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公开(公告)号:US20240358652A1
公开(公告)日:2024-10-31
申请号:US18291808
申请日:2022-08-17
申请人: Monash University
IPC分类号: A61K9/51 , A61K31/713 , A61K39/00 , A61K48/00 , A61P37/08
CPC分类号: A61K9/5146 , A61K9/5123 , A61K31/713 , A61K39/0005 , A61K48/0041 , A61P37/08 , A61K2039/53 , A61K2039/55555 , A61K2039/572
摘要: The present invention is directed to lipid nanoparticles, formulations containing lipid nanoparticles and methods of treating diseases or conditions with said lipid nanoparticles and formulations thereof. A lipid nanoparticle comprising (a) an active agent; (b) a cationic and/or ionisable lipid comprising from about 40 mol % to about 60 mol % of the total lipid present in the nanoparticle; (c) a phospholipid comprising from about 5 mol % to about 20 mol % of the total lipid present in the nanoparticle; (d) a structural lipid comprising from about 30 mol % to about 50 mol % of the total lipid present in the nanoparticle; (e) a PEGylated lipid comprising from about 0.05 mol % to less than 0.5 mol % of the total lipid present in the nanoparticle.
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公开(公告)号:US20240141360A1
公开(公告)日:2024-05-02
申请号:US18310289
申请日:2023-05-01
IPC分类号: C12N15/113
CPC分类号: C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3233 , C12N2310/3513 , C12N2320/30 , C12N2320/33
摘要: An isolated or purified AON for modifying pre-mRNA splicing in the Receptor for Advanced Glycation End-products (RAGE) to modulate splicing of the RAGE gene transcript or part thereof is provided.
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公开(公告)号:US11954823B2
公开(公告)日:2024-04-09
申请号:US17055522
申请日:2019-05-14
申请人: MONASH UNIVERSITY
IPC分类号: G06T3/40 , G01R33/48 , G01R33/56 , G06T3/4046 , G06T3/4076
CPC分类号: G06T3/4076 , G01R33/4818 , G01R33/5608 , G06T3/4046
摘要: A method and system for reconstructing magnetic resonance (MR) images, the method including the steps of: receiving an under-sampled MR image, the under-sampled MR image being transformed from under-sampled k-spaced data; classifying intensity of each pixel in the under-sampled MR image to one of a plurality of predetermined quantized values of intensity by using a neural network; and generating a reconstructed MR image based on the classified quantized value of the intensity for each pixel in the under-sampled MR image.
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公开(公告)号:USD1019932S1
公开(公告)日:2024-03-26
申请号:US29765322
申请日:2021-01-07
申请人: Monash University
设计人: Richard Morfuni , Daphne Flynn , Rowan Page , Mark C. Armstrong , Tuncay Alan , Jason Brenker
摘要: FIG. 1 is a top perspective view of an inhaler showing our new design;
FIG. 2 is a bottom perspective view thereof;
FIG. 3 is a top plan view thereof;
FIG. 4 is a front elevational view thereof;
FIG. 5 is a rear elevational view thereof;
FIG. 6 is a bottom plan view thereof; and,
FIG. 7 is a left side elevational view thereof, the right side elevational view being a mirror image thereof.
The broken lines in the figures depict portions of the inhaler which form no part of the claimed design.
The black areas in the figures depict portions of the inhaler having a contrasting surface appearance, such as contrasting color, including black.-
公开(公告)号:US11878165B2
公开(公告)日:2024-01-23
申请号:US17346971
申请日:2021-06-14
申请人: MONASH UNIVERSITY
CPC分类号: A61N1/36031 , A61B5/369 , A61B5/375 , A61B5/4064 , A61B5/4836 , A61B5/7203 , A61N1/36025 , A61B5/0042 , A61B5/318 , A61B5/389 , A61B5/6814 , A61N1/0476
摘要: Closed-loop transcranial stimulation and monitoring is disclosed that includes generating a stimulation signal having a set of first oscillation parameters; applying the stimulation signal transcranially to a patient; monitoring the stimulation signal as applied to the patient; receiving a brain activity signal from the patient; generating a feedback signal based on the monitored stimulation signal as applied to the patient; and generating a modified activity signal by subtracting the feedback signal from the brain activity signal; determining one or more second oscillation parameters of the modified activity signal; and adjusting the set of first oscillation parameters of the stimulation signal based on the one or more second oscillation parameters of the modified activity signal. Closed-loop transcranial stimulation and monitoring is also disclosed in which the patient is engaged in a cognitive task.
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6.
公开(公告)号:US20230282944A1
公开(公告)日:2023-09-07
申请号:US18006404
申请日:2021-07-23
申请人: MONASH UNIVERSITY
IPC分类号: H01M50/497 , H01M50/403 , H01M50/417 , B82Y30/00 , B82Y40/00 , H01M10/052
CPC分类号: H01M50/497 , H01M50/403 , H01M50/417 , B82Y30/00 , B82Y40/00 , H01M10/052 , H01M2300/0082 , H01M2300/0094
摘要: A method of making a polyelectrolyte complex membrane separator for a Lithium-Sulfur battery to support lean electrolyte operation, comprising the steps of: forming polyelectrolyte complex nanoparticles by the addition of polyethylenimine (PEI) to tannic acid (TA); adding bovine serum albumin (BSA); purifying the nanoparticles; re-dispersing the nanoparticles in water to form a nanoparticle suspension; and dipcoating a polyolefin membrane in the nanoparticle suspension.
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公开(公告)号:US20230277736A1
公开(公告)日:2023-09-07
申请号:US18314951
申请日:2023-05-10
申请人: Alfred Health , Monash University
CPC分类号: A61M1/04 , A61B17/3462 , A61B17/3496 , A61B17/3403 , A61B17/3421 , A61B2017/00455
摘要: A surgical system for use in establishing and maintaining an opening to an anatomical space of a body, the system comprising an obturator assembly having a cutting portion at a distal end and a cannula, the cannula being detachably coupled to the cutting portion and deployable into the anatomical space of a patient, the cannula comprises a locking portion, and a lengthwise extendable body; a valve assembly comprising a passage for receiving the cannula, a first end for coupling to a fluid extraction device and a second end for placement external and adjacent the anatomical space; a base comprising a plate for placement on a patient external and adjacent the anatomical space, the plate has an aperture configured for receiving the obturator assembly and coupling means located about the aperture for coupling with the valve assembly; and wherein, in use, the locking portion of the cannula is configured to be retained in the valve assembly with the extendable body extended into the anatomical space to facilitate a path for fluid extraction, and wherein the cannula comprises means for retaining the cannula in its extended state.
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公开(公告)号:US20230270859A1
公开(公告)日:2023-08-31
申请号:US17906601
申请日:2021-03-19
申请人: MONASH UNIVERSITY
发明人: Joshua OOI , Peter EGGENHUIZEN , Eric MORAND
IPC分类号: A61K39/00 , C07K14/725 , C07K16/28 , A61P37/06
CPC分类号: A61K39/4632 , C07K14/7051 , C07K16/2833 , A61K39/4611 , A61P37/06 , C07K2319/00 , A61K2239/13
摘要: The present invention relates to compositions and methods for the treatment of lupus, particularly systemic lupus erythematosus. The present invention involves, amongst other things, a binding protein comprising a T cell receptor (TCR) α-chain variable (Vα or Valpha) domain and a TCR β-chain variable (Vβ or Vbeta) domain, wherein the binding protein is capable of binding to a complex of a fragment of a Smith protein and an HLA-DR15 or HLA-DR3 molecule.
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公开(公告)号:US20230227580A1
公开(公告)日:2023-07-20
申请号:US18000557
申请日:2021-06-25
CPC分类号: C07K16/36 , A61P7/02 , C07K2317/76 , C07K2317/565 , C07K2317/567 , C07K2317/622
摘要: The invention also relates to antigen binding proteins and related fragments thereof for binding Von Willebrand factor (VWF) and uses thereof. In one aspect, the present invention provides an antigen binding protein comprising an antigen binding domain that binds to or specifically binds to Von Willebrand factor (VWF) under shear gradient conditions. Preferably, the antigen binding protein comprises an antigen binding domain that does not bind to VWF under constant shear conditions.
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公开(公告)号:US20230220112A1
公开(公告)日:2023-07-13
申请号:US17772090
申请日:2020-10-28
申请人: MONASH UNIVERSITY
发明人: James Whisstock , Ruby Law , Adam Quek , Paul Conroy , Guojie Wu
CPC分类号: C07K16/40 , A61P7/00 , C07K2317/92 , C07K2317/567 , C07K2317/565
摘要: The present invention provides an antigen binding protein comprising an antigen binding domain that binds to plasmin, wherein the antigen binding protein reduces the activity of plasmin. The invention also provides compositions comprising the antigen binding protein, and uses and method of treatment comprising the same.
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