公开(公告)号：US10288618B2

公开(公告)日：2019-05-14

申请号：US15302849

申请日：2015-04-02

Applicant: Randox Laboratories Ltd.

Inventor： Alex Chacko ,  Ivan McConnell ,  Peter Fitzgerald ,  John V. Lamont

IPC: G01N33/53 ,  G01N33/574 ,  A61P35/00 ,  A61P35/04 ,  G01N33/68 ,  C07K14/54

Abstract: The present invention describes methods for screening for cancer in a subject, by measuring the level of dimeric IL-18 in a sample obtained from the subject, and comparing that level with the level in a normal control sample.The present invention also describes an assay for screening for cancer in a subject, by measuring the level of dimeric IL-18 in a sample obtained from the subject, whereby an elevated level of dimeric IL-18 is indicative of cancer.

公开(公告)号：US20170030917A1

公开(公告)日：2017-02-02

申请号：US15302849

申请日：2015-04-02

Applicant: Randox Laboratories Ltd.

Inventor： Alex Chacko ,  Ivan McConnell ,  Peter Fitzgerald ,  John V. Lamont

IPC: G01N33/574

CPC classification number: G01N33/57484 ,  A61P35/00 ,  A61P35/04 ,  C07K14/54 ,  G01N33/53 ,  G01N33/57423 ,  G01N33/6869 ,  G01N2333/54 ,  G01N2800/52

Abstract: The present invention describes methods for screening for cancer in a subject, by measuring the level of dimeric IL-18 in a sample obtained from the subject, and comparing that level with the level in a normal control sample.The present invention also describes an assay for screening for cancer in a subject, by measuring the level of dimeric IL-18 in a sample obtained from the subject, whereby an elevated level of dimeric IL-18 is indicative of cancer.

Abstract translation: 本发明还描述了通过测量从受试者获得的样品中的二聚体IL-18的水平来筛选受试者中的癌症的测定，由此提高的二聚体IL-18水平是癌症的指示。