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公开(公告)号：US20190154672A1
公开(公告)日：2019-05-23
申请号：US16313316
申请日：2017-06-30
Applicant: Randox Laboratories Ltd. , Randox Teoranta
Inventor： Ivan McConnell , Peter Fitzgerald , John Lamont , Ciaran Richardson
IPC: G01N33/543 , G01N33/92 , C07K16/18
Abstract: The present invention relates to a multiplexing system comprising a support substrate having immobilised thereto one or more of the following proteins, fragments thereof or a binding molecule, wherein the binding molecule binds specifically to one of the following proteins: E-FABP, B-FABP, IL-FABP, I-FABP, M-FABP, A-FABP, H-FABP, L-FABP or T-FABP. Another aspect is directed to a method for characterising the pattern of FABP antigens existing within a biological sample to reveal information useful in the diagnosis or disease or injury.
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公开(公告)号：US20190247820A1
公开(公告)日：2019-08-15
申请号：US16388527
申请日：2019-04-18
Applicant: Randox Laboratories Ltd. , Randox Teoranta
Inventor： Peter Fitzgerald , John Lamont , Ivan McConnell , Elouard Benchikh , Deepesh Upadhyay , Ciaran Richardson
IPC: B01J19/00 , C12M1/00 , G01N33/543 , C09D11/102 , C09D11/03
CPC classification number: B01J19/0046 , B01J2219/00608 , B01J2219/00637 , C09D11/03 , C09D11/102 , C12M1/00 , G01N33/54393
Abstract: A substrate comprising a coating of a masking material, and a plurality of discrete reaction zones onto which one or more binding agents are intended to be attached, wherein said zones are uncoated areas on the substrate.
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公开(公告)号：US10279332B2
公开(公告)日：2019-05-07
申请号：US15983484
申请日：2018-05-18
Applicant: Randox Laboratories Ltd. , Randox Teoranta
Inventor： Peter Fitzgerald , John Lamont , Ivan McConnell , Elouard Benchikh , Deepesh Upadhyay , Ciaran Richardson
IPC: B01J19/00 , C09D11/03 , C09D11/102 , C12M1/00 , G01N33/543
Abstract: A substrate comprising a coating of a masking material, and a plurality of discrete reaction zones onto which one or more binding agents are intended to be attached, wherein said zones are uncoated areas on the substrate.
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公开(公告)号：US20180339282A1
公开(公告)日：2018-11-29
申请号：US15983484
申请日：2018-05-18
Applicant: Randox Laboratories Ltd. , Randox Teoranta
Inventor： Peter Fitzgerald , John Lamont , Ivan McConnell , Elouard Benchikh , Deepesh Upadhyay , Ciaran Richardson
IPC: B01J19/00 , C09D11/03 , C09D11/102 , C12M1/00
CPC classification number: B01J19/0046 , B01J2219/00608 , B01J2219/00637 , C09D11/03 , C09D11/102 , C12M1/00 , G01N33/54393
Abstract: A substrate comprising a coating of a masking material, and a plurality of discrete reaction zones onto which one or more binding agents are intended to be attached, wherein said zones are uncoated areas on the substrate.
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公开(公告)号：US20220341943A1
公开(公告)日：2022-10-27
申请号：US17765383
申请日：2020-10-07
Applicant: Randox Laboratories Ltd , Randox Teoranta
Inventor： Ivan McConnell , Peter Fitzgerald , Ciaran Richardson , Kenneth Martin
IPC: G01N33/68 , G01N33/50 , G01N33/543
Abstract: Methods, devices and kits for the detection and quantification of XBP1s and XBP1u are described.
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公开(公告)号：US11467163B2
公开(公告)日：2022-10-11
申请号：US16065646
申请日：2016-12-23
Applicant: Randox Laboratories Ltd. , Randox Teoranta
Inventor： Ivan McConnell , Peter Fitzgerald , John Lamont , Ciaran Richardson
IPC: G01N33/574
Abstract: The present invention describes methods of determining the glycosylation signature and determining the level of a protein in a sample obtained from a patient.
The present invention also describes use of a patient protein glycosylation profile to identify the presence or absence of a disease in subjects.
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公开(公告)号：US11383216B2
公开(公告)日：2022-07-12
申请号：US16424330
申请日：2019-05-28
Applicant: Randox Laboratories Ltd. , Randox Teoranta
Inventor： Peter Fitzgerald , John Lamont , Ivan McConnell , Elouard Benchikh , Deepesh Upadhyay , Ciaran Richardson
IPC: B01J19/00 , C09D11/102 , C09D11/03 , G01N33/543 , C12M1/00
Abstract: A substrate comprising a coating of a masking material, and a plurality of discrete reaction zones onto which one or more binding agents are intended to be attached, wherein said zones are uncoated areas on the substrate.
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公开(公告)号：US20240201178A1
公开(公告)日：2024-06-20
申请号：US18284783
申请日：2022-03-31
Applicant: RANDOX LABORATORIES LTD. , RANDOX TEORANTA
Inventor： Peter Fitzgerald , John Victor Lamont , Ivan McConnell , Ciaran Richardson , Philip Lowry , Jim Curry
IPC: G01N33/543 , G01N33/68
CPC classification number: G01N33/54353 , G01N33/54393 , G01N33/6857 , G01N2650/00
Abstract: The present invention relates to improved detection assays via the utilisation of a substrate with an analyte immobilised on its surface by means of a linking agent and a cross-linker. The present invention also relates to a method of producing a substrate for use in detection assays and a method of detecting an analyte using said substrate.
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公开(公告)号：US20240091783A1
公开(公告)日：2024-03-21
申请号：US18273737
申请日：2022-01-21
Applicant: RANDOX LABORATORIES LTD , Randox Teoranta
Inventor： Dale Love , Peter Fitzgerald , Ivan McConnell , Christina McFadden
IPC: B01L9/00
CPC classification number: B01L9/523 , B01L2200/025
Abstract: There is provided a bracket for a biological sample analyser. The bracket comprises abase and an arm extending from the base, the base being engageable with a platform of a biological sample analyser, wherein, when the base is engaged with the platform, the arm extends into a sample plate bay of the biological sample analyser prohibiting access to a portion of the bay. The arm thereby limits misalignment of a sample plate in the bay by blocking access to a portion of the bay only required when the sample plate is loaded into the bay in an incorrect orientation. A biological sample analyser comprising a bay in which a sample plate is loadable in use and the bracket is also provided.
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公开(公告)号：US20220349882A1
公开(公告)日：2022-11-03
申请号：US17630101
申请日：2020-07-26
Applicant: Randox Laboratories Ltd , Randox Teoranta
Inventor： Peter Fitzgerald , Ivan McConnell , Ciaran Richardson , John Lamont
IPC: G01N33/543 , G01N33/569
Abstract: The current invention provides a multiplex method for screening bovine samples for antibodies against several important pathogens. These pathogens include Bovine Viral Diarrhoea Virus (BVDV), Bovine Herpesvirus-1 (BoHV-1), Mycobacterium paratuberculosis (MAP), Leptospira species, Neospora caninum and Fasciola hepatica. This multiplex screening is enabled by substrates with immobilized pathogen antigens and offer multiple advantages for the routine testing of farm animals.
