公开(公告)号：US20240131198A1

公开(公告)日：2024-04-25

申请号：US18225564

申请日：2023-07-24

申请人： Davide Brambilla ,  Samuel Babity

发明人： Davide Brambilla ,  Samuel Babity

IPC分类号： A61K49/00 ,  A61M37/00

CPC分类号： A61K49/0032 ,  A61K49/0006 ,  A61K49/0054 ,  A61M37/0015 ,  A61M2037/0061

摘要： The present disclosure relates to ratiometric detection compositions comprising a reference dye and a sensor dye that are PEGylated dyes, and microneedles comprising said compositions. The present disclosure further relates to methods of ratiometric detection/measurement/monitoring of analytes in a subject using the ratiometric detection compositions of the present disclosure.

公开(公告)号：US11752335B1

公开(公告)日：2023-09-12

申请号：US16270211

申请日：2019-02-07

申请人： Mary Kay Inc.

发明人： Shoná Burkes-Henderson ,  Geetha Kalahasti ,  David Gan

IPC分类号： A61N1/36 ,  A61B5/00 ,  A61K38/48 ,  A61Q19/08 ,  A61N1/04 ,  A61K49/00

CPC分类号： A61N1/36014 ,  A61B5/4519 ,  A61K38/4893 ,  A61Q19/08 ,  A61K49/0006 ,  A61N1/0452

摘要： A method for quantitatively assessing muscle contraction and corresponding kits are described. The method can include assessing muscle contraction of a facial muscle by applying an external electrical stimulus to facial skin sufficient to contract a facial muscle, and measuring the contractile activity of the contracted facial muscle. The method can be used to determine the ability of a treatment material to reduce contraction of the facial muscle.

公开(公告)号：US20180305416A1

公开(公告)日：2018-10-25

申请号：US15827151

申请日：2017-11-30

申请人： Aeras ,  Institut National De La Sante Et De La Recherche Medicale (INSERM)

发明人： John Fulkerson ,  Michael Brennan ,  Kamalakannan Velmurugan ,  Camille Locht

IPC分类号： C07K14/35 ,  A61K49/00 ,  A61K39/04 ,  A61K39/00

CPC分类号： C07K14/35 ,  A61K39/04 ,  A61K49/0006 ,  A61K2039/523 ,  A61K2039/53 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/40 ,  C07K2319/90

摘要： Recombinant Mycobacteria (rMyc) which contain sequences encoding a heparin-binding hemagglutinin (HBHA) fission protein are provided, as are methods of making and using the rMyc and the fusion protein. The fusion protein includes an amino terminal mycobacterial antigen Ag85B leader peptide and transcription of the fusion protein is driven by an Ag85B promoter sequence. The recombinant fusion protein is produced in abundance by the rMyc, is post-translationally methylated, and is highly antigenic.

公开(公告)号：US20180272008A1

公开(公告)日：2018-09-27

申请号：US15762260

申请日：2016-09-26

申请人： University of Notre Dame du Lac

发明人： Zihni Basar BILGICER ,  Peter DEAK ,  Tanyel KIZILTEPE BILGICER ,  Jared Francis STEFANICK ,  Jonathan Darryl ASHLEY

IPC分类号： A61K49/00 ,  C12Q1/40

CPC分类号： A61K49/0006 ,  A61K9/0014 ,  A61K9/1271 ,  A61K39/35 ,  A61K47/6911 ,  A61K2039/60 ,  C12Q1/40 ,  C12Y302/01052 ,  G01N33/586 ,  G01N33/6854 ,  G01N33/686 ,  G01N2800/24

摘要： Embodiments of the present disclosure provide a nanoparticle based platform, and nanoallergens for identifying, evaluating and studying allergen mimotopes as multiple copies of a single mimotope or various combinations on the same particle. The nanoparticle is extremely versatile and allows multivalent binding to IgEs specific to a variety of mimotopes, simulating allergen proteins. Nanoparticles can include various molecular ratios of components. For example, the nanoallergens can include about 0.1-40% mimotope-lipid conjugate and about 60-99.9% lipid. The mimotope-lipid conjugate includes a mimotope, a first linker, and lipid molecule. Nanoallergens can be used in in vitro and in vivo applications to identify a specific patient's sensitivity to a set of epitopes and predict a symptomatic clinical response, identify allergen epitopes through blind screening peptide sequences from allergen protein, and in a clinical application similar to a scratch test.

公开(公告)号：US20180243448A1

公开(公告)日：2018-08-30

申请号：US15755127

申请日：2016-08-26

申请人： AlkaliDx, Inc.

发明人： Michael M. SEGAL

IPC分类号： A61K49/00 ,  A61K9/00 ,  A61K31/167 ,  A61K31/245 ,  A61K31/585 ,  A61K31/522 ,  A61B5/16 ,  A61B5/00 ,  A61B5/01

CPC分类号： A61K49/0006 ,  A61B5/0053 ,  A61B5/01 ,  A61B5/1106 ,  A61B5/168 ,  A61B5/4017 ,  A61B5/4821 ,  A61B5/4824 ,  A61B5/483 ,  A61B5/4848 ,  A61C19/08 ,  A61K9/006 ,  A61K9/0063 ,  A61K9/7092 ,  A61K31/167 ,  A61K31/245 ,  A61K31/522 ,  A61K31/585 ,  A61K33/00 ,  A61P23/02 ,  A61K2300/00

摘要： In general, the invention provides kits, devices, and methods for determining the ineffectiveness of an anesthetic, (e.g., lidocaine), using a topical approach that avoids injection. The methods typically employ the placement of aliquots of two different formulations, at least one including an anesthetic, in different locations on a subject. Further embodiments may employ a single formulation including the anesthetic.

公开(公告)号：US09844604B2

公开(公告)日：2017-12-19

申请号：US15019532

申请日：2016-02-09

申请人： Rutgers, The State University of New Jersey

发明人： Maria L. Gennaro

IPC分类号： A61K39/04 ,  G01N33/53 ,  A61K39/02 ,  A61K49/00 ,  C07K14/35 ,  G01N33/569 ,  G01N33/50 ,  A61K38/00 ,  A61K39/00

CPC分类号： A61K49/0006 ,  A61K38/00 ,  A61K39/00 ,  A61K39/04 ,  A61K2039/53 ,  C07K14/35 ,  G01N33/5091 ,  G01N33/5695 ,  G01N2333/35 ,  G01N2333/57 ,  G01N2800/26 ,  Y10S435/863

摘要： The present invention is directed to reagents useful for generating immune responses to Mycobacterium tuberculosis and for diagnosing infection and disease in a subject that has been exposed to M. tuberculosis.

公开(公告)号：US20170008938A1

公开(公告)日：2017-01-12

申请号：US15116338

申请日：2015-02-04

申请人： Bernd Helmut Adam REHM ,  Bryce Malcolm BUDDLE ,  David Neil WEDLOCK

发明人： Bernd Helmut Adam REHM ,  Bryce Malcolm BUDDLE ,  David Neil WEDLOCK

IPC分类号： C07K14/35 ,  G01N33/68 ,  A61K49/00

CPC分类号： C07K14/35 ,  A61K38/44 ,  A61K38/45 ,  A61K38/51 ,  A61K39/04 ,  A61K49/0006 ,  C07K2319/00 ,  C12N9/1025 ,  G01N33/6866 ,  G01N33/6893 ,  G01N2333/35 ,  G01N2333/57 ,  G01N2800/26

摘要： The present invention relates to polymer particles and uses thereof. In particular the present invention relates to functionalised polymer particles, processes of production and uses thereof in the diagnosis, treatment or prevention of tuberculosis.

摘要翻译： 本发明涉及聚合物颗粒及其用途。 特别地，本发明涉及官能化聚合物颗粒，其生产方法及其在诊断，治疗或预防结核病中的用途。

公开(公告)号：US20160213791A1

公开(公告)日：2016-07-28

申请号：US14913733

申请日：2014-08-22

申请人： PREGTECH PTY LTD

发明人： Nicolas Hans VOELKER

IPC分类号： A61K49/00

CPC分类号： A61K49/0006 ,  A61B5/0082 ,  A61B5/4343 ,  A61B10/0012 ,  A61D17/002 ,  A61D17/006 ,  A61K49/0004 ,  G01N33/54373 ,  G01N33/689 ,  G01N33/76 ,  G01N2333/59

摘要： The present disclosure relates to methods for detecting a biological parameter and to sensors for detecting a biological parameter. Certain embodiments of the present disclosure provide a method of detecting a biological parameter in a subject, the method comprising: implanting a sensor into the subject, wherein the sensor comprises an optical reflectance property between 400 and 1200 nm which is responsive to the biological parameter; detecting an optical reflectance property between 400 and 1200 nm through the skin of the subject from the implanted sensor, and using the optical reflectance property to detect the biological parameter.

摘要翻译： 本公开涉及用于检测生物参数的方法和用于检测生物参数的传感器。 本公开的某些实施例提供了一种检测受试者的生物学参数的方法，所述方法包括：将传感器植入到所述受试者中，其中所述传感器包括响应于所述生物学参数的400至1200nm的光学反射特性; 通过来自植入的传感器的被检体的皮肤检测400〜1200nm的光反射率，使用光反射率检测生物参数。

公开(公告)号：US20160169888A1

公开(公告)日：2016-06-16

申请号：US15019532

申请日：2016-02-09

申请人： Rutgers, The State University of New Jersey

发明人： Maria L. Gennaro

IPC分类号： G01N33/569

CPC分类号： A61K49/0006 ,  A61K38/00 ,  A61K39/00 ,  A61K39/04 ,  A61K2039/53 ,  C07K14/35 ,  G01N33/5091 ,  G01N33/5695 ,  G01N2333/35 ,  G01N2333/57 ,  G01N2800/26 ,  Y10S435/863

摘要： The present invention is directed to reagents useful for generating immune responses to Mycobacterium tuberculosis and for diagnosing infection and disease in a subject that has been exposed to M. tuberculosis.

公开(公告)号：US20160074291A1

公开(公告)日：2016-03-17

申请号：US14853051

申请日：2015-09-14

申请人： The Procter & Gamble Company

发明人： Makio TAMURA ,  Rosemarie OSBORNE ,  Heather Lynn ROCCHETTA

IPC分类号： A61K8/06 ,  A61K49/00 ,  A61Q19/08

CPC分类号： A61K31/202 ,  A23L29/10 ,  A23L33/12 ,  A23L33/30 ,  A23L33/40 ,  A23V2002/00 ,  A61K8/062 ,  A61K8/31 ,  A61K8/342 ,  A61K8/345 ,  A61K8/368 ,  A61K8/37 ,  A61K8/585 ,  A61K8/64 ,  A61K8/67 ,  A61K8/97 ,  A61K9/0029 ,  A61K9/107 ,  A61K35/60 ,  A61K49/0006 ,  A61K2800/20 ,  A61K2800/48 ,  A61K2800/884 ,  A61Q19/08

摘要： Multi-step cosmetic regimens are provided to improve the appearance of aging skin. A target portion of skin that exhibits a sign of skin aging is identified. A first formulation is topically applied, comprising at least one active possessing an ability to transcriptionally up-regulate an eigengene derived from a genetic co-expression module for one or more biological themes associated with skin cleansing and/or skin detoxification, and/or skin hydration to the target portion of skin. A second formulation is also topically applied, comprising at least one active possessing an ability to transcriptionally up-regulate an eigengene derived from a co-expression module for one or more biological themes associated with skin repair and/or rebuilding to the target portion of skin.

摘要翻译： 提供多步化妆品方案以改善皮肤老化的外观。 鉴定出皮肤老化迹象的皮肤目标部分。 局部施用第一制剂，其包含至少一种活性物质，其具有转录上调来自遗传共表达模块的一种或多种与皮肤清洁和/或皮肤解毒有关的生物学主题的皮肤和/或皮肤的能力 水合到皮肤的目标部分。 还局部施用第二种制剂，其包含至少一种活性物质，其具有转录上调来自共表达模块的一种或多种与皮肤修复相关的生物学主题和/或重建皮肤目标部分的共同表达模块的eigengene 。