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公开(公告)号：US20190293662A1
公开(公告)日：2019-09-26
申请号：US16462924
申请日：2017-11-23
Applicant: Randox Laboratories Ltd , Randox Teoranta
Inventor： Ciaran Richardson , Ivan McConnell , John Lamont , Stephen Peter Fitzgerald
Abstract: Described are methods and kits for diagnosing stroke using GFAP derivatives.
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公开(公告)号：US10168331B2
公开(公告)日：2019-01-01
申请号：US15304473
申请日：2015-04-02
Applicant: Randox Laboratories Ltd.
Inventor： Mark Ruddock , Cherith Reid , John Lamont , Stephen Fitzgerald , Ricardo De Matos Simoes , Kathleen Williamson
IPC: G01N33/574 , G01N33/68 , G01N33/543 , G01N33/577
Abstract: The present invention provides a method and a solid state device for identifying the presence of urothelial cancer in a patient comprising assigning the subject to a sub-population according to smoking habits, measuring the level of each biomarker of a panel of biomarkers in one or more samples obtained from the subject; and correlating the measured levels of the panel of biomarkers with the likelihood of the subject having urothelial cancer such that the subject can be classified as having urothelial cancer or as being a control.
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公开(公告)号：US09927429B2
公开(公告)日：2018-03-27
申请号：US14411496
申请日：2013-07-08
Applicant: Randox Laboratories Ltd.
Inventor： Maria Zellner , Ellen Umlauf
IPC: G01N33/53 , G01N33/566 , C07K16/00 , G01N33/68
CPC classification number: G01N33/5308 , G01N33/6896 , G01N2333/4712 , G01N2800/2814 , G01N2800/2821
Abstract: The present invention provides an in vitro method to aid the diagnosis of Alzheimer's disease (AD) or Mild Cognitive Impairment (MCI), comprising determining the level of expression of one or more tropomyosin isoform(s) corresponding to P09493-3 and/or P09493-1 in a patient's sample. A kit comprising probes that bind to tropomyosin isoforms P09493-3 and P09493-1 is also provided.
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公开(公告)号：US09892229B2
公开(公告)日：2018-02-13
申请号：US14435991
申请日：2013-10-16
Applicant: RANDOX LABORATORIES LTD.
Inventor： Mark William Ruddock , Cherith N. Reid , Kate E. Williamson , Frank Emmert-Streib , John V. Lamont , Peter Fitzgerald
CPC classification number: G06F19/18 , G01N33/57407 , G01N33/57484 , G01N2333/4737 , G01N2333/4742 , G01N2333/475 , G01N2333/485 , G01N2333/523 , G01N2333/525 , G01N2333/5406 , G01N2333/5412 , G01N2333/5421 , G01N2333/545 , G01N2333/55 , G01N2333/70578 , G01N2333/70596 , G01N2333/7151 , G01N2333/7452 , G01N2333/928 , G01N2333/96433 , G01N2333/96494 , G01N2333/988 , G01N2400/00 , G06F19/00 , G06F19/24 , G16H50/30
Abstract: The invention provides a method of defining the likelihood of a subject having bladder cancer, comprising the steps of: (A) assessing the subject's likelihood of having bladder cancer by: i. identifying at least one sub-population group appropriate to the subject; ii. determining the level of one or more biomarkers selected according to the sub-population group in a sample obtained from the subject; iii. inputting each of the biomarker values into an algorithm to produce an output value; and iv. correlating the output value with the likelihood of the subject having bladder cancer, wherein the sub-population group is selected according to smoking habits, gender, presence/absence of stone disease, history of benign prostate enlargement (BPE) or prescription of anti-hypertensive, anti-platelet and/or anti-ulcer medication, and (B) determining the subject's stratified risk level of serious disease by: v. determining the level of one or more biomarkers specific for one or more risk classifiers defined using Random Forest Classifiers (RFC), logistic regression or another appropriate systems biology or statistical approach in a sample obtained from the subject, vi. inputting each of the biomarker values into an algorithm or algorithms to produce an output value; and vii. correlating the output value with a stratified risk level of underlying serious disease, wherein the likelihood of having bladder cancer is combined with the stratified risk level of having serious disease, wherein the risk of having bladder cancer and/or serious disease is categorized as: high-risk bladder cancer requiring immediate cystoscopy; low-risk bladder cancer requiring urgent cystoscopy; high-risk control requiring close evaluation and further investigation; or low-risk control requiring primary care monitoring.
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公开(公告)号：US20170348692A1
公开(公告)日：2017-12-07
申请号：US15534460
申请日：2015-12-14
Applicant: Randox Laboratories Ltd.
Inventor： Stuart JACKSON , Ivan MCCONNELL , John LAMONT , Peter FITZGERALD , Marc WHARRY
CPC classification number: B01L9/52 , B01L3/508 , B01L2200/0689 , B01L2200/142 , B01L2300/042 , B01L2300/044 , B01L2300/045 , B01L2300/047 , B01L2300/0636 , B01L2300/0832 , B01L2300/161 , B65B7/2871 , C12M23/38
Abstract: The present invention is directed to a cap for a biochip storage well. The cap comprises a resilient sealant layer capable, under the application of pressure, of forming a vapour-proof seal with a line contact interface formation extending around the perimeter of a biochip storage well.An assay assembly comprising the cap of the invention and a biochip storage is disclosed. Methods of sealing a biochip storage well using a cap of the invention are also disclosed.
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Patent Agency Ranking
公开(公告)号：US20170030917A1
公开(公告)日：2017-02-02
申请号：US15302849
申请日：2015-04-02
Applicant: Randox Laboratories Ltd.
Inventor： Alex Chacko , Ivan McConnell , Peter Fitzgerald , John V. Lamont
IPC: G01N33/574
CPC classification number: G01N33/57484 , A61P35/00 , A61P35/04 , C07K14/54 , G01N33/53 , G01N33/57423 , G01N33/6869 , G01N2333/54 , G01N2800/52
Abstract: The present invention describes methods for screening for cancer in a subject, by measuring the level of dimeric IL-18 in a sample obtained from the subject, and comparing that level with the level in a normal control sample.The present invention also describes an assay for screening for cancer in a subject, by measuring the level of dimeric IL-18 in a sample obtained from the subject, whereby an elevated level of dimeric IL-18 is indicative of cancer.
Abstract translation: 本发明还描述了通过测量从受试者获得的样品中的二聚体IL-18的水平来筛选受试者中的癌症的测定，由此提高的二聚体IL-18水平是癌症的指示。
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公开(公告)号：US20170003308A1
公开(公告)日：2017-01-05
申请号：US15200558
申请日：2016-07-01
Applicant: Randox Laboratories Ltd
Inventor： Ivan McConnell , Philip Lowry , Elouard Benchikh , Peter Fitzgerald
IPC: G01N33/94 , C07C225/20 , C07C229/14 , C07K16/44 , C07K14/435
CPC classification number: G01N33/94 , C07C225/20 , C07C229/14 , C07K14/43504 , C07K16/44 , C07K2317/33 , C07K2317/92
Abstract: Components for enabling immunodetection of methoxetamine are described including immunogens, haptens, antibodies and kits.
Abstract translation: 描述了用于实现甲氧胺的免疫检测的组分，包括免疫原，半抗原，抗体和试剂盒。
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公开(公告)号：US20160245800A1
公开(公告)日：2016-08-25
申请号：US15042095
申请日：2016-02-11
Applicant: Randox Laboratories Ltd.
Inventor： Elouard Benchik , Ivan McConnell , Peter FitzGerald , Philip Lowry
CPC classification number: G01N33/5308 , C07K16/44 , C07K2317/14 , C07K2317/33 , C07K2317/92 , G01N33/9486
Abstract: Antibodies, immunoassay methods and kits for the detection and determination of 3,4,-dichloro-N-[(1-(dimethylamino)cyclohexyl)methyl]benzamide and 3,4,-dichloro-N-[(1-(methylamino)cyclohexyl)methyl]benzamide, as well as the precursory immunogens, are described.
Abstract translation: 用于检测和测定3,4， - 二氯-N - [（1-（二甲基氨基）环己基）甲基]苯甲酰胺和3,4， - 二氯-N - [（1-（甲基氨基）苯基）苯甲酰胺的抗体，免疫测定方法和试剂盒， 环己基）甲基]苯甲酰胺，以及前体免疫原。
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公开(公告)号：US20140072987A1
公开(公告)日：2014-03-13
申请号：US14025623
申请日：2013-09-12
Applicant: RANDOX LABORATORIES LTD.
Inventor： Mark W. Ruddock , Cherith N. Reid , Kathleen Williamson , John V. Lamont , Stephen P. Fitzgerald
IPC: G01N33/68
CPC classification number: G01N33/6893 , G01N33/57407 , G01N2800/52 , G01N2800/60
Abstract: The disclosure relates to methods of detecting bladder cancer including assaying a patient sample for the levels of certain combinations of biomarkers. The disclosure also relates to methods for determining the efficacy of a drug for the treatment of bladder cancer.
Abstract translation: 本公开涉及检测膀胱癌的方法，包括测定患者样品中生物标志物的某些组合的水平。 本公开还涉及用于确定药物治疗膀胱癌的功效的方法。
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公开(公告)号：US20020086338A1
公开(公告)日：2002-07-04
申请号：US10011300
申请日：2001-12-11
Applicant: RANDOX LABORATORIES, LTD.
Inventor： Lynne Hamilton , Paul Graham Winyard
IPC: G01N033/53 , C07C39/40
CPC classification number: C07C309/40 , G01R33/60 , Y10T436/177692 , Y10T436/18 , Y10T436/20 , Y10T436/24
Abstract: A compound of the formula 1 wherein X is Cl or CH3, or a salt thereof, is useful as a spin trap in various assays.
Abstract translation: 下式的化合物其中X是Cl或CH3，或其盐可用作各种测定中的自旋阱。
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