公开(公告)号：US09371273B2

公开(公告)日：2016-06-21

申请号：US14468516

申请日：2014-08-26

Applicant: RHODIA OPERATIONS

Inventor： Massimo Guglieri ,  Olivier Jentzer

IPC: C07C235/08 ,  C07C231/02 ,  A01N25/02 ,  C07C235/06 ,  C07C51/08 ,  C07C67/22 ,  C07C231/06 ,  C07C231/10 ,  C07C253/30

CPC classification number: C07C235/08 ,  A01N25/02 ,  C07C51/08 ,  C07C67/22 ,  C07C231/02 ,  C07C231/06 ,  C07C231/10 ,  C07C235/06 ,  C07C253/30 ,  A01N33/18 ,  A01N33/22 ,  A01N37/22 ,  A01N43/653 ,  A01N47/22 ,  A01N53/00 ,  A01N57/12 ,  A01N57/16

Abstract: Ether-amide compounds having the formula RaRbC(OR1)—CHRc—CONR2R3 are described. Also described, are processes for the preparation and use thereof, especially as solvents, for example in phytosanitary formulations.

Abstract translation: 描述了具有式RaRbC（OR1）-CHRc-CONR2R3的醚 - 酰胺化合物。 还描述了其制备和使用的方法，特别是作为溶剂，例如植物检疫制剂。

公开(公告)号：US20110318515A1

公开(公告)日：2011-12-29

申请号：US12995282

申请日：2009-05-28

Applicant: Jean-Luc Dubois ,  Jean Francois Crolzy ,  Lucie Campora ,  Camille Croizy ,  Pauline Croizy

Inventor： Jean-Luc Dubois ,  Jean Francois Crolzy ,  Lucie Campora ,  Camille Croizy ,  Pauline Croizy

IPC: C07C69/54 ,  C08F301/00 ,  C08F293/00 ,  B32B27/30 ,  C08L53/02 ,  C08L55/00 ,  B32B1/08 ,  C07C67/22 ,  C08L53/00

CPC classification number: C07C67/22 ,  B32B27/08 ,  B32B27/20 ,  B32B27/30 ,  B32B27/308 ,  B32B2250/24 ,  B32B2419/00 ,  B32B2432/00 ,  B32B2605/00 ,  B32B2605/08 ,  C07B2200/05 ,  C07C67/20 ,  C07C69/54 ,  C08F220/14 ,  Y10T428/139 ,  Y10T428/2998

Abstract: The invention relates to methyl methacrylate characterized in that at least one portion of the carbons thereof is biologically sourced and, more specifically, in that it contains between 0.2×10−10 and 1.2×10−10 wt.-% of 14C in relation to total carbon weight according to the ASTM D6866 standard. The preparation method comprises the use of acetone cyanohydrin as a raw material, said acetone cyanohydrin being obtained by condensing cyanohydric acid on acetone, and the methyl methacrylate is prepared using a process involving the addition of methanol. According to the invention, at least one from among the acetone, cyanohydric acid and methanol is obtained by means of a reaction or series of reactions involving the biomass.

Abstract translation: 本发明涉及甲基丙烯酸甲酯，其特征在于其至少一部分碳是生物来源的，更具体地说，其含有相对于14C的0.2×10-10和1.2×10-10重量％ 总碳重量符合ASTM D6866标准。 制备方法包括使用丙酮氰醇作为原料，所述丙酮氰醇是通过将氰基羟基在丙酮上缩合得到的，甲基丙烯酸甲酯是通过加入甲醇的方法制备的。 根据本发明，通过涉及生物质的反应或一系列反应获得丙酮，氰基羟基和甲醇中的至少一种。

公开(公告)号：US20040236141A1

公开(公告)日：2004-11-25

申请号：US10719660

申请日：2003-11-21

Inventor： Raveendra Khandurao Tikare

IPC: C07C069/76

CPC classification number: C07C67/22 ,  Y02P20/55 ,  C07C69/732

Abstract: A process is described for the stereospecific preparation of an ester of formula (I): wherein * signifies the (R) stereoisomer; R1 is selected from C1-6 alkyl, preferably ethyl; and R2 is hydrogen, a protecting group or a leaving group which process comprises reaction of a nitrile of formula (II): wherein * signifies the (R) stereoisonomer; and Ph is the phenyl group C6 H5 with a solution of an inorganic acid in an alcohol and optional conversion of the compound of formula (I) wherein R2 is H so prepared to any other desired compound of formula (I) by standard methods in the art. The compounds of formula (I) are chiral esters, useful as intermediates in the synthesis of the family of acetylcholine esterase (ACE) inhibitors known as nullprilsnull, such as lisinopril, cilazapril, enalapril, benazepril, ramipril, delapril, enalaprilat, imidapril, spirapril, trandolapril and others.*Ph-CH2nullCH2nullCH(OR2)nullCOOR1nullnull(I)*Ph-CH2nullCH2nullCH(OH)nullCNnullnull(II)

Abstract translation: 描述了式（I）的酯的立体特异性制备的方法：其中*表示（R）立体异构体; R 1选自C 1-6烷基，优选乙基; 并且R 2是氢，保护基团或离去基团，该方法包括式（II）的腈的反应：其中*表示（R）立体异构体; Ph是苯基C6H5，其中无机酸在醇中的溶液，并且任选地将其中R 2为H的式（I）化合物转化为任何其它所需的式（I）化合物，通过标准 本领域的方法。 式（I）化合物是手性酯，可用作合成称为“prils”的乙酰胆碱酯酶（ACE）抑制剂家族的中间体，例如赖诺普利，西拉普利，依那普利，贝那普利，雷米普利，地拉普利，依那普利拉，咪达匹尔 ，咯普利，群多普利等。 * Ph-CH 2 -CH 2 -CH（OR 2）-COOR 1（I）* Ph-CH 2 -CH 2 -CH（OH）-CN（II）

公开(公告)号：US5856560A

公开(公告)日：1999-01-05

申请号：US750822

申请日：1996-12-10

Applicant: Herbert Bayer ,  Heinz Isak ,  Horst Wingert ,  Hubert Sauter ,  Michael Keil ,  Markus Nett ,  Remy Benoit ,  Ruth Muller

Inventor： Herbert Bayer ,  Heinz Isak ,  Horst Wingert ,  Hubert Sauter ,  Michael Keil ,  Markus Nett ,  Remy Benoit ,  Ruth Muller

IPC: C07C67/22 ,  C07C69/716 ,  C07C69/738 ,  C07C235/78 ,  C07C249/08 ,  C07C249/12 ,  C07C251/48 ,  C07C251/60 ,  C07C255/41 ,  C07C255/62 ,  C07D249/12 ,  C07D521/00 ,  C07C59/86 ,  C07C69/73 ,  C07C229/36 ,  C07C231/06 ,  C07C251/24

CPC classification number: C07D249/12 ,  C07C235/78 ,  C07C249/08 ,  C07C249/12 ,  C07C251/48 ,  C07C251/60 ,  C07C67/22

Abstract: A process and intermediates for preparing .alpha.-methoxyiminocarboxylic acid methylamides (I) by Pinner reaction of a cyanoketone (II) with an alcohol and subsequent reaction of the resulting ester (IV) with hydroxylamine to give the oxime (V), methylation of (V) to give the oxime ether (VI) and subsequent reaction of (VI) with methylamine: ##STR1##

Abstract translation: 一种通过氰基酮（II）与醇的缩合反应制备α-甲氧基亚氨基羧酸甲基酰胺（I）的方法和中间体，随后将所得酯（IV）与羟胺反应得到肟（V），（V ）得到肟醚（Ⅵ），随后的（Ⅵ）与甲胺的反应：X =硝基，三氟甲基，卤素，烷基或烷氧基; n = 0,1,2,3或4; Y = C-有机基团。

公开(公告)号：US5527949A

公开(公告)日：1996-06-18

申请号：US294680

申请日：1994-08-23

Applicant: Sudhir K. Agarwal ,  Rajiv M. Banavali ,  Bharati D. Chheda ,  Samuel F. Reed, Jr.

Inventor： Sudhir K. Agarwal ,  Rajiv M. Banavali ,  Bharati D. Chheda ,  Samuel F. Reed, Jr.

IPC: C07C67/22 ,  C07C209/62 ,  C07C67/00

CPC classification number: C07C209/62 ,  C07C67/22

Abstract: A method for making an amine includes the steps of heating a reaction mixture including a nitrile, an acid, water and a substrate compound capable of generating a carbonium ion by reaction with the acid to generate a first reaction intermediate; treating the first reaction intermediate with an acid in the presence of a primary alkanol to form a second reaction intermediate and an alkyl ester; separating the alkyl ester from the second reaction intermediate; and treating the second reaction intermediate with a base to form the amine.

Abstract translation: 一种制备胺的方法包括以下步骤：通过与酸反应生成包含腈，酸，水和能产生碳鎓离子的底物的反应混合物，生成第一反应中间体; 在一级烷醇存在下用酸处理第一反应中间体以形成第二反应中间体和烷基酯; 将烷基酯与第二反应中间体分离; 并用碱处理第二反应中间体以形成胺。

公开(公告)号：US4450112A

公开(公告)日：1984-05-22

申请号：US325028

申请日：1981-11-25

Applicant: Stanley S. Wreford

Inventor： Stanley S. Wreford

IPC: C07C67/22 ,  C11C3/02

CPC classification number: C07C67/22

Abstract: Reaction of a nitrile, an alcohol and water in the presence of a catalyst comprising rhodium, iridium or platinum complexed with hydroxo and tertiary phosphine moieties, to produce the corresponding carboxylic ester.

Abstract translation: 在含有铑，铱或与氢和叔膦部分配位的铂的催化剂存在下，腈，醇和水的反应，以产生相应的羧酸酯。

公开(公告)号：US3567749A

公开(公告)日：1971-03-02

申请号：US3567749D

申请日：1966-08-08

Applicant: DEGUSSA

Inventor： NEUGEBAUER WALTER ,  SCHMIDT LOTHAR ,  SPERKA GERHARD

IPC: C07C67/22 ,  C07C69/34 ,  C07C69/38 ,  C07C69/54 ,  C07C69/76 ,  C07C69/78 ,  C07C67/00

CPC classification number: C07C69/76 ,  C07C67/22 ,  C07C69/34 ,  C07C69/38 ,  C07C69/54 ,  C07C69/78 ,  C07C69/44 ,  C07C69/14 ,  C07C69/675

Abstract: CARBOXYLIC ACID ESTERS ARE PREPARED BY REACTING CARBOXYLIC ACID NITRILES WITH ALCOHOLS IN THE PRESENCE OF WATER IN ACID MELT AT A TEMPERATURE BETWEEN 90 AND 300* C., THE CARBOXYLIC ACID ESTER AND ANY UNCONVERTED NITRILE AND ALCOHOL FROM THE MELT AND HEATING THE MELT TO A TEMPERATURE BETWEEN ABOUT 300 AND 500*C. TO DRIVE OFF AMMONIA TAKEN UP BY THE ACID SALT.

公开(公告)号：US3395173A

公开(公告)日：1968-07-30

申请号：US44407565

申请日：1965-03-30

Applicant: SHOWA DENKO KK

Inventor： TAIJIRO OGA ,  MICHITOSHI KITABATAKE ,  MASASHI TANABE ,  MASATOMO ITO ,  NORIYOSHI AOZUKA ,  TAKASHI IKEDA

IPC: C08G63/44

CPC classification number: C07C67/22 ,  C08G63/181 ,  C08G63/44 ,  C08G63/85 ,  C07C69/82 ,  C07C69/80 ,  C07C69/78

公开(公告)号：US3067241A

公开(公告)日：1962-12-04

申请号：US2198560

申请日：1960-04-13

Applicant: KNAPSACK AG

Inventor： WILHELM VOGT ,  KURT SENNEWALD

IPC: C07C67/22 ,  C07C69/54

CPC classification number: C07C69/54 ,  C07C67/22

公开(公告)号：US2786739A

公开(公告)日：1957-03-26

申请号：US42876854

申请日：1954-05-10

Applicant: ALLIED CHEM & DYE CORP

Inventor： ECK JOHN C ,  TUNKEL STEVEN J

IPC: C07C67/22 ,  C07C69/54

CPC classification number: C07C67/22 ,  C07C69/54