol, butyric acid, succinic acid, 1,4-butanediol, 1-pentanol, pentanoic acid, glutaric acid, 1,5-pentanediol, 1-hexanol, hexanoic acid, adipic acid, 1,6-hexanediol, 6-hydroxy hexanoic acid, ε-Caprolactone, 6-amino-hexanoic acid, ε-Caprolactam, hexamethylenediamine, linear fatty acids and linear fatty alcohols that are between 7-25 carbons long, linear alkanes and linear α-alkenes that are between 6-24 carbons long, sebacic acid and dodecanedioic acid comprising: a) converting a CN aldehyde and pyruvate to a CN+3 β-hydroxyketone intermediate through an aldol addition; and b) converting the CN+3β-hydroxyketone intermediate to the compounds through enzymatic steps, or a combination of enzymatic and chemical steps.
摘要翻译： 本文提供了用于制备化合物如1-丁醇，丁酸，琥珀酸，1,4-丁二醇，1-戊醇，戊酸，戊二酸，1,5-戊二醇的方法，组合物和非天然存在的微生物生物 ，1-己醇，己酸，己二酸，1,6-己二醇，6-羟基己酸，ε-己内酯，6-氨基 - 己酸，ε-己内酰胺，六亚甲基二胺，线性脂肪酸和线性脂肪醇， 7-25碳原子长度为6-24个碳原子的直链烷烃和直链α-烯烃，癸二酸和十二烷二酸包括：a）通过醛醇加成将CN醛和丙酮酸盐转化为CN +3β-羟基酮中间体 ; 和b）通过酶促步骤或酶和化学步骤的组合将CN +3β-羟基酮中间体转化为化合物。
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公开(公告)号：US11976310B2
公开(公告)日：2024-05-07
申请号：US17800484
申请日：2021-02-16
发明人： Arren Bar-Even , Hai He , Philippe Marliere
CPC分类号： C12P13/04 , C12N15/52 , C12N15/70 , C12Y101/01103 , C12Y101/03013 , C12Y203/01029 , C12Y401/02 , C12Y403/01 , C12N2800/101
摘要： The present disclosure relates to a method for the incorporation of formaldehyde into biomass comprising the following enzymatically catalyzed steps: (1) condensation of pyruvate with formaldehyde into 4-hydroxy-2-oxobutanoic acid (HOB); (2) amination of the thus produced 4-hydroxy-2-oxobutanoic acid (HOB) to produce homoserine; (3) conversion of thus produced homoserine to threonine; (4) conversion of the thus produced threonine into glycine and acetaldehyde or acetyl-CoA; (5) condensation of the thus produced glycine with formaldehyde to produce serine; and (6) conversion of the thus produced serine to produce pyruvate, wherein said pyruvate can then be used as a substrate in step (1). The disclosure also relates to enzymes for catalyzing the corresponding enzymatic reactions and recombinant microorganisms which express the enzymes for catalyzing the corresponding enzymatic reactions.
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公开(公告)号：US20150240226A1
公开(公告)日：2015-08-27
申请号：US14630006
申请日：2015-02-24
发明人： Eric J. Mathur , Cathy Chang
IPC分类号： C12N9/88 , C12Q1/04 , C12N9/80 , C12N9/26 , C12N9/08 , C07K2/00 , C12N9/14 , C12N9/16 , C12N9/02 , C12N9/78 , C12N9/12 , C12N9/24 , C12Q1/02 , C12N9/42
CPC分类号： C12N9/88 , C07K2/00 , C12N9/00 , C12N9/0061 , C12N9/0065 , C12N9/0071 , C12N9/1241 , C12N9/14 , C12N9/16 , C12N9/2411 , C12N9/2428 , C12N9/2437 , C12N9/2445 , C12N9/2482 , C12N9/78 , C12N9/80 , C12Q1/02 , C12Q1/04 , C12Y111/01016 , C12Y301/03 , C12Y302/01004 , C12Y303/02009 , C12Y305/01004 , C12Y401/02 , C12Y402/02002
摘要： The invention provides polypeptides, including enzymes, structural proteins and binding proteins, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. Polypeptides, including enzymes and antibodies, and nucleic acids of the invention can be used in industrial, experimental, food and feed processing, nutritional and pharmaceutical applications, e.g., for food and feed supplements, colorants, neutraceuticals, cosmetic and pharmaceutical needs.
摘要翻译： 本发明提供了多肽，包括酶，结构蛋白和结合蛋白，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。 本发明的多肽，包括酶和抗体以及核酸可用于工业，实验，食品和饲料加工，营养和药物应用中，例如用于食品和饲料添加剂，着色剂，中性药物，化妆品和药物需求。
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公开(公告)号：US20240254525A1
公开(公告)日：2024-08-01
申请号：US18433739
申请日：2024-02-06
CPC分类号： C12P13/04 , C12N15/52 , C12N15/70 , C12Y101/01103 , C12Y101/03013 , C12Y203/01029 , C12Y401/02 , C12Y403/01 , C12N2800/101
摘要： The present disclosure relates to a method for the incorporation of formaldehyde into biomass comprising the following enzymatically catalyzed steps: (1) condensation of pyruvate with formaldehyde into 4-hydroxy-2-oxobutanoic acid (HOB); (2) amination of the thus produced 4-hydroxy-2-oxobutanoic acid (HOB) to produce homoserine; (3) conversion of thus produced homoserine to threonine; (4) conversion of the thus produced threonine into glycine and acetaldehyde or acetyl-CoA; (5) condensation of the thus produced glycine with formaldehyde to produce serine; and (6) conversion of the thus produced serine to produce pyruvate, wherein said pyruvate can then be used as a substrate in step (1). The disclosure also relates to enzymes for catalyzing the corresponding enzymatic reactions and recombinant microorganisms which express the enzymes for catalyzing the corresponding enzymatic reactions.
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公开(公告)号：US09540652B2
公开(公告)日：2017-01-10
申请号：US14342335
申请日：2012-08-31
申请人： Darmawi Juminaga , Jay D. Keasling
发明人： Darmawi Juminaga , Jay D. Keasling
CPC分类号： C12N15/70 , C12N9/001 , C12N9/88 , C12N15/52 , C12P7/42 , C12P13/22 , C12P13/225 , C12P13/227 , C12Y103/01012 , C12Y401/02 , Y02P20/52
摘要： The present disclosure relates to engineered microorganisms that produce amino acids and amino acid intermediates. In particular, the disclosure relates to recombinant nucleic acids encoding operons that increase production of aromatic amino acids and the aromatic amino acid intermediate shikimate; microorganisms with increased production of aromatic amino acids and the aromatic amino acid intermediate shikimate; and methods related to the production of aromatic amino acids, the aromatic amino acid intermediate shikimate, and commodity chemicals derived therefrom.
摘要翻译： 本公开涉及产生氨基酸和氨基酸中间体的工程微生物。 具体地，本公开涉及编码增加芳族氨基酸的产生和芳香族氨基酸中间体莽草酸的操纵子的重组核酸; 芳香族氨基酸生成微生物和芳香族氨基酸中间体莽草酸; 以及与芳香族氨基酸的生成，芳香族氨基酸中间体莽草酸以及从其衍生的商品化学品有关的方法。
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公开(公告)号：US20150044734A1
公开(公告)日：2015-02-12
申请号：US14342335
申请日：2012-08-31
申请人： Darmawi Juminaga , Jay D. Keasling
发明人： Darmawi Juminaga , Jay D. Keasling
CPC分类号： C12N15/70 , C12N9/001 , C12N9/88 , C12N15/52 , C12P7/42 , C12P13/22 , C12P13/225 , C12P13/227 , C12Y103/01012 , C12Y401/02 , Y02P20/52
摘要： The present disclosure relates to engineered microorganisms that produce amino acids and amino acid intermediates. In particular, the disclosure relates to recombinant nucleic acids encoding operons that increase production of aromatic amino acids and the aromatic amino acid intermediate shikimate; microorganisms with increased production of aromatic amino acids and the aromatic amino acid intermediate shikimate; and methods related to the production of aromatic amino acids, the aromatic amino acid intermediate shikimate, and commodity chemicals derived therefrom.
摘要翻译： 本公开涉及产生氨基酸和氨基酸中间体的工程微生物。 具体地，本公开涉及编码增加芳族氨基酸的产生和芳香族氨基酸中间体莽草酸的操纵子的重组核酸; 芳香族氨基酸生成微生物和芳香族氨基酸中间体莽草酸; 以及与芳香族氨基酸的生成，芳香族氨基酸中间体莽草酸以及从其衍生的商品化学品有关的方法。
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公开(公告)号：US20100011456A1
公开(公告)日：2010-01-14
申请号：US11817403
申请日：2006-03-03
申请人： Eric J. Mathur , Cathy Chang
发明人： Eric J. Mathur , Cathy Chang
IPC分类号： A01K67/027 , C12N15/11 , C07H21/04 , C12N9/00 , C12P19/34 , C12N15/00 , C12N1/21 , C12N1/19 , C12N1/14 , C12N5/04 , A01H5/00 , C07H21/02 , C07K14/00 , C12N9/40 , C12N9/26 , C12N9/02 , C12N9/16 , C12N9/88 , C40B40/10 , C40B40/08 , C07K16/00 , G01N33/566 , G01N33/573 , A61K39/00 , C12P21/02 , C12Q1/68
CPC分类号： C12N9/88 , C07K2/00 , C12N9/00 , C12N9/0061 , C12N9/0065 , C12N9/0071 , C12N9/1241 , C12N9/14 , C12N9/16 , C12N9/2411 , C12N9/2428 , C12N9/2437 , C12N9/2445 , C12N9/2482 , C12N9/78 , C12N9/80 , C12Q1/02 , C12Q1/04 , C12Y111/01016 , C12Y301/03 , C12Y302/01004 , C12Y303/02009 , C12Y305/01004 , C12Y401/02 , C12Y402/02002
摘要： The invention provides polypeptides, including enzymes, structural proteins and binding proteins, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. Polypeptides, including enzymes and antibodies, and nucleic acids of the invention can be used in industrial, experimental, food and feed processing, nutritional and pharmaceutical applications, e.g., for food and feed supplements, colorants, neutraceuticals, cosmetic and pharmaceutical needs.
摘要翻译： 本发明提供了多肽，包括酶，结构蛋白和结合蛋白，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。 本发明的多肽，包括酶和抗体以及核酸可用于工业，实验，食品和饲料加工，营养和药物应用中，例如用于食品和饲料添加剂，着色剂，中性药物，化妆品和药物需求。
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公开(公告)号：US20240301448A1
公开(公告)日：2024-09-12
申请号：US18401511
申请日：2023-12-31
申请人： Hubei University
发明人： Shihui YANG , Xiongying YAN , Mian LI , Xia WANG , Qiaoning HE
CPC分类号： C12P7/18 , C12N9/0006 , C12N9/0008 , C12N9/88 , C12N15/74 , C12Y101/01001 , C12Y101/01175 , C12Y102/01021 , C12Y401/02 , C12Y402/01082
摘要： Recombinant Zymomonas mobilis for producing ethylene glycol, method and uses thereof are provided. The recombinant Zymomonas mobilis carries and expresses genes related to a synthesis pathway of xylonic acid and genes related to a synthesis pathway of ethylene glycol.
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公开(公告)号：US20240218146A1
公开(公告)日：2024-07-04
申请号：US18286324
申请日：2022-04-12
发明人： Kari KOIVURANTA , Irina TSITKO , Sandra CASTILLO , Heli NYGREN
IPC分类号： C08J11/10 , C12N9/02 , C12N9/08 , C12N9/18 , C12N9/48 , C12N9/64 , C12N9/88 , C12P5/00 , C12P5/02 , C12P7/26 , C12P7/6409
CPC分类号： C08J11/105 , C12N9/0065 , C12N9/0069 , C12N9/18 , C12N9/485 , C12N9/6408 , C12N9/88 , C12P5/002 , C12P5/026 , C12P7/26 , C12P7/6409 , C12Y111/01007 , C12Y111/0101 , C12Y111/01018 , C12Y111/02001 , C12Y113/11 , C12Y301/01001 , C12Y301/01002 , C12Y301/01003 , C12Y301/01024 , C12Y303/02003 , C12Y304/11005 , C12Y308/01005 , C12Y401/02
摘要： The present invention relates to the fields of life sciences, micro-organisms and degradation of polyolefin polymers. Specifically, the invention relates to an isolated specific enzyme or a fragment thereof, wherein said enzyme or fragment is capable of degrading a polyolefin, and to a micro-organism or a host cell comprising the enzyme or a fragment thereof. Also, the present invention relates to a polynucleotide encoding the enzyme or fragment thereof, and to an expression vector or plasmid comprising the polynucleotide of the present invention. And still, the present invention relates to use of the enzyme, fragment, micro-organism, host cell, polynucleotide, expression vector or plasmid of the present invention for degrading a polyolefin: to a method of degrading a polyolefin with the specific enzyme or a fragment thereof: and to a method of producing the enzyme or fragment thereof of the present invention.
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