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    Cooling Compounds
    54.
    发明申请
    Cooling Compounds 审中-公开
    冷却化合物

    公开(公告)号：US20080319055A1

    公开(公告)日：2008-12-25

    申请号：US11884980

    申请日：2006-03-15

    申请人： Lucienne Cole ,  Stefan Michael Furrer ,  Christophe C. Galopin ,  Pablo Victor Krawec ,  Jay Patrick Slack

    发明人： Lucienne Cole ,  Stefan Michael Furrer ,  Christophe C. Galopin ,  Pablo Victor Krawec ,  Jay Patrick Slack

    IPC分类号： A61K31/166 ,  A61K31/277 ,  A61K31/235 ,  A61K31/357 ,  C07C229/54 ,  C07C255/58 ,  C07C233/67 ,  C07D317/68

    CPC分类号： C07C233/65 ,  A23L27/204 ,  A23L27/205 ,  A24B15/301 ,  A24B15/36 ,  A24B15/385 ,  A61K8/42 ,  A61K8/4973 ,  A61K2800/244 ,  A61Q11/00 ,  C07C255/57 ,  C07C2601/14 ,  C07C2602/42 ,  C07D317/48

    摘要： A method of providing a cooling sensation to the skin or the mucous membranes of the body by applying thereto a compound of Formula I in which X is H or (CH2)n—R, n is 0 or 1, Y and Z are selected independently from the group consisting of H, OH, phenyl, C1-C4 straight or branched alkyl, or, a C1-C4 straight or branched alkoxy, or X and Y form together a bivalent radical selected from the group consisting of —O—CH2—O—, —N═CH—O— and —N═CH—S— which forms together with the carbon atoms to which they are attached a 5-membered ring; and R is a group with non-bonding electrons, R1 is H or C1-C5 branched alkyl, R2 and R3 are C1-C4 branched alkyls, or R2 and R3 taken together form a monocyclic, bicyclic or tricyclic radical of up to 10 carbons provided that R1, R2 and R3 together comprise at least 6 carbons. The compounds may be incorporated into products such as dentifrices, foodstuffs, confectionery, beverages, and cosmetic and medicinal preparations.

    摘要翻译： 通过向其中施加X为H或（CH 2）n R，n为0或1的式I化合物，其中Y和Z独立地选自其中的任意一种，可以向身体的皮肤或粘膜提供冷却感觉的方法， 由H，OH，苯基，C 1 -C 4直链或支链烷基或C 1 -C 4直链或支链烷氧基组成的基团，或X和Y一起形成选自-O-CH 2 -O- ，-N-CH-O-和-N-CH-S-与它们所连接的碳原子一起形成5元环; 并且R是具有非键合电子的基团，R 1是H或C 1 -C 5支链烷基，R 2和R 3是C 1 -C 4支链烷基，或者R 2和R 3一起形成多至10个碳的单环，双环或三环基团 条件是R1，R2和R3一起包含至少6个碳。 这些化合物可以掺入诸如洁牙剂，食品，糖果，饮料，化妆品和药物制剂的产品中。

    Method For Producing Optionally Substituted Methylenedioxybenzene
    55.
    发明申请
    Method For Producing Optionally Substituted Methylenedioxybenzene 有权
    制备任选取代的亚甲基二氧基苯的方法

    公开(公告)号：US20080021228A1

    公开(公告)日：2008-01-24

    申请号：US11587293

    申请日：2005-04-19

    申请人： Roland Jacquot ,  Jean-Roger Desmurs

    发明人： Roland Jacquot ,  Jean-Roger Desmurs

    IPC分类号： C07D317/50

    CPC分类号： C07D317/50 ,  C07D317/46 ,  C07D317/48

    摘要： The invention relates to a method for producing optionally substituted methylenedioxybenzene. The invention particularly relates to the production of methylenedioxybenzene. The inventive production method is characterized by the fact that it involves the reaction of an optionally substituted catechol with an aldehyde in the presence of a solid acid catalyst selected among: a titanium silicalite and a zeolite that is doped with tin and/or titanium.

    摘要翻译： 本发明涉及一种生产任选取代的亚甲二氧基苯的方法。 本发明特别涉及亚甲二氧基苯的制备。 本发明的制备方法的特征在于它包括在选自以下的固体酸催化剂存在下任选取代的邻苯二酚与醛的反应：钛硅沸石和掺杂有锡和/或钛的沸石。

    Carboxylic acid compounds and medicinal compositions containing the same as the active ingredient
    56.
    发明申请
    Carboxylic acid compounds and medicinal compositions containing the same as the active ingredient 有权
    羧酸化合物和含有与活性成分相同的药物组合物

    公开(公告)号：US20070004716A1

    公开(公告)日：2007-01-04

    申请号：US10572578

    申请日：2004-09-16

    申请人： Atsushi Naganawa ,  Maki Iwahashi ,  Atsushi Kinoshita ,  Atsushi Shimabukuro ,  SeijiKoji Ogawa ,  Koji Yano ,  Kaoru Kobayashi ,  Yutaka Okada ,  Yoko Kishida ,  Shouji Kawauchi ,  Kohki Tsukamoto ,  Yoko Matsunaga ,  Fumio Nambu

    发明人： Atsushi Naganawa ,  Maki Iwahashi ,  Atsushi Kinoshita ,  Atsushi Shimabukuro ,  SeijiKoji Ogawa ,  Koji Yano ,  Kaoru Kobayashi ,  Yutaka Okada ,  Yoko Kishida ,  Shouji Kawauchi ,  Kohki Tsukamoto ,  Yoko Matsunaga ,  Fumio Nambu

    IPC分类号： A61K31/538 ,  C07D265/36

    CPC分类号： C07D307/80 ,  A61K31/343 ,  A61K31/538 ,  C07D265/36 ,  C07D317/48

    摘要： A compound represented by formula (I) wherein the symbols in the formula are the same meanings as those in specification, salts thereof, solvates thereof, or prodrugs thereof binds to DP receptor and shows antagonistic activity for DP receptor. Thus, it is useful for prevention and/or treatment of diseases such as allergic disease (e.g., allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, urticaria, eczema, diseases accompanied by itch (e.g., atopic dermatitis and urticaria), diseases (e.g., cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (e.g., scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis, etc. Since it specifically binds to DP receptor and binds weakly to other prostaglandins receptors, they can be pharmaceuticals having little side effect.

    摘要翻译： 由式（I）表示的化合物，其中式中的符号与说明书中的符号相同，其盐，溶剂合物或其前药与DP受体结合并显示DP受体的拮抗活性。 因此，它可用于预防和/或治疗过敏性疾病（例如过敏性鼻炎，过敏性结膜炎，特应性皮炎，支气管哮喘和食物过敏），系统性肥大细胞增多症，伴有全身性肥大细胞活化的病症，过敏性休克， 支气管收缩，荨麻疹，湿疹，伴有瘙痒的疾病（例如特应性皮炎和荨麻疹），伴随瘙痒的行为的结果产生的疾病（例如白内障，视网膜脱离，炎症，感染和睡眠障碍）（例如， 搔抓和殴打），炎症，慢性阻塞性肺疾病，缺血再灌注损伤，脑血管意外，慢性类风湿关节炎，胸膜炎，溃疡性结肠炎等。由于其特异性结合DP受体并且弱结合到其他前列腺素受体，它们可以是具有 小副作用。

    Pesticidal compositions containing benzodioxole derivatives and methods of combating pests
    60.
    发明授权
    Pesticidal compositions containing benzodioxole derivatives and methods of combating pests 失效
    含有苯并间二氧杂环戊烯衍生物的杀虫剂组合物和防治害虫的方法

    公开(公告)号：US4056625A

    公开(公告)日：1977-11-01

    申请号：US641925

    申请日：1975-12-18

    申请人： Peter Stuart Gates ,  John Gillon

    发明人： Peter Stuart Gates ,  John Gillon

    IPC分类号： C07D317/46 ,  C07D317/48 ,  C07D317/64 ,  C07D317/72 ,  A01N9/28

    CPC分类号： C07D317/72 ,  C07D317/46 ,  C07D317/48 ,  C07D317/64

    摘要： Substituted benzodioxoles of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are hydrogen or alkyl of 1 to 6 carbon atoms or together with the linking carbon atom form a cycloalkane or cycloalkene ring of 5 to 7 carbon atoms;R.sup.3 is hydrogen, alkyl of 1 to 4 carbon atoms or acyl;R.sup.4 is alkyl of up to 4 carbon atoms, alkenyl of up to 4 carbon atoms or alkynyl of up to 4 carbon atoms; andR.sup.5, r.sup.6 and R.sup.7 are hydrogen, halogen or alkyl of 1 to 4 carbon atomsAre valuable pesticides, particularly insecticides.

    摘要翻译： 取代的下式的苯并二恶烷：其中R 1和R 2是氢或1至6个碳原子的烷基或与连接碳原子一起形成5至7个碳原子的环烷烃或环烯烃环; R3是氢，1至4个碳原子的烷基或酰基; R4是至多4个碳原子的烷基，至多4个碳原子的链烯基或至多4个碳原子的炔基; 并且R 5，R 6和R 7是氢，卤素或1至4个碳原子的烷基是有价值的杀虫剂，特别是杀虫剂。