公开(公告)号：US3748332A

公开(公告)日：1973-07-24

申请号：US3748332D

申请日：1970-07-07

申请人： JOHNSON MATTHEY CO LTD

发明人： WILKINSON G

IPC分类号： C07C5/02 ,  B01J31/00 ,  B01J31/04 ,  B01J31/16 ,  B01J31/18 ,  B01J31/22 ,  B01J31/24 ,  C07B31/00 ,  C07B35/02 ,  C07B61/00 ,  C07C1/00 ,  C07C5/03 ,  C07C5/05 ,  C07C5/08 ,  C07C5/09 ,  C07C45/50 ,  C07C51/12 ,  C07C51/41 ,  C07C53/10 ,  C07C67/00 ,  C07D213/18 ,  C07F1/00 ,  C07F9/02 ,  C07F11/00 ,  C07F15/00 ,  C08F4/64

CPC分类号： C07F15/0053 ,  B01J31/181 ,  B01J31/2239 ,  B01J31/2404 ,  B01J2231/645 ,  B01J2531/0219 ,  B01J2531/821 ,  C07C5/03 ,  C07C5/05 ,  C07C5/08 ,  C07C5/09 ,  C07C45/50 ,  C07C51/12 ,  C07C51/412 ,  C07C53/10 ,  C07C2531/04 ,  C07C2531/22 ,  C07C2531/24 ,  C07F1/005 ,  C07F9/02 ,  C07F11/005 ,  C07F15/0013 ,  Y10S585/906 ,  C07C53/08 ,  C07C47/02

摘要： RUTHENIUM (II) CARBOXYLATES OF THE GENERAL FORMULA RU2(OCOR)4, AND PROCESSES FOR PREPARING THEM BY HEATING TOGETHER A SOLUBLE SALT OF RUTHENIUM, A SOLUBLE SALT OF CARBOXYLATE AND THE CORRESPONDING CARBOXYLIC ACID.

公开(公告)号：US11364449B2

公开(公告)日：2022-06-21

申请号：US17374962

申请日：2021-07-13

申请人： Energy Integration, Inc.

发明人： Lynn Allen Crawford ,  William Bryan Schafer, III

IPC分类号： B01D1/28 ,  B01D1/26 ,  B01D3/14 ,  B01D3/00 ,  B01D1/00 ,  B01D9/00 ,  C07B31/00 ,  C07B33/00 ,  C07B35/02 ,  C07B35/04 ,  C07B35/08 ,  C07B37/08 ,  C07B37/10 ,  C10B55/00 ,  C10G7/00 ,  C10G9/00 ,  C10G11/00 ,  C10G31/06 ,  C10G45/00 ,  C10G47/00 ,  C10G49/00 ,  C10G50/00 ,  C10G51/00 ,  C10G53/00 ,  C10G55/00 ,  C10G57/00 ,  C10G59/00 ,  C10G61/00 ,  C10G63/00 ,  C10G65/00 ,  C10G67/00 ,  C10G69/00

摘要： The present invention utilizes mechanical vapor compression and/or thermal vapor compression integrating compression loops across multiple process stages. A sequential network of compressors is utilized to increase the pressure and condensing temperature of the vapors within each process stage, as intra-vapor flow, and branching between process stages, as inter-vapor flow. Because the vapors available are shared among and between compressor stages, the number of compressors can be reduced, improving economics. Balancing vapor mass flow through incremental compressor stages which traverse multiple process stages by splitting vapors between compressor stages enables the overall vapor-compression system to be tailored to individual process energy requirements and to accommodate dynamic fluctuations in process conditions.

公开(公告)号：US10954185B2

公开(公告)日：2021-03-23

申请号：US15766454

申请日：2016-10-07

申请人： Council of Scientific & Industrial Research

发明人： Kannan Srinivasan ,  Sreedhar Gundekari

IPC分类号： C07C209/72 ,  C07C29/141 ,  C07C29/145 ,  C07C29/20 ,  C07C41/20 ,  C07C5/03 ,  C07C51/36 ,  C07C29/19 ,  C07B35/02 ,  C07D307/44 ,  C07D307/33 ,  B01J23/46

摘要： The invention discloses a process for hydrogenation (alkenes, carbonyl compounds and aromatics) and hydrodeoxygenation (methoxy phenols) of organic molecules using hydrous ruthenium oxide (HRO) and its supported form as a recyclable heterogeneous catalyst in aqueous medium with good yield of desired products (70-100%) under mild reaction conditions.

公开(公告)号：US10899760B2

公开(公告)日：2021-01-26

申请号：US16745418

申请日：2020-01-17

申请人： Principia Biopharma, Inc.

发明人： Jiang Zhu ,  Mohammad Masjedizadeh

IPC分类号： C07D471/04 ,  A61P35/00 ,  C07B35/02 ,  C07B35/06 ,  C07B39/00 ,  C07B43/04 ,  C07B43/06 ,  C07B45/04

摘要： Disclosed herein are processes for preparing 8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one and FGFR inhibitor, as well as polymorphs and/or salt forms thereof.

公开(公告)号：US10538518B2

公开(公告)日：2020-01-21

申请号：US15748212

申请日：2016-08-10

申请人： Principia Biopharma, Inc.

发明人： Jiang Zhu ,  Mohammad Masjedizadeh

IPC分类号： C07D471/04 ,  A61P35/00 ,  C07B35/02 ,  C07B35/06 ,  C07B39/00 ,  C07B43/04 ,  C07B43/06 ,  C07B45/04

摘要： To an appropriate reactor equipped with mechanical stirrer was charged acetic acid (12 L), tert-butyl 4-(3-(6-(3,5-dimethoxyphenyl)-2-(methylthio)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)propyl)piperazine-1-carboxylate (2000 g) and triethylamine (639 g, 2.3 eq.). Internal temperature was adjusted to approximately 20° C. and N-chlorosuccinimide (1651 g, 4.5 eq.) was added at 20-30° C. Reaction was stirred for 2 hours. Ethyl acetate (30 L) was added. 5% aqueous NaCl solution (20 L) was added. The organic layer was separated and the aqueous layer was extracted with EtOAc. The combined organic layers were washed with 30% aqueous potassium carbonate solution (14 L). The organic layer was concentrated to ˜12 L and used for next step directly.

公开(公告)号：US20190210940A1

公开(公告)日：2019-07-11

申请号：US16325676

申请日：2017-08-16

申请人： Organofuel Sweden AB

发明人： Armando Córdova ,  Samson Afewerki

IPC分类号： C07B35/02 ,  C07C45/29 ,  C07C45/30 ,  C07C45/62 ,  C07C45/72

CPC分类号： C07B35/02 ,  C07B31/00 ,  C07B33/00 ,  C07B35/04 ,  C07C45/29 ,  C07C45/294 ,  C07C45/30 ,  C07C45/62 ,  C07C45/72 ,  C07D319/06 ,  Y02P20/584 ,  C07C47/02 ,  C07C47/21 ,  C07C47/11

摘要： Embodiments herein concerns the eco-friendly conversion of simple alcohols to linear or branched functionalized alkanes, by integrated catalysis. The alcohols are firstlyoxidized either chemically or enzymatically to the corresponding aldehydes or ketones, followed by aldol condensations using a catalyst to give the corresponding enals or enones. The enals or enones are subsequently and selectively hydrogenated using a recyclable heterogeneous metal catalyst, organocatalyst or an enzyme to provide linear or branched functionalized alkanes with an aldehyde, keto- or alcohol functionality. The process is also iterative and can be further extended by repeating the above integrated catalysis for producing long-chain functionalized alkanes from simple alcohols.

公开(公告)号：US10047019B2

公开(公告)日：2018-08-14

申请号：US14651505

申请日：2013-12-18

申请人： DSM IP ASSETS B.V.

发明人： Jonathan Alan Medlock ,  Gerardus Karel Maria Verzijl ,  Edwin Gerard Ijpeij ,  Andreas Hendrikus Maria De Vries

IPC分类号： C07C45/62 ,  C07B35/02 ,  C07D311/72 ,  C07B53/00

摘要： The present invention relates to a process of the asymmetric hydrogenation of an unsaturated ketone or aldehyde by molecular hydrogen in the presence of at least one chiral iridium complex and in the presence of at least one additive and a halogenated alcohol. This process yields chiral compounds in a very efficient way and is very advantageous in that the amount of iridium complex can be remarkably reduced.

公开(公告)号：US20180215714A1

公开(公告)日：2018-08-02

申请号：US15505760

申请日：2015-08-20

申请人： G. Pratap REDDY

发明人： G. Pratap REDDY ,  Venkataiah SUNKU ,  Sunkaraneni Suresh BABU

IPC分类号： C07D215/26 ,  C07C45/46 ,  C07B35/02 ,  C07B41/06

CPC分类号： C07D215/26 ,  C07B35/02 ,  C07B41/06 ,  C07C17/16 ,  C07C17/354 ,  C07C45/46 ,  Y02P20/55 ,  C07C49/80 ,  C07C23/18

摘要： The present invention relates to a process for preparing indacaterol or salts thereof. The process comprises of forming compound of Formula 1 by reacting compound of Formula 2 and compound of Formula 3 in the presence of a solvent to Form compound of Formula 4, which on removal of the protecting groups forms compound of Formula 1.

公开(公告)号：US09676622B2

公开(公告)日：2017-06-13

申请号：US14459673

申请日：2014-08-14

申请人： Shiono Chemical Co., Ltd.

发明人： Hironao Sajiki ,  Yasunari Monguchi ,  Yoshinari Sawama ,  Shinichi Kondo

IPC分类号： C01B3/10 ,  C01B3/08 ,  C01B4/00 ,  C07B31/00 ,  C07B35/02 ,  C07B35/06 ,  C07B59/00 ,  C07C1/26 ,  C07C5/09 ,  C07C5/10 ,  C07C29/143 ,  C07C29/17 ,  C07C41/20 ,  C07C41/24 ,  C07C41/26 ,  C07C45/61 ,  C07C209/36 ,  C07C213/02 ,  C07C221/00

CPC分类号： C01B3/10 ,  C01B3/08 ,  C01B4/00 ,  C01B2203/0277 ,  C01B2203/1047 ,  C01B2203/1064 ,  C07B31/00 ,  C07B35/02 ,  C07B35/06 ,  C07B59/00 ,  C07B2200/05 ,  C07C1/26 ,  C07C5/09 ,  C07C5/10 ,  C07C29/143 ,  C07C29/17 ,  C07C41/20 ,  C07C41/24 ,  C07C41/26 ,  C07C45/61 ,  C07C209/36 ,  C07C213/02 ,  C07C221/00 ,  C07C2523/745 ,  C07C2601/14 ,  Y02E60/364 ,  C07C215/68 ,  C07C211/58 ,  C07C217/84 ,  C07C225/22 ,  C07C33/20 ,  C07C43/2055 ,  C07C33/22 ,  C07C43/205 ,  C07C43/23 ,  C07C49/807 ,  C07C15/18 ,  C07C13/28 ,  C07C15/24 ,  C07C15/52 ,  C07C9/15

摘要： An object is to provide a process for providing hydrogen or heavy hydrogens conveniently without the necessity of large-scale equipment and a process capable of performing hydrogenation (protiation, deuteration or tritiation) reaction conveniently without the use of an expensive reagent and a special catalyst. The production process includes a process for producing hydrogen or heavy hydrogens, containing subjecting water or heavy water to mechanochemical reaction in the presence of a catalyst metal, and a process for producing a hydrogenated (protiated, deuterated or tritiated) organic compound, containing subjecting an organic compound and water or heavy water to mechanochemical reaction in the presence of a catalyst metal.

公开(公告)号：US09561989B2

公开(公告)日：2017-02-07

申请号：US14652562

申请日：2013-12-18

申请人： DSM IP ASSETS B.V.

发明人： Werner Bonrath ,  Thomas Netscher ,  Jonathan Alan Medlock ,  Gerardus Karel Maria Verzijl ,  Andreas Hendrikus Maria De Vries

IPC分类号： C07D507/02 ,  C07B35/02 ,  C07D317/12 ,  C07C41/48 ,  C07B53/00 ,  C07D311/72 ,  C07D319/06 ,  B01J31/18 ,  C07C41/56 ,  C07C41/58

CPC分类号： C07B35/02 ,  B01J31/189 ,  B01J2231/34 ,  B01J2531/827 ,  C07B53/00 ,  C07B2200/07 ,  C07B2200/09 ,  C07C41/48 ,  C07C41/56 ,  C07C41/58 ,  C07D311/72 ,  C07D317/12 ,  C07D319/06 ,  C07C43/303 ,  C07C43/313

摘要： The present invention relates to a process of the asymmetric hydrogenation of a ketal of an unsaturated ketone or an acetal of an unsaturated aldehyde by molecular hydrogen in the presence of at least one chiral iridium complex. This process yields chiral compounds in a very efficient way and is very advantageous in that the amount of iridium complex can be remarkably reduced.

摘要翻译： 本发明涉及在至少一种手性铱络合物的存在下，通过分子氢在不饱和酮或不饱和醛的缩醛中缩酮的不对称氢化的方法。 该方法以非常有效的方式产生手性化合物，并且非常有利的是铱络合物的量可以显着降低。