知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

405 条记录 (耗时 0.035 秒)

    Functional optical coherent imaging
    2.
    发明授权
    Functional optical coherent imaging 有权

    公开(公告)号：US09757039B2

    公开(公告)日：2017-09-12

    申请号：US14753997

    申请日：2015-06-29

    申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)

    发明人： Theo Lasser ,  Dimitri Van De Ville ,  Erica Martin-Williams ,  Marcel Leutenegger ,  Iwan Maerki ,  Michael Friedrich ,  Martin Villiger

    IPC分类号： A61B6/00 ,  A61B5/00 ,  A61B3/12 ,  A61B5/02 ,  A61B3/10

    CPC分类号： A61B5/0066 ,  A61B3/102 ,  A61B3/1233 ,  A61B5/0048 ,  A61B5/0059 ,  A61B5/02028 ,  A61B5/413 ,  A61B5/7203 ,  A61B5/726 ,  A61B5/7278 ,  A61B5/742

    摘要： A functional optical coherent imaging (fOCI) platform includes at least one active camera unit (ACU) having a coherent and/or a partially coherent light source, and means for spectral filtering and imaging a selected body area of interest; an image processing unit (IPU) for pre-processing data received from an ACU; at least one stimulation unit (STU) transmitting a stimulation to a subject; at least one body function reference measurement unit (BFMU); a central clock and processing unit (CCU), with interconnections to the ACU, the IPU, the STU, for collecting pre-processed data from the IPU, stimuli from the STU body function reference data from the BFMU in a synchronized manner; a post-processing unit (statistical analysis unit, SAU); and an operator interface (HOD. A process for acquiring stimuli activated subject data includes aligning a body function unit at a subject and monitoring pre-selected body function; selecting a stimulus or stimuli; imaging a body area of interest; exerting one or a series of stimuli on the subject; imaging the body area of interest synchronous with said stimuli and the preselected body functions; and transferring said synchronized image, stimuli and body function data to a statistical analysis unit (SAU) and performing calculations to generate results pertaining to body functions.

    Optimal Remote Ischemic Preconditioning (ORIP) for mitigating DNA damage
    4.
    发明申请
    Optimal Remote Ischemic Preconditioning (ORIP) for mitigating DNA damage 审中-公开
    用于减轻DNA损伤的最佳远程缺血预处理（ORIP）

    公开(公告)号：US20150265286A1

    公开(公告)日：2015-09-24

    申请号：US14222744

    申请日：2014-03-24

    申请人： Fazal Raheman

    发明人： Fazal Raheman

    IPC分类号： A61B17/135

    CPC分类号： A61B17/1355 ,  A61B5/022 ,  A61B5/412 ,  A61B5/413 ,  A61B2017/00199 ,  A61B2017/00221

    摘要： DNA damage commonly results from exposure to diagnostic and therapeutic use of ionizing radiation, chemotoxic agents, smoking, diet and even from sedentary lifestyle. It is also a function of aging. Unrepaired DNA damage may result in accelerated aging and various forms of cancers. The invention discloses a method to harness the innate power of repetitive transient ischemia and reperfusion for protecting organs against imminent DNA damage, prevent senescence (aging) and for boosting DNA repair. This method of optimal remote ischemic preconditioning (ORIP) comprises of utilizing a pair of programmable pneumatic cuffs that inflate/deflate alternately occluding blood circulation to each of the limbs for pre-defined time intervals. ORIP can be self-administered and remotely monitored by clinician. ORIP may also be deployed as an adjunct in radiotherapy and chemotherapy for reducing the damage to normal tissue and boosting the treatment efficacy. The apparatus delivers maximal ORIP dose in shortest possible time.

    摘要翻译： DNA损伤通常来自暴露于电离辐射，化学毒物，吸烟，饮食甚至久坐生活方式的诊断和治疗用途。 它也是老化的功能。 未修复的DNA损伤可能导致加速老化和各种形式的癌症。 本发明公开了一种利用重复性短暂性脑缺血再灌注的先天功能来保护器官免受即将发生的DNA损伤，防止衰老（老化）和促进DNA修复的方法。 这种最佳远程缺血预处理（ORIP）的方法包括利用一对可编程的气动袖带，以预定义的时间间隔对每个肢体交替地封闭血液循环进行充气/放气。 ORIP可以由临床医生进行自我管理和远程监控。 也可以将ORIP作为放射治疗和化学疗法的辅助部件，以减少对正常组织的损伤并提高治疗效果。 该设备在最短的时间内提供最大的ORIP剂量。

    AQUEOUS METHACETIN SOLUTIONS LABELLED WITH 13C HAVING PROPYLENE GLYCOL AS A SOLUBILIZER
    5.
    发明申请
    AQUEOUS METHACETIN SOLUTIONS LABELLED WITH 13C HAVING PROPYLENE GLYCOL AS A SOLUBILIZER 有权
    标记为具有作为溶剂的丙烯甘油的13C的水性甲基解决方案

    公开(公告)号：US20150079619A1

    公开(公告)日：2015-03-19

    申请号：US14553927

    申请日：2014-11-25

    申请人： FREIE UNIVERSITÄT BERLIN ,  CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN

    发明人： Martin STOCKMANN ,  Björn RIECKE

    IPC分类号： C12Q1/26

    CPC分类号： A61K49/10 ,  A61B5/00 ,  A61B5/0836 ,  A61B5/097 ,  A61B5/413 ,  A61B5/4244 ,  A61K49/0004 ,  A61K51/04 ,  A61M16/06 ,  A61M16/0858 ,  C12Q1/26 ,  G01N33/497 ,  G01N2333/90245 ,  Y10S436/90

    摘要： An analysis method determines a functional parameter of an organ by measuring 13CO2 content in exhaled air of an individual to which a substrate has been administered. The reaction of the substrate in the body of the individual enriches the exhaled air with 13CO2. The maximum reaction rate of the substrate in the body is determined via a change of the measured 13CO2 content in the exhaled air using zero-order enzyme kinetics. An aqueous methacetin solution having a pH greater than 7.0 is used in the analysis method. A face mask separates the exhaled air from inhaled air. The face mask is configured such that inhaled and exhaled air flows essentially completely through the face mask. Exhalation and inhalation valves in the face mask allow a flow of inhaled and exhaled air through the face mask. A diagnostic method is used to determine the functional parameters of the organ.

    摘要翻译： 分析方法通过测量已施用基质的个体的呼出空气中的13CO 2含量来确定器官的功能参数。 基体在人体内的反应使呼出的空气富含13CO2。 通过使用零级酶动力学在呼出空气中测量的13CO 2含量的变化来确定体内基质的最大反应速率。 在分析方法中使用pH大于7.0的美沙西丁水溶液。 面罩将呼出的空气与吸入的空气分开。 面罩配置成使得吸入和呼出的空气基本上完全流过面罩。 面罩中的呼气和吸入阀允许通过面罩吸入和呼出的空气。 使用诊断方法来确定器官的功能参数。

    Methods and apparatus for optimal remote ischemic preconditioning (ORIP) for preventing ischemia-reperfusion injuries to organs
    6.
    发明授权
    Methods and apparatus for optimal remote ischemic preconditioning (ORIP) for preventing ischemia-reperfusion injuries to organs 有权
    用于预防局部缺血再灌注损伤器官的最佳远端缺血预处理（ORIP）的方法和装置

    公开(公告)号：US08911469B2

    公开(公告)日：2014-12-16

    申请号：US12898259

    申请日：2010-10-05

    申请人： Fazal Raheman

    发明人： Fazal Raheman

    IPC分类号： A61B17/00

    CPC分类号： A61B17/1355 ,  A61B5/022 ,  A61B5/412 ,  A61B5/413 ,  A61B2017/00199 ,  A61B2017/00221

    摘要： Ischemia-reperfusion injury commonly results from any surgical procedure requiring stopping of blood supply to an organ followed by reperfusion such as in heart bypass, angioplasty or organ transplant. The invention discloses a method to harness the innate power of repetitive transient ischemia in protecting organs against imminent ischemia-reperfusion, or any patho-physiological insults. This method of optimal remote ischemic preconditioning (ORIP) comprises of utilizing a pair of programmable pneumatic cuffs that inflate/deflate alternately occluding blood circulation to each of the limbs for pre-defined time intervals. The apparatus delivers maximal ORIP dose in shortest possible time either as an EMS procedure during patient transportation to hospital, as elective pre-surgery treatment, or in critical care for preventing multiple-organ-dysfunction-syndrome. ORIP can be self-administered and remotely monitored by clinician especially in chronic patients for homeostasis of malfunctioning target organs. ORIP may also be deployed as adjunct in angioplasty, gene/stem cell heart repair therapies.

    摘要翻译： 缺血再灌注损伤通常来自需要停止向器官供血的再次再灌注的手术过程，例如在心脏旁路，血管成形术或器官移植中。 本发明公开了一种利用重复性短暂性脑缺血的先天功能来保护器官免于即将发生的缺血再灌注或任何病理生理损伤的方法。 这种最佳远程缺血预处理（ORIP）的方法包括利用一对可编程的气动袖带，以预定义的时间间隔将每个肢体交替地封闭血液循环。 该装置在患者运送到医院期间作为EMS手术在最短时间内提供最大的ORIP剂量，作为选择性手术前治疗，或者用于预防多器官功能障碍综合征的关键护理。 ORIP可以由临床医生，特别是慢性病人进行自我管理和远程监测，以维持目标器官功能失调。 ORIP也可以在血管成形术，基因/干细胞心脏修复疗法中作为辅助部署。

    METHOD AND SYSTEM FOR MONITORING OXYGENATION LEVELS OF COMPARTMENTS AND TISSUE
    7.
    发明申请
    METHOD AND SYSTEM FOR MONITORING OXYGENATION LEVELS OF COMPARTMENTS AND TISSUE 有权
    用于监测房间和组织的氧化水平的方法和系统

    公开(公告)号：US20140316215A1

    公开(公告)日：2014-10-23

    申请号：US14106734

    申请日：2013-12-14

    申请人： MICHAEL SIMMS SHULER

    发明人： MICHAEL SIMMS SHULER

    IPC分类号： A61B5/0205 ,  A61B5/00 ,  A61B5/08

    CPC分类号： A61B5/4519 ,  A61B5/0075 ,  A61B5/0205 ,  A61B5/02055 ,  A61B5/0215 ,  A61B5/022 ,  A61B5/024 ,  A61B5/08 ,  A61B5/0816 ,  A61B5/082 ,  A61B5/14539 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/412 ,  A61B5/413 ,  A61B5/416 ,  A61B5/4504 ,  A61B5/6824 ,  A61B5/6828 ,  A61B5/742 ,  A61B5/746 ,  A61B2560/0242

    摘要： A method and system for continually monitoring oxygenation levels in real-time in compartments of an animal limb, such as in a human leg or a human thigh or a forearm, can be used to assist in the diagnosis of a compartment syndrome. The method and system can include one or more near infrared compartment sensors in which each sensor can be provided with a compartment alignment mechanism and a central scan depth marker so that each sensor may be precisely positioned over a compartment of a living organism. The method and system may comprise hardware or software (or both) may adjust one or more algorithms based on whether tissue being monitored was traumatized or is healthy. The method and system can also monitor the relationship between blood pressure and oxygenation levels and activate alarms based on predetermined conditions relating to the oxygenation levels or blood pressure or both.

    摘要翻译： 可以使用用于在动物肢体（例如人腿或人大腿或前臂）的隔室中实时持续监测氧合水平的方法和系统来辅助诊断隔室综合征。 该方法和系统可以包括一个或多个近红外区隔传感器，其中每个传感器可以设置有隔室对准机构和中央扫描深度标记，使得每个传感器可以精确地定位在生物体的隔室上。 该方法和系统可以包括硬件或软件（或两者）可以基于被监测的组织是否被创伤或健康来调整一个或多个算法。 该方法和系统还可以监测血压和氧合水平之间的关系，并且基于与氧合水平或血压或两者相关的预定条件激活警报。

    Method for monitoring viability of tissue flaps
    8.
    发明授权
    Method for monitoring viability of tissue flaps 有权
    监测组织瓣活力的方法

    公开(公告)号：US08622918B1

    公开(公告)日：2014-01-07

    申请号：US12689138

    申请日：2010-01-18

    申请人： Jimmy Jian-min Mao ,  Robert E. Lash

    发明人： Jimmy Jian-min Mao ,  Robert E. Lash

    IPC分类号： A61B5/02

    CPC分类号： A61B5/14551 ,  A61B5/413

    摘要： Methods and apparatus are used to assess the viability of tissue such as flap tissue. According to one aspect of the present invention, a method for assessing the viability of flap tissue includes obtaining an oxygen saturation level associated with a first location on the flap tissue, determining whether the oxygen saturation level is less than a first level, and identifying the first location as having a poor blood supply if the oxygen saturation level is less than the first level.

    摘要翻译： 方法和装置用于评估组织如皮瓣组织的活力。 根据本发明的一个方面，一种用于评估瓣组织活力的方法包括获得与瓣组织上的第一位置相关联的氧饱和度水平，确定氧饱和度水平是否小于第一水平，并且识别 如果氧饱和度水平低于第一水平，则第一位置具有差的血液供应。

    LINEAR ELECTROMECHANICAL DEVICE-BASED ARTIFICIAL MUSCLES, BIO-VALVES AND RELATED APPLICATIONS
    9.
    发明申请
    LINEAR ELECTROMECHANICAL DEVICE-BASED ARTIFICIAL MUSCLES, BIO-VALVES AND RELATED APPLICATIONS 审中-公开
    线性机电装置人造血管，生物阀及相关应用

    公开(公告)号：US20140005785A1

    公开(公告)日：2014-01-02

    申请号：US14026186

    申请日：2013-09-13

    申请人： Orsen LLC

    发明人： Richard J. Massen ,  Luis M. Ortiz

    IPC分类号： A61F2/08

    CPC分类号： A61F2/08 ,  A61B5/037 ,  A61B5/1107 ,  A61B5/205 ,  A61B5/413 ,  A61F2/0036 ,  A61F2/2481 ,  A61F2002/0894 ,  A61F2250/0001 ,  A61M1/1037 ,  A61M1/1046 ,  A61M1/1049 ,  A61M1/1055 ,  A61M1/1068 ,  A61M1/12 ,  A61M1/122 ,  A61N2/02

    摘要： A biological function assist apparatus composed of a linear electronmechanical device or system wrapped in protective coating and controlled by a controller, which also provides power to the electromechanically-based system. The electromechanically-based system can be formed as a mesh using linear motors or linear actuators or a larger electromechanically grid and wrapped around a failing heart. The electromechanical system can be formed in a circle forming an artificial valve (e.g., sphincter). The electromechanically-based system can also operate as a bone-muscle interface, thereby functioning in place of tendons.

    摘要翻译： 一种由线性电子机械装置或包裹在保护涂层中并由控制器控制的系统组成的生物功能辅助装置，其还为基于机电的系统提供电力。 基于机电的系统可以使用线性电动机或线性致动器或更大的机电网格形成为网状物，并缠绕在故障心脏周围。 机电系统可以形成为形成人造瓣膜（例如括约肌）的圆形。 基于机电的系统还可以作为骨 - 肌界面进行操作，从而代替肌腱。