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    Metabolic engineering of the shikimate pathway
    4.
    发明授权
    Metabolic engineering of the shikimate pathway 有权
    莽草酸通道的代谢工程

    公开(公告)号：US09540652B2

    公开(公告)日：2017-01-10

    申请号：US14342335

    申请日：2012-08-31

    申请人： Darmawi Juminaga ,  Jay D. Keasling

    发明人： Darmawi Juminaga ,  Jay D. Keasling

    IPC分类号： C12N15/70 ,  C12N9/88 ,  C12N15/52 ,  C12P7/42 ,  C12P13/22 ,  C12N9/02

    CPC分类号： C12N15/70 ,  C12N9/001 ,  C12N9/88 ,  C12N15/52 ,  C12P7/42 ,  C12P13/22 ,  C12P13/225 ,  C12P13/227 ,  C12Y103/01012 ,  C12Y401/02 ,  Y02P20/52

    摘要： The present disclosure relates to engineered microorganisms that produce amino acids and amino acid intermediates. In particular, the disclosure relates to recombinant nucleic acids encoding operons that increase production of aromatic amino acids and the aromatic amino acid intermediate shikimate; microorganisms with increased production of aromatic amino acids and the aromatic amino acid intermediate shikimate; and methods related to the production of aromatic amino acids, the aromatic amino acid intermediate shikimate, and commodity chemicals derived therefrom.

    摘要翻译： 本公开涉及产生氨基酸和氨基酸中间体的工程微生物。 具体地，本公开涉及编码增加芳族氨基酸的产生和芳香族氨基酸中间体莽草酸的操纵子的重组核酸; 芳香族氨基酸生成微生物和芳香族氨基酸中间体莽草酸; 以及与芳香族氨基酸的生成，芳香族氨基酸中间体莽草酸以及从其衍生的商品化学品有关的方法。

    METABOLIC ENGINEERING OF THE SHIKIMATE PATHWAY
    5.
    发明申请
    METABOLIC ENGINEERING OF THE SHIKIMATE PATHWAY 有权
    代表路线的代谢工程

    公开(公告)号：US20150044734A1

    公开(公告)日：2015-02-12

    申请号：US14342335

    申请日：2012-08-31

    申请人： Darmawi Juminaga ,  Jay D. Keasling

    发明人： Darmawi Juminaga ,  Jay D. Keasling

    IPC分类号： C12N15/70 ,  C12P13/22 ,  C12P7/42

    CPC分类号： C12N15/70 ,  C12N9/001 ,  C12N9/88 ,  C12N15/52 ,  C12P7/42 ,  C12P13/22 ,  C12P13/225 ,  C12P13/227 ,  C12Y103/01012 ,  C12Y401/02 ,  Y02P20/52

    摘要： The present disclosure relates to engineered microorganisms that produce amino acids and amino acid intermediates. In particular, the disclosure relates to recombinant nucleic acids encoding operons that increase production of aromatic amino acids and the aromatic amino acid intermediate shikimate; microorganisms with increased production of aromatic amino acids and the aromatic amino acid intermediate shikimate; and methods related to the production of aromatic amino acids, the aromatic amino acid intermediate shikimate, and commodity chemicals derived therefrom.

    摘要翻译： 本公开涉及产生氨基酸和氨基酸中间体的工程微生物。 具体地，本公开涉及编码增加芳族氨基酸的产生和芳香族氨基酸中间体莽草酸的操纵子的重组核酸; 芳香族氨基酸生成微生物和芳香族氨基酸中间体莽草酸; 以及与芳香族氨基酸的生成，芳香族氨基酸中间体莽草酸以及从其衍生的商品化学品有关的方法。

    AROMATIC AMINO ACID BIOSYNTHETIC ENZYMES
    7.
    发明申请
    AROMATIC AMINO ACID BIOSYNTHETIC ENZYMES 失效
    芳香氨基酸生物合成酶

    公开(公告)号：US20020184658A1

    公开(公告)日：2002-12-05

    申请号：US09454279

    申请日：1999-12-03

    发明人： SAVERIO CARL FALCO ,  OMOLAYO O. FAMODU ,  JIAN-MING LEE

    IPC分类号： C12N015/82 ,  C12N015/87 ,  C12N015/29

    CPC分类号： C12N9/001 ,  A61K38/00 ,  C07K2319/00 ,  C12N9/90 ,  C12N15/8243 ,  C12N15/8251 ,  C12Y103/01012 ,  C12Y504/99005

    摘要： This invention relates to an isolated nucleic acid fragment encoding a tyrosine biosynthetic enzyme. The invention also relates to the construction of a chimeric gene encoding all or a portion of the tyrosine biosynthetic enzyme, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the tyrosine biosynthetic enzyme in a transformed host cell.

    摘要翻译： 本发明涉及编码酪氨酸生物合成酶的分离的核酸片段。 本发明还涉及在正义或反义方向上编码全部或部分酪氨酸生物合成酶的嵌合基因的构建，其中嵌合基因的表达导致转化宿主细胞中酪氨酸生物合成酶水平的改变 。

    Novel targets for herbicides and transgenic plants resistant to said herbicides
    10.
    发明申请
    Novel targets for herbicides and transgenic plants resistant to said herbicides 有权
    对所述除草剂具有抗性的除草剂和转基因植物的新靶标

    公开(公告)号：US20040117872A1

    公开(公告)日：2004-06-17

    申请号：US10433556

    申请日：2003-12-18

    发明人： Michel Matringe ,  Pascal Rippert

    IPC分类号： C07H021/04 ,  C12N009/04 ,  A01H001/00 ,  C12N015/82 ,  C12N005/04

    CPC分类号： C12N9/001 ,  C07K14/415 ,  C12N9/1096 ,  C12N15/8274 ,  C12Y103/01012 ,  C12Y103/01013 ,  Y02P20/582

    摘要： The invention concerns novel enzymes having an arogenate dehydrogenase activity, in particular arogenate dehydrogenase enzymes of plants, and the genes encoding said enzymes. The inventive arogenate dehydrogenase enzymes catalyze the last stage of the metabolic pathway of tyrosine biosynthesis, and constitute, as such, potential targets of herbicides. Hence the invention also concerns a method for identifying herbicide compounds targeting said enzymes, said herbicide compounds preventing tyrosine biosynthesis by being fixed on said enzymes. The invention further concerns transgenic plants tolerant to herbicide compounds targeting an enzyme involved in the tyrosine biosynthesis pathway, in particular an enzyme involved in the transformation of L-tyrosine prephenate, in particular an arogenate dehydrogenase enzyme. Said plants become tolerant by expression in their tissues of a prephenate dehydrogenase enzyme, said enzyme being insensitive to said herbicide compounds and enabling the plant to synthetize tyrosine despite being treated with said herbicide compounds.

    摘要翻译： 本发明涉及具有雄激素脱氢酶活性的新型酶，特别是植物的氢化脱氢酶，以及编码所述酶的基因。 本发明的雄激素脱氢酶催化酪氨酸生物合成的代谢途径的最后阶段，并且构成除草剂的潜在靶标。 因此，本发明还涉及用于鉴定靶向所述酶的除草剂化合物的方法，所述除草剂化合物通过固定在所述酶上来预防酪氨酸生物合成。 本发明还涉及对涉及酪氨酸生物合成途径的酶的除草剂化合物具有耐受性的转基因植物，特别是涉及转化L-酪氨酸预苯酸酯，特别是雄激素脱氢酶的酶。 所述植物通过在其预组酸脱氢酶的组织中表达而变得耐受，所述酶对所述除草剂化合物不敏感，并且能够使植物合成酪氨酸，尽管用所述除草剂化合物进行处理。