公开(公告)号：US20250044313A1

公开(公告)日：2025-02-06

申请号：US18717649

申请日：2022-12-09

Applicant: RANDOX LABORATORIES LTD.

Inventor： Ivan MCCONNELL ,  Lewis MCKINSTRY ,  Peter FITZGERALD

IPC: G01N35/02 ,  G01N33/543 ,  G01N35/00 ,  G01N35/04

Abstract: An apparatus for assaying one or more lateral flow test devices. The apparatus comprises at least one support device for supporting one or more lateral flow test devices in use and at least one sample receptacle configured to receive, in use, a respective liquid sample to be dispensed onto a corresponding lateral flow test device. The apparatus further comprises a dispensing apparatus configured to dispense a known volume of the received liquid sample from the sample receptacle onto the corresponding lateral flow test device supported by the support device.

公开(公告)号：US12208397B2

公开(公告)日：2025-01-28

申请号：US17265441

申请日：2019-08-02

Applicant: RANDOX LABORATORIES LTD

Inventor： Paul Courtney ,  Martin Reid ,  Stuart Jackson ,  John Lamont ,  Ivan McConnell ,  Peter Fitzgerald

IPC: B01L9/00 ,  B01L1/00 ,  B25J9/02

Abstract: There is provided a pipette tip disposal assembly. The assembly comprises a receiving element adapted to support an end of at least one pipette tip, the at least one pipette tip being toppled in use from the receiving element along a first direction; and a container positioned to receive the at least one toppled pipette tip, the at least one pipette tip falling towards a base of the container on being received by the container. The base of the container has a first linear dimension aligned with the first direction corresponding to the length of a pipette tip.

公开(公告)号：US20190247820A1

公开(公告)日：2019-08-15

申请号：US16388527

申请日：2019-04-18

Applicant: Randox Laboratories Ltd. ,  Randox Teoranta

Inventor： Peter Fitzgerald ,  John Lamont ,  Ivan McConnell ,  Elouard Benchikh ,  Deepesh Upadhyay ,  Ciaran Richardson

IPC: B01J19/00 ,  C12M1/00 ,  G01N33/543 ,  C09D11/102 ,  C09D11/03

CPC classification number: B01J19/0046 ,  B01J2219/00608 ,  B01J2219/00637 ,  C09D11/03 ,  C09D11/102 ,  C12M1/00 ,  G01N33/54393

Abstract: A substrate comprising a coating of a masking material, and a plurality of discrete reaction zones onto which one or more binding agents are intended to be attached, wherein said zones are uncoated areas on the substrate.

公开(公告)号：US10288618B2

公开(公告)日：2019-05-14

申请号：US15302849

申请日：2015-04-02

Applicant: Randox Laboratories Ltd.

Inventor： Alex Chacko ,  Ivan McConnell ,  Peter Fitzgerald ,  John V. Lamont

IPC: G01N33/53 ,  G01N33/574 ,  A61P35/00 ,  A61P35/04 ,  G01N33/68 ,  C07K14/54

Abstract: The present invention describes methods for screening for cancer in a subject, by measuring the level of dimeric IL-18 in a sample obtained from the subject, and comparing that level with the level in a normal control sample.The present invention also describes an assay for screening for cancer in a subject, by measuring the level of dimeric IL-18 in a sample obtained from the subject, whereby an elevated level of dimeric IL-18 is indicative of cancer.

公开(公告)号：US10279332B2

公开(公告)日：2019-05-07

申请号：US15983484

申请日：2018-05-18

Applicant: Randox Laboratories Ltd. ,  Randox Teoranta

Inventor： Peter Fitzgerald ,  John Lamont ,  Ivan McConnell ,  Elouard Benchikh ,  Deepesh Upadhyay ,  Ciaran Richardson

IPC: B01J19/00 ,  C09D11/03 ,  C09D11/102 ,  C12M1/00 ,  G01N33/543

Abstract: A substrate comprising a coating of a masking material, and a plurality of discrete reaction zones onto which one or more binding agents are intended to be attached, wherein said zones are uncoated areas on the substrate.

公开(公告)号：US10254297B2

公开(公告)日：2019-04-09

申请号：US15200558

申请日：2016-07-01

Applicant: Randox Laboratories Ltd

Inventor： Ivan McConnell ,  Philip Lowry ,  Elouard Benchikh ,  Peter Fitzgerald

IPC: G01N33/94 ,  C07K14/435 ,  C07K16/44 ,  C07C225/20 ,  C07C229/14

Abstract: Components for enabling immunodetection of methoxetamine are described including immunogens, haptens, antibodies and kits.

公开(公告)号：US20180339282A1

公开(公告)日：2018-11-29

申请号：US15983484

申请日：2018-05-18

Applicant: Randox Laboratories Ltd. ,  Randox Teoranta

Inventor： Peter Fitzgerald ,  John Lamont ,  Ivan McConnell ,  Elouard Benchikh ,  Deepesh Upadhyay ,  Ciaran Richardson

IPC: B01J19/00 ,  C09D11/03 ,  C09D11/102 ,  C12M1/00

CPC classification number: B01J19/0046 ,  B01J2219/00608 ,  B01J2219/00637 ,  C09D11/03 ,  C09D11/102 ,  C12M1/00 ,  G01N33/54393

Abstract: A substrate comprising a coating of a masking material, and a plurality of discrete reaction zones onto which one or more binding agents are intended to be attached, wherein said zones are uncoated areas on the substrate.

公开(公告)号：US09707561B2

公开(公告)日：2017-07-18

申请号：US15038024

申请日：2014-11-19

Applicant: Randox Laboratories Ltd.

Inventor： Jonathan Matear ,  Robson Pang ,  Stuart Jackson ,  David Sloan

IPC: G01N35/10 ,  G01N35/04 ,  F04B9/04 ,  B01L3/00 ,  G01N1/38 ,  G01N35/00

CPC classification number: B01L3/50273 ,  B01L3/502715 ,  B01L3/527 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2200/0605 ,  B01L2200/0621 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/123 ,  B01L2400/0478 ,  B01L2400/0481 ,  B01L2400/0487 ,  F04B9/042 ,  G01N35/00029 ,  G01N35/1002 ,  G01N2035/00148 ,  G01N2035/0486

Abstract: There is provided an assay fluid delivery system comprising an array of fluid reservoirs (62), each of which is selectively actuatable to deliver a respective fluid to a fluid channel structure; and a fluid delivery control system (50) comprising a plurality of reciprocally mounted actuators, each associated with a respective reservoir and being movable between a retracted position and an actuating position at which it causes fluid to be delivered from the corresponding reservoir, a plurality of cams (22) with different profiles mounted on a common, rotatable cam shaft (6), each cam being engaged with a respective one of the actuators whereby rotation of the cams causes movement of the corresponding actuators between the retracted and actuating positions, and a motor coupled to the cam shaft for rotating the cam shaft, wherein the cams are shaped relative to one another so as to cause the corresponding actuators to actuate the reservoirs in a predetermined sequence and for predetermined respective times.

公开(公告)号：US20150126385A1

公开(公告)日：2015-05-07

申请号：US14361880

申请日：2012-12-03

Applicant: Randox Laboratories Ltd.

Inventor： John Lamont ,  Ivan Mc Connell ,  Peter Fitzgerald

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/6842 ,  G01N2333/4737 ,  G01N2333/5412 ,  G01N2333/70503 ,  G01N2333/70525 ,  G01N2333/70542 ,  G01N2333/70564 ,  G01N2333/7151 ,  G01N2800/2871 ,  G01N2800/32 ,  G01N2800/60

Abstract: The present invention provides biomarker-based methods for diagnosing stroke in a patient suspected of having suffered a stroke, and also for discriminating between ischemic stroke and transient ischemic attack. Substrates comprising probes for specific combinations of biomarkers useful in the methods of the invention are also described.

Abstract translation: 本发明提供了用于诊断疑似患有中风的患者的中风的基于生物标志物的方法，并且还用于区分缺血性卒中和短暂性脑缺血发作。 还描述了包含用于本发明方法中的生物标志物的特定组合的探针的底物。

公开(公告)号：US20140007676A1

公开(公告)日：2014-01-09

申请号：US13821846

申请日：2011-08-05

Applicant: Ian Armstrong ,  Michael Duffy ,  Stephen Peter Fitzgerald

Inventor： Ian Armstrong ,  Michael Duffy ,  Stephen Peter Fitzgerald

IPC: G01F23/26

CPC classification number: G01F23/261 ,  G01F23/265 ,  G01F23/266 ,  G01F25/0061 ,  H03K17/955 ,  H03K2217/94026

Abstract: A capacitive liquid level sensor is provided comprising a capacitive probe having a capacitance and comprising a sensing tip wherein the capacitive probe is configured such that the capacitance of the probe changes when the sensing tip is exposed to liquid. A signal generator operates to supply an electrical signal alternating between a high and low state to the capacitive probe, the electrical signal being configured such that the probe is alternately charged and discharged when the signal is high or low respectively. A comparator operates to detect the magnitude of an electrical signal across the capacitive probe and provides a first output signal value when the detected signal magnitude is greater than a predetermined threshold value and a second output signal value when the signal magnitude is less than the threshold value. A timer operates to receive an output signal from the comparator and measures a time period starting when the comparator output signal transitions to the first output signal value and ending when the comparator output signal transitions to the second output signal value. Liquid detection means also operate to utilise the time period measured by the timer to determine if the sensing tip is exposed to liquid.

Abstract translation: 提供了一种电容式液位传感器，其包括具有电容并且包括感测尖端的电容式探针，其中电容式探针被配置为使得当感测尖端暴露于液体时探针的电容改变。 信号发生器操作以将电信号在高电平和低电平之间交替提供给电容式探针，电信号被配置为使得当信号分别为高电平或低电平时，探针被交替地充电和放电。 比较器操作以检测跨过电容探针的电信号的大小，并且当信号幅度小于阈值时检测到的信号幅度大于预定阈值和第二输出信号值时提供第一输出信号值 。 定时器操作以从比较器接收输出信号，并且测量从比较器输出信号转变到第一输出信号值开始的时间段，并且当比较器输出信号转变到第二输出信号值时结束。 液体检测装置还可操作以利用由定时器测量的时间段来确定感测尖端是否暴露于液体。