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1.发明申请ENANTIOSELECTIVE SYNTHESIS OF DIALKYLATED N,O-HETEROCYCLES BY PALLADIUM-CATALYZED ALLYLIC ALKYLATION 审中-公开通过钯催化的多烯烃化合物对二烷基的N，O-杂环化合物的选择性合成公开(公告)号：US20160096810A1
公开(公告)日：2016-04-07
申请号：US14877496
申请日：2015-10-07
IPC分类号： C07D265/32 , C07D265/36 , C07D265/10 , C07D261/04 , C07D265/02 , C07D267/04 , C07D279/12 , C07D263/18
CPC分类号： C07D265/32 , C07D261/04 , C07D263/18 , C07D265/02 , C07D265/10 , C07D265/36 , C07D267/04 , C07D279/12
摘要： This invention provides enantioenriched N,O-heterocyclic compounds with quaternary stereogenic centers and novel methods of preparing the compounds. Methods include the method for the preparation of a compound of formula (I): comprising treating a compound of formula (II): with a transition metal catalyst under alkylation conditions.
摘要翻译： 本发明提供具有四元立体中心的富含茚满的N，O-杂环化合物和制备该化合物的新方法。 方法包括制备式（I）化合物的方法：包括在烷基化条件下用过渡金属催化剂处理式（II）化合物。
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公开(公告)号：US20130012701A1
公开(公告)日：2013-01-10
申请号：US13531485
申请日：2012-06-22
申请人： Brian M. Stoltz , Scott C. Virgil , David E. White , Taiga Yurino , Yiyang Liu , Douglas C. Behenna , Douglas Duquette , Christian Eidamshaus
发明人： Brian M. Stoltz , Scott C. Virgil , David E. White , Taiga Yurino , Yiyang Liu , Douglas C. Behenna , Douglas Duquette , Christian Eidamshaus
IPC分类号： C07D211/78 , C07D207/277 , C07D223/10 , C07D265/32 , C07D309/08 , C07D309/30 , C07D207/36 , C07D241/08 , C07D223/04 , C07F7/18 , C07C229/00
CPC分类号： C07D207/06 , C07D207/08 , C07D207/10 , C07D207/26 , C07D207/263 , C07D207/27 , C07D207/46 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/76 , C07D211/88 , C07D211/94 , C07D211/96 , C07D223/04 , C07D223/10 , C07D241/04 , C07D241/08 , C07D241/52 , C07D265/30 , C07D265/32 , C07D309/04
摘要： A compound useful as a building block for the manufacture of various compounds is represented by Formula A or D. In Formula A and D, z is 0 or 1; Q is a heteroatom; R1 through R11 and Ra through Rf are each independently hydrogen, a substituted or unsubstituted hydrocarbyl group, a substituted or unsubstituted heteroatom containing hydrocarbyl group, or a functional group; d, e and f are each independently 0 or greater; each of A, B and D is independently a carbon atom or a heteroatom; and two or more of R1 though R11, Ra through Rf and Y optionally combine to form a ring. In some embodiments, R8 and R9 combine to form a carbonyl group. In some embodiments, R2 and Y combine to form a ring with the Q atom. In some embodiments, the ring includes at least one double bond.
摘要翻译： 可用作制备各种化合物的结构单元的化合物由式A或D表示。在式A和D中，z为0或1; Q是杂原子; R 1至R 11和R a至R f各自独立地为氢，取代或未取代的烃基，取代或未取代的含杂原子的烃基或官能团; d，e和f各自独立地为0以上; A，B和D各自独立地为碳原子或杂原子; 并且R 1至R 11中的两个或更多个，R a至R f和Y任选地结合形成环。 在一些实施方案中，R 8和R 9结合形成羰基。 在一些实施方案中，R 2和Y结合形成具有Q原子的环。 在一些实施方案中，环包括至少一个双键。
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公开(公告)号：US08822679B2
公开(公告)日：2014-09-02
申请号：US13531485
申请日：2012-06-22
申请人： Brian M Stoltz , Scott C. Virgil , David E White , Taiga Yurino , Yiyang Liu , Douglas C Behenna , Douglas Duquette , Christian Eidamshaus
发明人： Brian M Stoltz , Scott C. Virgil , David E White , Taiga Yurino , Yiyang Liu , Douglas C Behenna , Douglas Duquette , Christian Eidamshaus
IPC分类号： C07D211/78 , C07C229/00 , C07D207/277 , C07D207/36 , C07D223/04 , C07D223/10 , C07D241/08 , C07D265/32 , C07D309/08 , C07D309/30 , C07F7/18
CPC分类号： C07D207/06 , C07D207/08 , C07D207/10 , C07D207/26 , C07D207/263 , C07D207/27 , C07D207/46 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/76 , C07D211/88 , C07D211/94 , C07D211/96 , C07D223/04 , C07D223/10 , C07D241/04 , C07D241/08 , C07D241/52 , C07D265/30 , C07D265/32 , C07D309/04
摘要： A compound useful as a building block for the manufacture of various compounds is represented by Formula A or D. In Formula A and D, z is 0 or 1; Q is a heteroatom; R1 through R11 and Ra through Rf are each independently hydrogen, a substituted or unsubstituted hydrocarbyl group, a substituted or unsubstituted heteroatom containing hydrocarbyl group, or a functional group; d, e and f are each independently 0 or greater; each of A, B and D is independently a carbon atom or a heteroatom; and two or more of R1 though R11, Ra through Rf and Y optionally combine to form a ring. In some embodiments, R8 and R9 combine to form a carbonyl group. In some embodiments, R2 and Y combine to form a ring with the Q atom. In some embodiments, the ring includes at least one double bond.
摘要翻译： 可用作制备各种化合物的结构单元的化合物由式A或D表示。在式A和D中，z为0或1; Q是杂原子; R 1至R 11和R a至R f各自独立地为氢，取代或未取代的烃基，取代或未取代的含杂原子的烃基或官能团; d，e和f各自独立地为0以上; A，B和D各自独立地为碳原子或杂原子; 并且R 1至R 11中的两个或更多个，R a至R f和Y任选地结合形成环。 在一些实施方案中，R 8和R 9结合形成羰基。 在一些实施方案中，R 2和Y结合形成具有Q原子的环。 在一些实施方案中，环包括至少一个双键。
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公开(公告)号：US07235698B2
公开(公告)日：2007-06-26
申请号：US11215449
申请日：2005-08-29
CPC分类号： C07C45/67 , C07B2200/07 , C07C45/511 , C07C45/54 , C07C45/673 , C07C45/676 , C07C67/343 , C07C2601/14 , C07C2601/18 , C07C49/647 , C07C49/794 , C07C49/217 , C07C49/755 , C07C49/653 , C07C49/753 , C07C49/697 , C07C49/687 , C07C49/683 , C07C69/738
摘要： Compounds containing a substituted or unsubstituted allyl group directly bound to a chiral carbon atom are prepared enantioselectively. Starting reactants are either chiral or achiral, and may or may not contain an attached allyloxycarbonyl group as a substituent. Chiral ligands are employed, along with transition metal catalysts. The methods of the invention are effective in providing enantioconvergent allylation of chiral molecules.
摘要翻译： 对映选择性地制备含有与手性碳原子直接结合的取代或未取代的烯丙基的化合物。 起始反应物是手性或非手性的，并且可以含有或可以不含有连接的烯丙氧基羰基作为取代基。 使用手性配体以及过渡金属催化剂。 本发明的方法在提供手性分子的对映异构烯丙基化方面是有效的。
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