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    SOLID-PHASE SUPPORT FOR OLIGONUCLEOTIDE SYNTHESIS AND OLIGONUCLEOTIDE SYNTHESIS METHOD
    2.
    发明申请
    SOLID-PHASE SUPPORT FOR OLIGONUCLEOTIDE SYNTHESIS AND OLIGONUCLEOTIDE SYNTHESIS METHOD 有权
    寡核苷酸合成和寡核苷酸合成方法的固相支持

    公开(公告)号：US20130317206A1

    公开(公告)日：2013-11-28

    申请号：US13901266

    申请日：2013-05-23

    申请人： Nitto Denko Corporation

    发明人： Eri MAETA ,  Kenjiro MORI ,  Kazuya MIWA

    IPC分类号： C08F22/10 ,  C07H21/04

    CPC分类号： C08F22/105 ,  C07B35/04 ,  C07B61/02 ,  C07H19/04 ,  C07H19/06 ,  C07H19/16 ,  C07H21/04 ,  C08F2/18 ,  C08F8/12 ,  C08F12/22 ,  C08F212/08 ,  C08F212/36 ,  C08F2800/20 ,  C08F2220/286 ,  C08F212/14

    摘要： The present invention provides a solid-phase support for oligonucleotide synthesis for synthesizing long chain oligonucleotide, RNA oligonucleotide and modified oligonucleotide at high synthetic quantity and high purity with a low loading amount of a linker. Provided is a solid-phase support for oligonucleotide synthesis comprising a porous resin bead having a monovinyl monomer unit, a crosslinkable vinyl monomer unit and a polyethylene glycol unit and a cleavable linker loaded on its surface, the porous resin bead having a group capable of binding to a carboxy group by a dehydration condensation reaction on its surface, the cleavable linker having a carboxy group, wherein the carboxy group of the cleavable linker is bound to the group capable of binding to a carboxy group, by a dehydration condensation reaction, and a loading amount of the cleavable linker is 1 to 80 μmol/g relative to the weight of the porous resin bead.

    摘要翻译： 本发明提供了一种用于合成高链寡核苷酸，RNA寡核苷酸和高合成量和高纯度的具有低负载量的接头的高纯度的修饰的寡核苷酸的寡核苷酸合成的固相支持物。 提供了一种用于寡核苷酸合成的固相载体，其包含具有单乙烯基单体单元，可交联乙烯基单体单元和聚乙二醇单元的多孔树脂珠粒和其表面上负载的可切割连接物，所述多孔树脂珠粒具有能够结合的基团 通过其表面上的脱水缩合反应与羧基反应，可切割接头具有羧基，其中可切割接头的羧基通过脱水缩合反应与能结合羧基的基团结合，并且 可切割接头的负载量相对于多孔树脂珠的重量为1〜80μmol/ g。

    Dehydrogenation process
    3.
    发明授权
    Dehydrogenation process 失效
    脱氢工艺

    公开(公告)号：US08324388B2

    公开(公告)日：2012-12-04

    申请号：US12279548

    申请日：2007-02-07

    申请人： Stefan Kotrel ,  Martin Ernst

    发明人： Stefan Kotrel ,  Martin Ernst

    IPC分类号： C07D213/133

    CPC分类号： C07B35/04 ,  C07D213/06 ,  C07D213/133

    摘要： Processes comprising: providing a dehydrogenatable compound; and subjecting the dehydrogenatable compound to a dehydrogenation reaction at a temperature of from 150 to 400° C., in the presence of oxygen, and at a temperature profile of the dehydrogenation reaction which does not differ substantially from the temperature profile of the dehydrogenation reaction in the absence of oxygen under otherwise identical conditions.

    摘要翻译： 方法包括：提供可脱氢化合物; 并在150-400℃的温度下，在氧的存在下，在脱氢反应的温度分布下使脱氢反应进行脱氢反应，其脱氢反应的温度曲线与脱氢反应的温度曲线基本上不同 在其他相同条件下不存在氧气。

    DEHYDROGENATION PROCESS
    4.
    发明申请
    DEHYDROGENATION PROCESS 失效
    脱氢方法

    公开(公告)号：US20090099368A1

    公开(公告)日：2009-04-16

    申请号：US12279548

    申请日：2007-02-07

    申请人： Stefan Kotrel ,  Martin Ernst

    发明人： Stefan Kotrel ,  Martin Ernst

    IPC分类号： C07D213/00

    CPC分类号： C07B35/04 ,  C07D213/06 ,  C07D213/133

    摘要： Processes comprising: providing a dehydrogenatable compound; and subjecting the dehydrogenatable compound to a dehydrogenation reaction at a temperature of from 150 to 400° C., in the presence of oxygen, and at a temperature profile of the dehydrogenation reaction which does not differ substantially from the temperature profile of the dehydrogenation reaction in the absence of oxygen under otherwise identical conditions.

    摘要翻译： 方法包括：提供可脱氢化合物; 并在150-400℃的温度下，在氧的存在下，在脱氢反应的温度分布下使脱氢反应进行脱氢反应，其脱氢反应的温度曲线与脱氢反应的温度曲线基本上不同 在其他相同条件下不存在氧气。

    REACTOR FOR CARRYING OUT A CONTINUOUS OXYDEHYDROGENATION AND PROCESS
    5.
    发明申请
    REACTOR FOR CARRYING OUT A CONTINUOUS OXYDEHYDROGENATION AND PROCESS 有权
    用于实施连续氧化脱氢和过程的反应器

    公开(公告)号：US20080214883A1

    公开(公告)日：2008-09-04

    申请号：US11959067

    申请日：2007-12-18

    申请人： Gerhard OLBERT ,  Franz Corr ,  Sven Crone

    发明人： Gerhard OLBERT ,  Franz Corr ,  Sven Crone

    IPC分类号： C07C5/327 ,  B01J19/18

    CPC分类号： C07B35/04 ,  B01F5/0453 ,  B01J8/085 ,  B01J8/12 ,  C07C5/333 ,  C07C5/48 ,  C07C2521/04 ,  C07C2521/06 ,  C07C2521/08 ,  C07C2521/10 ,  C07C2523/02 ,  C07C2523/06 ,  C07C2523/08 ,  C07C2523/10 ,  C07C2523/12 ,  C07C2523/14 ,  C07C2523/42 ,  C07C2523/44 ,  Y02P20/52 ,  Y10T137/87652 ,  C07C11/06 ,  C07C11/02 ,  C07C11/08

    摘要： A reactor (1) for carrying out a continuous oxydehydrogenation of a feed gas stream (2) of saturated hydrocarbons after premixing with an oxygen-comprising gas stream (3) over a moving catalyst bed (4) which is introduced in the longitudinal direction of their reactor between two concentric cylindrical holding devices (5, 6) so as to leave a central interior space (7) and an intermediate space (8) between the moving catalyst bed (4) and the interior wall of the reactor to give a reaction gas mixture, wherein the reactor (1) has two or more reactor sections (9) which are separated from one another by disk-shaped deflection plates (10) arranged alternately in the central interior space (7) and divided in subregions by annular deflection plates (11) arranged in the intermediate space between the moving catalyst bed (4) and the interior wall of the reactor, in each case with a mixing-in device (12) which is located upstream of the moving catalyst bed (4) in the flow direction of the reaction gas mixture and comprises the following elements: two or three rows arranged behind one another of tubes (13) which have turbulence generators on their outside and constrict the flow cross section for the feed gas stream (2) to from ½ to 1/10 of the free flow cross section, with the oxygen-comprising gas stream (3) being passed through the interior spaces of the tubes (13) and being injected via openings (14) in the tubes (13) into the feed gas stream (2), and a perforated plate (17) upstream of the tubes (13) and a perforated plate (18) downstream of the tubes (13), is proposed.

    摘要翻译： 一种反应器（1），用于在与含氧气流（3）预先混合在移动的催化剂床（4）上进行饱和烃的进料气流（2）的连续氧化脱氢，所述催化剂床沿着纵向方向被引入 它们的反应器在两个同心的圆柱形保持装置（5,6）之间，以便在移动的催化剂床（4）和反应器的内壁之间留下中心的内部空间（7）和中间空间（8），以产生反应 气体混合物，其中所述反应器（1）具有两个或更多个反应器部分（9），所述反应器部分（9）通过交替设置在所述中心内部空间（7）中的盘形偏转板（10）彼此分开，并且通过环形偏转 布置在移动的催化剂床（4）和反应器的内壁之间的中间空间中的板（11），在每种情况下都具有位于移动催化剂床（4）上游的混合装置（12） 反应气体混合物的流动方向并且包括以下元件：彼此相邻的管（13）彼此排列的两排或三排，其外侧具有湍流发生器，并将进料气流（2）的流动横截面收缩 自由流动横截面的1/2至1/10，含氧气流（3）通过管（13）的内部空间，并通过管（13）中的开口（14）注入到管 进料气流（2）和管（13）上游的多孔板（17）和管（13）下游的多孔板（18）。

    Process for alkane group dehydrogenation with organometallic catalyst
    7.
    发明授权
    Process for alkane group dehydrogenation with organometallic catalyst 失效
    用有机金属催化剂进行烷烃脱氢的方法

    公开(公告)号：US5780701A

    公开(公告)日：1998-07-14

    申请号：US687717

    申请日：1996-07-26

    申请人： William C. Kaska ,  Craig M. Jensen

    发明人： William C. Kaska ,  Craig M. Jensen

    IPC分类号： B01J31/18 ,  B01J31/24 ,  C07B35/04 ,  C07C5/333 ,  C07F15/00 ,  C07C5/327 ,  C07C5/373 ,  C07F15/02

    CPC分类号： B01J31/24 ,  B01J31/18 ,  C07B35/04 ,  C07C5/333 ,  C07F15/0033 ,  C07F15/0073 ,  B01J2531/0244 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/825 ,  B01J2531/827 ,  B01J2531/828 ,  C07C2531/22

    摘要： An improved process is described for the catalytic dehydrogenation of organic molecules having a ##STR1## group to produce a ##STR2## group. The organic molecules are: ##STR3## wherein: A.sup.1, A.sup.2, A.sup.3, and A.sup.4 are each independently P, As or N: E.sup.2 is independently C or N; E.sup.3 is independently C, Si or Ge; E.sup.4 is independently C, Si, or Ge; and E.sup.5 is independently C, Si or Ge; M.sup.1, M.sup.2, M.sup.3, and M.sup.4 each is a metal atom independently selected from the group consisting of ruthenium, rhodium, palladium, osmium, iridium and platinum; Q.sup.1, Q.sup.2, Q.sup.3, and Q.sup.4 are each independently a direct bond, --CH.sub.2 --, --CH.sub.2 CH.sub.2 --, or CH.dbd.CH--; in structure I, structure II or structure IV, R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are each independently selected from alkyl, alkenyl, cycloalkyl, and aryl, or R.sup.1 and R.sup.2 together and R.sup.3 and R.sup.4 together form a ring structure having from 4 to 10 carbon atoms, or in structure III, R.sup.5, R.sup.6, R.sup.7, and R.sup.8 are each independently selected from alkyl, alkenyl, cycloalkyl, and aryl, or R.sup.5 and R.sup.6 together and R.sup.7 and R.sup.8 together form a ring structure having from 4 to 10 carbon atoms, at a temperature of between about 100.degree. and 250.degree. C. for between about 1 hr and 300 days in the absence of N.sub.2. The surprisingly stable catalyst is a complex of an organic ligand comprising H, C, Si, N, P atoms, and a platinum group metal. The dehydrogenation is performed between about 100 to 200.degree. C., and has increased turnover.

    摘要翻译： 对于具有组的有机分子的催化脱氢来描述用于产生组的改进方法。 有机分子是：其中：A1，A2，A3和A4各自独立地为P，As或N：E2独立地为C或N; E3独立地为C，Si或Ge; E4独立地为C，Si或Ge; 而E5独立地为C，Si或Ge; M1，M2，M3和M4各自是独立地选自钌，铑，钯，锇，铱和铂的金属原子; Q1，Q2，Q3和Q4各自独立地为直接键，-CH 2 - ， - CH 2 CH 2 - 或CH = CH-; 在结构I，结构II或结构IV中，R 1，R 2，R 3和R 4各自独立地选自烷基，烯基，环烷基和芳基，或者R 1和R 2一起并且R 3和R 4一起形成具有4至 10个碳原子，或在结构III中，R 5，R 6，R 7和R 8各自独立地选自烷基，烯基，环烷基和芳基，或者R 5和R 6一起并且R 7和R 8一起形成具有4至10个 碳原子，在约100℃至250℃的温度下，在不存在N 2的情况下约1小时至300天。 惊人稳定的催化剂是包含H，C，Si，N，P原子和铂族金属的有机配体的络合物。 脱氢在约100至200℃之间进行，并且具有增加的周转率。