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公开(公告)号：US20160074303A1
公开(公告)日：2016-03-17
申请号：US14857028
申请日：2015-09-17
CPC分类号： A61K8/64 , A61K2800/47 , A61K2800/78 , A61K2800/87 , A61Q19/00 , A61Q19/008 , A61Q19/08 , B65B63/00
摘要： A method of making a skin care product that includes a skin care composition containing a skin care active with a diamagnetic susceptibility of between about −400 and −600, constructing an applicator for applying the skin care composition to a target portion of skin, and packaging the composition and applicator for retail sale. The applicator includes a magnetic array tailored to enhance penetration of the skin care active into skin. The magnetic array may be unidirectional magnetic array or a bi-directional magnetic array.
摘要翻译： 一种制备护肤品的方法，其包括含有约-400至-600之间的抗磁化率的皮肤护理活性物质的护肤组合物，构建用于将皮肤护理组合物施用于皮肤的目标部分的涂布器，以及包装 用于零售的组合和涂抹器。 涂抹器包括定制的磁性阵列，以增强皮肤护理活性物质渗入皮肤。 磁性阵列可以是单向磁阵列或双向磁阵列。
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公开(公告)号：US20150292017A1
公开(公告)日：2015-10-15
申请号：US14749717
申请日：2015-06-25
发明人： Robert Lloyd Binder , Robert Scott Youngquist , Jun XU , Kenton Duane JUHLIN , Rosemarie OSBORNE , Scott Michael HARTMAN
CPC分类号： C12Q1/6883 , C12Q2600/148 , C12Q2600/158 , G06F19/18 , G06F19/20 , G06F19/28
摘要： A system for identifying connections between a cosmetic agent and at least one gene associated with a skin aging condition. The system includes a computer readable medium having stored thereon a plurality of instances and a skin aging gene expression signature. Each instance comprises an ordered list of identifiers representing a plurality of differentially expressed genes generated as a result of contact between the cosmetic agent and a human fibroblast cell or a human keratinocyte cell. The computing device includes computer-readable instructions for accessing the plurality of instances and the skin aging gene expression signature stored on the computer readable medium, comparing each of the instances to the skin aging gene expression signature, and assigning a connectivity score to each of the instances based on the comparison.
摘要翻译： 一种用于鉴定美容剂与至少一种与皮肤老化状况相关的基因之间的连接的系统。 该系统包括其上存储有多个实例和皮肤老化基因表达特征的计算机可读介质。 每个实例包括代表由化妆剂与人成纤维细胞或人角质形成细胞之间接触而产生的多个差异表达基因的标识符的有序列表。 计算设备包括用于访问存储在计算机可读介质上的多个实例和皮肤老化基因表达签名的计算机可读指令，将每个实例与皮肤老化基因表达签名进行比较，并将连接性分数分配给每个 基于比较的实例。
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公开(公告)号：US20170157030A1
公开(公告)日：2017-06-08
申请号：US15368844
申请日：2016-12-05
摘要： Personal care compositions that include bioactive ingredients derived from achachariu and methods of making the same. The bioactive compositions (ingredients) of the present invention may be free of or substantially free of benzophenones and/or protein, and may exhibit anti-inflammatory, anti-oxidant, anti-aging, and/or anti-protein loss properties. The achachariu ingredient may be in the form of a serum fraction and/or an extract. The personal care compositions are formulated for topical use on skin and/or hair.
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公开(公告)号：US20170020804A1
公开(公告)日：2017-01-26
申请号：US15287092
申请日：2016-10-06
CPC分类号： A61K8/97 , A61K8/062 , A61K8/368 , A61K8/41 , A61K8/675 , A61K8/737 , A61K2800/30 , A61K2800/5922 , A61K2800/596 , A61Q17/04 , A61Q19/08
摘要： A stable skin care composition for improving the appearance of aging skin is disclosed. The stable skin care composition that includes an effective amount of artichoke leaf extract and carob fruit extract that, in combination, can provide a synergistic increase in the up-regulation of key epidermal-associated genes related to skin aging, and thereby provide an improvement in the appearance of aging skin. The stable skin care composition is substantially free of complexing agents and includes sunscreen agents to help photostablize the composition.
摘要翻译： 公开了一种用于改善皮肤老化外观的稳定的护肤组合物。 稳定的护肤组合物，其包含有效量的朝鲜蓟叶提取物和角果果提取物，其组合可以提供与皮肤老化相关的关键表皮相关基因的上调的协同增加，从而提供改善 皮肤老化的外观。 稳定的皮肤护理组合物基本上不含络合剂，并且包括帮助光固化组合物的防晒剂。
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公开(公告)号：US20170172886A1
公开(公告)日：2017-06-22
申请号：US15448791
申请日：2017-03-03
发明人： Rosemarie OSBORNE
IPC分类号： A61K8/64 , A61K8/67 , A61K8/29 , A61K8/891 , A61Q5/00 , A61Q5/12 , A61Q19/00 , A61K8/06 , A61K8/04 , A61K8/97 , A61K8/49 , A61K8/60 , A61K8/41 , A61K8/63 , A61K8/34 , A61K8/37
CPC分类号： A61K8/64 , A61K8/046 , A61K8/062 , A61K8/064 , A61K8/29 , A61K8/347 , A61K8/37 , A61K8/41 , A61K8/498 , A61K8/60 , A61K8/63 , A61K8/67 , A61K8/675 , A61K8/676 , A61K8/678 , A61K8/891 , A61K8/97 , A61K2800/10 , A61K2800/5922 , A61Q5/00 , A61Q5/006 , A61Q5/02 , A61Q5/12 , A61Q17/04 , A61Q19/00 , A61Q19/02
摘要： Personal care compositions comprising a dipeptide and methods of using such compositions to treat the condition of keratinous tissue. The C terminal amino acid of said dipeptide is threonine. The personal care composition can be applied topically, ingested orally, injected, or used as part of a combined treatment regimen.
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6.发明申请公开(公告)号：US20170152556A1
公开(公告)日：2017-06-01
申请号：US15176465
申请日：2016-06-08
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , A61K2800/522 , A61Q17/04 , A61Q19/00 , A61Q19/08 , C12Q1/6883 , C12Q2600/106 , C12Q2600/148 , C12Q2600/158 , G01N33/5023 , G01N33/5044 , G01N33/5088
摘要： Provided are novel methods useful for the screening and generation of potential cosmetic agents that work in synchronization with the circadian rhythm of the skin for the treatment of aged skin. These novel methods allow for identification of new cosmetic agents that can be screened for their selective treatment of skin aging conditions and for the specific targeting of particular skin cell types, such as keratinocytes or fibroblasts.
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公开(公告)号：US20150023893A1
公开(公告)日：2015-01-22
申请号：US14302669
申请日：2014-06-12
摘要： A method of improving the appearance of aging skin that includes applying an effective amount of artichoke leaf extract and vitamin B3 compound in combination to a target area of skin that exhibits a sign of aging skin, and compositions that include an effective amount of artichoke leaf extract and vitamin B3 compound in combination. The composition is applied for a period of time sufficient for the combination of vitamin B3 compound and niacinamide to improve the appearance of the aging skin.
摘要翻译： 一种改善老化皮肤外观的方法，其包括将有效量的朝鲜蓟叶提取物和维生素B3化合物组合施用于显示皮肤老化迹象的皮肤目标区域，以及包含有效量的朝鲜蓟叶提取物 和维生素B3化合物组合。 将组合物施用足以使维生素B3化合物和烟酰胺组合的时间足以改善皮肤老化的外观。
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公开(公告)号：US20170157029A1
公开(公告)日：2017-06-08
申请号：US15368832
申请日：2016-12-05
IPC分类号： A61K8/97 , A61Q5/12 , A61Q9/02 , A61K8/368 , A61K8/44 , A61K8/23 , A61K8/36 , A61Q5/02 , A61K8/34
CPC分类号： A61K8/97 , A61K8/23 , A61K8/345 , A61K8/36 , A61K8/368 , A61K8/44 , A61K8/922 , A61K2800/30 , A61K2800/524 , A61K2800/782 , A61Q5/02 , A61Q5/12 , A61Q9/02 , A61Q19/008
摘要： A method of regulating mammalian keratinous tissue that includes applying a safe and effective amount of achachariu to a target portion of keratinous tissue. The achachariu can be in the form of a bioactive ingredient that exhibits anti-inflammatory, anti-oxidant, anti-aging, and/or anti-protein loss properties, and which is free or substantially free of benzophenones and/or protein. The achachariu ingredient may be a serum fraction and/or an extract, and may be incorporated into a personal care composition formulated for topical use on skin and/or hair.
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公开(公告)号：US20160074291A1
公开(公告)日：2016-03-17
申请号：US14853051
申请日：2015-09-14
CPC分类号： A61K31/202 , A23L29/10 , A23L33/12 , A23L33/30 , A23L33/40 , A23V2002/00 , A61K8/062 , A61K8/31 , A61K8/342 , A61K8/345 , A61K8/368 , A61K8/37 , A61K8/585 , A61K8/64 , A61K8/67 , A61K8/97 , A61K9/0029 , A61K9/107 , A61K35/60 , A61K49/0006 , A61K2800/20 , A61K2800/48 , A61K2800/884 , A61Q19/08
摘要： Multi-step cosmetic regimens are provided to improve the appearance of aging skin. A target portion of skin that exhibits a sign of skin aging is identified. A first formulation is topically applied, comprising at least one active possessing an ability to transcriptionally up-regulate an eigengene derived from a genetic co-expression module for one or more biological themes associated with skin cleansing and/or skin detoxification, and/or skin hydration to the target portion of skin. A second formulation is also topically applied, comprising at least one active possessing an ability to transcriptionally up-regulate an eigengene derived from a co-expression module for one or more biological themes associated with skin repair and/or rebuilding to the target portion of skin.
摘要翻译： 提供多步化妆品方案以改善皮肤老化的外观。 鉴定出皮肤老化迹象的皮肤目标部分。 局部施用第一制剂，其包含至少一种活性物质，其具有转录上调来自遗传共表达模块的一种或多种与皮肤清洁和/或皮肤解毒有关的生物学主题的皮肤和/或皮肤的能力 水合到皮肤的目标部分。 还局部施用第二种制剂，其包含至少一种活性物质，其具有转录上调来自共表达模块的一种或多种与皮肤修复相关的生物学主题和/或重建皮肤目标部分的共同表达模块的eigengene 。
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公开(公告)号：US20150157557A1
公开(公告)日：2015-06-11
申请号：US14618080
申请日：2015-02-10
CPC分类号： A61K8/97 , A61K8/922 , A61K2800/5922 , A61Q17/04 , A61Q19/08
摘要： A method of improving the appearance of aging skin that includes applying an effective amount of artichoke leaf extract and olive oil extract in combination to a target area of skin that exhibits a sign of aging skin, and compositions that include an effective amount of artichoke leaf extract and olive oil extract in combination. The composition is applied for a period of time sufficient to improve the appearance of the aging skin.
摘要翻译： 一种改善老化皮肤外观的方法，其包括将有效量的朝鲜蓟叶提取物和橄榄油提取物组合施用于显示皮肤老化症状的皮肤的目标区域，以及包含有效量的朝鲜蓟叶提取物 和橄榄油提取物组合。 施用组合物足以改善皮肤老化的外观的时间。
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