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    METHODS AND COMPOSITIONS FOR REDUCING THE IMPACT OF ENTERIC DISEASES
    2.
    发明申请
    METHODS AND COMPOSITIONS FOR REDUCING THE IMPACT OF ENTERIC DISEASES 审中-公开
    减少肠道疾病影响的方法和组合

    公开(公告)号：US20110033495A1

    公开(公告)日：2011-02-10

    申请号：US12867622

    申请日：2009-02-14

    Applicant: Michael Roof ,  Marc Eichmeyer

    Inventor： Michael Roof ,  Marc Eichmeyer

    IPC: A61K39/295 ,  A61K39/12 ,  A61P31/04 ,  A61P31/20

    CPC classification number: A61K39/12 ,  A61K2039/552 ,  A61K2039/70 ,  C12N2750/10034

    Abstract: The present invention relates to the use of an immunogenic composition that comprises a PCV2 antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with an enteric infection, even more preferably, with enteric disease. The use relates to a method comprising the steps of administering the composition to an animal in need thereof, preferably prior to disease exposure. Administration of PCV2 antigen, preferably ORF2 of PCV2, lessens the incidence and reduces the severity of the enteric disease.

    Abstract translation: 本发明涉及包含用于治疗几种临床表现（疾病）的PCV2抗原的免疫原性组合物的用途。 优选地，临床表现与肠道感染相关，甚至更优选与肠道疾病相关。 该用途涉及包括以下步骤的方法：优选在疾病暴露之前将组合物施用于有需要的动物。 PCV2抗原，优选PCV2的ORF2的施用降低了发病率，降低了肠道疾病的严重性。

    Methods of overexpression and recovery of porcine circovirus type 2 ORF2
    6.
    发明授权
    Methods of overexpression and recovery of porcine circovirus type 2 ORF2 有权
    猪圆环病毒2型ORF2的过表达和回收方法

    公开(公告)号：US07833707B2

    公开(公告)日：2010-11-16

    申请号：US11034797

    申请日：2005-01-13

    Applicant: Marc Eichmeyer ,  Greg Nitzel ,  Merrill Schaeffer

    Inventor： Marc Eichmeyer ,  Greg Nitzel ,  Merrill Schaeffer

    IPC: C12Q1/68

    CPC classification number: A61K39/12 ,  A61K33/00 ,  A61K45/06 ,  A61K2039/5258 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/55555 ,  C07K14/005 ,  C12N2710/14143 ,  C12N2710/14163 ,  C12N2750/10022 ,  C12N2750/10034 ,  C12N2750/10051 ,  C12N2770/10034

    Abstract: An improved method for recovering the protein expressed by open reading frame 2 from PCV2 is provided. The method generally involves the steps of transfecting recombinant virus containing open reading frame 2 coding sequences into cells contained in growth media, causing the virus to express open reading frame 2, and recovering the expressed protein in the supernate. This recovery should take place beginning approximately 5 days after infection of the cells in order to permit sufficient quantities of recombinant protein to be expressed and secreted from the cell into the growth media. Such methods avoid costly and time consuming extraction procedures required to separate and recover the recombinant protein from within the cells.

    Abstract translation: 提供了一种用于从PCV2回收由开放阅读框2表达的蛋白质的改进方法。 该方法通常包括将包含开放阅读框架2编码序列的重组病毒转染到生长培养基中所含的细胞的步骤，使病毒表达开放阅读框架2，并回收上清液中表达的蛋白质。 这种恢复应该在细胞感染后约5天开始，以便允许足够量的重组蛋白从细胞表达和分泌到生长培养基中。 这样的方法避免了从细胞内分离和回收重组蛋白质所需的昂贵且耗时的提取方法。

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