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    N-substituted p-menthane carboxamides
    2.
    发明授权
    N-substituted p-menthane carboxamides 有权
    N-取代的对薄荷烷甲酰胺

    公开(公告)号：US07414152B2

    公开(公告)日：2008-08-19

    申请号：US11437294

    申请日：2006-05-19

    Applicant: Christophe C. Galopin ,  Pablo Victor Krawec ,  Jay Patrick Slack ,  Lori W. Tigani

    Inventor： Christophe C. Galopin ,  Pablo Victor Krawec ,  Jay Patrick Slack ,  Lori W. Tigani

    IPC: C07C233/58 ,  A61K31/165

    CPC classification number: C07C255/60 ,  A61K8/42 ,  A61K2800/244 ,  A61Q11/00 ,  A61Q19/00 ,  C07C233/60 ,  C07C233/61 ,  C07C255/42 ,  C07C255/44 ,  C07C311/46 ,  C07C2601/14

    Abstract: Cooling compounds are provided having the formula: wherein, m is 0 or 1, Y and Z are selected independently from the group consisting of H, OH, C1-C4 straight or branched alkyl, and a C1-C4 straight or branched alkoxy, X is (CH2)n—R, where n is 0 or 1 and R is a group with non-bonding electrons, with the provisos that: (a) when Y and Z are H, X is not F, OH, MeO or NO2 in the 4-position and is not OH in the 2 or 6-position (b) when Y or Z is H then X, Y and Z are such that (i) the groups in the 3- and 4-positions are not both OMe, (ii) the groups in the 4- and 5-positions are not both OMe, (iii) the groups in 3- and 5-positions are not OMe if the group in the 4-position is OH, and (iv) the groups in the 3- and 5-positions are not OH if the group in the 4-position is methyl.

    Abstract translation: 提供具有下式的冷却化合物：其中m为0或1，Y和Z独立地选自H，OH，C 1 -C 4直链或支链烷基和C 1 -C 4直链或支链烷氧基，X 其中n为0或1，R为具有非键合电子的基团，前提条件是：（a）当Y（Y）为（CH 2） 并且Z是H，X不是4位的F，OH，MeO或NO 2 2，并且在Y或Z是H时不在2或6位（b）中的OH，则X ，Y和Z为（i）3-和4-位的基团不同时为OMe，（ii）4-和5-位的基团不同时为OMe，（iii）3 - 和5-位不是OMe，如果4位的基团是OH，和（iv）如果4位的基团是甲基，那么3-和5-位的基团不是OH。

    N-substituted P-menthane carboxamides
    3.
    再颁专利
    N-substituted P-menthane carboxamides 有权
    N-取代的对 - 薄荷烷甲酰胺

    公开(公告)号：USRE44339E1

    公开(公告)日：2013-07-02

    申请号：US13222947

    申请日：2011-08-31

    Applicant: Christophe C. Galopin ,  Pablo Victor Krawec ,  Jay Patrick Slack ,  Lori W. Tigani

    Inventor： Christophe C. Galopin ,  Pablo Victor Krawec ,  Jay Patrick Slack ,  Lori W. Tigani

    IPC: C07C233/58 ,  A61K31/165

    CPC classification number: C07C255/60 ,  A61K8/42 ,  A61K2800/244 ,  A61Q11/00 ,  A61Q19/00 ,  C07C233/60 ,  C07C233/61 ,  C07C255/42 ,  C07C255/44 ,  C07C311/46 ,  C07C2601/14

    Abstract: Cooling compounds are provided having the formula: wherein, m is 0 or 1, Y and Z are selected independently from the group consisting of H, OH, C1-C4 straight or branched alkyl, and a C1-C4 straight or branched alkoxy, X is (CH2)n—R, where n is 0 or 1 and R is a group with non-bonding electrons, with the provisos that: (a) when Y and Z are H, X is not F, OH, MeO or NO2 in the 4-position and is not OH in the 2 or 6-position (b) when Y or Z is H then X, Y and Z are such that (i) the groups in the 3- and 4-positions are not both OMe, (ii) the groups in the 4- and 5-positions are not both OMe, (iii) the groups in 3- and 5-positions are not OMe if the group in the 4-position is OH, and (iv) the groups in the 3- and 5-positions are not OH if the group in the 4-position is methyl.

    Abstract translation: 提供具有下式的冷却化合物：其中m为0或1，Y和Z独立地选自H，OH，C 1 -C 4直链或支链烷基和C 1 -C 4直链或支链烷氧基，X 是（CH 2）n R，其中n是0或1，R是具有非键合电子的基团，条件是：（a）当Y和Z为H时，X不为F，OH，MeO或NO 2 4位，而当Y或Z为H时，不是2或6位的OH（b），那么X，Y和Z使得（i）3位和4位的基团不同时为OMe， （ii）4位和5位的基团不能同时为OMe，（iii）如果4位的基团为OH，则3位和5位的基团不为OMe，（iv）基团 如果4-位上的基团是甲基，则3-和5-位不是OH。

    Cooling compounds
    5.
    发明申请
    Cooling compounds 审中-公开
    冷却化合物

    公开(公告)号：US20090105237A1

    公开(公告)日：2009-04-23

    申请号：US11920813

    申请日：2006-05-24

    Applicant: Karen Ann Bell ,  Stefan Michael Furrer ,  Christophe C. Galopin ,  Pablo Victor Krawec ,  Jay Patrick Slack

    Inventor： Karen Ann Bell ,  Stefan Michael Furrer ,  Christophe C. Galopin ,  Pablo Victor Krawec ,  Jay Patrick Slack

    IPC: A61K31/167 ,  A61K31/4965 ,  A61K31/357 ,  C07D295/14 ,  C07C229/40 ,  C07C237/24 ,  A61P17/00 ,  C07C229/36 ,  C07D317/30 ,  A61K31/216 ,  A61K31/5375

    CPC classification number: C07C237/42 ,  A23G3/34 ,  A23G4/06 ,  A23L27/204 ,  A61K8/42 ,  A61K8/494 ,  A61K2800/244 ,  A61Q11/00 ,  A61Q19/00 ,  C07C2601/14 ,  C07D295/192

    Abstract: A method of conferring a cooling effect on the skin or mucous membranes by applying thereto at least one compound of the Formula I: (a) wherein B is selected from H, CH3, C2H5, OCH3, OC2H5; and OH; and (b) wherein A is a moiety of the formula —CO-D, wherein D is selected from the following moieties: (i) —NR1R2, wherein R1 and R2 are independently selected from H and C1-C8 straight or branched-chain aliphatic, alkoxyalkyl, hydroxyalkyl, araliphatic and cycloalkyl groups, or R1 and R2 together with the nitrogen atom to which they are attached form part of an optionally-substituted, five- or six-membered heterocyclic ring; (ii) —NHCH2COOCH2CH3, —NHCH2CONH2, —NHCH2CH2OCH3, —NHCH2CH2OH, —NHCH2CH(OH)CH2OH and (iii) a moiety selected from the group consisting of: The compounds are useful for providing cooling effects in a variety of products, such as foodstuffs, confectionery, tobacco products, beverages, cosmetics, dentifrices, medicinal preparations, mouthwashes and toiletries.

    Abstract translation: 通过施用至少一种式I的化合物，赋予皮肤或粘膜冷却效果的方法：（a）其中B选自H，CH 3，C 2 H 5，OCH 3，OC 2 H 5; 和OH; 和（b）其中A是式-CO-D的部分，其中D选自以下部分：（i）-NR 1 R 2，其中R 1和R 2独立地选自H和C 1 -C 8直链或支链 脂族，烷氧基烷基，羟基烷基，芳脂族和环烷基，或者R1和R2与它们所连接的氮原子一起形成任选取代的五元或六元杂环的一部分; （ii）-NHCH 2 COOCH 2 CH 3，-NHCH 2 CONH 2，-NHCH 2 CH 2 OCH 3，-NHCH 2 CH 2 OH，-NHCH 2 CH（OH）CH 2 OH和（iii）选自以下的部分：该化合物可用于在各种产品中提供冷却效果， 食品，糖果，烟草制品，饮料，化妆品，洁牙剂，药用制剂，漱口剂和洗浴用品。

    Cooling Compounds
    8.
    发明申请
    Cooling Compounds 审中-公开
    冷却化合物

    公开(公告)号：US20080319055A1

    公开(公告)日：2008-12-25

    申请号：US11884980

    申请日：2006-03-15

    Applicant: Lucienne Cole ,  Stefan Michael Furrer ,  Christophe C. Galopin ,  Pablo Victor Krawec ,  Jay Patrick Slack

    Inventor： Lucienne Cole ,  Stefan Michael Furrer ,  Christophe C. Galopin ,  Pablo Victor Krawec ,  Jay Patrick Slack

    IPC: A61K31/166 ,  A61K31/277 ,  A61K31/235 ,  A61K31/357 ,  C07C229/54 ,  C07C255/58 ,  C07C233/67 ,  C07D317/68

    CPC classification number: C07C233/65 ,  A23L27/204 ,  A23L27/205 ,  A24B15/301 ,  A24B15/36 ,  A24B15/385 ,  A61K8/42 ,  A61K8/4973 ,  A61K2800/244 ,  A61Q11/00 ,  C07C255/57 ,  C07C2601/14 ,  C07C2602/42 ,  C07D317/48

    Abstract: A method of providing a cooling sensation to the skin or the mucous membranes of the body by applying thereto a compound of Formula I in which X is H or (CH2)n—R, n is 0 or 1, Y and Z are selected independently from the group consisting of H, OH, phenyl, C1-C4 straight or branched alkyl, or, a C1-C4 straight or branched alkoxy, or X and Y form together a bivalent radical selected from the group consisting of —O—CH2—O—, —N═CH—O— and —N═CH—S— which forms together with the carbon atoms to which they are attached a 5-membered ring; and R is a group with non-bonding electrons, R1 is H or C1-C5 branched alkyl, R2 and R3 are C1-C4 branched alkyls, or R2 and R3 taken together form a monocyclic, bicyclic or tricyclic radical of up to 10 carbons provided that R1, R2 and R3 together comprise at least 6 carbons. The compounds may be incorporated into products such as dentifrices, foodstuffs, confectionery, beverages, and cosmetic and medicinal preparations.

    Abstract translation: 通过向其中施加X为H或（CH 2）n R，n为0或1的式I化合物，其中Y和Z独立地选自其中的任意一种，可以向身体的皮肤或粘膜提供冷却感觉的方法， 由H，OH，苯基，C 1 -C 4直链或支链烷基或C 1 -C 4直链或支链烷氧基组成的基团，或X和Y一起形成选自-O-CH 2 -O- ，-N-CH-O-和-N-CH-S-与它们所连接的碳原子一起形成5元环; 并且R是具有非键合电子的基团，R 1是H或C 1 -C 5支链烷基，R 2和R 3是C 1 -C 4支链烷基，或者R 2和R 3一起形成多至10个碳的单环，双环或三环基团 条件是R1，R2和R3一起包含至少6个碳。 这些化合物可以掺入诸如洁牙剂，食品，糖果，饮料，化妆品和药物制剂的产品中。

    Taste Enhancement
    10.
    发明申请
    Taste Enhancement 审中-公开
    口味增强

    公开(公告)号：US20130302497A1

    公开(公告)日：2013-11-14

    申请号：US13822023

    申请日：2011-09-13

    Applicant: Tarun Bhowmik ,  Yili Wang ,  Pablo Victor Krawec

    Inventor： Tarun Bhowmik ,  Yili Wang ,  Pablo Victor Krawec

    IPC: A23L1/22

    CPC classification number: A23L27/88 ,  A23L27/202 ,  A23L27/30

    Abstract: A method of enhancing a taste sensation in a consumable composition, comprising the addition thereto of a taste provider selected from a taste provider compound and a mixture of a taste provider compound with a taste enhancement compound, there being additionally added thereto a taste sensation-enhancing quantity of choline chloride.

    Abstract translation: 一种增加消耗性组合物中的味觉感觉的方法，包括向味道提供者添加选自味道提供者化合物和味道提供者化合物与味觉增强化合物的混合物的添加剂，另外添加了味觉增强剂 氯化胆碱的量。

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