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公开(公告)号：US20180258165A1
公开(公告)日：2018-09-13
申请号：US15896309
申请日：2018-02-14
发明人： Annemarie Honegger , Titus Kretzschmar , Simone Schmitt , Abdijapar Shamshiev , Stefanie Grabulovski
CPC分类号： C07K16/245 , C07K2317/24 , C07K2317/33 , C07K2317/35 , C07K2317/41 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/76 , C07K2317/94 , G01N33/6869 , G01N2333/545
摘要： The present invention relates to anti-IL-1 beta antibodies and in particular to monovalent high potency IL-1 beta-binding antibody fragments being highly stable. Such antibodies can be used in the treatment of inflammatory and other diseases as well as in diagnostics. Also provided are related nucleic acids, vectors, cells, and compositions.
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公开(公告)号：US20180038871A1
公开(公告)日：2018-02-08
申请号：US15683487
申请日：2017-08-22
IPC分类号： G01N33/68
CPC分类号： G01N33/689 , G01N33/6869 , G01N2333/54 , G01N2333/5428 , G01N2333/5437 , G01N2333/545 , G01N2800/368
摘要： The invention relates to biomarkers associated with preterm delivery. More specifically, the invention provides methods of measuring biomarkers found in women that are at risk for preterm delivery.
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公开(公告)号：US09840558B2
公开(公告)日：2017-12-12
申请号：US14877964
申请日：2015-10-08
申请人： XBiotech, Inc.
发明人： John Simard
IPC分类号： C12N5/071 , C07K16/24 , C12N5/09 , G01N33/68 , C07K14/545 , C12N5/07 , C12N15/13 , A61K39/395 , C07K14/54 , A61K39/00
CPC分类号： C07K16/245 , A61K39/3955 , A61K2039/55527 , C07K14/5412 , C07K14/545 , C07K16/24 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N5/069 , C12N5/0693 , C12N2330/50 , G01N33/6863 , G01N33/6869 , G01N2333/545
摘要： Fully human monoclonal Abs includes (i) an antigen-binding variable region that exhibits very high binding affinity for IL-1α and (ii) a constant region that is effective at both activating the complement system though C1q binding and binding to several different Fc receptors.
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公开(公告)号：US20170051054A1
公开(公告)日：2017-02-23
申请号：US15202982
申请日：2016-07-06
发明人： Stefanie GRABULOVSKI , Titus KRETZSCHMAR , Simone SCHMITT , Abdijapar SHAMSHIEV , Thorsten Alexander SCHAFER
IPC分类号： C07K16/24 , A61K39/395
CPC分类号： C07K16/245 , A61K39/3955 , A61K2039/505 , C07K2317/24 , C07K2317/35 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/94 , G01N33/6869 , G01N2333/545
摘要： The present invention relates to anti-IL-1 beta binding members and in particular to monovalent high potency IL-1 beta-binding antibody fragments being highly stable and soluble. Such binding members may be used in the treatment of inflammatory and other diseases as well as in diagnostics. Also provided are related nucleic acids, vectors, cells, and compositions.
摘要翻译： 本发明涉及抗IL-1β结合成员，特别涉及高稳定性和可溶性的单价高效IL-1β结合抗体片段。 这样的结合成员可用于治疗炎症和其它疾病以及诊断。 还提供了相关的核酸，载体，细胞和组合物。
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公开(公告)号：US20170049673A1
公开(公告)日：2017-02-23
申请号：US15254426
申请日：2016-09-01
发明人： Karl Shiqing WEI
CPC分类号： A61K8/31 , A61K8/03 , A61K8/96 , A61K49/0006 , A61K2800/87 , A61Q19/10 , G01N33/5088 , G01N33/62 , G01N33/6812 , G01N33/6827 , G01N33/6869 , G01N33/6881 , G01N33/92 , G01N2333/4742 , G01N2333/545 , G01N2500/04 , G01N2800/20 , G06Q30/0201
摘要： A skin treatment regimen for delivery of a rinse-off personal skin care composition is provided. The rinse-off personal skin care composition includes varying ratios of a lathering agent to a hydrophobic benefit agent. The rinse-off personal skin care composition can be applied to skin of a user in phases over and/or in a treatment cycle. Each of the phases of the treatment cycle can include a ratio of the varying ratios that can be different such as higher or lower than a ratio of adjacent phase.
摘要翻译： 提供用于递送漂洗个人护肤组合物的皮肤治疗方案。 漂洗的个人护肤组合物包括起泡剂与疏水有益剂的不同比例。 漂洗的个人护肤组合物可以在治疗周期和/或治疗周期中分阶段地应用于使用者的皮肤。 处理循环的每个阶段可以包括可以不同的变化比例的比例，例如高于或低于相邻相的比率。
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公开(公告)号：US09447183B2
公开(公告)日：2016-09-20
申请号：US14107988
申请日：2013-12-16
申请人： AbbVie, Inc.
IPC分类号： C12P21/08 , A61K38/00 , C07K14/545 , C07K16/24 , A61K47/48 , A61K45/06 , G01N33/68 , A61K39/395 , A61K9/00
CPC分类号： C07K16/245 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K9/0053 , A61K9/006 , A61K9/007 , A61K9/0085 , A61K38/00 , A61K39/3955 , A61K45/06 , A61K47/6879 , C07K14/545 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , G01N33/6869 , G01N2333/545 , G01N2800/00 , Y02A50/385 , Y02A50/401 , Y02A50/409 , Y02A50/412 , Y02A50/463 , Y02A50/478 , Y02A50/481
摘要： Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.
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公开(公告)号：US09441038B2
公开(公告)日：2016-09-13
申请号：US14109606
申请日：2013-12-17
申请人： AbbVie, Inc.
IPC分类号： A61K38/00 , C07K14/545 , C07K16/24 , A61K39/395 , A61K47/48 , A61K45/06 , G01N33/68 , A61K9/00
CPC分类号： C07K16/245 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K9/0053 , A61K9/006 , A61K9/007 , A61K9/0085 , A61K38/00 , A61K39/3955 , A61K45/06 , A61K47/6879 , C07K14/545 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , G01N33/6869 , G01N2333/545 , G01N2800/00 , Y02A50/385 , Y02A50/401 , Y02A50/409 , Y02A50/412 , Y02A50/463 , Y02A50/478 , Y02A50/481
摘要： Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.
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公开(公告)号：US20160231333A1
公开(公告)日：2016-08-11
申请号：US15022041
申请日：2014-09-17
发明人： Jayne Sutherland
CPC分类号： G01N33/6893 , A61K45/06 , C12Q1/6883 , G01N33/5695 , G01N33/6863 , G01N2333/485 , G01N2333/50 , G01N2333/5428 , G01N2333/5437 , G01N2333/5443 , G01N2333/545 , G01N2333/57 , G01N2800/26
摘要： In one aspect, provided herein is a method for detecting tuberculosis in a subject, comprising (a) determining a level of one or more host immune system biomarkers in a sputum sample obtained from the subject; and (b) comparing the levels of the biomarkers in the sputum sample to one or more reference values; wherein the levels of the biomarkers in the sputum sample compared to the reference values are indicative of the presence or absence of tuberculosis in the subject.
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公开(公告)号：US20160185845A1
公开(公告)日：2016-06-30
申请号：US14460001
申请日：2014-08-14
IPC分类号： C07K16/22 , C12N15/113 , G01N33/68 , A61K31/4409 , C12Q1/68 , A61K38/18 , A61K31/551
CPC分类号： C07K16/22 , A61K31/4409 , A61K31/551 , A61K38/1891 , A61K49/0008 , C07K14/515 , C07K2317/76 , C12N15/113 , C12N15/1138 , C12N2310/14 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N33/6893 , G01N2333/485 , G01N2333/515 , G01N2333/525 , G01N2333/5412 , G01N2333/545 , G01N2333/9129 , G01N2800/32
摘要： Disclosed herein are methods for treating a vascular leak disorder, hypotension, or a procoagulant state using angiopoietin-2 (Ang-2) antagonist compounds. Also disclosed are methods for treating a vascular leak disorder associated with high dose IL-2 therapy using angiopoietin-2 antagonist compounds. Methods for diagnosing and monitoring vascular leak disorders, hypotension, or a procoagulant state that include the measurement of Ang-2 polypeptide or nucleic acid levels are also disclosed. Methods for inducing a vascular leak using an Ang-2 agonist are also disclosed.
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10.发明申请公开(公告)号：US20150344590A1
公开(公告)日：2015-12-03
申请号：US14713251
申请日：2015-05-15
申请人： ABBVIE INC.
发明人： Tariq Ghayur , JiJie Gu , Maria Harris , Carrie Goodreau , Sonal Saluja
CPC分类号： C07K16/468 , A61K39/3955 , A61K45/06 , A61K47/6845 , A61K47/6879 , C07K16/244 , C07K16/245 , C07K2317/31 , C07K2317/626 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00 , G01N33/6869 , G01N2333/54 , G01N2333/545
摘要： Engineered multivalent and multispecific binding proteins that bind IL-1β and/or IL-17 are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.
摘要翻译： 结合IL-1和bgr的工程化多价和多特异性结合蛋白 和/或IL-17，以及在预防，诊断和/或治疗疾病中的制备和用途的方法。
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