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    Compositions and methods for detection and isolation of phosphorylated molecules
    1.
    发明申请
    Compositions and methods for detection and isolation of phosphorylated molecules 审中-公开
    用于磷酸化分子检测和分离的组合物和方法

    公开(公告)号：US20100009381A1

    公开(公告)日：2010-01-14

    申请号：US12500854

    申请日：2009-07-10

    Applicant: Brian Agnew ,  Joseph Beechem ,  Kyle Gee ,  Richard Haugland ,  Thomas Steinberg ,  Wayne Patton

    Inventor： Brian Agnew ,  Joseph Beechem ,  Kyle Gee ,  Richard Haugland ,  Thomas Steinberg ,  Wayne Patton

    IPC: G01N33/53

    CPC classification number: G01N33/5008 ,  C12Q1/42 ,  C12Q1/485 ,  G01N33/502 ,  G01N33/5091 ,  G01N2333/4709 ,  Y10T436/142222 ,  Y10T436/145555 ,  Y10T436/147777 ,  Y10T436/201666

    Abstract: The present invention relates to phosphate-binding compounds that find use in binding, detecting and isolating phosphorylated target molecules including the subsequent identification of target molecules that interact with phosphorylated target molecules or molecules capable of being phosphorylated. A binding solution is provide that comprises a phosphate-binding compound, an acid and a metal ion wherein the metal ion simultaneously interacts with an exposed phosphate group on a target molecule and the metal chelating moiety of the phosphate-binding compound forming a bridge between the phosphate-binding compound and a phosphorylated target molecule resulting in a ternary complex. The binding solution of the present invention finds use in binding and detecting immobilized and solubilized phosphorylated target molecules, isolation of phosphorylated target molecules from a complex mixture and aiding in proteomic analysis wherein kinase and phosphatase substrates and enzymes can be identified.

    Abstract translation: 本发明涉及用于结合，检测和分离磷酸化靶分子的磷酸盐结合化合物，包括随后鉴定与磷酸化靶分子或能够被磷酸化的分子相互作用的靶分子。 提供的结合溶液包括磷酸盐结合化合物，酸和金属离子，其中金属离子同时与靶分子上暴露的磷酸基团相互作用，并且磷酸盐结合化合物的金属螯合部分形成在 磷酸化结合化合物和导致三元复合物的磷酸化靶分子。 本发明的结合溶液用于结合和检测固定和溶解的磷酸化靶分子，从复杂混合物中分离磷酸化靶分子，并辅助蛋白质组分析，其中可以鉴定激酶和磷酸酶底物和酶。

    Apparatus, methods, and kits for assaying a plurality of fluid samples for a common analyte
    2.
    发明申请
    Apparatus, methods, and kits for assaying a plurality of fluid samples for a common analyte 审中-公开
    用于测定常见分析物的多个流体样品的装置，方法和试剂盒

    公开(公告)号：US20060024209A1

    公开(公告)日：2006-02-02

    申请号：US11193069

    申请日：2005-07-28

    Applicant: Brian Agnew

    Inventor： Brian Agnew

    IPC: B01L3/00

    CPC classification number: B01L3/50255 ,  B01L3/5085 ,  B01L2300/0806 ,  B01L2300/0829

    Abstract: Methods and apparatus useful for the processing of fluid samples are disclosed. The apparatus can be used to process samples containing one or more biological, chemical, or clinical analytes of interest. The apparatus contains a microplate component and a backing plate. The microplate component and/or the backing plate can have a matrix of throughbores, each being mutually fluidly noncommunicating with each other. The support can be fixedly positioned between the microplate component and the backing plate, and can be removed from the apparatus for further processing.

    Abstract translation: 公开了用于处理流体样品的方法和设备。 该装置可用于处理含有一种或多种感兴趣的生物，化学或临床分析物的样品。 该装置包含微板组件和背板。 微板组件和/或背板可以具有通孔的矩阵，每个通孔彼此相互流体地不通信。 支撑件可以固定地定位在微板组件和背板之间，并且可以从设备中移除以进一步处理。

    Anti-Viral Azide Containing Compounds
    3.
    发明申请
    Anti-Viral Azide Containing Compounds 审中-公开

    公开(公告)号：US20130209364A1

    公开(公告)日：2013-08-15

    申请号：US13812533

    申请日：2011-07-28

    Applicant: Brian Agnew ,  Upinder Singh ,  Scott Grecian

    Inventor： Brian Agnew ,  Upinder Singh ,  Scott Grecian

    IPC: A61K31/655

    CPC classification number: A61K31/655 ,  A61K31/7008 ,  C12N7/00 ,  C12N2710/14151 ,  C12N2710/14163 ,  C12N2740/16051 ,  C12N2740/16063

    Abstract: Methods of using azide-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to inhibit infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a virus, such as human immunodeficiency virus, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. Also, provided are methods of tracking a virus in vivo, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. The azide-modified biomolecules may be combined with a pharmaceutically acceptable excipient to produce a pharmaceutical composition, optionally containing another anti-viral agent and/or a delivery agent, such as a liposome.

    Compositions and methods for detection and isolation of phosphorylated molecules
    7.
    发明授权
    Compositions and methods for detection and isolation of phosphorylated molecules 有权
    用于磷酸化分子检测和分离的组合物和方法

    公开(公告)号：US07445894B2

    公开(公告)日：2008-11-04

    申请号：US10821522

    申请日：2004-04-09

    Applicant: Brian Agnew ,  Kyle R. Gee ,  Vladimir V. Martin

    Inventor： Brian Agnew ,  Kyle R. Gee ,  Vladimir V. Martin

    IPC: G01N33/50

    CPC classification number: G01N33/5008 ,  G01N33/502 ,  G01N33/5091 ,  G01N2333/4709

    Abstract: The present invention relates to phosphate-binding compounds that find use in binding, detecting and isolating phosphorylated target molecules including the subsequent identification of target molecules that interact with phosphorylated target molecules or molecules capable of being phosphorylated. A binding solution is provide that comprises a phosphate-binding compound, an acid and a metal ion wherein the metal ion simultaneously interacts with an exposed phosphate group on a target molecule and the metal chelating moiety of the phosphate-binding compound forming a bridge between the phosphate-binding compound and a phosphorylated target molecule resulting in a ternary complex. The binding solution of the present invention finds use in binding and detecting immobilized and solubilized phosphorylated target molecules, isolation of phosphorylated target molecules from a complex mixture and aiding in proteomic analysis wherein kinase and phosphatase substrates and enzymes can be identified.

    Abstract translation: 本发明涉及用于结合，检测和分离磷酸化靶分子的磷酸盐结合化合物，包括随后鉴定与磷酸化靶分子或能够被磷酸化的分子相互作用的靶分子。 提供的结合溶液包括磷酸盐结合化合物，酸和金属离子，其中金属离子同时与靶分子上暴露的磷酸基团相互作用，并且磷酸盐结合化合物的金属螯合部分形成在 磷酸化结合化合物和导致三元复合物的磷酸化靶分子。 本发明的结合溶液用于结合和检测固定和溶解的磷酸化靶分子，从复杂混合物中分离磷酸化靶分子，并辅助蛋白质组分析，其中可以鉴定激酶和磷酸酶底物和酶。

    Compositions and methods for detection and isolation of phosphorylated molecules
    8.
    发明授权
    Compositions and methods for detection and isolation of phosphorylated molecules 有权
    用于磷酸化分子检测和分离的组合物和方法

    公开(公告)号：US07102005B2

    公开(公告)日：2006-09-05

    申请号：US10428192

    申请日：2003-05-02

    Applicant: Brian Agnew ,  Joseph Beechem ,  Kyle Gee ,  Richard Haugland ,  Jixiang Liu ,  Vladimir Martin ,  Wayne Patton ,  Thomas Steinberg

    Inventor： Brian Agnew ,  Joseph Beechem ,  Kyle Gee ,  Richard Haugland ,  Jixiang Liu ,  Vladimir Martin ,  Wayne Patton ,  Thomas Steinberg

    IPC: C07D239/88 ,  C07D277/62 ,  C07D311/82 ,  C07D417/02 ,  C07D495/04

    CPC classification number: G01N33/50 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5091 ,  G01N2333/4709

    Abstract: The present invention relates to phosphate-binding compounds that find use in binding, detecting and isolating phosphorylated target molecules including the subsequent identification of target molecules that interact with phosphorylated target molecules or molecules capable of being phosphorylated. A binding solution is provide that comprises a phosphate-binding compound, an acid and a metal ion wherein the metal ion simultaneously interacts with an exposed phosphate group on a target molecule and the metal chelating moiety of the phosphate-binding compound forming a bridge between the phosphate-binding compound and a phosphorylated target molecule resulting in a ternary complex. The binding solution of the present invention finds use in binding and detecting immobilized and solubilized phosphorylated target molecules, isolation of phosphorylated target molecules from a complex mixture and aiding in proteomic analysis wherein kinase and phosphatase substrates and enzymes can be identified.

    Abstract translation: 本发明涉及用于结合，检测和分离磷酸化靶分子的磷酸盐结合化合物，包括随后鉴定与磷酸化靶分子或能够被磷酸化的分子相互作用的靶分子。 提供的结合溶液包括磷酸盐结合化合物，酸和金属离子，其中金属离子同时与靶分子上暴露的磷酸基团相互作用，并且磷酸盐结合化合物的金属螯合部分形成在 磷酸化结合化合物和导致三元复合物的磷酸化靶分子。 本发明的结合溶液用于结合和检测固定和溶解的磷酸化靶分子，从复杂混合物中分离磷酸化靶分子，并辅助蛋白质组分析，其中可以鉴定激酶和磷酸酶底物和酶。

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