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    METHODS AND COMPOSITIONS USING FGF23 VARIANT POLYPEPTIDES
    1.
    发明申请
    METHODS AND COMPOSITIONS USING FGF23 VARIANT POLYPEPTIDES 审中-公开

    公开(公告)号：US20170166618A1

    公开(公告)日：2017-06-15

    申请号：US14678165

    申请日：2015-04-03

    申请人： David GLASS ,  Shou-Ih HU

    发明人： David GLASS ,  Shou-Ih HU

    IPC分类号： C07K14/50 ,  C12N9/24

    CPC分类号： C07K14/50 ,  A61K38/00 ,  A61K38/1825 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/30 ,  C07K2319/74 ,  C12N9/2402 ,  C12Y302/01031

    摘要： The present disclosure is directed to methods, kits and compositions for preventing or treating age-related conditions or metabolic disorders. The fusion polypeptides of the disclosure include FGF23 or an active fragment thereof. In one embodiment, the fusion polypeptide comprises (a) a polypeptide comprising fibroblast growth factor 23 (FGF23), or a functionally active variant or derivative thereof, wherein FGF23 has a mutation at one or more of the positions Q156, C206 and C244; and (b) either a modified Fc fragment having decreased affinity for Fc-gamma-receptor and/or increased serum half-life, or a polypeptide comprising at least one extracellular subdomain of a Klotho protein, or a functionally active variant or derivative thereof and, optionally (c) a linker. The Klotho fusion proteins are useful in the treatment and prevention of a variety of age-related conditions and metabolic disorders. In another embodiment, the fusion polypeptide comprises a FGF (such as FGF23), or a functionally active variant or derivative thereof; and a modified Fc fragment, or a functionally active variant or derivative thereof In various embodiments of the fusion polypeptides, FGF23 has mutations which decrease aggregation and protease-mediated cleavage.

    METHODS AND COMPOSITIONS USING KLOTO-FGF FUSION POLYPEPTIDES
    3.
    发明申请
    METHODS AND COMPOSITIONS USING KLOTO-FGF FUSION POLYPEPTIDES 审中-公开

    公开(公告)号：US20130324458A1

    公开(公告)日：2013-12-05

    申请号：US13904574

    申请日：2013-05-29

    申请人： David GLASS ,  Shou-Ih HU

    发明人： David GLASS ,  Shou-Ih HU

    IPC分类号： C07K14/435

    CPC分类号： C07K14/435 ,  A61K38/00 ,  C07K14/50 ,  C07K2319/00 ,  C12N9/2402 ,  C12Y302/01031

    摘要： The present invention is directed to methods, kits and compositions for preventing or treating age-related conditions or metabolic disorders. The Klotho fusion polypeptides of the invention include at least a Klotho protein or an active fragment thereof. In one embodiment, the fusion polypeptide comprises a Klotho polypeptide, a FGF (such as FGF23) and (optionally) a modified Fc fragment. The Fc fragment can, for example, have decreased binding to Fc-gamma-receptor and increased serum half-life. The Klotho fusion proteins are useful in the treatment and prevention of a variety of age-related conditions and metabolic disorders. In another embodiment, the fusion polypeptide comprises a FGF (such as FGF23) and a modified Fc fragment.

    METHODS AND COMPOSITIONS USING KLOTO-FGF FUSION POLYPEPTIDES
    5.
    发明申请
    METHODS AND COMPOSITIONS USING KLOTO-FGF FUSION POLYPEPTIDES 有权
    使用KLOTO-FGF融合多肽的方法和组合物

    公开(公告)号：US20130224196A1

    公开(公告)日：2013-08-29

    申请号：US13796711

    申请日：2013-03-12

    申请人： David GLASS ,  Shou-Ih HU

    发明人： David GLASS ,  Shou-Ih HU

    IPC分类号： C07K14/50

    CPC分类号： C07K14/50 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/32 ,  C12N9/2445 ,  C12N9/93 ,  C12Y302/00 ,  C12Y302/01021 ,  C12Y602/01003

    摘要： The present invention is directed to methods, kits and compositions for preventing or treating age-related conditions or metabolic disorders. The Klotho fusion polypeptides of the invention include at least a Klotho protein or an active fragment thereof. In one embodiment, the fusion polypeptide comprises a Klotho polypeptide, a FGF (such as FGF23) and (optionally) a modified Fc fragment. The Fc fragment can, for example, have decreased binding to Fc-gamma-receptor and increased serum half-life. The Klotho fusion proteins are useful in the treatment and prevention of a variety of age-related conditions and metabolic disorders. In another embodiment, the fusion polypeptide comprises a FGF (such as FGF23) and a modified Fc fragment.

    摘要翻译： 本发明涉及用于预防或治疗年龄相关病症或代谢紊乱的方法，试剂盒和组合物。 本发明的Klotho融合多肽至少包括Klotho蛋白或其活性片段。 在一个实施方案中，融合多肽包含Klotho多肽，FGF（例如FGF23）和（任选地）修饰的Fc片段。 例如，Fc片段可以降低与Fc-γ受体的结合并增加血清半衰期。 Klotho融合蛋白可用于治疗和预防各种年龄相关病症和代谢紊乱。 在另一个实施方案中，融合多肽包含FGF（例如FGF23）和修饰的Fc片段。