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    Anti-Viral Azide Containing Compounds
    3.
    发明申请
    Anti-Viral Azide Containing Compounds 审中-公开

    公开(公告)号：US20130209364A1

    公开(公告)日：2013-08-15

    申请号：US13812533

    申请日：2011-07-28

    Applicant: Brian Agnew ,  Upinder Singh ,  Scott Grecian

    Inventor： Brian Agnew ,  Upinder Singh ,  Scott Grecian

    IPC: A61K31/655

    CPC classification number: A61K31/655 ,  A61K31/7008 ,  C12N7/00 ,  C12N2710/14151 ,  C12N2710/14163 ,  C12N2740/16051 ,  C12N2740/16063

    Abstract: Methods of using azide-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to inhibit infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a virus, such as human immunodeficiency virus, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. Also, provided are methods of tracking a virus in vivo, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. The azide-modified biomolecules may be combined with a pharmaceutically acceptable excipient to produce a pharmaceutical composition, optionally containing another anti-viral agent and/or a delivery agent, such as a liposome.

    Anti-viral azide containing compounds
    4.
    发明授权
    Anti-viral azide containing compounds 有权
    含抗病毒叠氮化合物的化合物

    公开(公告)号：US09144575B2

    公开(公告)日：2015-09-29

    申请号：US13192959

    申请日：2011-07-28

    Applicant: Brian Agnew ,  David Graham ,  Upinder Singh ,  Scott Grecian

    Inventor： Brian Agnew ,  David Graham ,  Upinder Singh ,  Scott Grecian

    IPC: A61K31/655 ,  A61K31/7024 ,  A61K45/06

    CPC classification number: A61K31/655 ,  A61K31/7024 ,  A61K31/7088 ,  A61K38/212 ,  A61K38/215 ,  A61K45/06 ,  A61K2300/00

    Abstract: Methods of using azide-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to inhibit infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a virus, such as human immunodeficiency virus, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. Also, provided are methods of tracking a virus in vivo, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. The azide-modified biomolecules may be combined with a pharmaceutically acceptable excipient to produce a pharmaceutical composition, optionally containing another anti-viral agent and/or a delivery agent, such as a liposome.

    Abstract translation: 提供了使用叠氮化物修饰的生物分子如脂肪酸，碳水化合物和脂质来治疗植物，昆虫或感染病毒的动物或抑制病毒如人类免疫缺陷病毒的感染性的方法。 还提供了用叠氮化物修饰的生物分子如脂肪酸，碳水化合物或类异戊二烯脂质来标记病毒（例如人类免疫缺陷病毒）的方法。 此外，提供了利用叠氮化物修饰的生物分子如脂肪酸，碳水化合物或类异戊二烯脂质体内追踪病毒的方法。 叠氮化物修饰的生物分子可以与药学上可接受的赋形剂组合以产生药物组合物，任选地含有另一种抗病毒剂和/或递送剂，例如脂质体。

    FLUORESCENT ISOTOPE TAGS AND THEIR METHOD OF USE
    7.
    发明申请
    FLUORESCENT ISOTOPE TAGS AND THEIR METHOD OF USE 审中-公开
    荧光同位素标记及其使用方法

    公开(公告)号：US20100081203A1

    公开(公告)日：2010-04-01

    申请号：US12487945

    申请日：2009-06-19

    Applicant: Brian Agnew ,  Kyle Richard Gee

    Inventor： Brian Agnew ,  Kyle Richard Gee

    IPC: G01N33/48 ,  C07D403/12 ,  C07D311/82 ,  C07D405/12 ,  C07D235/02

    CPC classification number: G01N33/582 ,  C09B11/24 ,  G01N33/533 ,  G01N33/534 ,  G01N33/583 ,  G01N33/60 ,  G01N33/6848

    Abstract: The present invention provides novel reactive fluorescent compounds that incorporate stable isotopic (deuterium, 13-carbon, 15-nitrogen, 18-oxygen) substitutions. The invention includes the use of these compounds, in combination with non-isotopically substituted analogs, for the purification, identification and relative quantification of proteins, peptides, saccharides, metabolites, and other biologically important compounds by combining liquid chromatography (LC) and mass spectrometry (MS). Fluorescent labeling of target compounds in this manner provides orders-of-magnitude sensitivity enhancement over traditional stable isotope labels, and also affords the possibility of simultaneous multiplexed analysis due to the multiwavelength nature of different fluorophores.

    Abstract translation: 本发明提供了引入稳定同位素（氘，13-碳，15-氮，18-氧）取代的新型反应性荧光化合物。 本发明包括将这些化合物与非同位素取代的类似物组合用于通过液相色谱（LC）和质谱法的组合来纯化，鉴定和相对定量蛋白质，肽，糖，代谢物和其它生物学上重要的化合物 （女士）。 目标化合物的荧光标记以这种方式提供超过传统稳定同位素标记的数量级的灵敏度增强，并且由于不同荧光团的多波长性质，也提供同时多重分析的可能性。

    Compositions and methods for detection and isolation of phosphorylated molecules
    8.
    发明申请
    Compositions and methods for detection and isolation of phosphorylated molecules 审中-公开
    用于磷酸化分子检测和分离的组合物和方法

    公开(公告)号：US20100009381A1

    公开(公告)日：2010-01-14

    申请号：US12500854

    申请日：2009-07-10

    Applicant: Brian Agnew ,  Joseph Beechem ,  Kyle Gee ,  Richard Haugland ,  Thomas Steinberg ,  Wayne Patton

    Inventor： Brian Agnew ,  Joseph Beechem ,  Kyle Gee ,  Richard Haugland ,  Thomas Steinberg ,  Wayne Patton

    IPC: G01N33/53

    CPC classification number: G01N33/5008 ,  C12Q1/42 ,  C12Q1/485 ,  G01N33/502 ,  G01N33/5091 ,  G01N2333/4709 ,  Y10T436/142222 ,  Y10T436/145555 ,  Y10T436/147777 ,  Y10T436/201666

    Abstract: The present invention relates to phosphate-binding compounds that find use in binding, detecting and isolating phosphorylated target molecules including the subsequent identification of target molecules that interact with phosphorylated target molecules or molecules capable of being phosphorylated. A binding solution is provide that comprises a phosphate-binding compound, an acid and a metal ion wherein the metal ion simultaneously interacts with an exposed phosphate group on a target molecule and the metal chelating moiety of the phosphate-binding compound forming a bridge between the phosphate-binding compound and a phosphorylated target molecule resulting in a ternary complex. The binding solution of the present invention finds use in binding and detecting immobilized and solubilized phosphorylated target molecules, isolation of phosphorylated target molecules from a complex mixture and aiding in proteomic analysis wherein kinase and phosphatase substrates and enzymes can be identified.

    Abstract translation: 本发明涉及用于结合，检测和分离磷酸化靶分子的磷酸盐结合化合物，包括随后鉴定与磷酸化靶分子或能够被磷酸化的分子相互作用的靶分子。 提供的结合溶液包括磷酸盐结合化合物，酸和金属离子，其中金属离子同时与靶分子上暴露的磷酸基团相互作用，并且磷酸盐结合化合物的金属螯合部分形成在 磷酸化结合化合物和导致三元复合物的磷酸化靶分子。 本发明的结合溶液用于结合和检测固定和溶解的磷酸化靶分子，从复杂混合物中分离磷酸化靶分子，并辅助蛋白质组分析，其中可以鉴定激酶和磷酸酶底物和酶。

    Apparatus, methods, and kits for assaying a plurality of fluid samples for a common analyte
    9.
    发明申请
    Apparatus, methods, and kits for assaying a plurality of fluid samples for a common analyte 审中-公开
    用于测定常见分析物的多个流体样品的装置，方法和试剂盒

    公开(公告)号：US20060024209A1

    公开(公告)日：2006-02-02

    申请号：US11193069

    申请日：2005-07-28

    Applicant: Brian Agnew

    Inventor： Brian Agnew

    IPC: B01L3/00

    CPC classification number: B01L3/50255 ,  B01L3/5085 ,  B01L2300/0806 ,  B01L2300/0829

    Abstract: Methods and apparatus useful for the processing of fluid samples are disclosed. The apparatus can be used to process samples containing one or more biological, chemical, or clinical analytes of interest. The apparatus contains a microplate component and a backing plate. The microplate component and/or the backing plate can have a matrix of throughbores, each being mutually fluidly noncommunicating with each other. The support can be fixedly positioned between the microplate component and the backing plate, and can be removed from the apparatus for further processing.

    Abstract translation: 公开了用于处理流体样品的方法和设备。 该装置可用于处理含有一种或多种感兴趣的生物，化学或临床分析物的样品。 该装置包含微板组件和背板。 微板组件和/或背板可以具有通孔的矩阵，每个通孔彼此相互流体地不通信。 支撑件可以固定地定位在微板组件和背板之间，并且可以从设备中移除以进一步处理。

    METHODS AND COMPOSITIONS FOR LABELING NUCLEIC ACIDS
    10.
    发明申请
    METHODS AND COMPOSITIONS FOR LABELING NUCLEIC ACIDS 有权
    标记核酸的方法和组合物

    公开(公告)号：US20100311063A1

    公开(公告)日：2010-12-09

    申请号：US12785999

    申请日：2010-05-24

    Applicant: Kyle R. Gee ,  Brian Agnew ,  Adrian Salic ,  Timothy J. Mitchison

    Inventor： Kyle R. Gee ,  Brian Agnew ,  Adrian Salic ,  Timothy J. Mitchison

    IPC: C12Q1/68

    CPC classification number: C12Q1/6806 ,  C12Q1/68 ,  C12Q1/6816 ,  C12Q1/6841 ,  G01N33/5011 ,  G01N33/582 ,  C12Q2525/101 ,  C12Q2563/107

    Abstract: The present invention relates to methods for the labeling of nucleic acid polymers in vitro and in vivo. Certain methods are provided that include a [3+2] cycloaddition between a nucleotide analogue incorporated into a nucleic acid polymer and a reagent attached to a label. Other methods are provided that include a Staudinger ligation between a nucleotide analogue incorporated into a nucleic acid polymer and a reagent comprising a substituted triarylphosphine attached to a label. Such methods do not require fixation and denaturation and therefore can be applied to the labeling of nucleic acid polymers in living cells and in organisms. Also provided are methods for measuring cellular proliferation. In these methods, the amount of label incorporated into the DNA is measured as an indication of cellular proliferation. The methods of the invention can be used in a wide variety of applications including clinical diagnosis of diseases and disorders in which cellular proliferation is involved, toxicity assays, and as a tool for the study of chromosomes' ultrastructures.

    Abstract translation: 本发明涉及体外和体内标记核酸聚合物的方法。 提供了包括掺入核酸聚合物的核苷酸类似物与附着于标记物上的试剂之间的[3 + 2]环加成的某些方法。 提供了包括掺入核酸聚合物的核苷酸类似物与包含连接到标签上的取代的三芳基膦的试剂之间的施陶丁格连接的其它方法。 这种方法不需要固定和变性，因此可以应用于活细胞和生物体中核酸聚合物的标记。 还提供了测量细胞增殖的方法。 在这些方法中，测量结合到DNA中的标记量作为细胞增殖的指示。 本发明的方法可用于各种应用，包括涉及细胞增殖的疾病和病症的临床诊断，毒性测定以及用于研究染色体超微结构的工具。

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