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    Cooling Compounds
    2.
    发明申请
    Cooling Compounds 审中-公开
    冷却化合物

    公开(公告)号：US20080319055A1

    公开(公告)日：2008-12-25

    申请号：US11884980

    申请日：2006-03-15

    Applicant: Lucienne Cole ,  Stefan Michael Furrer ,  Christophe C. Galopin ,  Pablo Victor Krawec ,  Jay Patrick Slack

    Inventor： Lucienne Cole ,  Stefan Michael Furrer ,  Christophe C. Galopin ,  Pablo Victor Krawec ,  Jay Patrick Slack

    IPC: A61K31/166 ,  A61K31/277 ,  A61K31/235 ,  A61K31/357 ,  C07C229/54 ,  C07C255/58 ,  C07C233/67 ,  C07D317/68

    CPC classification number: C07C233/65 ,  A23L27/204 ,  A23L27/205 ,  A24B15/301 ,  A24B15/36 ,  A24B15/385 ,  A61K8/42 ,  A61K8/4973 ,  A61K2800/244 ,  A61Q11/00 ,  C07C255/57 ,  C07C2601/14 ,  C07C2602/42 ,  C07D317/48

    Abstract: A method of providing a cooling sensation to the skin or the mucous membranes of the body by applying thereto a compound of Formula I in which X is H or (CH2)n—R, n is 0 or 1, Y and Z are selected independently from the group consisting of H, OH, phenyl, C1-C4 straight or branched alkyl, or, a C1-C4 straight or branched alkoxy, or X and Y form together a bivalent radical selected from the group consisting of —O—CH2—O—, —N═CH—O— and —N═CH—S— which forms together with the carbon atoms to which they are attached a 5-membered ring; and R is a group with non-bonding electrons, R1 is H or C1-C5 branched alkyl, R2 and R3 are C1-C4 branched alkyls, or R2 and R3 taken together form a monocyclic, bicyclic or tricyclic radical of up to 10 carbons provided that R1, R2 and R3 together comprise at least 6 carbons. The compounds may be incorporated into products such as dentifrices, foodstuffs, confectionery, beverages, and cosmetic and medicinal preparations.

    Abstract translation: 通过向其中施加X为H或（CH 2）n R，n为0或1的式I化合物，其中Y和Z独立地选自其中的任意一种，可以向身体的皮肤或粘膜提供冷却感觉的方法， 由H，OH，苯基，C 1 -C 4直链或支链烷基或C 1 -C 4直链或支链烷氧基组成的基团，或X和Y一起形成选自-O-CH 2 -O- ，-N-CH-O-和-N-CH-S-与它们所连接的碳原子一起形成5元环; 并且R是具有非键合电子的基团，R 1是H或C 1 -C 5支链烷基，R 2和R 3是C 1 -C 4支链烷基，或者R 2和R 3一起形成多至10个碳的单环，双环或三环基团 条件是R1，R2和R3一起包含至少6个碳。 这些化合物可以掺入诸如洁牙剂，食品，糖果，饮料，化妆品和药物制剂的产品中。

    Methods for treatment predicated on the presence of advanced glycosylation endproducts in tobacco and its combustion byproducts
    4.
    发明授权
    Methods for treatment predicated on the presence of advanced glycosylation endproducts in tobacco and its combustion byproducts 失效
    治疗方法是基于烟草及其燃烧副产物中先进的糖基化终产物的存在

    公开(公告)号：US6110968A

    公开(公告)日：2000-08-29

    申请号：US189191

    申请日：1998-11-10

    Applicant: Richard J. Bucala ,  Helen Vlassara ,  Anthony Cerami ,  Carla J. Cerami ,  Henry W. Founds

    Inventor： Richard J. Bucala ,  Helen Vlassara ,  Anthony Cerami ,  Carla J. Cerami ,  Henry W. Founds

    IPC: A24B15/36 ,  A24D3/14 ,  A61K31/27 ,  A61K31/275

    CPC classification number: G01N33/6842 ,  A24B15/36 ,  A24B15/365 ,  A24D3/14

    Abstract: Methods are provided for measuring the accumulation of advanced glycosylation endproducts (AGEs), and for lowering the accumulation of advanced glycosylation endproducts, which are predicated on the discovery that such AGEs and their precedent glycotoxins are present in tobacco and its byproducts. More particularly, the methods focus on the observation that individuals who smoke or otherwise use tobacco have increased levels of AGEs relative to non-smoking individuals. The present methods relate to the measurement of AGE levels in both individuals and in tobacco and its byproduct, smoke, and to the treatment of such individuals with agents capable of reacting with glycosylation products to either avert or diminish the accretion of AGEs in the body. Methods are also provided for the evaluation of the tobacco products to determine their storage status and organoleptic capacity and potential, for the treatment of the ambient atmosphere to lower AGE levels, and for the treatment of the tobacco products and combustion byproducts to lower AGE levels therein. For example, air or other samples may be taken and evaluated by a dosimeter or like device, to determine whether AGE levels exceed normal, after which measures could be implemented to remediate the ambient condition. Likewise, filters and similar devices for removing AGEs from tobacco smoke are provided. All such methods and corresponding materials are contemplated and included.

    Abstract translation: 提供了用于测量晚期糖基化终产物（AGEs）的积累以及用于降低晚期糖基化终产物的积累的方法，其基于发现这样的AGEs及其先例的糖类毒素存在于烟草及其副产物中。 更具体地说，这些方法着重于观察吸烟或以其他方式使用烟草的个体相对于非吸烟者的AGEs水平的增加。 本方法涉及测量个体和烟草及其副产物，烟雾中的AGE水平，以及能够与糖基化产物反应的试剂对这些个体的治疗，以反转或减少AGEs在体内的积累。 还提供了用于评价烟草制品以确定其储存状态和感官能力和潜力的方法，用于处理环境大气以降低AGE水平，以及用于处理烟草制品和燃烧副产物以降低其AGE水平 。 例如，空气或其他样品可以通过剂量计或类似装置进行评估，以确定AGE水平是否超过正常，之后可以实施措施来修复环境条件。 同样，提供了用于从AGE烟草烟雾中除去的过滤器和类似装置。 所有这些方法和相应的材料都被考虑并包括在内。

    Methods for measurement and treatment predicated on the presence of advanced glycosylation endproducts in tobacco and its combustion byproducts
    5.
    发明授权
    Methods for measurement and treatment predicated on the presence of advanced glycosylation endproducts in tobacco and its combustion byproducts 失效
    基于烟草及其燃烧副产物中高级糖基化终产物的存在的测量和处理方法

    公开(公告)号：US5850840A

    公开(公告)日：1998-12-22

    申请号：US772335

    申请日：1996-12-23

    Applicant: Carla J. Cerami ,  Richard J. Bucala ,  Helen Vlassara ,  Anthony Cerami ,  Henry W. Founds

    Inventor： Carla J. Cerami ,  Richard J. Bucala ,  Helen Vlassara ,  Anthony Cerami ,  Henry W. Founds

    IPC: A24B15/36 ,  A24D3/14 ,  A24D3/16 ,  A24F1/10

    CPC classification number: G01N33/6842 ,  A24B15/36 ,  A24B15/365 ,  A24D3/14 ,  A24D3/16

    Abstract: Methods are provided for measuring the accumulation of advanced glycosylation endproducts (AGEs), and for lowering the accumulation of advanced glycosylation endproducts, which are predicated on the discovery that such AGEs and their precedent glycotoxins are present in tobacco and its byproducts. More particularly, the methods focus on the observation that individuals who smoke or otherwise use tobacco have increased levels of AGEs relative to non-smoking individuals. The present methods relate to the measurement of AGE levels in both individuals and in tobacco and its byproduct, smoke, and to the treatment of such individuals with agents capable of reacting with glycosylation products to either avert or diminish the accretion of AGEs in the body. Methods are also provided for the evaluation of the tobacco products to determine their storage status and organoleptic capacity and potential, for the treatment of the ambient atmosphere to lower AGE levels, and for the treatment of the tobacco products and combustion byproducts to lower AGE levels therein. For example, air or other samples may be taken and evaluated by a dosimeter or like device, to determine whether AGE levels exceed normal, after which measures could be implemented to remediate the ambient condition. Likewise, filters and similar devices for removing AGEs from tobacco smoke are provided. All such methods and corresponding materials are contemplated and included.

    Abstract translation: 提供了用于测量晚期糖基化终产物（AGEs）的积累以及用于降低晚期糖基化终产物的积累的方法，其基于发现这样的AGEs及其先例的糖类毒素存在于烟草及其副产物中。 更具体地说，这些方法着重于观察吸烟或以其他方式使用烟草的个体相对于非吸烟者的AGEs水平的增加。 本方法涉及测量个体和烟草及其副产物，烟雾中的AGE水平，以及能够与糖基化产物反应的试剂对这些个体的治疗，以反转或减少AGEs在体内的积累。 还提供了用于评价烟草制品以确定其储存状态和感官能力和潜力的方法，用于处理环境大气以降低AGE水平，以及用于处理烟草制品和燃烧副产物以降低其AGE水平 。 例如，空气或其他样品可以通过剂量计或类似装置进行评估，以确定AGE水平是否超过正常，之后可以实施措施来修复环境条件。 同样，提供了用于从AGE烟草烟雾中除去的过滤器和类似装置。 所有这些方法和相应的材料都被考虑并包括在内。

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