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    Apparatus and Methods for Detecting Propellant Degradation in Solid Propellant Fuel
    5.
    发明申请
    Apparatus and Methods for Detecting Propellant Degradation in Solid Propellant Fuel 审中-公开
    用于检测固体推进剂燃料中推进剂降解的装置和方法

    公开(公告)号：US20140246589A1

    公开(公告)日：2014-09-04

    申请号：US14055592

    申请日：2013-10-16

    申请人： United States of America as represented by the Secretary of the Army

    发明人： Christina L. Brantley ,  Eugene Edwards ,  Paul B. Ruffin ,  Fang Luo

    IPC分类号： G01N21/35

    CPC分类号： G01N21/3504 ,  B82Y15/00 ,  G01J3/42 ,  G01N1/22 ,  G01N1/2202 ,  G01N1/2205 ,  G01N1/24 ,  G01N21/65 ,  G01N33/222 ,  G01N2021/3155 ,  G01N2021/3595 ,  Y10T436/177692 ,  Y10T436/178459 ,  Y10T436/204998 ,  Y10T436/205831

    摘要： The present disclosure relates to a gas sensor, including: a gas collecting chamber including: (a) a nanoporous wall including alumina, on a portion of the gas collecting chamber in the near vicinity of the solid propellant fuel; a micro pump attached to the gas collecting chamber; and a gas analysis device connected to the gas collecting chamber. The gas analysis device measures both type and concentration of gases collected in the gas collecting chamber via the nanoporous wall, the gases measured being selected from the group consisting of CO, CO2, NO, N2O, NO2 and combinations thereof. The present disclosure also relates to a method of sensing propellant degradation in solid fuel and a method of using a gas collecting chamber to sense such degradation.

    摘要翻译： 本发明涉及一种气体传感器，包括：气体收集室，包括：（a）在固体推进剂燃料附近的气体收集室的一部分上的包括氧化铝的纳米多孔壁; 附接到气体收集室的微型泵; 以及与气体收集室连接的气体分析装置。 气体分析装置通过纳米多孔壁测量在气体收集室中收集的气体的类型和浓度，所测量的气体选自CO，CO 2，NO，N 2 O，NO 2及其组合。 本公开还涉及一种感测固体燃料中的推进剂降解的方法以及使用气体收集室来感测这种降解的方法。

    Methods to determine susceptibility to treatment with leukotriene modifiers
    6.
    发明授权
    Methods to determine susceptibility to treatment with leukotriene modifiers 有权
    确定用白三烯调节剂治疗易感性的方法

    公开(公告)号：US08685740B2

    公开(公告)日：2014-04-01

    申请号：US12404984

    申请日：2009-03-16

    申请人： Nathan Rabinovitch ,  Erwin Gelfand

    发明人： Nathan Rabinovitch ,  Erwin Gelfand

    IPC分类号： G01N33/497 ,  G01N33/50

    CPC分类号： G01N33/88 ,  A61K31/47 ,  G01N33/497 ,  G01N2033/4975 ,  G01N2800/24 ,  G01N2800/52 ,  Y10T436/177692

    摘要： The present invention provides a method of determining the susceptibility of a subject to treatment with a leukotriene modifier by determining the subject's cysteinyl leukotriene (CysLT) level and the subject's level of eosinophilic airway inflammation and identifying a subject with a high ratio of CysLT levels to eosinophilic airway inflammation as susceptible to treatment with the leukotriene modifier. Also discussed is a method of treatment of subjects who are susceptible to treatment that includes administering a leukotriene modifier to such a subject.

    摘要翻译： 本发明提供了一种通过测定受试者的半胱氨酰白三烯（CysLT）水平和受试者的嗜酸粒细胞性气道炎症水平来确定受试者用白细胞三烯改良剂治疗的敏感性的方法，并鉴定了具有高比例的CysLT水平与嗜酸性粒细胞 气道炎症易受白三烯修饰剂的治疗。 还讨论了治疗易受治疗的受试者的方法，其包括向这样的受试者施用白三烯改性剂。

    Optical Nanosensors Comprising Photoluminescent Nanostructures
    7.
    发明申请
    Optical Nanosensors Comprising Photoluminescent Nanostructures 有权
    包含光致发光纳米结构的光学纳米传感器

    公开(公告)号：US20140080122A1

    公开(公告)日：2014-03-20

    申请号：US13942241

    申请日：2013-07-15

    申请人： Massachusetts Institute of Technology

    发明人： Michael S. Strano ,  Jong-Ho Kim ,  Jinqing Zhang ,  Daniel A. Heller

    IPC分类号： G01N33/84

    CPC分类号： G01N33/84 ,  B82Y15/00 ,  B82Y30/00 ,  G01N21/6428 ,  G01N21/6489 ,  G01N33/54346 ,  G01N33/54373 ,  G01N2021/6432 ,  G01N2021/7786 ,  Y10T436/177692

    摘要： Systems and methods related to optical nanosensors comprising photoluminescent nanostructures are generally described. Generally, the nanosensors comprise a photoluminescent nanostructure and a polymer that interacts with the photoluminescent nanostructure. In some cases, the interaction between the polymer and the nanostructure can be non-covalent (e.g., via van der Waals interactions). The nanosensors comprising a polymer and a photoluminescent nanostructure may be particularly useful in determining the presence and/or concentration of relatively small molecules, in some embodiments. In addition, in some instances the nanosensors may be capable of determining relatively low concentrations of analytes, in some cases determining as little as a single molecule. In some embodiments, the interaction between the analyte and the nanosensor (e.g., between the analyte and the photoluminescent nanostructure) can be reversible, which may allow, for example, for the reuse of a nanosensor after it has been exposed to an analyte.

    摘要翻译： 通常描述与包含光致发光纳米结构的光学纳米传感器有关的系统和方法。 通常，纳米传感器包含光致发光纳米结构和与光致发光纳米结构相互作用的聚合物。 在一些情况下，聚合物和纳米结构之间的相互作用可以是非共价的（例如，通过范德华相互作用）。 在一些实施方案中，包含聚合物和光致发光纳米结构的纳米传感器可以特别用于确定相对较小分子的存在和/或浓度。 此外，在一些情况下，纳米传感器可能能够确定相对低浓度的分析物，在某些情况下确定与单个分子一样少。 在一些实施方案中，分析物和纳米传感器之间的相互作用（例如分析物和光致发光纳米结构之间）之间的相互作用可以是可逆的，这可以允许例如纳米传感器暴露于分析物之后重新利用它们。

    Fluorescent probe
    8.
    发明授权
    Fluorescent probe 有权
    荧光探针

    公开(公告)号：US08673957B2

    公开(公告)日：2014-03-18

    申请号：US13425802

    申请日：2012-03-21

    申请人： Tetsuo Nagano ,  Yu Gabe ,  Yasuteru Urano

    发明人： Tetsuo Nagano ,  Yu Gabe ,  Yasuteru Urano

    IPC分类号： A61K31/40 ,  C07D209/56

    CPC分类号： C07F5/022 ,  C09K11/06 ,  C09K2211/1055 ,  G01N31/22 ,  Y10T436/145555 ,  Y10T436/177692

    摘要： A compound represented by the formula (I) wherein R1 and R2 represent amino groups that substitute at adjacent positions on the benzene ring, wherein one of the amino groups may have one alkyl group; R3 and R4 represent hydrogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group, R5 and R8 independently represent a C1-6 alkyl group, R6 and R9 represent a carboxy-substituted C1-6 alkyl group, an alkoxycarbonyl-substituted C1-6 alkyl group, a sulfo-substituted C1-6 alkyl group, or an alkyl sulfonate-substituted C1-6 alkyl group, and R7 and R10 represent a C1-6 alkyl group, an aryl group, a C1-6 alkoxycarbonyl group, a vinyl group, a thienyl group, or a pyrrolyl group, and an agent for measurement of nitrogen monoxide containing the compound. Said compound can give a fluorescent substance that is free from change in fluorescence intensity in a wide pH range.

    摘要翻译： 由式（I）表示的化合物，其中R 1和R 2表示在苯环上的相邻位置取代的氨基，其中一个氨基可以具有一个烷基; R3和R4表示氢原子，C1-6烷基或C1-6烷氧基，R5和R8独立地表示C1-6烷基，R6和R9表示羧基取代的C1-6烷基，烷氧基羰基 取代的C 1-6烷基，磺基取代的C 1-6烷基或烷基磺酸酯取代的C 1-6烷基，R 7和R 10表示C 1-6烷基，芳基，C 1-6 烷氧基羰基，乙烯基，噻吩基或吡咯基，以及含有该化合物的一氧化氮测定用试剂。 所述化合物可以产生在宽pH范围内没有荧光强度变化的荧光物质。

    Method and system for determining levels of gases
    9.
    发明授权
    Method and system for determining levels of gases 失效
    用于确定气体水平的方法和系统

    公开(公告)号：US08621911B2

    公开(公告)日：2014-01-07

    申请号：US13013374

    申请日：2011-01-25

    申请人： William J. McFaul

    发明人： William J. McFaul

    IPC分类号： G01N33/18

    CPC分类号： G01N33/0004 ,  G01N33/18 ,  G01N33/497 ,  Y10T436/177692 ,  Y10T436/184

    摘要： A method and system for measuring or assessing the homeostatic relationship between gases in the body, environment or water. The measured or assessed level of gases in the body, environment or air uses the interrelationships of the various components in order to establish guidelines for treating individuals, the environment or water.

    摘要翻译： 用于测量或评估身体，环境或水中气体之间的稳态关系的方法和系统。 测量或评估的身体，环境或空气中的气体水平使用各种组分的相互关系，以建立治疗个人，环境或水的指导方针。