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    Bio-sensing nanodevice
    3.
    发明授权
    Bio-sensing nanodevice 有权

    公开(公告)号：US09714941B2

    公开(公告)日：2017-07-25

    申请号：US12183916

    申请日：2008-07-31

    申请人： Shuguang Zhang ,  Andreas Mershin ,  Liselotte Kaiser ,  Brian Cook ,  Johanna F. Graveland-Bikker ,  Manu Prakash ,  David Kong ,  Yael Maguire

    发明人： Shuguang Zhang ,  Andreas Mershin ,  Liselotte Kaiser ,  Brian Cook ,  Johanna F. Graveland-Bikker ,  Manu Prakash ,  David Kong ,  Yael Maguire

    IPC分类号： G01N33/543

    CPC分类号： G01N33/54366 ,  G01N2333/726

    摘要： The invention provides a bio-sensing nanodevice comprising: a stabilized biologically-derived G-protein coupled receptor—the olfactory receptor—on a support, a real time receptor-ligand binding detection method, an odorant delivery system and an odorant recognition program. The biologically-derived G-protein coupled receptor can be stabilized on nanotechnology using surfactant peptide. The said nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized biologically-derived G-protein coupled receptor—the olfactory receptor—immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.

    Multiplexed olfactory receptor-based microsurface plasmon polariton detector
    4.
    发明授权
    Multiplexed olfactory receptor-based microsurface plasmon polariton detector 有权
    基于多重嗅觉受体的微表面等离子体激元检测器

    公开(公告)号：US08748111B2

    公开(公告)日：2014-06-10

    申请号：US13015851

    申请日：2011-01-28

    申请人： Andreas Mershin ,  Brian Cook ,  Liselotte Kaiser ,  Johanna F. Bikker ,  Yoshikatsu Miura ,  Daisuke Niwa ,  Dai Ohnishi ,  Atsushi Tazuke ,  Shuguang Zhang

    发明人： Andreas Mershin ,  Brian Cook ,  Liselotte Kaiser ,  Johanna F. Bikker ,  Yoshikatsu Miura ,  Daisuke Niwa ,  Dai Ohnishi ,  Atsushi Tazuke ,  Shuguang Zhang

    IPC分类号： G01N33/53 ,  C07K2/00 ,  B82Y30/00 ,  G01N33/00 ,  G01N21/55

    CPC分类号： G01N21/553 ,  B82Y30/00 ,  C07K2/00 ,  G01N21/554 ,  G01N33/0031 ,  G01N2201/06113 ,  G01N2201/08

    摘要： The invention provides a bio-sensing nanodevice comprising: a stabilized G-protein coupled receptor on a support, a real time receptor-ligand binding detection method, a test composition delivery system and a test composition recognition program. The G-protein coupled receptor can be stabilized using surfactant peptide. The nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized G-protein coupled receptor immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.

    摘要翻译： 本发明提供了一种生物感测纳米装置，其包括：载体上的稳定的G-蛋白偶联受体，实时受体 - 配体结合检测方法，测试组合物递送系统和测试组合物识别程序。 G蛋白偶联受体可以使用表面活性肽稳定。 纳米器件提供更大的表面积，以提高气味检测的精度和灵敏度。 本发明进一步提供了一种微流控芯片，其含有固定在载体上的稳定化的G蛋白偶联受体，并且被布置在至少二维微阵列系统中。 本发明还提供了一种递送加臭剂的方法，其包括在复杂微流体网络中操作气泡的步骤，其中气泡在携带各种气体样品的微流体通道中移动到芯片上的精确位置。 本发明还提供了制备hOR17-4嗅觉受体的方法。

    Method for improving print performance of flexographic printing elements
    5.
    发明授权
    Method for improving print performance of flexographic printing elements 有权
    提高柔版印刷元件印刷性能的方法

    公开(公告)号：US08669041B2

    公开(公告)日：2014-03-11

    申请号：US13183558

    申请日：2011-07-15

    申请人： Brian Cook ,  David A. Recchia ,  Timothy Gotsick

    发明人： Brian Cook ,  David A. Recchia ,  Timothy Gotsick

    IPC分类号： G03F7/00 ,  G03F7/26 ,  B41N1/00

    CPC分类号： G03F7/092 ,  G03F7/202

    摘要： A method of making a relief image printing element having a relief pattern comprising a plurality of relief dots, wherein the photocurable printing blank comprises a backing layer having at least one photocurable layer disposed thereon and a masking layer on the at least one photocurable layer is provided. The method comprising the steps of: a) selectively ablating the masking layer to create an overall image in the masking layer, such that the overall image comprises a sub-image, comprising a pattern of cells, in it; b) applying an oxygen barrier layer on top of the masking layer; c) exposing the printing element to actinic radiation through the oxygen barrier layer and the masking layer; and d) developing the printing blank by removing the barrier layer and the uncured portions of the photocurable layer to reveal the relief image.

    摘要翻译： 一种形成具有包括多个浮雕点的浮雕图案的浮雕图像打印元件的方法，其中所述光固化印刷坯料包括其上设置有至少一个光固化层的背衬层，并且在所述至少一个光固化层上设置掩模层 。 该方法包括以下步骤：a）选择性地烧蚀掩模层以在掩模层中产生整体图像，使得整个图像包括其中包含单元格图案的子图像; b）在掩蔽层的顶部上施加氧阻挡层; c）将印刷元件暴露于通过氧阻隔层和掩蔽层的光化辐射; 以及d）通过去除光固化层的阻挡层和未固化部分来显影印刷毛坯以露出浮雕图像。

    Methods and apparatuses for measuring print area using hand-held printer
    6.
    发明申请
    Methods and apparatuses for measuring print area using hand-held printer 审中-公开
    使用手持打印机测量打印区域的方法和设备

    公开(公告)号：US20070076082A1

    公开(公告)日：2007-04-05

    申请号：US11241094

    申请日：2005-09-30

    申请人： Brian Cook

    发明人： Brian Cook

    IPC分类号： B41J3/36

    CPC分类号： B41J3/36 ,  B41J11/003

    摘要： The size of a print area may be determined using a hand-held printer including an internal tracking device, such as an optical mouse device. Based on the size of the print area, and one or more user settings, an image to be printed on the print surface by the hand-held printer may be scaled and/or repositioned. The hand-held printer may print the image to a desired size while centering the image or otherwise repositioning it, scaling it to fit within user-defined margins or areas, and the like.

    摘要翻译： 可以使用包括诸如光学鼠标装置的内部跟踪装置的手持式打印机来确定打印区域的尺寸。 基于打印区域的大小和一个或多个用户设置，可以缩放和/或重新定位由手持打印机在打印表面上打印的图像。 手持打印机可以将图像打印到期望的尺寸，同时使图像居中或以其它方式重新定位，将其缩放以适合用户定义的边缘或区域等。

    Carrier sheet for a photosensitive printing element
    7.
    发明授权
    Carrier sheet for a photosensitive printing element 有权
    用于感光印刷元件的载体片

    公开(公告)号：US09069255B2

    公开(公告)日：2015-06-30

    申请号：US12620715

    申请日：2009-11-18

    申请人： Jim Hennessy ,  David X. Elwell ,  Nicholas R. Pina ,  Brian Cook ,  Ryan Vest

    发明人： Jim Hennessy ,  David X. Elwell ,  Nicholas R. Pina ,  Brian Cook ,  Ryan Vest

    IPC分类号： B41N6/00 ,  B41N10/02 ,  G03F7/34 ,  B41F27/00

    CPC分类号： G03F7/34 ,  B41F27/00 ,  B41N6/00 ,  B41N10/02

    摘要： An improved apparatus for thermally developing a flexographic printing element to reveal a relief image on the surface and a method of using the apparatus to develop a flexographic printing element. The apparatus typically comprises means for softening or melting a crosslinked photopolymer on the imaged and exposed surface of the flexographic printing element; at least one roll that is contactable with the imaged surface of the flexographic printing element and capable of moving over at least a portion of the imaged surface of the flexographic printing element to remove the softened or melted non-crosslinked photopolymer on the imaged and exposed surface of the flexographic printing element; and means for maintaining contact between the at least one roll and the imaged and exposed surface of the flexographic printing element. A layer of resilient compressible material is positioned between the flexographic printing element and a supporting conveying means. The means for softening or melting non-crosslinked photopolymer on the imaged and exposed surface of the flexographic printing element comprise a heater positioned adjacent to the imaged surface of the flexographic printing element and/or heating the at least one roll that contactable with the imaged surface of the flexographic printing element. The apparatus may also contain an exposure device to crosslink and cure the imaged surface of the flexographic printing element prior to thermal development.

    摘要翻译： 用于热显影柔性版印刷元件以在表面上露出浮雕图像的改进的装置以及使用该装置来开发柔性版印刷元件的方法。 该装置通常包括用于软化或熔化柔性版印刷元件的成像和暴露表面上的交联光聚合物的装置; 至少一个辊，其能够与柔性版印刷元件的成像表面接触并且能够移动柔性版印刷元件的成像表面的至少一部分以去除成像和曝光表面上的软化或熔融的非交联光聚合物 的柔性版印刷元件; 以及用于保持柔性版印刷元件的至少一个辊与成像和暴露的表面之间的接触的装置。 弹性可压缩材料层位于柔性版印刷元件和支撑输送装置之间。 用于软化或熔化柔性版印刷元件的成像和暴露表面上的非交联光聚合物的装置包括邻近柔性版印刷元件的成像表面定位的加热器和/或加热可与成像表面接触的至少一个辊 的柔性版印刷元件。 该装置还可以包含用于在热显影之前交联和固化柔性版印刷元件的成像表面的曝光装置。

    Bio-Sensing Nanodevice
    9.
    发明申请
    Bio-Sensing Nanodevice 有权
    生物传感纳米技术

    公开(公告)号：US20090156427A1

    公开(公告)日：2009-06-18

    申请号：US12183916

    申请日：2008-07-31

    申请人： Shuguang Zhang ,  Andreas Mershin ,  Liselotte Kaiser ,  Brian Cook ,  Johanna F. Graveland-Bikker ,  Manu Prakash ,  David Kong ,  Yael Maguire

    发明人： Shuguang Zhang ,  Andreas Mershin ,  Liselotte Kaiser ,  Brian Cook ,  Johanna F. Graveland-Bikker ,  Manu Prakash ,  David Kong ,  Yael Maguire

    IPC分类号： C40B30/10 ,  B01J19/00 ,  C40B40/10 ,  C40B60/12 ,  C40B30/00 ,  C12P21/00

    CPC分类号： G01N33/54366 ,  G01N2333/726

    摘要： The invention provides a bio-sensing nanodevice comprising: a stabilized biologically-derived G-protein coupled receptor—the olfactory receptor—on a support, a real time receptor-ligand binding detection method, an odorant delivery system and an odorant recognition program. The biologically-derived G-protein coupled receptor can be stabilized on nanotechnology using surfactant peptide. The said nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized biologically-derived G-protein coupled receptor—the olfactory receptor—immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.

    摘要翻译： 本发明提供一种生物感测纳米装置，其包括：稳定的生物衍生的G蛋白偶联受体 - 支持物上的嗅觉受体，实时受体 - 配体结合检测方法，加味剂递送系统和气味识别程序。 生物衍生的G蛋白偶联受体可以使用表面活性剂肽在纳米技术上稳定。 所述纳米器件提供更大的表面积，以提高气味检测的精度和灵敏度。 本发明进一步提供了一种微流控芯片，其包含稳定的生物衍生的G蛋白偶联受体 - 嗅觉受体 - 固定在载体上，并且布置在至少二维微阵列系统中。 本发明还提供了一种递送加臭剂的方法，其包括在复杂微流体网络中操作气泡的步骤，其中气泡在携带各种气体样品的微流体通道中移动到芯片上的精确位置。 本发明还提供了制备hOR17-4嗅觉受体的方法。

    Imaging apparatus including a movable media sensor
    10.
    发明申请
    Imaging apparatus including a movable media sensor 有权
    成像设备包括可移动介质传感器

    公开(公告)号：US20060071391A1

    公开(公告)日：2006-04-06

    申请号：US10930446

    申请日：2004-08-31

    申请人： Mahesan Chelvayohan ,  Brian Cook ,  Timothy Howard ,  Kevin Johnson ,  William Klein ,  Michael Lawrence

    发明人： Mahesan Chelvayohan ,  Brian Cook ,  Timothy Howard ,  Kevin Johnson ,  William Klein ,  Michael Lawrence

    IPC分类号： B65H5/00 ,  B65H7/02

    CPC分类号： B65H7/02 ,  B65H2402/54 ,  B65H2403/72 ,  B65H2511/51 ,  B65H2553/81

    摘要： An imaging apparatus includes a printing mechanism having a media path. A print media source is provided for supplying a sheet of print media to the printing mechanism. A drive unit is provided, with a drive shaft coupled to the drive unit. A media sensor device is mounted to the drive shaft, wherein as the drive shaft is rotated in a first direction the media sensor device is moved from a first position that is out of the media path to a second position that is in the media path for sensing the sheet of print media. As the drive shaft is rotated in a second direction opposite to the first direction the media sensor device is moved from the second position that is in the media path for sensing the sheet of print media to the first position that is out of the media path.

    摘要翻译： 成像装置包括具有媒体路径的打印机构。 提供了一种打印介质源，用于将一张打印介质供给到打印机构。 提供了一个驱动单元，其中驱动轴联接到驱动单元。 介质传感器装置安装到驱动轴上，其中当驱动轴沿第一方向旋转时，介质传感器装置从介质路径外的第一位置移动到位于介质路径中的第二位置 感测印张介质。 当驱动轴沿与第一方向相反的第二方向旋转时，介质传感器装置从用于感测印张介质的介质路径的第二位置移动到介质路径外的第一位置。