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    Ectoparasitic insect pest controllers for animals and their usage
    51.
    发明申请
    Ectoparasitic insect pest controllers for animals and their usage 有权
    用于动物的寄生虫害虫控制器及其用途

    公开(公告)号：US20030199579A1

    公开(公告)日：2003-10-23

    申请号：US10399327

    申请日：2003-05-21

    Inventor： Rikio Yamaguchi ,  Tetsuyoshi Nishimatsu ,  Kazuhiro Takagi

    IPC: A01N037/12 ,  A01N047/34 ,  A01N037/44 ,  A01N037/34

    CPC classification number: A01N37/18 ,  A01N37/24 ,  A01N37/34 ,  A01N37/44 ,  A01N47/34 ,  A01N47/40 ,  C07C243/22 ,  C07C251/44 ,  C07C251/86 ,  C07C255/66 ,  C07C281/06 ,  C07C281/14 ,  C07C317/42 ,  C07C323/44 ,  C07C337/06 ,  C07C337/08

    Abstract: 1 Ectoparasitic insect pest controllers for animals, containing hydrazine derivatives of the general formula (I) as the active ingredient, and methods for application of the same: (I) nullwherein A is (II), (III), (IV), (V) (wherein R4 and R5 are each H, C1-6alkyl, or the like; and X is H, or one to five substituents selected from among halogeno and optionally halogenated C1-6alkyl groups); R1 is H or C1-6alkyl; R2 and R3 are each H, OH, C1-6alkyl, phenylcarbonyl, or the like; Y is H, or one to five substituents selected from among halogeno, nitro, and cyano; Z is halogeno, cyano, C1-6alkyl, or the like; and W is O or Snull. The insect pest controllers exert remarkable controlling effects on parasitic insect pests harmful to domestic or pet animals, e.g. fleas, lice, ticks.

    Abstract translation: 含有通式（I）的肼衍生物作为活性成分的动物的寄生虫害虫控制剂及其应用方法：（I）[其中A是（II），（III），（IV）， V）（其中R 4和R 5各自为H，C 1-6烷基等; X为H，或1至5个选自卤代和任意卤代的C 1-6烷基的取代基）; R 1是H或C 1-6烷基; R 2和R 3各自为H，OH，C 1-6烷基，苯基羰基等; Y是H或选自卤代，硝基和氰基的一至五个取代基; Z是卤代，氰基，C 1-6烷基等; W为O或S]。 昆虫害虫控制剂对对家畜或宠物有害的寄生昆虫害虫具有显着的防治作用， 跳蚤，虱子，蜱虫。

    HALOGENATED ANTITUBERCULOSIS AGENTS
    52.
    发明申请
    HALOGENATED ANTITUBERCULOSIS AGENTS 失效
    致病抗体药物

    公开(公告)号：US20020173548A1

    公开(公告)日：2002-11-21

    申请号：US09803006

    申请日：2001-03-09

    Inventor： Farzad Kobarfard ,  Joel M. Kauffman

    IPC: A61K031/175 ,  C07C337/02 ,  C07C281/02

    CPC classification number: C07C281/14 ,  C07C337/08

    Abstract: Halogenated derivatives of two synthetic anti-tuberculosis agents, thioacetazone and p-aminosalicylic acid, have been synthesized. In general, the halogenated compound has the structure of Structure I: 1 wherein X1 is a halogen and X2 is a second halogen or hydrogen, and Y is sulfur or oxygen; or, has the structure of Structure IV: 2 wherein X1 is a halogen and X2 is a second halogen or hydrogen. Alternatively, the halogenated compounds may be pharmaceutically acceptable salts of these compounds. These halogenated derivatives possess anti-mycobacterial activity and are particularly useful for the treatment of Mycobacterium tuberculosis infections. In particular, fluorinated analogs of thioacetazone and p-amino-salicylic acid have been synthesized for use as anti-tuberculosis therapeutic agents either alone or in combination with other conventional anti-tuberculosis therapeutic agents.

    Abstract translation: 已经合成了两种合成抗结核药物硫代乙酮和对氨基水杨酸的卤代衍生物。 通常，卤代化合物具有结构I的结构：其中X1是卤素，X2是第二个卤素或氢，Y是硫或氧; 或具有结构IV的结构：其中X1是卤素，X2是第二个卤素或氢。 或者，卤化化合物可以是这些化合物的药学上可接受的盐。 这些卤代衍生物具有抗分枝杆菌活性，特别可用于治疗结核分枝杆菌感染。 特别地，已经合成硫代乙酮和对氨基水杨酸的氟化类似物单独使用或与其它常规抗结核治疗剂组合用作抗结核治疗剂。

    Triazine derivative, production and use thereof
    54.
    发明授权
    Triazine derivative, production and use thereof 失效
    三嗪衍生物，其生产和使用

    公开(公告)号：US06211178B1

    公开(公告)日：2001-04-03

    申请号：US09335918

    申请日：1999-06-18

    Applicant: Hideki Miki ,  Koichi Iwanaga ,  Toshimi Matsuno ,  Isao Aoki

    Inventor： Hideki Miki ,  Koichi Iwanaga ,  Toshimi Matsuno ,  Isao Aoki

    IPC: A61K3153

    CPC classification number: C07D253/06 ,  A01N43/707 ,  C07C281/10 ,  C07C281/14 ,  C07C323/48 ,  C07D213/61 ,  C07D253/07 ,  C07D253/075 ,  C07D271/06 ,  C07D277/32 ,  C07D333/28 ,  C07D401/04 ,  C07D401/10 ,  C07D403/12 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10

    Abstract: The present invention provides a novel triazine derivative of the formula wherein ring A is an optionally substituted aromatic group which be; X is an oxygen or sulfur atom; R1 and R6 are each a hydrogen atom or an optionally substituted hydrocarbon residue or heterocyclic group which may bound through a hetero-atom; R2 and R3 are each independently a hydrogen atom, a halogen atom, or a group bound through a carbon, oxygen or sulfur atom, or taken together, represent ═S; R4 and R5 are each independently a hydrogen atom, a halogen atom, or a group bound through a carbon, oxygen, nitrogen or sulfur atom; R1 and R2, and R5 and R6, may each bind together to form a chemical bond; provided that where ring A is a phenyl group having at least a halogen atom in position-2 or 4 and X is an oxygen atom, R4 and R5 do not conjoinedly represent a chemical bond and an antiprotozoan composition containing the same or salt thereof.

    Abstract translation: 本发明提供了一种新的三氟乙烯衍生物，其中A为任选取代的芳基，X为氧或硫原子; R 1和R 6各自为氢原子或任选取代的烃残基或可结合的杂环基 通过杂原子; R 2和R 3各自独立地为氢原子，卤素原子或通过碳，氧或硫原子结合的基团，或一起表示= S; R 4和R 5各自独立地为氢原子 卤素原子或通过碳，氧，氮或硫原子结合的基团; R 1和R 2以及R 5和R 6可以各自键合在一起形成化学键; 条件是当环A为至少具有2或4位的卤素原子且X为氧原子的苯基时，R 4和R 5不连结地表示化学键，而含有该化合键的抗原生动物组合物或其盐。

    Intermediates for cephalosporin compounds
    57.
    发明授权
    Intermediates for cephalosporin compounds 失效
    头孢菌素化合物的中间体

    公开(公告)号：US5126444A

    公开(公告)日：1992-06-30

    申请号：US733152

    申请日：1991-07-19

    Applicant: David G. Acton ,  David H. Davies ,  Jeffrey P. Poyser

    Inventor： David G. Acton ,  David H. Davies ,  Jeffrey P. Poyser

    IPC: C07D501/38 ,  A61K31/545 ,  A61K31/546 ,  C07C281/14 ,  C07D501/18 ,  C07D501/46

    CPC classification number: C07D501/46 ,  C07C281/14

    Abstract: Cephalosporin antibiotics having a 3-position substituent of the formula: ##STR1## are described; wherein R.sup.1 is hydrogen or certain substituted alkyl groups, Z is CH or N, R.sup.2 and R.sup.3 are hydroxy or in vivo hydrolysable esters thereof, (R.sup.12).sub.n represents various optional substituents and X=Y is an olefin, oxime, azo or related group. Processes for their preparation and use are described.

    Abstract translation: 描述具有下式的3位取代基的头孢菌素抗生素：; 其中R 1是氢或某些取代的烷基，Z是CH或N，R 2和R 3是羟基或其体内可水解的酯，（R 12）n表示各种任选的取代基，X = Y是烯烃，肟，偶氮或相关基团 。 描述了其制备和使用的方法。

    Benzylidenesemicarbazide compounds having insecticidal activity
    58.
    发明授权
    Benzylidenesemicarbazide compounds having insecticidal activity 失效
    具有杀虫活性的苯甲酰氨基脲化合物

    公开(公告)号：US3885042A

    公开(公告)日：1975-05-20

    申请号：US33000473

    申请日：1973-02-06

    Applicant: PHILIPS CORP

    Inventor： MULDER RUDOLF ,  HANDELE MARTIN JACOB

    IPC: A01N47/34 ,  C07C67/00 ,  C07C239/00 ,  C07C281/08 ,  C07C281/14 ,  A01N9/12 ,  A01N9/20

    CPC classification number: C07C281/14

    Abstract: Insecticidal use of compounds of the formula

    WHEREIN R is a moiety selected from the group consisting of 3,4dichloro and para-positioned substituents selected from the group consisting of hydrogen, chlorine, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbons and amino substituted with 1 to 2 alkyls of 1 to 4 carbons each, and A is a member selected from the group consisting of hydrogen, cyclopropyl, alkyl of 1 to 4 carbons, phenyl substituted alkyl of 1 to 4 carbons and halogen substituted alkyl of 1 to 4 carbons, B is a moiety selected from the group consisting of hydrogen and methyl, R'' is a moiety selected from the group consisting of 3, 4 dichloro and parapositioned substituents selected from the group consisting of chlorine, alkyl of 1 to 4 carbons, alkoxy of 1 to 4 carbons, and amino containing 1 to 2 alkyls of 1 to 4 carbons.

    Abstract translation: 杀虫剂使用下式的化合物，其中R是选自3,4-二氯和对位的取代基的部分，所述取代基选自氢，氯，1至4个碳原子的烷基，1至 4个碳原子和1〜2个碳原子数为1〜2的烷基取代的氨基，A为选自氢，环丙基，碳原子数1〜4的烷基，碳原子数1〜4的苯基取代烷基，卤素取代基 1至4个碳原子的烷基，B是选自氢和甲基的部分，R'是选自3,4-二氯和对位取代基的部分，所述取代基选自氯，烷基 1至4个碳的烷氧基，1至4个碳原子的烷氧基和1至2个碳原子数为1至2的烷基的氨基。

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