专利检索 cpc:"C12Y302/00" 第 1 页

1.

发明申请
METHOD FOR PRODUCING STEVIOL AND STEVIOL GLYCOSIDE BY USING AOBGL11 HOMOLOG 审中-公开

公开(公告)号：US20190203246A1

公开(公告)日：2019-07-04

申请号：US16303849

申请日：2017-05-25

申请人： SUNTORY HOLDINGS LIMITED

发明人： Misa OCHIAI , Eiichiro ONO

IPC分类号： C12P19/56 , C12P15/00 , C12P19/14 , C12N15/81 , C12N15/74 , C12N15/52 , C12N15/82

CPC分类号： C12P19/56 , C12N5/10 , C12N9/24 , C12N15/09 , C12N15/52 , C12N15/74 , C12N15/81 , C12N15/82 , C12P15/00 , C12P19/14 , C12P19/44 , C12Y302/00

摘要： There has been a demand for a new method for producing a steviol glycoside and steviol. The present invention provides a method for producing a steviol glycoside and/or steviol, the method comprising a step of breaking bonds of steviol glycoside: a glucosidic bond at position 13; a glucosyl ester bond at position 19; and/or a glycosidic bond in a side chain (excluding a rhamnoside bond).

2.

发明申请
METHODS AND COMPOSITIONS USING KLOTO-FGF FUSION POLYPEPTIDES 审中-公开

公开(公告)号：US20160031961A1

公开(公告)日：2016-02-04

申请号：US14531620

申请日：2014-11-03

申请人： David GLASS , Shou-Ih HU

发明人： David GLASS , Shou-Ih HU

IPC分类号： C07K14/50 , C07K14/705

CPC分类号： C07K14/50 , A61K38/00 , C07K14/705 , C07K2319/00 , C07K2319/30 , C07K2319/32 , C12N9/2445 , C12N9/93 , C12Y302/00 , C12Y302/01021 , C12Y602/01003

摘要： The present invention is directed to methods, kits and compositions for preventing or treating age-related conditions or metabolic disorders. The Klotho fusion polypeptides of the invention include at least a Klotho protein or an active fragment thereof. In one embodiment, the fusion polypeptide comprises a Klotho polypeptide, a FGF (such as FGF23) and (optionally) a modified Fc fragment. The Fc fragment can, for example, have decreased binding to Fc-gamma-receptor and increased serum half-life. The Klotho fusion proteins are useful in the treatment and prevention of a variety of age-related conditions and metabolic disorders. In another embodiment, the fusion polypeptide comprises a FGF (such as FGF23) and a modified Fc fragment.

3.

发明申请
Technology for the Preparation of Microparticles 审中-公开
标题翻译：微粒制备技术

公开(公告)号：US20140099696A1

公开(公告)日：2014-04-10

申请号：US13874424

申请日：2013-04-30

申请人： Ansun Biopharma, Inc.

发明人： Michael P. Malakhov , Fang Fang

IPC分类号： A61K9/16

CPC分类号： A61K9/1682 , A61K9/0048 , A61K9/0075 , A61K9/1652 , A61K9/1658 , A61K9/19 , A61K9/5089 , A61K31/198 , A61K31/337 , A61K31/343 , A61K31/405 , A61K31/43 , A61K31/555 , A61K31/557 , A61K31/5575 , A61K31/65 , A61K31/7036 , A61K31/721 , A61K31/724 , A61K35/76 , A61K38/08 , A61K38/12 , A61K38/14 , A61K38/168 , A61K38/1709 , A61K38/1808 , A61K38/38 , A61K38/385 , A61K38/42 , A61K38/465 , A61K38/47 , A61K38/4826 , C07D305/14 , C07K9/008 , C07K14/765 , C12N7/00 , C12N9/96 , C12N15/113 , C12N15/1137 , C12N2310/111 , C12N2310/14 , C12N2310/50 , C12N2330/30 , C12N2770/00021 , C12N2770/00051 , C12Y301/21001 , C12Y301/27005 , C12Y302/00 , C12Y302/01017 , C12Y302/01018 , C12Y304/21004 , Y02A50/385 , Y02A50/387 , Y02A50/393 , Y02A50/401 , Y02A50/402 , Y02A50/411 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/478 , Y02A50/481 , Y02A50/483 , Y02A50/49 , Y02A50/491

摘要： Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals, nutraceuticals, cosmetic products and the like of defined dimensions.

摘要翻译： 通过使溶剂中的大分子或小分子的溶液与抗溶剂和抗衡离子接触，并冷却溶液来制备微球体。微球可用于制备具有限定尺寸的药物，营养品，化妆品等。

4.

发明申请
METHODS AND COMPOSITIONS USING KLOTO-FGF FUSION POLYPEPTIDES 有权
标题翻译：使用KLOTO-FGF融合多肽的方法和组合物

公开(公告)号：US20130224196A1

公开(公告)日：2013-08-29

申请号：US13796711

申请日：2013-03-12

申请人： David GLASS , Shou-Ih HU

发明人： David GLASS , Shou-Ih HU

IPC分类号： C07K14/50

CPC分类号： C07K14/50 , A61K38/00 , C07K14/705 , C07K2319/00 , C07K2319/30 , C07K2319/32 , C12N9/2445 , C12N9/93 , C12Y302/00 , C12Y302/01021 , C12Y602/01003

摘要： The present invention is directed to methods, kits and compositions for preventing or treating age-related conditions or metabolic disorders. The Klotho fusion polypeptides of the invention include at least a Klotho protein or an active fragment thereof. In one embodiment, the fusion polypeptide comprises a Klotho polypeptide, a FGF (such as FGF23) and (optionally) a modified Fc fragment. The Fc fragment can, for example, have decreased binding to Fc-gamma-receptor and increased serum half-life. The Klotho fusion proteins are useful in the treatment and prevention of a variety of age-related conditions and metabolic disorders. In another embodiment, the fusion polypeptide comprises a FGF (such as FGF23) and a modified Fc fragment.

摘要翻译： 本发明涉及用于预防或治疗年龄相关病症或代谢紊乱的方法，试剂盒和组合物。本发明的Klotho融合多肽至少包括Klotho蛋白或其活性片段。在一个实施方案中，融合多肽包含Klotho多肽，FGF（例如FGF23）和（任选地）修饰的Fc片段。例如，Fc片段可以降低与Fc-γ受体的结合并增加血清半衰期。 Klotho融合蛋白可用于治疗和预防各种年龄相关病症和代谢紊乱。在另一个实施方案中，融合多肽包含FGF（例如FGF23）和修饰的Fc片段。

5.

发明申请
Method for preparing flour doughs and products made from such doughs using glycerol oxidase 失效
标题翻译：使用甘油氧化酶制备由面团制成的面团面团和产品的方法

公开(公告)号：US20030108641A1

公开(公告)日：2003-06-12

申请号：US10040394

申请日：2002-01-09

发明人： Jorn Borch Soe , Charlotte Horsmans Poulsen , Preben Rasmussen , Susan Mampusti Madrid , Masoud R. Zargahi

IPC分类号： A21D002/00

CPC分类号： C12Y101/03005 , A21D2/16 , A21D2/26 , A21D8/042 , A23L7/107 , C07K2319/00 , C12N9/20 , C12N9/80 , C12Y301/01003 , C12Y301/01004 , C12Y301/01026 , C12Y302/00

摘要： Method of improving the rheological properties of a flour dough and the quality of bread, alimentary paste products, noodles and cakes wherein glycerol oxidase or a combination of glycerol oxidase and a lipase is added to the dough and dough improving compositions comprising these enzymes. The strength of (B/C ratio) and the gluten index of the dough was improved and in the resulting products the improvements were higher specific volume, increased crumb pore homogeneity and reduced average crumb pore diameter.

摘要翻译： 提高面粉面团的流变性能的方法以及其中甘油氧化酶或甘油氧化酶和脂肪酶的组合的面包，消化糊制品，面条和蛋糕的质量被加入到包含这些酶的面团和面团改良组合物中。（B / C比）的强度和面团的面筋指数得到改善，并且在所得产品中，改进的比体积增加，碎屑孔均匀性增加，平均碎屑孔直径减小。

6.

发明申请
Starch Compositions Useful For Thickening Aqueous Liquids 审中-公开

公开(公告)号：US20170208851A1

公开(公告)日：2017-07-27

申请号：US15313629

申请日：2015-05-27

申请人： Tate & Lyle Americas LLC

发明人： Christopher C. Kerwood , Marshall Hull , William Skelding , Marvin V. Wiederhold

IPC分类号： A23L33/00 , A23C9/137 , A61K47/36 , A23L29/219 , A23L29/30 , C08B31/12 , A23L33/125 , A23L2/52

CPC分类号： A23L33/40 , A23C9/137 , A23L2/52 , A23L29/219 , A23L29/35 , A23L33/00 , A23L33/125 , A23V2002/00 , A61K9/00 , A61K9/0095 , A61K9/2059 , A61K47/36 , C08B30/12 , C08B31/003 , C08B31/006 , C08B31/12 , C08L3/00 , C08L3/04 , C08L3/08 , C12Y302/00 , C12Y304/00 , A23V2200/242 , A23V2200/244 , A23V2250/5118

摘要： The present invention relates specifically to starch products and starch compositions useful for thickening aqueous liquids, for example, for use by people suffering from dysphagia. In one aspect, the invention provides a pregelatinized, hydroxypropylated starch, having a level of hydroxypropylation in the range of about 1% to about 10%; an RVA viscosity in the range of about 400 cP to about 3500 cP; wherein the pregelatinized, hydroxypropylated starch is readily dispersible in milk. Another aspect provides a provides a pregelatinized, hydroxypropylated starch, having a level of hydroxypropylation in the range of about 1% to about 10%; and an RVA viscosity in the range of about 400 cP to about 3500 cP; and less than about 80%>of the surface protein of the corresponding native starch.

7.

发明申请
Technology for the Preparation of Microparticles 审中-公开

公开(公告)号：US20170079920A1

公开(公告)日：2017-03-23

申请号：US15369734

申请日：2016-12-05

申请人： Ansun Biopharma, Inc.

发明人： Michael P. Malakhov , Fang Fang

IPC分类号： A61K9/16 , A61K38/38 , A61K38/48 , A61K38/16 , A61K38/46 , A61K38/17 , A61K31/7036 , A61K31/43 , A61K38/14 , C12N15/113 , C12N7/00 , A61K38/12 , A61K38/08 , A61K31/65 , A61K31/555 , A61K31/557 , A61K38/47

CPC分类号： A61K9/1682 , A61K9/0048 , A61K9/0075 , A61K9/1652 , A61K9/1658 , A61K9/19 , A61K9/5089 , A61K31/198 , A61K31/337 , A61K31/343 , A61K31/405 , A61K31/43 , A61K31/555 , A61K31/557 , A61K31/5575 , A61K31/65 , A61K31/7036 , A61K31/721 , A61K31/724 , A61K35/76 , A61K38/08 , A61K38/12 , A61K38/14 , A61K38/168 , A61K38/1709 , A61K38/1808 , A61K38/38 , A61K38/385 , A61K38/42 , A61K38/465 , A61K38/47 , A61K38/4826 , C07D305/14 , C07K9/008 , C07K14/765 , C12N7/00 , C12N9/96 , C12N15/113 , C12N15/1137 , C12N2310/111 , C12N2310/14 , C12N2310/50 , C12N2330/30 , C12N2770/00021 , C12N2770/00051 , C12Y301/21001 , C12Y301/27005 , C12Y302/00 , C12Y302/01017 , C12Y302/01018 , C12Y304/21004 , Y02A50/385 , Y02A50/387 , Y02A50/393 , Y02A50/401 , Y02A50/402 , Y02A50/411 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/478 , Y02A50/481 , Y02A50/483 , Y02A50/49 , Y02A50/491

摘要： Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals, nutraceuticals, cosmetic products and the like of defined dimensions.

8.

发明申请
ANTI-METALLOPROTEASE ANTIBODY FOR DIAGNOSIS AND TREATMENT OF CANCERS 有权
标题翻译：用于诊断和治疗癌症的抗金属蛋白酶抗体

公开(公告)号：US20170008976A1

公开(公告)日：2017-01-12

申请号：US15116487

申请日：2015-02-04

申请人： MONASH UNIVERSITY , MEMORIAL SLOAN-KETTERING CANCER CENTRE , LUDWIG INSTITUTE FOR CANCER RESEARCH LTD

发明人： Martin LACKMANN , Peter W. JANES , Lakmali Atapattu MUDIYANSELAGE , Andrew M. SCOTT , Dimitar B. NIKOLOV , Nayanendu SAHA

IPC分类号： C07K16/40 , G01N33/574 , C07K16/30

CPC分类号： C07K16/40 , A61K31/4745 , A61K39/39558 , A61K2039/505 , C07K16/30 , C07K16/3023 , C07K16/3038 , C07K16/3053 , C07K16/3069 , C07K2299/00 , C07K2317/34 , C07K2317/54 , C07K2317/565 , C07K2317/76 , C12Y302/00 , G01N33/573 , G01N33/574 , G01N33/57484 , G01N33/57492 , G01N2333/96486 , A61K2300/00

摘要： Expression of proteolytically active, high molecular weight ADAM protease is relatively increased in tumour cells that also express the putative tumour stem cell marker CD133. An antibody or antibody fragment such as 8C7 monoclonal antibody may be used to selectively bind to proteolytically active, high molecular weight ADAM10 protease to thereby detect tumour cells and also as a therapeutic agent for treating cancers, tumours and other malignancies inclusive of leukemia, lymphoma, lung cancer, colon cancer, adenoma, neuroblastoma, brain tumour, renal tumour, prostate cancer, sarcoma and/or melanoma.

摘要翻译： 蛋白水解活性的高分子量ADAM蛋白酶的表达在也表达推定的肿瘤干细胞标志物CD133的肿瘤细胞中相对增加。抗体或抗体片段如8C7单克隆抗体可用于选择性结合蛋白水解活性的高分子量ADAM10蛋白酶，从而检测肿瘤细胞，并且还可用作治疗癌症，肿瘤和其它恶性肿瘤的治疗剂，包括白血病，淋巴瘤，肺癌，结肠癌，腺瘤，神经母细胞瘤，脑肿瘤，肾肿瘤，前列腺癌，肉瘤和/或黑素瘤。