公开(公告)号：US12208397B2

公开(公告)日：2025-01-28

申请号：US17265441

申请日：2019-08-02

Applicant: RANDOX LABORATORIES LTD

Inventor： Paul Courtney ,  Martin Reid ,  Stuart Jackson ,  John Lamont ,  Ivan McConnell ,  Peter Fitzgerald

IPC: B01L9/00 ,  B01L1/00 ,  B25J9/02

Abstract: There is provided a pipette tip disposal assembly. The assembly comprises a receiving element adapted to support an end of at least one pipette tip, the at least one pipette tip being toppled in use from the receiving element along a first direction; and a container positioned to receive the at least one toppled pipette tip, the at least one pipette tip falling towards a base of the container on being received by the container. The base of the container has a first linear dimension aligned with the first direction corresponding to the length of a pipette tip.

公开(公告)号：US20190247820A1

公开(公告)日：2019-08-15

申请号：US16388527

申请日：2019-04-18

Applicant: Randox Laboratories Ltd. ,  Randox Teoranta

Inventor： Peter Fitzgerald ,  John Lamont ,  Ivan McConnell ,  Elouard Benchikh ,  Deepesh Upadhyay ,  Ciaran Richardson

IPC: B01J19/00 ,  C12M1/00 ,  G01N33/543 ,  C09D11/102 ,  C09D11/03

CPC classification number: B01J19/0046 ,  B01J2219/00608 ,  B01J2219/00637 ,  C09D11/03 ,  C09D11/102 ,  C12M1/00 ,  G01N33/54393

Abstract: A substrate comprising a coating of a masking material, and a plurality of discrete reaction zones onto which one or more binding agents are intended to be attached, wherein said zones are uncoated areas on the substrate.

公开(公告)号：US10288618B2

公开(公告)日：2019-05-14

申请号：US15302849

申请日：2015-04-02

Applicant: Randox Laboratories Ltd.

Inventor： Alex Chacko ,  Ivan McConnell ,  Peter Fitzgerald ,  John V. Lamont

IPC: G01N33/53 ,  G01N33/574 ,  A61P35/00 ,  A61P35/04 ,  G01N33/68 ,  C07K14/54

Abstract: The present invention describes methods for screening for cancer in a subject, by measuring the level of dimeric IL-18 in a sample obtained from the subject, and comparing that level with the level in a normal control sample.The present invention also describes an assay for screening for cancer in a subject, by measuring the level of dimeric IL-18 in a sample obtained from the subject, whereby an elevated level of dimeric IL-18 is indicative of cancer.

公开(公告)号：US10279332B2

公开(公告)日：2019-05-07

申请号：US15983484

申请日：2018-05-18

Applicant: Randox Laboratories Ltd. ,  Randox Teoranta

Inventor： Peter Fitzgerald ,  John Lamont ,  Ivan McConnell ,  Elouard Benchikh ,  Deepesh Upadhyay ,  Ciaran Richardson

IPC: B01J19/00 ,  C09D11/03 ,  C09D11/102 ,  C12M1/00 ,  G01N33/543

Abstract: A substrate comprising a coating of a masking material, and a plurality of discrete reaction zones onto which one or more binding agents are intended to be attached, wherein said zones are uncoated areas on the substrate.

公开(公告)号：US10254297B2

公开(公告)日：2019-04-09

申请号：US15200558

申请日：2016-07-01

Applicant: Randox Laboratories Ltd

Inventor： Ivan McConnell ,  Philip Lowry ,  Elouard Benchikh ,  Peter Fitzgerald

IPC: G01N33/94 ,  C07K14/435 ,  C07K16/44 ,  C07C225/20 ,  C07C229/14

Abstract: Components for enabling immunodetection of methoxetamine are described including immunogens, haptens, antibodies and kits.

公开(公告)号：US20180339282A1

公开(公告)日：2018-11-29

申请号：US15983484

申请日：2018-05-18

Applicant: Randox Laboratories Ltd. ,  Randox Teoranta

Inventor： Peter Fitzgerald ,  John Lamont ,  Ivan McConnell ,  Elouard Benchikh ,  Deepesh Upadhyay ,  Ciaran Richardson

IPC: B01J19/00 ,  C09D11/03 ,  C09D11/102 ,  C12M1/00

CPC classification number: B01J19/0046 ,  B01J2219/00608 ,  B01J2219/00637 ,  C09D11/03 ,  C09D11/102 ,  C12M1/00 ,  G01N33/54393

Abstract: A substrate comprising a coating of a masking material, and a plurality of discrete reaction zones onto which one or more binding agents are intended to be attached, wherein said zones are uncoated areas on the substrate.

公开(公告)号：US20150126385A1

公开(公告)日：2015-05-07

申请号：US14361880

申请日：2012-12-03

Applicant: Randox Laboratories Ltd.

Inventor： John Lamont ,  Ivan Mc Connell ,  Peter Fitzgerald

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/6842 ,  G01N2333/4737 ,  G01N2333/5412 ,  G01N2333/70503 ,  G01N2333/70525 ,  G01N2333/70542 ,  G01N2333/70564 ,  G01N2333/7151 ,  G01N2800/2871 ,  G01N2800/32 ,  G01N2800/60

Abstract: The present invention provides biomarker-based methods for diagnosing stroke in a patient suspected of having suffered a stroke, and also for discriminating between ischemic stroke and transient ischemic attack. Substrates comprising probes for specific combinations of biomarkers useful in the methods of the invention are also described.

Abstract translation: 本发明提供了用于诊断疑似患有中风的患者的中风的基于生物标志物的方法，并且还用于区分缺血性卒中和短暂性脑缺血发作。 还描述了包含用于本发明方法中的生物标志物的特定组合的探针的底物。

公开(公告)号：US20230406933A1

公开(公告)日：2023-12-21

申请号：US18035070

申请日：2021-11-02

Applicant: Randox Laboratories Ltd.

Inventor： Marshall Dunlop ,  Shirley Schon ,  John Lamont ,  Peter Fitzgerald

IPC: C07K16/28

CPC classification number: C07K16/2827 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2317/33 ,  C07K2317/22 ,  C07K2317/94 ,  C07K2317/76

Abstract: The present invention relates to therapeutic antibodies, or antigen-binding portions thereof, for use in the treatment of cancer and infectious disease. Specifically, the present invention relates to therapeutic antibodies, or antigen-binding portions thereof, that target the programmed death-ligand 1 polypeptide. The present invention also relates to pharmaceutical compositions comprising said therapeutic antibody, or antigen-binding portions thereof.

公开(公告)号：US20220412994A1

公开(公告)日：2022-12-29

申请号：US17775217

申请日：2020-11-06

Applicant: Randox Laboratories Ltd

Inventor： Paul Innocenzi ,  Mark Ruddock ,  John Lamont ,  Peter Fitzgerald

IPC: G01N33/68

Abstract: Described is the use of GFAP as a marker of drug-induced cellular toxicity and depression.

公开(公告)号：US20220193685A1

公开(公告)日：2022-06-23

申请号：US17602897

申请日：2020-04-08

Applicant: RANDOX LABORATORIES LTD

Inventor： Proinnsias McGleenan ,  P Evans ,  Stuart Jackson ,  Martin Reid ,  Peter Fitzgerald

IPC: B01L9/00

Abstract: A pipette tip carrier assembly suitable for storing elongate pipette tips in a biochemical analyser is described. The pipette tip carrier assembly comprises one or more holding elements each adapted to hold, in use, a respective pipette tip oriented such that the elongate dimension of the held pipette tip is parallel to a first axis. The pipette tip carrier assembly also includes a light source arranged to produce, at a position distal to the one or more holding elements along the first axis, light directed towards each of the one or more holding elements so as to be intercepted by one or more pipette tips held in 10 use by the one or more holding elements.