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1.发明申请ENANTIOSELECTIVE SYNTHESIS OF DIALKYLATED N,O-HETEROCYCLES BY PALLADIUM-CATALYZED ALLYLIC ALKYLATION 审中-公开通过钯催化的多烯烃化合物对二烷基的N，O-杂环化合物的选择性合成公开(公告)号：US20160096810A1
公开(公告)日：2016-04-07
申请号：US14877496
申请日：2015-10-07
IPC分类号： C07D265/32 , C07D265/36 , C07D265/10 , C07D261/04 , C07D265/02 , C07D267/04 , C07D279/12 , C07D263/18
CPC分类号： C07D265/32 , C07D261/04 , C07D263/18 , C07D265/02 , C07D265/10 , C07D265/36 , C07D267/04 , C07D279/12
摘要： This invention provides enantioenriched N,O-heterocyclic compounds with quaternary stereogenic centers and novel methods of preparing the compounds. Methods include the method for the preparation of a compound of formula (I): comprising treating a compound of formula (II): with a transition metal catalyst under alkylation conditions.
摘要翻译： 本发明提供具有四元立体中心的富含茚满的N，O-杂环化合物和制备该化合物的新方法。 方法包括制备式（I）化合物的方法：包括在烷基化条件下用过渡金属催化剂处理式（II）化合物。
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公开(公告)号：US20130012701A1
公开(公告)日：2013-01-10
申请号：US13531485
申请日：2012-06-22
申请人： Brian M. Stoltz , Scott C. Virgil , David E. White , Taiga Yurino , Yiyang Liu , Douglas C. Behenna , Douglas Duquette , Christian Eidamshaus
发明人： Brian M. Stoltz , Scott C. Virgil , David E. White , Taiga Yurino , Yiyang Liu , Douglas C. Behenna , Douglas Duquette , Christian Eidamshaus
IPC分类号： C07D211/78 , C07D207/277 , C07D223/10 , C07D265/32 , C07D309/08 , C07D309/30 , C07D207/36 , C07D241/08 , C07D223/04 , C07F7/18 , C07C229/00
CPC分类号： C07D207/06 , C07D207/08 , C07D207/10 , C07D207/26 , C07D207/263 , C07D207/27 , C07D207/46 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/76 , C07D211/88 , C07D211/94 , C07D211/96 , C07D223/04 , C07D223/10 , C07D241/04 , C07D241/08 , C07D241/52 , C07D265/30 , C07D265/32 , C07D309/04
摘要： A compound useful as a building block for the manufacture of various compounds is represented by Formula A or D. In Formula A and D, z is 0 or 1; Q is a heteroatom; R1 through R11 and Ra through Rf are each independently hydrogen, a substituted or unsubstituted hydrocarbyl group, a substituted or unsubstituted heteroatom containing hydrocarbyl group, or a functional group; d, e and f are each independently 0 or greater; each of A, B and D is independently a carbon atom or a heteroatom; and two or more of R1 though R11, Ra through Rf and Y optionally combine to form a ring. In some embodiments, R8 and R9 combine to form a carbonyl group. In some embodiments, R2 and Y combine to form a ring with the Q atom. In some embodiments, the ring includes at least one double bond.
摘要翻译： 可用作制备各种化合物的结构单元的化合物由式A或D表示。在式A和D中，z为0或1; Q是杂原子; R 1至R 11和R a至R f各自独立地为氢，取代或未取代的烃基，取代或未取代的含杂原子的烃基或官能团; d，e和f各自独立地为0以上; A，B和D各自独立地为碳原子或杂原子; 并且R 1至R 11中的两个或更多个，R a至R f和Y任选地结合形成环。 在一些实施方案中，R 8和R 9结合形成羰基。 在一些实施方案中，R 2和Y结合形成具有Q原子的环。 在一些实施方案中，环包括至少一个双键。
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公开(公告)号：US07235698B2
公开(公告)日：2007-06-26
申请号：US11215449
申请日：2005-08-29
CPC分类号： C07C45/67 , C07B2200/07 , C07C45/511 , C07C45/54 , C07C45/673 , C07C45/676 , C07C67/343 , C07C2601/14 , C07C2601/18 , C07C49/647 , C07C49/794 , C07C49/217 , C07C49/755 , C07C49/653 , C07C49/753 , C07C49/697 , C07C49/687 , C07C49/683 , C07C69/738
摘要： Compounds containing a substituted or unsubstituted allyl group directly bound to a chiral carbon atom are prepared enantioselectively. Starting reactants are either chiral or achiral, and may or may not contain an attached allyloxycarbonyl group as a substituent. Chiral ligands are employed, along with transition metal catalysts. The methods of the invention are effective in providing enantioconvergent allylation of chiral molecules.
摘要翻译： 对映选择性地制备含有与手性碳原子直接结合的取代或未取代的烯丙基的化合物。 起始反应物是手性或非手性的，并且可以含有或可以不含有连接的烯丙氧基羰基作为取代基。 使用手性配体以及过渡金属催化剂。 本发明的方法在提供手性分子的对映异构烯丙基化方面是有效的。
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4.发明申请ASYMMETRIC CATALYTIC DECARBOXYLATIVE ALKYL ALKYLATION USING LOW CATALYST CONCENTRATIONS AND A ROBUST PRECATALYST 审中-公开使用低催化剂浓度和稳定的预处理的不对称催化脱碳酸烷基酯公开(公告)号：US20160280623A1
公开(公告)日：2016-09-29
申请号：US15081157
申请日：2016-03-25
申请人： Brian M. Stoltz , Alexander N. Marziale , Robert A. Craig , Douglas Duquette , Kelly E. Kim , Marc Liniger , Yoshitaka Numajiri
发明人： Brian M. Stoltz , Alexander N. Marziale , Robert A. Craig , Douglas Duquette , Kelly E. Kim , Marc Liniger , Yoshitaka Numajiri
IPC分类号： C07C45/65 , B01J31/04 , C07D317/72 , C07D211/94 , C07D223/10
CPC分类号： C07C45/65 , B01J31/04 , B01J2231/44 , B01J2531/004 , C07C2601/14 , C07C2601/18 , C07C2601/20 , C07C2602/10 , C07D211/94 , C07D223/10 , C07D317/72 , C07C49/647 , C07C49/683
摘要： This invention provides efficient and scalable enantioselective methods that yield 2-alkyl-2-allylcycloalkyanone compounds with quaternary stereogenic centers. Methods include the method for the preparation of a compound of formula (I): comprising treating a compound of formula (II) or (III): with a palladium (II) catalyst under alkylation conditions.
摘要翻译： 与钯（II）催化剂在烷基化条件下反应。
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公开(公告)号：US20090253717A1
公开(公告)日：2009-10-08
申请号：US12321463
申请日：2009-01-20
申请人： Steven J. Brown , Tsui-Fen Chou , Raymond Deshaies , Amanda C. Jones , Hugh Rosen , Brian M. Stoltz
发明人： Steven J. Brown , Tsui-Fen Chou , Raymond Deshaies , Amanda C. Jones , Hugh Rosen , Brian M. Stoltz
IPC分类号： A61K31/519 , A61P35/00
CPC分类号： A61K31/519
摘要： One aspect of the invention relates to compounds that inhibit the activity of p97, such as by binding covalently to a cysteine residue in the active site. In certain embodiments, the invention relates to the treatment of disease, such as cancer, comprising administering a compound of the invention.
摘要翻译： 本发明的一个方面涉及抑制p97活性的化合物，例如通过与活性位点中的半胱氨酸残基共价结合。 在某些实施方案中，本发明涉及疾病如癌症的治疗，其包括施用本发明的化合物。
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公开(公告)号：US20180327343A1
公开(公告)日：2018-11-15
申请号：US15977638
申请日：2018-05-11
IPC分类号： C07C51/08 , C07C57/03 , C07C67/22 , C07C69/52 , C07C231/18 , C07C233/09 , B01J31/12 , B01J31/18
CPC分类号： C07C51/08 , B01J31/12 , B01J31/122 , B01J31/186 , B01J2231/44 , B01J2531/827 , C07B2200/07 , C07C57/03 , C07C67/00 , C07C67/22 , C07C69/52 , C07C201/12 , C07C231/18 , C07C233/09 , C07C253/30 , C07C2601/14 , C07C2601/16 , C07C255/38 , C07C205/57 , C07C57/42 , C07C57/60 , C07C59/48 , C07C57/26 , C07C69/65
摘要： The present disclosure provides methods for enantioselective synthesis of acyclic α-quaternary carboxylic acid derivatives via iridium-catalyzed allylic alkylation.
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公开(公告)号：US07038043B1
公开(公告)日：2006-05-02
申请号：US09482235
申请日：2000-01-13
IPC分类号： C07D273/00
CPC分类号： C07D498/22 , C07C45/68
摘要： Indolocarbazoles are furanosylated (e.g., 7) with acetals (e.g., 8) or their open chain congeners (e.g., 9) under conditions known to promote acetal exchange or formation, such as protic or Lewis acids. Furanosylated indolocarbazoles (e.g., 10) are also prepared via ring contraction of pyranosylated indolocarbazoles (e.g., 11) under conditions know to effect oxidation and benzylic acid type rearrangements, and pyranosylated indolocarbazoles (e.g., 11) are prepared via ring expansion of the furanosylated congeners (e.g., 10)
摘要翻译： 在已知可促进乙缩醛交换或形成的条件下，例如质子酸或路易斯酸，吲哚并吡唑类化合物（例如7）具有缩醛（例如8）或其开链同系物（例如9）。 呋喃糖基化吲哚并唑（例如，10）也是通过吡喃糖基化吲哚并唑（例如11）在已知有效氧化和苄酸型重排的条件下通过环收缩来制备的，吡喃糖基化的吲哚并唑（例如，11）是通过呋喃糖基化同系物 （例如10）
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8.发明申请公开(公告)号：US20190135754A1
公开(公告)日：2019-05-09
申请号：US16177926
申请日：2018-11-01
申请人： Brian M. Stoltz , Aurapat Ngamnithiporn , Carina I. Jette , Shoshana Bachman , Scott C. Virgil , Sebastian Lackner
发明人： Brian M. Stoltz , Aurapat Ngamnithiporn , Carina I. Jette , Shoshana Bachman , Scott C. Virgil , Sebastian Lackner
IPC分类号： C07D211/86 , B01J31/24 , C07D309/32
CPC分类号： C07D211/86 , B01J31/2409 , B01J2231/4272 , B01J2531/004 , B01J2531/847 , C07B37/04 , C07B2200/07 , C07D211/76 , C07D309/30 , C07D309/32 , C07D407/06 , C07D409/06
摘要： The present disclosure provides methods for enantioselective synthesis of cyclic and acyclic α-quaternary carboxylic acid derivatives via nickel-catalyzed allylic alkylation.
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公开(公告)号：US09089572B2
公开(公告)日：2015-07-28
申请号：US12321463
申请日：2009-01-20
申请人： Steven J. Brown , Tsui-Fen Chou , Raymond Deshaies , Amanda C. Jones , Hugh Rosen , Brian M. Stoltz
发明人： Steven J. Brown , Tsui-Fen Chou , Raymond Deshaies , Amanda C. Jones , Hugh Rosen , Brian M. Stoltz
IPC分类号： A61K31/519
CPC分类号： A61K31/519
摘要： One aspect of the invention relates to compounds that inhibit the activity of p97, such as by binding covalently to a cysteine residue in the active site. In certain embodiments, the invention relates to the treatment of disease, such as cancer, comprising administering a compound of the invention.
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公开(公告)号：US07166754B2
公开(公告)日：2007-01-23
申请号：US10091372
申请日：2002-03-04
申请人： Eric M. Ferreira , Brian M. Stoltz
发明人： Eric M. Ferreira , Brian M. Stoltz
CPC分类号： C07C45/39 , C07B53/00 , C07B57/00 , C07C29/88 , C07C45/32 , C07C2602/08 , C07C2602/10 , C07C49/747 , C07C49/788 , C07C49/78 , C07C33/26 , C07C33/20 , C07C35/32 , C07C35/36
摘要： This invention provides methods and catalyst systems for catalyzing enantioselective oxidation reactions, including cyclization reactions and enantioselective oxidation reactions of secondary alcohols and other similarly reactive organic substrates. Use of the methods and catalyst systems for kinetic resolution of racemic mixtures of secondary alcohols is also described.
摘要翻译： 本发明提供用于催化对映选择性氧化反应的方法和催化剂体系，包括仲醇和其它类似反应性有机底物的环化反应和对映选择性氧化反应。 还描述了使用方法和催化剂体系用于仲醇的外消旋混合物的动力学拆分。
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