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    ANTI-VIRAL AZIDE-CONTAINING COMPOUNDS
    3.
    发明申请
    ANTI-VIRAL AZIDE-CONTAINING COMPOUNDS 审中-公开
    含抗氧化剂的化合物

    公开(公告)号：US20120028335A1

    公开(公告)日：2012-02-02

    申请号：US12888371

    申请日：2010-09-22

    Applicant: Brian AGNEW

    Inventor： Brian AGNEW

    IPC: C12N7/00

    CPC classification number: A61K31/655 ,  A61K31/7008 ,  C12N7/00 ,  C12N2710/14151 ,  C12N2710/14163 ,  C12N2740/16051 ,  C12N2740/16063

    Abstract: Methods of using azide-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant or an animal infected with a virus or to inhibit infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a human immunodeficiency virus with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. The azide-modified biomolecules may be combined with a pharmaceutically acceptable excipient to produce a pharmaceutical composition, optionally containing another anti-viral agent and/or a delivery agent, such as a liposome.

    Abstract translation: 提供了使用叠氮化物改性的生物分子如脂肪酸，碳水化合物和脂质来治疗感染病毒的植物或动物或抑制病毒如人类免疫缺陷病毒的感染性的方法。 还提供了用叠氮化物修饰的生物分子如脂肪酸，碳水化合物或类异戊二烯脂质标记人类免疫缺陷病毒的方法。 叠氮化物修饰的生物分子可以与药学上可接受的赋形剂组合以产生药物组合物，任选地含有另一种抗病毒剂和/或递送剂，例如脂质体。

    PCV2 immunogenic compositions and methods of producing such compositions
    4.
    发明授权
    PCV2 immunogenic compositions and methods of producing such compositions 有权
    PCV2免疫原性组合物及其制备方法

    公开(公告)号：US07829101B2

    公开(公告)日：2010-11-09

    申请号：US12137960

    申请日：2008-06-12

    Applicant: Marc Eichmeyer ,  Greg Nitzel ,  Merrill Schaeffer

    Inventor： Marc Eichmeyer ,  Greg Nitzel ,  Merrill Schaeffer

    IPC: A61K39/12

    CPC classification number: A61K39/12 ,  A61K33/00 ,  A61K45/06 ,  A61K2039/5258 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/55555 ,  C07K14/005 ,  C12N2710/14143 ,  C12N2710/14163 ,  C12N2750/10022 ,  C12N2750/10034 ,  C12N2750/10051 ,  C12N2770/10034

    Abstract: An improved method for recovering the protein expressed by open reading frame 2 from porcine circovirus type 2 is provided. The method generally involves the steps of transfecting recombinant virus containing open reading frame 2 coding sequences into cells contained in growth media, causing the virus to express open reading frame 2, and recovering the expressed protein in the supernate. This recovery should take place beginning approximately 5 days after infection of the cells in order to permit sufficient quantities of recombinant protein to be expressed and secreted from the cell into the growth media. Such methods avoid costly and time-consuming extraction procedures required to separate and recover the recombinant protein from within the cells.

    Abstract translation: 提供了一种用于从猪圆环病毒2型开放阅读框架2回收蛋白质的改进方法。 该方法通常包括将包含开放阅读框架2编码序列的重组病毒转染到生长培养基中所含的细胞的步骤，导致病毒表达开放阅读框架2，并回收上清液中表达的蛋白质。 这种恢复应该在细胞感染后约5天开始，以便允许足够量的重组蛋白从细胞表达和分泌到生长培养基中。 这样的方法避免了从细胞内分离和回收重组蛋白质所需的昂贵且耗时的提取程序。

    Anti-Viral Azide Containing Compounds
    6.
    发明申请
    Anti-Viral Azide Containing Compounds 审中-公开

    公开(公告)号：US20170333457A1

    公开(公告)日：2017-11-23

    申请号：US15671360

    申请日：2017-08-08

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Brian AGNEW ,  Upinder SINGH ,  Scott GRECIAN

    IPC: A61K31/655 ,  A61K31/7008 ,  C12N7/00

    CPC classification number: A61K31/655 ,  A61K31/7008 ,  C12N7/00 ,  C12N2710/14151 ,  C12N2710/14163 ,  C12N2740/16051 ,  C12N2740/16063

    Abstract: Methods of using azide-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to inhibit infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a virus, such as human immunodeficiency virus, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. Also, provided are methods of tracking a virus in vivo, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. The azide-modified biomolecules may be combined with a pharmaceutically acceptable excipient to produce a pharmaceutical composition, optionally containing another anti-viral agent and/or a delivery agent, such as a liposome.

    Methods of overexpression and recovery of porcine circovirus type 2 ORF2
    7.
    发明申请
    Methods of overexpression and recovery of porcine circovirus type 2 ORF2 有权
    猪圆环病毒2型ORF2的过表达和回收方法

    公开(公告)号：US20090042245A1

    公开(公告)日：2009-02-12

    申请号：US11034797

    申请日：2005-01-13

    Applicant: Mark Eichmeyer ,  Greg Nitzel ,  Merrill Schaeffer

    Inventor： Mark Eichmeyer ,  Greg Nitzel ,  Merrill Schaeffer

    IPC: C12P21/04

    CPC classification number: A61K39/12 ,  A61K33/00 ,  A61K45/06 ,  A61K2039/5258 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/55555 ,  C07K14/005 ,  C12N2710/14143 ,  C12N2710/14163 ,  C12N2750/10022 ,  C12N2750/10034 ,  C12N2750/10051 ,  C12N2770/10034

    Abstract: An improved method for recovering the protein expressed by open reading frame 2 from PCV2 is provided. The method generally involves the steps of transfecting recombinant virus containing open reading frame 2 coding sequences into cells contained in growth media, causing the virus to express open reading frame 2, and recovering the expressed protein in the supernate. This recovery should take place beginning approximately 5 days after infection of the cells in order to permit sufficient quantities of recombinant protein to be expressed and secreted from the cell into the growth media. Such methods avoid costly and time consuming extraction procedures required to separate and recover the recombinant protein from within the cells.

    Abstract translation: 提供了一种用于从PCV2回收由开放阅读框2表达的蛋白质的改进方法。 该方法通常包括将包含开放阅读框架2编码序列的重组病毒转染到生长培养基中所含的细胞的步骤，使病毒表达开放阅读框架2，并回收上清液中表达的蛋白质。 这种恢复应该在细胞感染后约5天开始，以便允许足够量的重组蛋白从细胞表达和分泌到生长培养基中。 这样的方法避免了从细胞内分离和回收重组蛋白质所需的昂贵且耗时的提取方法。

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